SU475776A3 - Способ получени 7-хлор-1-(2-диэтиламиноэтил)-5-(2-фторфенил)-1,3-дигидро-2н-1,4-бензодиазепин-2-он-моногидрохлорида - Google Patents

Способ получени 7-хлор-1-(2-диэтиламиноэтил)-5-(2-фторфенил)-1,3-дигидро-2н-1,4-бензодиазепин-2-он-моногидрохлорида

Info

Publication number: SU475776A3
Authority: SU; USSR - Soviet Union
Prior art keywords: diethylaminoethyl; chloro; fluorophenyl; dihydro; benzodiazepin
Prior art date: 1971-06-08

Application number

SU1959119A

Other languages

English (en)

Russian (ru)

Inventor

Хеллербах Жозеф

Original Assignee

Ф.Гоффманн-Ля Рош И Ко.Аг (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-06-08

Filing date

1971-11-29

Publication date

1975-06-30

1971-11-29 Application filed by Ф.Гоффманн-Ля Рош И Ко.Аг (Фирма) filed Critical Ф.Гоффманн-Ля Рош И Ко.Аг (Фирма)

1975-06-30 Application granted granted Critical

1975-06-30 Publication of SU475776A3 publication Critical patent/SU475776A3/ru

Links

-1 2-diethylaminoethyl Chemical group 0.000 title description 11
125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 title description 10
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title description 4
238000000034 method Methods 0.000 title description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
239000000047 product Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
PSLIMVZEAPALCD-UHFFFAOYSA-N ethanol;ethoxyethane Chemical compound CCO.CCOCC PSLIMVZEAPALCD-UHFFFAOYSA-N 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SU1959119A 1971-06-08 1971-11-29 Способ получени 7-хлор-1-(2-диэтиламиноэтил)-5-(2-фторфенил)-1,3-дигидро-2н-1,4-бензодиазепин-2-он-моногидрохлорида SU475776A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH832571A CH553792A (de)	1971-06-08	1971-06-08	Verfahren zur herstellung von 7-chlor-1-(2-diaethyl-aminoaethyl)-5-(2-fluorphenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-on-monohydrochlorid.

Publications (1)

Publication Number	Publication Date
SU475776A3 true SU475776A3 (ru)	1975-06-30

Family

ID=4338591

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SU1959119A SU475776A3 (ru)	1971-06-08	1971-11-29	Способ получени 7-хлор-1-(2-диэтиламиноэтил)-5-(2-фторфенил)-1,3-дигидро-2н-1,4-бензодиазепин-2-он-моногидрохлорида
SU1721027A SU444369A3 (ru)	1971-06-08	1971-11-29	Способ получения 7-хлор-1-(2-диэтиламиноэтил)-5-(2-фторфенил)1,3-дигидро-2н-1,4-бензодиазепин2-он-моногидрохлорида

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SU1721027A SU444369A3 (ru)	1971-06-08	1971-11-29	Способ получения 7-хлор-1-(2-диэтиламиноэтил)-5-(2-фторфенил)1,3-дигидро-2н-1,4-бензодиазепин2-он-моногидрохлорида

Country Status (31)

Country	Link
JP (1)	JPS5230568B1 (fr)
AT (1)	AT313281B (fr)
BE (1)	BE777897A (fr)
BG (1)	BG19173A3 (fr)
BR (1)	BR7108123D0 (fr)
CA (1)	CA945989A (fr)
CH (1)	CH553792A (fr)
CS (2)	CS155105B2 (fr)
CY (1)	CY868A (fr)
DD (1)	DD98679A5 (fr)
DE (1)	DE2157112C3 (fr)
DK (1)	DK127506B (fr)
ES (1)	ES397552A1 (fr)
FI (1)	FI51352C (fr)
FR (1)	FR2140371B1 (fr)
GB (1)	GB1331823A (fr)
HU (1)	HU170152B (fr)
IE (1)	IE35846B1 (fr)
IL (1)	IL38252A (fr)
KE (1)	KE2652A (fr)
LU (1)	LU65469A1 (fr)
MX (1)	MX149567A (fr)
MY (1)	MY7400115A (fr)
NL (1)	NL7116376A (fr)
NO (1)	NO133714C (fr)
PH (1)	PH13530A (fr)
PL (1)	PL81437B1 (fr)
RO (2)	RO59000A (fr)
SE (2)	SE388856B (fr)
SU (2)	SU475776A3 (fr)
ZA (1)	ZA717880B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1199304A1 (fr) *	1997-03-05	2002-04-24	Takeda Chemical Industries, Ltd.	Composés bicycliques et composition pharmaceutique contenant un composé tricyclique pour le traitement ou la prévention de troubles de sommeil

1971
- 1971-02-01 ES ES397552A patent/ES397552A1/es not_active Expired
- 1971-06-08 CH CH832571A patent/CH553792A/xx not_active IP Right Cessation
- 1971-11-15 FI FI713268A patent/FI51352C/fi active
- 1971-11-15 NO NO4214/71A patent/NO133714C/no unknown
- 1971-11-16 SE SE7114654A patent/SE388856B/xx unknown
- 1971-11-16 DK DK561771AA patent/DK127506B/da not_active IP Right Cessation
- 1971-11-17 DE DE2157112A patent/DE2157112C3/de not_active Expired
- 1971-11-17 HU HUHO1433A patent/HU170152B/hu unknown
- 1971-11-18 AT AT996671A patent/AT313281B/de not_active IP Right Cessation
- 1971-11-22 PL PL1971151697A patent/PL81437B1/pl unknown
- 1971-11-23 ZA ZA717880A patent/ZA717880B/xx unknown
- 1971-11-23 CA CA128,336A patent/CA945989A/en not_active Expired
- 1971-11-23 CY CY868A patent/CY868A/xx unknown
- 1971-11-23 GB GB5436871A patent/GB1331823A/en not_active Expired
- 1971-11-24 IE IE1489/71A patent/IE35846B1/xx unknown
- 1971-11-25 BG BG019094A patent/BG19173A3/xx unknown
- 1971-11-29 SU SU1959119A patent/SU475776A3/ru active
- 1971-11-29 SU SU1721027A patent/SU444369A3/ru active
- 1971-11-29 IL IL38252A patent/IL38252A/xx unknown
- 1971-11-29 NL NL7116376A patent/NL7116376A/xx unknown
- 1971-12-02 RO RO68930A patent/RO59000A/ro unknown
- 1971-12-02 RO RO75458A patent/RO58965A/ro unknown
- 1971-12-02 JP JP46096838A patent/JPS5230568B1/ja active Pending
- 1971-12-04 MX MX131834A patent/MX149567A/es unknown
- 1971-12-08 BR BR8123/71A patent/BR7108123D0/pt unknown
- 1971-12-09 PH PH13088A patent/PH13530A/en unknown
- 1971-12-29 DD DD159994A patent/DD98679A5/xx unknown
- 1971-12-30 CS CS913171A patent/CS155105B2/cs unknown
- 1971-12-30 CS CS752472A patent/CS155106B2/cs unknown
1972
- 1972-01-11 FR FR7200802A patent/FR2140371B1/fr not_active Expired
- 1972-01-11 BE BE777897A patent/BE777897A/fr not_active IP Right Cessation
- 1972-06-06 LU LU65469A patent/LU65469A1/xx unknown
1974
- 1974-12-30 MY MY115/74A patent/MY7400115A/xx unknown
1975
- 1975-11-20 SE SE7513088A patent/SE7513088L/xx unknown
1976
- 1976-07-21 KE KE2652*UA patent/KE2652A/xx unknown

Also Published As

Publication number	Publication date
ES397552A1 (es)	1975-03-16
CS155106B2 (fr)	1974-05-30
SE7513088L (sv)	1975-11-20
IL38252A (en)	1974-11-29
NO133714C (fr)	1976-06-16
MY7400115A (en)	1974-12-31
BG19173A3 (bg)	1975-04-30
DE2157112B2 (de)	1980-10-09
FI51352C (fi)	1976-12-10
CS155105B2 (fr)	1974-05-30
RO58965A (fr)	1975-09-15
HU170152B (fr)	1977-04-28
LU65469A1 (fr)	1973-12-14
IL38252A0 (en)	1972-01-27
DK127506B (da)	1973-11-19
DD98679A5 (fr)	1973-07-05
FR2140371A1 (fr)	1973-01-19
CA945989A (en)	1974-04-23
CY868A (en)	1976-12-17
MX149567A (es)	1983-11-25
KE2652A (en)	1976-08-13
GB1331823A (en)	1973-09-26
NO133714B (fr)	1976-03-08
FR2140371B1 (fr)	1975-06-13
FI51352B (fr)	1976-08-31
IE35846B1 (en)	1976-06-09
IE35846L (en)	1972-12-08
BR7108123D0 (pt)	1973-07-03
BE777897A (fr)	1972-07-11
ZA717880B (en)	1973-01-31
JPS5230568B1 (fr)	1977-08-09
PH13530A (en)	1980-06-19
CH553792A (de)	1974-09-13
SU444369A3 (ru)	1974-09-25
NL7116376A (fr)	1972-12-12
PL81437B1 (fr)	1975-08-30
DE2157112A1 (de)	1972-12-28
RO59000A (fr)	1975-12-15
SE388856B (sv)	1976-10-18
DE2157112C3 (de)	1981-09-03
AT313281B (de)	1974-02-11

Similar Documents

Publication	Publication Date	Title
US3121076A (en)	1964-02-11	Benzodiazepinones and processes
SU873887A3 (ru)	1981-10-15	Способ получени производных имидазо/2,1-в/тиазолина или имидазо /2,1-в/тиазина или их кислотно-аддитивных солей,в виде смеси изомеров или отдельных изомеров
SU475776A3 (ru)	1975-06-30	Способ получени 7-хлор-1-(2-диэтиламиноэтил)-5-(2-фторфенил)-1,3-дигидро-2н-1,4-бензодиазепин-2-он-моногидрохлорида
US3560566A (en)	1971-02-02	Diphenyl-ureas,-thioureas,-guanidines and -parabanic acids
SU447886A1 (ru)	1974-10-25	Способ получени защищенной 4,6-0-алкилиден- - -глюкопиранозы
CH520680A (de)	1972-03-31	Verfahren zur Herstellung neuer Mutterkornpeptidalkaloide
DE2510634A1 (de)	1976-09-23	L-3-(3,4-dihydroxy-phenyl)-2- methyl-alanin-peptide und verfahren zu deren herstellung
US3121114A (en)	1964-02-11	Certificate of correction
US4191760A (en)	1980-03-04	Dibenzodiazepines
US3121074A (en)	1964-02-11	Nitro substituted jh-l
US3192199A (en)	1965-06-29	Process for the production of 1-cycloalkyl derivatives of 1, 4-benzodiazepine
SU489327A3 (ru)	1975-10-25	Способ получени четырех замещенных имидазолинов
JPS60231694A (ja)	1985-11-18	アスパルチルペプチドの調整に関する組成物および方法
US3926952A (en)	1975-12-16	1,4-Benzodiazepin-2-ones and their synthesis
CH497384A (de)	1970-10-15	Verfahren zur Herstellung eines Dekapeptides
SU655317A3 (ru)	1979-03-30	Способ получени винкана или его солей,или четвертичных солей
VanVerst et al.	1979	Amine‐induced lossen rearrangements of 3‐hydroxy‐5, 6‐dihydrouracil and N‐hydroxysuccinimide benzenesulfontes
JPH078853B2 (ja)	1995-02-01	ドーパミン誘導体の製法
US3221050A (en)	1965-11-30	2-cycloalkylcarbonylamido-5-halobenzophenones
AT319226B (de)	1974-12-10	Verfahren zur Herstellung von neuen cyclischen Amidinen, ihren Salzen und Estern
SU456410A3 (ru)	1975-01-05	Способ очистки производных 1,4-бензодиазепин-2-она
US3413346A (en)	1968-11-26	2-(2-haloethylamino)-5-halo-benzophenones
US3757006A (en)	1973-09-04	Process for the production of 5-phenyl-1,4-benzodiazepines
US3766169A (en)	1973-10-16	Process for the preparation of 3-aminomethylidene - 1,5 - benzodiazepine-2,4-(3h,5h)-diones
US3499929A (en)	1970-03-10	D(_)-and l(+)-threo-1-p-nitrophenyl-2-n,n-dimethylamino-propane 1,3 - diols and the salts thereof