SU519138A3 - Способ выращивани вируса щура - Google Patents

Способ выращивани вируса щура

Info

Publication number: SU519138A3
Authority: SU; USSR - Soviet Union
Prior art keywords: virus; suspension; cultivation; hours; growing
Prior art date: 1972-02-12

Application number

SU1882920A

Other languages

English (en)

Russian (ru)

Inventor

Ранеберг Хорст-Ульрих

Original Assignee

Байер Аг (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-02-12

Filing date

1973-01-31

Publication date

1976-06-25

1973-01-31 Application filed by Байер Аг (Фирма) filed Critical Байер Аг (Фирма)

1976-06-25 Application granted granted Critical

1976-06-25 Publication of SU519138A3 publication Critical patent/SU519138A3/ru

Links

241000700605 Viruses Species 0.000 title claims description 31
238000000034 method Methods 0.000 title description 5
239000000725 suspension Substances 0.000 claims description 15
241000283690 Bos taurus Species 0.000 claims description 5
210000002919 epithelial cell Anatomy 0.000 claims description 5
210000004027 cell Anatomy 0.000 claims description 3
241000282849 Ruminantia Species 0.000 claims 1
210000004400 mucous membrane Anatomy 0.000 claims 1
210000002784 stomach Anatomy 0.000 claims 1
208000015181 infectious disease Diseases 0.000 description 9
239000000427 antigen Substances 0.000 description 8
108091007433 antigens Proteins 0.000 description 8
102000036639 antigens Human genes 0.000 description 8
239000000203 mixture Substances 0.000 description 7
239000002609 medium Substances 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
235000015097 nutrients Nutrition 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000002458 infectious effect Effects 0.000 description 3
231100000241 scar Toxicity 0.000 description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
239000000084 colloidal system Substances 0.000 description 2
230000000295 complement effect Effects 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000000605 extraction Methods 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
210000004767 rumen Anatomy 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
229960005486 vaccine Drugs 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
239000004470 DL Methionine Substances 0.000 description 1
208000001840 Dandruff Diseases 0.000 description 1
240000006890 Erythroxylum coca Species 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
241000190534 Inkoo virus Species 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
108010093965 Polymyxin B Proteins 0.000 description 1
241000220221 Rosales Species 0.000 description 1
101710140501 Sulfate adenylyltransferase subunit 2 1 Proteins 0.000 description 1
244000299461 Theobroma cacao Species 0.000 description 1
235000009470 Theobroma cacao Nutrition 0.000 description 1
206010047623 Vitamin C deficiency Diseases 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
235000008957 cocaer Nutrition 0.000 description 1
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
230000034994 death Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
208000018459 dissociative disease Diseases 0.000 description 1
239000004744 fabric Substances 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
238000011534 incubation Methods 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
235000006109 methionine Nutrition 0.000 description 1
229940053050 neomycin sulfate Drugs 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
229960000988 nystatin Drugs 0.000 description 1
VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
229940014662 pantothenate Drugs 0.000 description 1
235000019161 pantothenic acid Nutrition 0.000 description 1
239000011713 pantothenic acid Substances 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
229920000024 polymyxin B Polymers 0.000 description 1
229960005266 polymyxin b Drugs 0.000 description 1
208000010233 scurvy Diseases 0.000 description 1
ALNUHUMOGUVHIO-XXJNWDAFSA-M sodium;7-[(1r,2s)-2-hexyl-5-hydroxycyclopentyl]heptanoate Chemical compound [Na+].CCCCCC[C@H]1CCC(O)[C@@H]1CCCCCCC([O-])=O ALNUHUMOGUVHIO-XXJNWDAFSA-M 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229940031418 trivalent vaccine Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/135—Foot- and mouth-disease virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32161—Methods of inactivation or attenuation
- C12N2770/32164—Methods of inactivation or attenuation by serial passage

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Mycology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

SU1882920A 1972-02-12 1973-01-31 Способ выращивани вируса щура SU519138A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2206779A DE2206779A1 (de)	1972-02-12	1972-02-12	Verfahren zur massenzuechtung von mksviren

Publications (1)

Publication Number	Publication Date
SU519138A3 true SU519138A3 (ru)	1976-06-25

Family

ID=5835863

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU1882920A SU519138A3 (ru)	1972-02-12	1973-01-31	Способ выращивани вируса щура

Country Status (17)

Country	Link
JP (1)	JPS4891262A (de)
AR (1)	AR193480A1 (de)
AT (1)	AT321464B (de)
BE (1)	BE795293A (de)
CH (1)	CH577031A5 (de)
CS (1)	CS199547B2 (de)
DD (1)	DD105252A5 (de)
DE (1)	DE2206779A1 (de)
DK (1)	DK137766C (de)
ES (1)	ES411484A1 (de)
FR (1)	FR2171425B1 (de)
GB (1)	GB1375154A (de)
KE (1)	KE2550A (de)
NL (1)	NL7301892A (de)
RO (1)	RO62814A (de)
SU (1)	SU519138A3 (de)
ZA (1)	ZA73926B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN109097320A (zh) *	2018-07-23	2018-12-28	南京农业大学	一种绵羊羔羊瘤胃上皮细胞培养方法

0
- BE BE795293D patent/BE795293A/xx unknown
1972
- 1972-02-12 DE DE2206779A patent/DE2206779A1/de active Pending
1973
- 1973-01-31 SU SU1882920A patent/SU519138A3/ru active
- 1973-02-03 AR AR246515A patent/AR193480A1/es active
- 1973-02-09 ZA ZA730926A patent/ZA73926B/xx unknown
- 1973-02-09 CH CH186773A patent/CH577031A5/xx not_active IP Right Cessation
- 1973-02-09 DD DD168792A patent/DD105252A5/xx unknown
- 1973-02-09 DK DK73173A patent/DK137766C/da active
- 1973-02-09 RO RO197373792A patent/RO62814A/ro unknown
- 1973-02-09 JP JP48015801A patent/JPS4891262A/ja active Pending
- 1973-02-09 AT AT121073A patent/AT321464B/de not_active IP Right Cessation
- 1973-02-09 NL NL7301892A patent/NL7301892A/xx not_active Application Discontinuation
- 1973-02-10 ES ES411484A patent/ES411484A1/es not_active Expired
- 1973-02-12 CS CS731009A patent/CS199547B2/cs unknown
- 1973-02-12 GB GB680173A patent/GB1375154A/en not_active Expired
- 1973-02-12 FR FR7304836A patent/FR2171425B1/fr not_active Expired
1975
- 1975-08-08 KE KE2550*UA patent/KE2550A/xx unknown

Also Published As

Publication number	Publication date
JPS4891262A (de)	1973-11-28
FR2171425B1 (de)	1976-11-05
RO62814A (fr)	1977-11-15
AT321464B (de)	1975-04-10
NL7301892A (de)	1973-08-14
KE2550A (en)	1975-08-22
AR193480A1 (es)	1973-04-23
DE2206779A1 (de)	1973-08-16
DK137766B (da)	1978-05-01
FR2171425A1 (de)	1973-09-21
DD105252A5 (de)	1974-04-12
CH577031A5 (de)	1976-06-30
ZA73926B (en)	1973-11-28
GB1375154A (de)	1974-11-27
BE795293A (fr)	1973-08-13
DK137766C (da)	1978-10-09
ES411484A1 (es)	1976-01-01
CS199547B2 (en)	1980-07-31

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Fishman	1961	Antibody formation in vitro
Andrewes et al.	1937	Influenza: further experiments on the active immunization of mice
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Ezell et al.	1952	Soluble specific leptospiral complement-fixing antigens
Ross	1938	Photodynamic action of methylene blue on antipneumococcal serum
US2720485A (en)	1955-10-11	Preparation of concentrated, purified ultraviolet inactivated hog cholera vaccine
US2720484A (en)	1955-10-11	Process for separation of viral substances from animal tissues
US3318775A (en)	1967-05-09	Production of viral antigens with n-acetyl-ethyleneimine
Boone et al.	1973	Preparation of membrane fractions with enhanced tumor-transplantation-antigen activity from tumor cells infected with influenza virus
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CA1243949A (en)	1988-11-01	Processes for development of acceptance of transplanted organs and tissues
RU2070819C1 (ru)	1996-12-27	Способ получения вакцины против эшерихиоза телят
Fakhri et al.	1970	Studies of the rat immune response to plasmacytoma 5563 in C3H mice
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US3627874A (en)	1971-12-14	Vaccine preparation