SMT202000208T1 - Derivati di 2-(2,4,5-anilino-sostituita) pirimidina come modulatori di egfr utili per trattare il cancro - Google Patents

Derivati di 2-(2,4,5-anilino-sostituita) pirimidina come modulatori di egfr utili per trattare il cancro

Info

Publication number
SMT202000208T1
SMT202000208T1 SM20200208T SMT202000208T SMT202000208T1 SM T202000208 T1 SMT202000208 T1 SM T202000208T1 SM 20200208 T SM20200208 T SM 20200208T SM T202000208 T SMT202000208 T SM T202000208T SM T202000208 T1 SMT202000208 T1 SM T202000208T1
Authority
SM
San Marino
Prior art keywords
anilino
substituted
treating cancer
pyrimidine derivatives
modulators useful
Prior art date
Application number
SM20200208T
Other languages
English (en)
Inventor
Sam Butterworth
Maurice Raymond Verschoyle Finlay
Richard Andrew Ward
Heather Marie Redfearn
Vasantha Krishna Kadambar
Chandrasekhara Reddy Chintakuntla
Andiappan Murugan
Claudio Edmundo Chuaqui
Original Assignee
Astrazeneca Ab
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46875901&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT202000208(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SMT202000208T1 publication Critical patent/SMT202000208T1/it

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)
  • Luminescent Compositions (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
SM20200208T 2011-07-27 2012-07-25 Derivati di 2-(2,4,5-anilino-sostituita) pirimidina come modulatori di egfr utili per trattare il cancro SMT202000208T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161512061P 2011-07-27 2011-07-27
US201261591363P 2012-01-27 2012-01-27
EP17194307.9A EP3333161B1 (en) 2011-07-27 2012-07-25 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer

Publications (1)

Publication Number Publication Date
SMT202000208T1 true SMT202000208T1 (it) 2020-05-08

Family

ID=46875901

Family Applications (3)

Application Number Title Priority Date Filing Date
SM20210652T SMT202100652T1 (it) 2011-07-27 2012-07-25 Composti di 2-(2,4,5-anilino-sostituita) pirimidina
SM20200208T SMT202000208T1 (it) 2011-07-27 2012-07-25 Derivati di 2-(2,4,5-anilino-sostituita) pirimidina come modulatori di egfr utili per trattare il cancro
SM201600070T SMT201600070B (it) 2011-07-27 2016-03-10 Derivati di 2-(2,4,5-anilino-sostituita) pirimidina come modulatori di egfr utili per trattare il cancro

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SM20210652T SMT202100652T1 (it) 2011-07-27 2012-07-25 Composti di 2-(2,4,5-anilino-sostituita) pirimidina

Family Applications After (1)

Application Number Title Priority Date Filing Date
SM201600070T SMT201600070B (it) 2011-07-27 2016-03-10 Derivati di 2-(2,4,5-anilino-sostituita) pirimidina come modulatori di egfr utili per trattare il cancro

Country Status (38)

Country Link
US (8) US8946235B2 (it)
EP (7) EP4119551A1 (it)
JP (3) JP5427321B2 (it)
KR (3) KR101422619B1 (it)
CN (7) CN103702990B (it)
AR (1) AR087336A1 (it)
AU (1) AU2012288626C1 (it)
BR (4) BR122014026114B1 (it)
CA (5) CA2881991C (it)
CL (1) CL2013003281A1 (it)
CO (1) CO6811863A2 (it)
CR (1) CR20130629A (it)
CY (4) CY1117431T1 (it)
DK (5) DK3686193T3 (it)
DO (1) DOP2013000263A (it)
EA (3) EA033733B1 (it)
EC (1) ECSP13013033A (it)
ES (5) ES2564671T3 (it)
GT (1) GT201300288A (it)
HR (4) HRP20211682T1 (it)
HU (4) HUE026429T2 (it)
IL (6) IL229199A (it)
LT (3) LT3686194T (it)
ME (3) ME02887B (it)
MX (3) MX377900B (it)
MY (2) MY194532A (it)
NI (1) NI201300134A (it)
PE (1) PE20141700A1 (it)
PH (2) PH12013502312A1 (it)
PL (5) PL3686194T3 (it)
PT (4) PT3686194T (it)
RS (4) RS56679B1 (it)
SG (5) SG10201910986QA (it)
SI (4) SI3009431T1 (it)
SM (3) SMT202100652T1 (it)
TW (3) TWI583386B (it)
UY (1) UY34219A (it)
WO (1) WO2013014448A1 (it)

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