SU620215A3 - Способ получени антибиотического комплекса, обладающего противогрибковой активностью - Google Patents

Способ получени антибиотического комплекса, обладающего противогрибковой активностью

Info

Publication number: SU620215A3
Authority: SU; USSR - Soviet Union
Prior art keywords: antibiotic; methanol; fractions; microns; medium
Prior art date: 1975-10-02

Application number

SU762404253A

Other languages

English (en)

Russian (ru)

Inventor

Мартин Хоен Марвин (Сша)

Хайнц Михель Карл (Фрг)

Original Assignee

Эли Лилли Энд Компани, (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-10-02

Filing date

1976-09-29

Publication date

1978-08-15

1976-09-29 Application filed by Эли Лилли Энд Компани, (Фирма) filed Critical Эли Лилли Энд Компани, (Фирма)

1978-08-15 Application granted granted Critical

1978-08-15 Publication of SU620215A3 publication Critical patent/SU620215A3/ru

Links

230000003115 biocidal effect Effects 0.000 title description 32
238000000034 method Methods 0.000 title description 4
230000001857 anti-mycotic effect Effects 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 66
239000002609 medium Substances 0.000 description 26
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 23
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
239000000203 mixture Substances 0.000 description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
238000000855 fermentation Methods 0.000 description 11
230000004151 fermentation Effects 0.000 description 11
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
239000000243 solution Substances 0.000 description 8
229920001817 Agar Polymers 0.000 description 7
238000010521 absorption reaction Methods 0.000 description 7
239000008272 agar Substances 0.000 description 7
210000004027 cell Anatomy 0.000 description 7
210000000170 cell membrane Anatomy 0.000 description 7
238000004519 manufacturing process Methods 0.000 description 7
244000005700 microbiome Species 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
239000003242 anti bacterial agent Substances 0.000 description 5
239000002244 precipitate Substances 0.000 description 5
239000000741 silica gel Substances 0.000 description 5
229910002027 silica gel Inorganic materials 0.000 description 5
239000000126 substance Substances 0.000 description 5
238000004809 thin layer chromatography Methods 0.000 description 5
230000000843 anti-fungal effect Effects 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
239000007788 liquid Substances 0.000 description 4
230000007935 neutral effect Effects 0.000 description 4
239000003208 petroleum Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
YRMCBQLZVBXOSJ-PCFSSPOYSA-N (e)-3-[(6r,6as)-4-hydroxy-6-methoxy-3-methyl-11-oxo-5,6,6a,7-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-8-yl]prop-2-enamide Chemical compound CO[C@H]1NC2=C(O)C(C)=CC=C2C(=O)N2C=C(\C=C\C(N)=O)C[C@@H]12 YRMCBQLZVBXOSJ-PCFSSPOYSA-N 0.000 description 3
108090000790 Enzymes Proteins 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 3
230000002378 acidificating effect Effects 0.000 description 3
229940088710 antibiotic agent Drugs 0.000 description 3
125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
239000000284 extract Substances 0.000 description 3
238000001914 filtration Methods 0.000 description 3
238000002329 infrared spectrum Methods 0.000 description 3
239000002054 inoculum Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 2
241000222120 Candida <Saccharomycetales> Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
229960004217 benzyl alcohol Drugs 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
150000002170 ethers Chemical class 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
239000000499 gel Substances 0.000 description 2
210000004276 hyalin Anatomy 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
239000011707 mineral Substances 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
239000000047 product Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
238000002211 ultraviolet spectrum Methods 0.000 description 2
239000012808 vapor phase Substances 0.000 description 2
WOEPIQOANYGRGK-RJMJUYIDSA-N (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol propane-1,2,3-triol Chemical compound OCC(O)CO.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O WOEPIQOANYGRGK-RJMJUYIDSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241000303945 Alyssum murale Species 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical class OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 1
241000237509 Patinopecten sp. Species 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
KYGRCGGBECLWMH-UHFFFAOYSA-N Sterigmatocystin Natural products COc1cc2OC3C=COC3c2c4Oc5cccc(O)c5C(=O)c14 KYGRCGGBECLWMH-UHFFFAOYSA-N 0.000 description 1
UTSVPXMQSFGQTM-UHFFFAOYSA-N Sterigmatrocystin Natural products O1C2=CC=CC(O)=C2C(=O)C2=C1C(C1C=COC1O1)=C1C=C2OC UTSVPXMQSFGQTM-UHFFFAOYSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
238000000862 absorption spectrum Methods 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
ZAYITQDIKSBHDD-UHFFFAOYSA-N benzene methane Chemical compound C.C1=CC=CC=C1.C1=CC=CC=C1 ZAYITQDIKSBHDD-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
238000011953 bioanalysis Methods 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000002242 deionisation method Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
RHGQIWVTIHZRLI-UHFFFAOYSA-N dihydrosterigmatocystin Natural products O1C2=CC=CC(O)=C2C(=O)C2=C1C(C1CCOC1O1)=C1C=C2OC RHGQIWVTIHZRLI-UHFFFAOYSA-N 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
210000000416 exudates and transudate Anatomy 0.000 description 1
-1 for example Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
229930195712 glutamate Natural products 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000010355 oscillation Effects 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
235000020030 perry Nutrition 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000003495 polar organic solvent Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000005070 sampling Methods 0.000 description 1
235000020637 scallop Nutrition 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
239000010454 slate Substances 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000002594 sorbent Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
UTSVPXMQSFGQTM-DCXZOGHSSA-N sterigmatocystin Chemical compound O1C2=CC=CC(O)=C2C(=O)C2=C1C([C@@H]1C=CO[C@@H]1O1)=C1C=C2OC UTSVPXMQSFGQTM-DCXZOGHSSA-N 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000037303 wrinkles Effects 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Compounds Of Unknown Constitution (AREA)

SU762404253A 1975-10-02 1976-09-29 Способ получени антибиотического комплекса, обладающего противогрибковой активностью SU620215A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US61910775A	1975-10-02	1975-10-02

Publications (1)

Publication Number	Publication Date
SU620215A3 true SU620215A3 (ru)	1978-08-15

Family

ID=24480483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU762404253A SU620215A3 (ru)	1975-10-02	1976-09-29	Способ получени антибиотического комплекса, обладающего противогрибковой активностью

Country Status (28)

Country	Link
JP (1)	JPS5242801A (cs)
AR (1)	AR209993A1 (cs)
AT (1)	AT346479B (cs)
AU (1)	AU506777B2 (cs)
BE (1)	BE846829A (cs)
BG (1)	BG25380A3 (cs)
CA (1)	CA1080145A (cs)
CH (1)	CH629531A5 (cs)
CS (1)	CS212776B2 (cs)
DD (1)	DD127442A5 (cs)
DE (1)	DE2643485A1 (cs)
DK (1)	DK143608C (cs)
ES (1)	ES452021A1 (cs)
FR (1)	FR2326200A1 (cs)
GB (2)	GB1499710A (cs)
GR (1)	GR61730B (cs)
HU (1)	HU173445B (cs)
IE (1)	IE43663B1 (cs)
IL (1)	IL50429A (cs)
NL (1)	NL7610808A (cs)
NZ (1)	NZ182123A (cs)
PL (1)	PL103996B1 (cs)
PT (1)	PT65617B (cs)
RO (1)	RO69985A (cs)
SE (1)	SE7610943L (cs)
SU (1)	SU620215A3 (cs)
YU (1)	YU236076A (cs)
ZA (1)	ZA765320B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5452797A (en) *	1977-10-04	1979-04-25	Meiji Seika Kaisha Ltd	Novel antibiotic substance bn-200, and its preparation
CA1170598A (en) *	1979-12-13	1984-07-10	Bernard J. Abbott	Process for the preparation of cyclic peptide nuclei
GB2180464A (en) *	1985-09-18	1987-04-01	British Gas Corp	Gas-solid phase reactions and apparatus therefor
FI76004B (fi) *	1986-03-24	1988-05-31	Seppo Kalervo Ruottu	Cirkulationsmassareaktor.

1976
- 1976-09-06 IE IE1974/76A patent/IE43663B1/en unknown
- 1976-09-07 ZA ZA00765320A patent/ZA765320B/xx unknown
- 1976-09-08 IL IL50429A patent/IL50429A/xx unknown
- 1976-09-16 GR GR51709A patent/GR61730B/el unknown
- 1976-09-20 CA CA261,528A patent/CA1080145A/en not_active Expired
- 1976-09-21 NZ NZ182123A patent/NZ182123A/xx unknown
- 1976-09-21 PT PT65617A patent/PT65617B/pt unknown
- 1976-09-22 JP JP51114357A patent/JPS5242801A/ja active Pending
- 1976-09-23 AU AU18080/76A patent/AU506777B2/en not_active Expired
- 1976-09-23 GB GB39477/76A patent/GB1499710A/en not_active Expired
- 1976-09-24 BG BG034273A patent/BG25380A3/xx unknown
- 1976-09-27 DE DE19762643485 patent/DE2643485A1/de not_active Withdrawn
- 1976-09-27 GB GB39954/76A patent/GB1565821A/en not_active Expired
- 1976-09-27 YU YU02360/76A patent/YU236076A/xx unknown
- 1976-09-29 NL NL7610808A patent/NL7610808A/xx not_active Application Discontinuation
- 1976-09-29 SU SU762404253A patent/SU620215A3/ru active
- 1976-09-29 CS CS766294A patent/CS212776B2/cs unknown
- 1976-09-30 DK DK440276A patent/DK143608C/da active
- 1976-09-30 ES ES452021A patent/ES452021A1/es not_active Expired
- 1976-09-30 CH CH1241376A patent/CH629531A5/de not_active IP Right Cessation
- 1976-10-01 AR AR264953A patent/AR209993A1/es active
- 1976-10-01 FR FR7629604A patent/FR2326200A1/fr active Granted
- 1976-10-01 AT AT730976A patent/AT346479B/de not_active IP Right Cessation
- 1976-10-01 HU HU76EI703A patent/HU173445B/hu unknown
- 1976-10-01 SE SE7610943A patent/SE7610943L/ not_active Application Discontinuation
- 1976-10-01 PL PL1976192798A patent/PL103996B1/pl unknown
- 1976-10-01 BE BE1007661A patent/BE846829A/xx unknown
- 1976-10-01 DD DD195092A patent/DD127442A5/xx unknown
- 1976-10-02 RO RO7687891A patent/RO69985A/ro unknown

Also Published As

Publication number	Publication date
ES452021A1 (es)	1977-12-01
PT65617A (en)	1976-10-01
BE846829A (fr)	1977-04-01
NL7610808A (nl)	1977-04-05
GR61730B (en)	1978-12-30
NZ182123A (en)	1978-06-02
AU506777B2 (en)	1980-01-24
IE43663L (en)	1977-04-02
IE43663B1 (en)	1981-04-22
DK143608C (da)	1982-02-15
FR2326200A1 (fr)	1977-04-29
BG25380A3 (en)	1978-09-15
PT65617B (en)	1978-04-05
CS212776B2 (en)	1982-03-26
HU173445B (hu)	1979-05-28
ZA765320B (en)	1978-04-26
DK143608B (da)	1981-09-14
AR209993A1 (es)	1977-06-15
DD127442A5 (cs)	1977-09-21
FR2326200B1 (cs)	1980-03-07
CA1080145A (en)	1980-06-24
CH629531A5 (en)	1982-04-30
YU236076A (en)	1983-04-30
AT346479B (de)	1978-11-10
JPS5242801A (en)	1977-04-04
GB1499710A (en)	1978-02-01
AU1808076A (en)	1978-04-06
RO69985A (ro)	1981-05-15
DK440276A (da)	1977-04-03
PL103996B1 (pl)	1979-07-31
GB1565821A (en)	1980-04-23
SE7610943L (sv)	1977-04-03
DE2643485A1 (de)	1977-04-14
ATA730976A (de)	1978-03-15
IL50429A0 (en)	1976-11-30
IL50429A (en)	1979-11-30

Publication	Publication Date	Title
Fujiwara et al.	1982	Fermentation, isolation and characterization of isonitrile antibiotics
DD153213A5 (de)	1981-12-30	Verfahren zur herstellung der die faktoren a,b,d und h von a-30912 enthaltenden antibiotikummischung a-42355 sowie der einzelnen faktoren
SU620215A3 (ru)	1978-08-15	Способ получени антибиотического комплекса, обладающего противогрибковой активностью
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