SU1405703A3 - Способ получени 2-метил-4-гидрокси-2Н-1,2-бензотиазин-1,1-диоксид-3-N-(2-пиридил)-карбоксамида - Google Patents

Способ получени 2-метил-4-гидрокси-2Н-1,2-бензотиазин-1,1-диоксид-3-N-(2-пиридил)-карбоксамида Download PDF

Info

Publication number: SU1405703A3
Authority: SU; USSR - Soviet Union
Prior art keywords: methyl; dioxide; benzothiazine; carboxamide; pyridyl
Prior art date: 1983-10-06

Application number

SU843805901A

Other languages

English (en)

Russian (ru)

Inventor

Юхани Кайрисало Пекка

Юхани Хонканен Эркки

Эвард Вальдемар Йоханссон Магнус

Карху Матти

Тапио Норе Пентти

Килликки Пиппури Айно

Ритва Хелена Куримо Ирма

Original Assignee

Пфайзер Инк. (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-06

Filing date

1984-10-05

Publication date

1988-06-23

1984-10-05 Application filed by Пфайзер Инк. (Фирма) filed Critical Пфайзер Инк. (Фирма)

1988-06-23 Application granted granted Critical

1988-06-23 Publication of SU1405703A3 publication Critical patent/SU1405703A3/ru

Links

238000000034 method Methods 0.000 title claims description 5
ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 claims description 10
OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 claims description 6
238000007098 aminolysis reaction Methods 0.000 claims description 4
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
239000012442 inert solvent Substances 0.000 claims 1
239000000047 product Substances 0.000 description 5
YMWUJEATGCHHMB-UHFFFAOYSA-N dichloromethane Substances ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 3
229960002702 piroxicam Drugs 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
230000003110 anti-inflammatory effect Effects 0.000 description 2
239000003054 catalyst Substances 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
239000000203 mixture Substances 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
WJGAPUXHSQQWQF-UHFFFAOYSA-N acetic acid;hydrochloride Chemical compound Cl.CC(O)=O WJGAPUXHSQQWQF-UHFFFAOYSA-N 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
230000001760 anti-analgesic effect Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
244000309464 bull Species 0.000 description 1
150000003857 carboxamides Chemical class 0.000 description 1
150000007942 carboxylates Chemical class 0.000 description 1
150000002391 heterocyclic compounds Chemical class 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
229910052611 pyroxene Inorganic materials 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
235000012712 vegetable carbon Nutrition 0.000 description 1
239000004108 vegetable carbon Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

SU843805901A 1983-10-06 1984-10-05 Способ получени 2-метил-4-гидрокси-2Н-1,2-бензотиазин-1,1-диоксид-3-N-(2-пиридил)-карбоксамида SU1405703A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI833628A FI72317C (fi)	1983-10-06	1983-10-06	Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-metyl-4-hydroxi-2h-1,2-benzotiazin-1,1-dioxid -3-(n-2-pyridyl)-karboxamid och i foerfarandet anvaendbar mellanprodukt.

Publications (1)

Publication Number	Publication Date
SU1405703A3 true SU1405703A3 (ru)	1988-06-23

Family

ID=8517867

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU843805901A SU1405703A3 (ru)	1983-10-06	1984-10-05	Способ получени 2-метил-4-гидрокси-2Н-1,2-бензотиазин-1,1-диоксид-3-N-(2-пиридил)-карбоксамида

Country Status (16)

Country	Link
AT (1)	AT387775B (cs)
BE (1)	BE900758A (cs)
CA (1)	CA1246066A (cs)
CS (1)	CS253593B2 (cs)
DD (1)	DD224594A5 (cs)
DK (1)	DK154504C (cs)
ES (1)	ES8505937A1 (cs)
FI (1)	FI72317C (cs)
HU (2)	HU194559B (cs)
IT (1)	IT1218850B (cs)
NO (1)	NO159275C (cs)
PL (1)	PL143957B1 (cs)
PT (1)	PT79326B (cs)
SE (2)	SE460789B (cs)
SU (1)	SU1405703A3 (cs)
YU (2)	YU43381B (cs)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4289879A (en) *	1980-09-29	1981-09-15	Pfizer Inc.	Synthetic method and intermediate for piroxicam
JPH08270888A (ja) *	1995-03-30	1996-10-15	Nec Eng Ltd	断熱締結機構

1983
- 1983-10-06 FI FI833628A patent/FI72317C/fi not_active IP Right Cessation
1984
- 1984-10-01 NO NO843949A patent/NO159275C/no not_active IP Right Cessation
- 1984-10-02 DK DK471284A patent/DK154504C/da not_active IP Right Cessation
- 1984-10-03 HU HU843746A patent/HU194559B/hu unknown
- 1984-10-03 HU HU844649A patent/HU195493B/hu unknown
- 1984-10-03 CS CS847493A patent/CS253593B2/cs unknown
- 1984-10-04 YU YU1708/84A patent/YU43381B/xx unknown
- 1984-10-04 IT IT22981/84A patent/IT1218850B/it active
- 1984-10-04 PT PT79326A patent/PT79326B/pt not_active IP Right Cessation
- 1984-10-05 ES ES536544A patent/ES8505937A1/es not_active Expired
- 1984-10-05 CA CA000464861A patent/CA1246066A/en not_active Expired
- 1984-10-05 AT AT0316384A patent/AT387775B/de active
- 1984-10-05 SU SU843805901A patent/SU1405703A3/ru active
- 1984-10-05 BE BE0/213782A patent/BE900758A/fr not_active IP Right Cessation
- 1984-10-05 DD DD84268074A patent/DD224594A5/de not_active IP Right Cessation
- 1984-10-05 SE SE8405002A patent/SE460789B/sv not_active IP Right Cessation
- 1984-10-05 PL PL1984249918A patent/PL143957B1/pl unknown
1986
- 1986-08-27 YU YU1496/86A patent/YU43603B/xx unknown
1989
- 1989-01-24 SE SE8900248A patent/SE464411B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI833628A0 (fi)	1983-10-06
IT1218850B (it)	1990-04-24
ES536544A0 (es)	1985-07-01
CS253593B2 (en)	1987-11-12
ATA316384A (de)	1988-08-15
HU195493B (en)	1988-05-30
NO843949L (no)	1985-04-09
YU43381B (en)	1989-06-30
PL143957B1 (en)	1988-03-31
NO159275C (no)	1988-12-14
IT8422981A0 (it)	1984-10-04
BE900758A (fr)	1985-02-01
PL249918A1 (en)	1985-07-30
YU43603B (en)	1989-08-31
SE8900248L (sv)	1989-01-24
FI72317C (fi)	1987-05-11
AT387775B (de)	1989-03-10
DK154504C (da)	1989-04-10
SE460789B (sv)	1989-11-20
FI833628A7 (fi)	1985-04-07
HU194559B (en)	1988-02-29
DK154504B (da)	1988-11-21
HUT37427A (en)	1985-12-28
PT79326B (en)	1986-09-08
SE8405002D0 (sv)	1984-10-05
PT79326A (en)	1984-11-01
NO159275B (no)	1988-09-05
CA1246066A (en)	1988-12-06
YU170884A (en)	1986-12-31
SE464411B (sv)	1991-04-22
SE8405002L (sv)	1985-04-07
ES8505937A1 (es)	1985-07-01
FI72317B (fi)	1987-01-30
DD224594A5 (de)	1985-07-10
SE8900248D0 (sv)	1989-01-24
YU149686A (en)	1986-12-31
DK471284D0 (da)	1984-10-02
DK471284A (da)	1985-04-07

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