SU451702A1 - The method of obtaining eight-membered heterocyclic organophosphorus compounds - Google Patents

Description

This invention relates to the field of organophosphorus CHEMISTRY, in particular, to a method for producing new eight-membered heterocyclic organophosphorus compounds of the general formula odH2 (JH2 H-CH3CH2OH (I) sn / R) alkyl C.C. , flotation reagents, corrosion inhibitors, as well as an active base in cosmetic AND WASHING COMPOSITIONS. The proposed method for producing compounds of formula (I) is based on the known method of producing heterocyclic compounds of phospho and by the interaction of phosphonic ACID dihalogen anhydrides with amino alcohols in the presence of pyridine, I conclude that the corresponding alkyl alkylphosphonic ACID dichlorohydrides are reacted with triethanolamine in an organic solvent, for example chloroform. using a chromatographic column filled with OXIDE aluminum. They are light brown thick oils, soluble in water, lower alcohols, halohydrocarbons, and insoluble in ether. The purity of the product is controlled by thin-layer chromatography on alumina in the system toluene - ethanol (9: 1) and benzene - methanol - acetone - acetic acid (70: 20:: 5: 5). About the vodka - iodine vapor The structure of the obtained products was proved by the data of elemental analysis, IR spectra, and mass and NMR spectra. In the IR spectra, bands corresponding to oscillations Р-О-С (1050 cm-), Р 0 (1230 cm-1), Р-С (940, 780 cm-) and ОН (3350-3340 cm-1) were found. communications Example. Diethyl-p, p - (Y-ethoxy) -hexylphosphonate. 44.7 g (0.3 mol) of dry, distilled triethanolamine in 50 ml of dry chloroform are placed in a three-necked flask equipped with a broom, a reverse REFRIGERATOR and an addition funnel. 20.3 g (0.1 mol) of hexylphosphonic acid dichlorohydride in 30 ml of chloroform are added dropwise to this solution for 2.5 hours. The reaction mixture is left

 fc,. four

for the night. Then, filters 1 B1 | e jSbi.atocv, {yield 90.3% of theory) diethyl-p, p- (L-etoloy triethanolamine salt (. L76 - lJ7, Cj); xi) -hexylphosphonate.

blot it with chloroform, and from the filtrate of the Compounds in the table, half-after removal of the solvent, 25.3 grams are isolated under the same conditions. The outputs and the data of elemental analysis of dethyl- ;, - (M-ethoxy) -alkylphosphonates of the general formula / OCHZSigch in-p (; c-sn2CH25n (H ccshsn /

Subject invention

Claims (2)

1. A method of producing eight-membered heterocyclic organophosphorus compounds of the general formula / OCH2CH2ch 11-P (; N-Cii2CiIoO i (I) {1ЧСН2СП2 where R is alkyl Ce-Cy, wherein the alkylphosphonic acid dichloride is reacted with triethanolamine in an organic solvent medium, followed by isolation of the target product by known methods. 2. A method according to claim 1, characterized in that alkylphosphonic acid dichloride and triethanolamine are used in a ratio of 15 scientific research institute 1: 3, respectively.