SMT202000372T1 - Metodo di purificazione di coniugati a base di il-15/il-15ralfa - Google Patents

Metodo di purificazione di coniugati a base di il-15/il-15ralfa

Info

Publication number
SMT202000372T1
SMT202000372T1 SM20200372T SMT202000372T SMT202000372T1 SM T202000372 T1 SMT202000372 T1 SM T202000372T1 SM 20200372 T SM20200372 T SM 20200372T SM T202000372 T SMT202000372 T SM T202000372T SM T202000372 T1 SMT202000372 T1 SM T202000372T1
Authority
SM
San Marino
Prior art keywords
15ralpha
purification method
based conjugates
conjugates purification
purification
Prior art date
Application number
SM20200372T
Other languages
English (en)
Inventor
David Bechard
Martynoff Guy De
Original Assignee
Cytune Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytune Pharma filed Critical Cytune Pharma
Publication of SMT202000372T1 publication Critical patent/SMT202000372T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SM20200372T 2014-03-03 2015-03-03 Metodo di purificazione di coniugati a base di il-15/il-15ralfa SMT202000372T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14000742.8A EP2915569A1 (en) 2014-03-03 2014-03-03 IL-15/IL-15Ralpha based conjugates purification method
PCT/EP2015/000473 WO2015131994A1 (en) 2014-03-03 2015-03-03 Il-15/il-15ralpha based conjugates purification method
EP15708730.5A EP3113858B1 (en) 2014-03-03 2015-03-03 Il-15/il-15ralpha based conjugates purification method

Publications (1)

Publication Number Publication Date
SMT202000372T1 true SMT202000372T1 (it) 2020-09-10

Family

ID=50235863

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20200372T SMT202000372T1 (it) 2014-03-03 2015-03-03 Metodo di purificazione di coniugati a base di il-15/il-15ralfa

Country Status (21)

Country Link
US (2) US10808022B2 (it)
EP (2) EP2915569A1 (it)
JP (2) JP2017509618A (it)
KR (1) KR102361954B1 (it)
CN (2) CN111018946B (it)
AU (2) AU2015226504B2 (it)
CA (1) CA2938649C (it)
CY (1) CY1123450T1 (it)
DK (1) DK3113858T3 (it)
ES (1) ES2807758T3 (it)
HR (1) HRP20201122T1 (it)
HU (1) HUE050138T2 (it)
IL (1) IL247469B (it)
LT (1) LT3113858T (it)
PL (1) PL3113858T3 (it)
PT (1) PT3113858T (it)
RS (1) RS60627B1 (it)
RU (1) RU2701301C2 (it)
SI (1) SI3113858T1 (it)
SM (1) SMT202000372T1 (it)
WO (1) WO2015131994A1 (it)

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Publication number Publication date
ES2807758T3 (es) 2021-02-24
SI3113858T1 (sl) 2020-10-30
PL3113858T3 (pl) 2020-11-02
CN111018946B (zh) 2024-04-05
EP2915569A1 (en) 2015-09-09
RU2016138469A (ru) 2018-04-04
KR102361954B1 (ko) 2022-02-11
CY1123450T1 (el) 2022-03-24
HRP20201122T1 (hr) 2021-01-22
IL247469A0 (en) 2016-11-30
AU2019203422A1 (en) 2019-06-06
KR20160127035A (ko) 2016-11-02
WO2015131994A1 (en) 2015-09-11
JP2017509618A (ja) 2017-04-06
PT3113858T (pt) 2020-07-24
US20170056874A1 (en) 2017-03-02
IL247469B (en) 2022-03-01
JP2020063288A (ja) 2020-04-23
CA2938649A1 (en) 2015-09-11
RS60627B1 (sr) 2020-09-30
DK3113858T3 (da) 2020-07-27
RU2701301C2 (ru) 2019-09-25
AU2015226504B2 (en) 2019-04-18
AU2019203422B2 (en) 2020-04-30
HUE050138T2 (hu) 2020-11-30
RU2016138469A3 (it) 2018-09-19
AU2015226504A1 (en) 2016-09-08
US10808022B2 (en) 2020-10-20
EP3113858B1 (en) 2020-05-06
US12060407B2 (en) 2024-08-13
US20210009658A1 (en) 2021-01-14
CA2938649C (en) 2023-10-17
JP7086920B2 (ja) 2022-06-20
CN111018946A (zh) 2020-04-17
CN106457070A (zh) 2017-02-22
EP3113858A1 (en) 2017-01-11
LT3113858T (lt) 2020-08-10
CN106457070B (zh) 2020-01-10

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