SMT202000371T1 - Derivati della piperidina diarilmetilidene e loro uso come agonisti dei recettori degli oppioidi delta - Google Patents

Derivati della piperidina diarilmetilidene e loro uso come agonisti dei recettori degli oppioidi delta

Info

Publication number
SMT202000371T1
SMT202000371T1 SM20200371T SMT202000371T SMT202000371T1 SM T202000371 T1 SMT202000371 T1 SM T202000371T1 SM 20200371 T SM20200371 T SM 20200371T SM T202000371 T SMT202000371 T SM T202000371T SM T202000371 T1 SMT202000371 T1 SM T202000371T1
Authority
SM
San Marino
Prior art keywords
receptor agonists
opioid receptor
piperidine derivatives
delta opioid
diarylmethylidene piperidine
Prior art date
Application number
SM20200371T
Other languages
English (en)
Inventor
Ingemar Starke
Mentzer Bengt Von
Peter Brandt
Original Assignee
Pharmnovo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmnovo Ab filed Critical Pharmnovo Ab
Publication of SMT202000371T1 publication Critical patent/SMT202000371T1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
SM20200371T 2014-12-19 2015-12-17 Derivati della piperidina diarilmetilidene e loro uso come agonisti dei recettori degli oppioidi delta SMT202000371T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1451616 2014-12-19
EP15870465.0A EP3233825B1 (en) 2014-12-19 2015-12-17 Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
PCT/SE2015/051363 WO2016099393A1 (en) 2014-12-19 2015-12-17 Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists

Publications (1)

Publication Number Publication Date
SMT202000371T1 true SMT202000371T1 (it) 2020-09-10

Family

ID=56127081

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20200371T SMT202000371T1 (it) 2014-12-19 2015-12-17 Derivati della piperidina diarilmetilidene e loro uso come agonisti dei recettori degli oppioidi delta

Country Status (17)

Country Link
US (1) US10118921B2 (it)
EP (1) EP3233825B1 (it)
JP (1) JP6691135B2 (it)
CN (1) CN107531670B (it)
AU (1) AU2015363757B2 (it)
CA (1) CA2970256C (it)
DK (1) DK3233825T3 (it)
ES (1) ES2808667T3 (it)
HR (1) HRP20201050T1 (it)
HU (1) HUE050241T2 (it)
LT (1) LT3233825T (it)
PL (1) PL3233825T3 (it)
PT (1) PT3233825T (it)
RS (1) RS60744B1 (it)
SI (1) SI3233825T1 (it)
SM (1) SMT202000371T1 (it)
WO (1) WO2016099393A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230174525A1 (en) * 2020-07-17 2023-06-08 Pharmnovo Ab Polymorphs of a hydrochloride salt of pn6047

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE0101768D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0103313D0 (sv) * 2001-10-03 2001-10-03 Astrazeneca Ab Novel compounds
SE0300103D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300105D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0300987D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301445D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
MY148880A (en) * 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression

Also Published As

Publication number Publication date
JP2018501314A (ja) 2018-01-18
SI3233825T1 (sl) 2020-10-30
HUE050241T2 (hu) 2020-11-30
EP3233825A4 (en) 2018-08-15
EP3233825A1 (en) 2017-10-25
CA2970256C (en) 2022-03-29
LT3233825T (lt) 2020-08-10
DK3233825T3 (da) 2020-06-29
PT3233825T (pt) 2020-07-15
JP6691135B2 (ja) 2020-04-28
AU2015363757A1 (en) 2017-08-03
EP3233825B1 (en) 2020-04-29
HRP20201050T1 (hr) 2020-10-30
US10118921B2 (en) 2018-11-06
CA2970256A1 (en) 2016-06-23
PL3233825T3 (pl) 2020-11-02
ES2808667T3 (es) 2021-03-01
CN107531670B (zh) 2020-12-15
AU2015363757B2 (en) 2019-11-14
US20170327491A1 (en) 2017-11-16
WO2016099393A1 (en) 2016-06-23
CN107531670A (zh) 2018-01-02
RS60744B1 (sr) 2020-10-30

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