SU31432A1 - The method of producing methyl and ethyl amide salicylacetate - Google Patents
The method of producing methyl and ethyl amide salicylacetateInfo
- Publication number
- SU31432A1 SU31432A1 SU123853A SU123853A SU31432A1 SU 31432 A1 SU31432 A1 SU 31432A1 SU 123853 A SU123853 A SU 123853A SU 123853 A SU123853 A SU 123853A SU 31432 A1 SU31432 A1 SU 31432A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- salicylacetate
- producing methyl
- ethyl amide
- amide
- ethyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
в предлагаемом способе получени этилового эфира амидсалицилуксусной кислоты примен ют конденсацию салициламида с этиловым эфиром монохлоруксусной кислоты в абсолютном спирте в присутствии этилата натри In the proposed method of producing amide salicylacetate ethyl ester, salicylamide is condensed with monochloroacetic acid ethyl ester in absolute alcohol in the presence of sodium ethoxide.
НО OCHaCOOCaHsBUT OCHaCOOCaHs
/- jj X1 CaHsONg г ц X/ - jj X1 CaHsONg g c X
-бП4 -{- л./-. rnor н 4 -bP4 - {- l./-. rnor n 4
CONHaС1СН,СООС,Н5 CONH2CONHaС1СН, СООС, Н5 CONH2
Впервые полученный амид имеет точку плавлени 130-131°, мало растворим в холодном спирту, лучше в кип щем, на холоду омыл етс щелочами, дава соответствующую кислоту СбН с температурой плавлени 213 - 215°, впервые выделенную.The amide obtained for the first time has a melting point of 130-131 °, slightly soluble in cold alcohol, preferably in boiling water, washed with alkalis in the cold, giving the corresponding acid СНН with a melting point of 213-215 °, first isolated.
Таким же путем был получен метиловый эфир этой кислоты.In the same way was obtained methyl ester of this acid.
Пример. В п тилитровую колбу с мешалкой и обратным холодильником загружают 2,7 л абсолютного спирта и при помешивании добавл ют 168 г металлического натри . По растворении всего натри добавл ют 1 кг салициламида. Постепенно при помешивании подымают температуру до кипени , добавл ют 1100 г этилового эфира монохлоруксусной кислоты. Нагревание при кипении ведут несколько часов до исчезновени щелочной реакции. Гор чий раствор сливают и по охлаждении выпадает этиловый эфир амидсалицилуксусной кислоты. Выход около от теории.Example. In a five-liter flask with a stirrer and reflux condenser, 2.7 liters of absolute alcohol are charged and 168 g of metallic sodium are added with stirring. Once all the sodium has dissolved, 1 kg of salicylamide is added. While stirring, gradually raising the temperature to a boil, 1100 g of monochloroacetic acid ethyl ester are added. Heating during boiling is carried out for several hours until the alkaline reaction disappears. The hot solution is drained off and upon cooling, ethyl amide salicylacetic acid ethyl ester is precipitated. Exit about from theory.
Предмет изобретени .The subject matter of the invention.
Способ получени метилового или этилового эфира амидсалицилуксусной кислоты, отличающийс тем, что салициламид конденсируют с этиловым или метиловым эфиром монохлоруксусной кислоты в присутствии этилата или метилата натри .A method of producing methyl or ethyl amide salicylacetate, in which salicylamide is condensed with ethyl or methyl monochloroacetic acid in the presence of ethylate or sodium methylate.
CONHa CONHa
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU123853A SU31432A1 (en) | 1933-02-13 | 1933-02-13 | The method of producing methyl and ethyl amide salicylacetate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU123853A SU31432A1 (en) | 1933-02-13 | 1933-02-13 | The method of producing methyl and ethyl amide salicylacetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU31432A1 true SU31432A1 (en) | 1933-08-31 |
Family
ID=48348752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU123853A SU31432A1 (en) | 1933-02-13 | 1933-02-13 | The method of producing methyl and ethyl amide salicylacetate |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU31432A1 (en) |
-
1933
- 1933-02-13 SU SU123853A patent/SU31432A1/en active
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