SU646915A3 - Способ получени три -п- толуолсульфоната -аденозил- -метионина - Google Patents

Способ получени три -п- толуолсульфоната -аденозил- -метионина

Info

Publication number: SU646915A3
Authority: SU; USSR - Soviet Union
Prior art keywords: water; sam; solution; acid; evaporated
Prior art date: 1972-08-02

Application number

SU731945967A

Other languages

English (en)

Russian (ru)

Inventor

Фиеччи Альберта

Original Assignee

Биоресерч Лимитед Партнершип Оф Д-Р Ливио Камоззи Энд К (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-08-02

Filing date

1973-08-01

Publication date

1979-02-05

1973-08-01 Application filed by Биоресерч Лимитед Партнершип Оф Д-Р Ливио Камоззи Энд К (Фирма) filed Critical Биоресерч Лимитед Партнершип Оф Д-Р Ливио Камоззи Энд К (Фирма)

1979-02-05 Application granted granted Critical

1979-02-05 Publication of SU646915A3 publication Critical patent/SU646915A3/ru

Links

238000000034 method Methods 0.000 title claims description 8
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 25
239000000243 solution Substances 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 9
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
229920005989 resin Polymers 0.000 claims description 7
239000011347 resin Substances 0.000 claims description 7
150000003839 salts Chemical class 0.000 claims description 7
239000007864 aqueous solution Substances 0.000 claims description 6
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 4
229920001429 chelating resin Polymers 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 4
239000003960 organic solvent Substances 0.000 claims description 4
240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 3
150000001805 chlorine compounds Chemical class 0.000 claims description 3
238000001914 filtration Methods 0.000 claims description 3
229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 3
238000005406 washing Methods 0.000 claims description 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
230000009089 cytolysis Effects 0.000 claims description 2
238000001556 precipitation Methods 0.000 claims description 2
229910021653 sulphate ion Inorganic materials 0.000 claims description 2
239000000126 substance Substances 0.000 claims 5
150000003467 sulfuric acid derivatives Chemical class 0.000 claims 3
AYJRCSIUFZENHW-UHFFFAOYSA-L barium carbonate Chemical compound [Ba+2].[O-]C([O-])=O AYJRCSIUFZENHW-UHFFFAOYSA-L 0.000 claims 2
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
-1 SAM sulfates Chemical class 0.000 claims 1
KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
239000007900 aqueous suspension Substances 0.000 claims 1
RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 claims 1
229910001863 barium hydroxide Inorganic materials 0.000 claims 1
239000003729 cation exchange resin Substances 0.000 claims 1
210000004027 cell Anatomy 0.000 claims 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
239000000706 filtrate Substances 0.000 claims 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
238000011835 investigation Methods 0.000 claims 1
XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims 1
229940006461 iodide ion Drugs 0.000 claims 1
239000002244 precipitate Substances 0.000 claims 1
239000000047 product Substances 0.000 claims 1
239000002904 solvent Substances 0.000 claims 1
239000000725 suspension Substances 0.000 claims 1
125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 claims 1
210000005253 yeast cell Anatomy 0.000 claims 1
MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 1
150000008043 acidic salts Chemical class 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
229960004452 methionine Drugs 0.000 description 1
230000009965 odorless effect Effects 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
HHAVHBDPWSUKHZ-UHFFFAOYSA-N propan-2-ol;propan-2-one Chemical compound CC(C)O.CC(C)=O HHAVHBDPWSUKHZ-UHFFFAOYSA-N 0.000 description 1
FZUJWWOKDIGOKH-UHFFFAOYSA-N sulfuric acid hydrochloride Chemical compound Cl.OS(O)(=O)=O FZUJWWOKDIGOKH-UHFFFAOYSA-N 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
238000002211 ultraviolet spectrum Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Obesity (AREA)
General Engineering & Computer Science (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hematology (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

SU731945967A 1972-08-02 1973-08-01 Способ получени три -п- толуолсульфоната -аденозил- -метионина SU646915A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2779372		1972-08-02

Publications (1)

Publication Number	Publication Date
SU646915A3 true SU646915A3 (ru)	1979-02-05

Family

ID=11222342

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU731945967A SU646915A3 (ru)	1972-08-02	1973-08-01	Способ получени три -п- толуолсульфоната -аденозил- -метионина

Country Status (29)

Country	Link
US (1)	US3893999A (2)
JP (1)	JPS5235726B2 (2)
AR (1)	AR195350A1 (2)
AT (1)	AT341684B (2)
AU (1)	AU474015B2 (2)
BE (1)	BE802981A (2)
CA (1)	CA1006872A (2)
CH (1)	CH592112A5 (2)
CS (1)	CS195254B2 (2)
DD (1)	DD107461A5 (2)
DE (1)	DE2336401C3 (2)
DK (1)	DK131868C (2)
ES (1)	ES417377A1 (2)
FI (1)	FI52466C (2)
FR (1)	FR2194425B1 (2)
GB (1)	GB1425384A (2)
HK (1)	HK31580A (2)
HU (1)	HU167266B (2)
IE (1)	IE37913B1 (2)
IL (1)	IL42764A (2)
MX (1)	MX4544E (2)
NL (1)	NL152864B (2)
NO (1)	NO137941C (2)
PL (1)	PL87381B1 (2)
RO (1)	RO63451A (2)
SE (1)	SE400085B (2)
SU (1)	SU646915A3 (2)
YU (1)	YU36037B (2)
ZA (1)	ZA734876B (2)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE39517B1 (en) *	1973-06-27	1978-10-25	Bioresearch Sas	Double salts of s-adenosyl-l-methhionine
AR221676A1 (es) *	1974-07-12	1981-03-13	Bioresearch Sas	Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
US4109079A (en) *	1975-10-16	1978-08-22	Yamasa Shoyu Kabushiki Kaisha	Stabilized s-adenosyl-l-methionine preparations
GB2064523B (en) *	1979-12-04	1983-06-29	Kanegafuchi Chemical Ind	Stable composition of s-adenosyl-l-methionine
IT1137640B (it) *	1981-08-24	1986-09-10	Bioresearch Srl	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) *	1981-08-24	1986-09-10	Bioresearch Srl	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) *	1981-09-11	1986-09-24	Bioresearch Srl	Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
IT1169774B (it) *	1983-08-24	1987-06-03	Bioresearch Spa	Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1169773B (it) *	1983-08-24	1987-06-03	Bioresearch Spa	Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1173990B (it) *	1984-05-16	1987-06-24	Bioresearch Spa	Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1173992B (it) *	1984-05-16	1987-06-24	Bioresearch Spa	Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1200589B (it) *	1985-02-14	1989-01-27	Gibipharma Spa	Derivati naturali attivita farmagologica
ATE80165T1 (de) *	1987-10-09	1992-09-15	Vincenzo Zappia	Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten.
DE19515275A1 (de) *	1995-04-26	1996-10-31	Knoll Ag	Neue Verwendung von (S)-Adenosyl-L-methionin(SAMe)
US6759395B2 (en)	2000-12-18	2004-07-06	Orchid Chemicals & Pharmaceuticals, Ltd.	Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
WO2006079212A1 (en) *	2005-01-26	2006-08-03	Diamedica Inc.	Use of s-adenosylmethionme, vitamin e, and vitamin c for the treatment of oxidative liver injury or insulin resistance
US20090012036A1 (en) *	2005-05-24	2009-01-08	Hebert Rolland F	Stable S-adenosyl-L-methionine
ITMI20060026A1 (it) *	2006-01-10	2007-07-11	Truffini & Regge Farmaceutici Srl	Composizioni per uso rale a base di s-adenosilmetionina e processo per il loro ottenimento
ITMI20060629A1 (it)	2006-03-31	2007-10-01	Daniele Giovannone	Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
US20090088404A1 (en) *	2007-01-31	2009-04-02	Methylation Sciences International Srl	Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20090197824A1 (en) *	2008-01-31	2009-08-06	Methylation Sciences International Srl	Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
AU2008210327B2 (en) *	2007-01-31	2011-06-16	Methylation Sciences International Srl	Extended release pharmaceutical formulations of S-adenosylmethionine
ITMI20071374A1 (it) *	2007-07-10	2009-01-11	Gnosis Spa	Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) *	2008-07-01	2010-01-07	Rolland F Hebert	Compositions of S-adenosyl-L-methionine.
US8329208B2 (en) *	2009-07-28	2012-12-11	Methylation Sciences International Srl	Pharmacokinetics of S-adenosylmethionine formulations
US20110027342A1 (en)	2009-07-28	2011-02-03	Msi Methylation Sciences, Inc.	S-adenosylmethionine formulations with enhanced bioavailability
WO2012139227A1 (en)	2011-04-15	2012-10-18	Scimar Ltd.	Use of s-adenosylmethionine, vitamin e, and vitamin c for the prevention and treatment of cardiovascular dysfunction
ES2540581T3 (es)	2012-10-17	2015-07-10	Methylation Sciences International Srl	Composiciones que comprenden S-adenosilmetionina y un éster de ácido gálico
US9534010B2 (en)	2013-01-16	2017-01-03	Hebert Sam-E Llc	Stable indole-3-propionate salts of S-adenosyl-L-methionine
AU2024274445A1 (en)	2023-05-15	2025-11-27	Bonafide Health, Llc	Sleep-improving compositions and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2946781A (en) *	1957-02-06	1960-07-26	Merck & Co Inc	Process for the preparation of adenosyl homocysteine
US3642772A (en) *	1968-09-04	1972-02-15	Boehringer Mannheim Gmbh	Process for preparing s-adenosyl homocysteine

1973
- 1973-07-16 IE IE1192/73A patent/IE37913B1/xx unknown
- 1973-07-17 IL IL42764A patent/IL42764A/en unknown
- 1973-07-17 ZA ZA734876A patent/ZA734876B/xx unknown
- 1973-07-17 US US380097A patent/US3893999A/en not_active Expired - Lifetime
- 1973-07-17 DE DE2336401A patent/DE2336401C3/de not_active Expired
- 1973-07-19 GB GB3449973A patent/GB1425384A/en not_active Expired
- 1973-07-19 FR FR7326500A patent/FR2194425B1/fr not_active Expired
- 1973-07-25 RO RO7300075582A patent/RO63451A/ro unknown
- 1973-07-26 CS CS735374A patent/CS195254B2/cs unknown
- 1973-07-26 YU YU2030/73A patent/YU36037B/xx unknown
- 1973-07-27 CA CA177,689A patent/CA1006872A/en not_active Expired
- 1973-07-27 AR AR249310A patent/AR195350A1/es active
- 1973-07-27 AT AT664173A patent/AT341684B/de not_active IP Right Cessation
- 1973-07-30 BE BE134028A patent/BE802981A/xx not_active IP Right Cessation
- 1973-07-30 AU AU58680/73A patent/AU474015B2/en not_active Expired
- 1973-07-30 ES ES417377A patent/ES417377A1/es not_active Expired
- 1973-08-01 SE SE7310587A patent/SE400085B/xx unknown
- 1973-08-01 MX MX737933U patent/MX4544E/es unknown
- 1973-08-01 PL PL1973164439A patent/PL87381B1/pl unknown
- 1973-08-01 DK DK422773A patent/DK131868C/da not_active IP Right Cessation
- 1973-08-01 SU SU731945967A patent/SU646915A3/ru active
- 1973-08-01 NO NO3084/73A patent/NO137941C/no unknown
- 1973-08-01 HU HUEE2163A patent/HU167266B/hu unknown
- 1973-08-01 DD DD172669A patent/DD107461A5/xx unknown
- 1973-08-02 NL NL737310706A patent/NL152864B/xx not_active IP Right Cessation
- 1973-08-02 JP JP48086440A patent/JPS5235726B2/ja not_active Expired
- 1973-08-02 CH CH1125173A patent/CH592112A5/xx not_active IP Right Cessation
- 1973-08-02 FI FI732438A patent/FI52466C/fi active
1980
- 1980-06-12 HK HK315/80A patent/HK31580A/xx unknown

Also Published As

Publication number	Publication date
CA1006872A (en)	1977-03-15
CH592112A5 (2)	1977-10-14
HU167266B (2)	1975-09-27
HK31580A (en)	1980-06-20
SE400085B (sv)	1978-03-13
IE37913L (en)	1974-02-02
IL42764A (en)	1976-04-30
AR195350A1 (es)	1973-09-28
JPS4992215A (2)	1974-09-03
FI52466C (fi)	1977-09-12
DE2336401B2 (de)	1979-07-12
MX4544E (es)	1982-06-08
JPS5235726B2 (2)	1977-09-10
ZA734876B (en)	1974-06-26
NL7310706A (2)	1974-02-05
NL152864B (nl)	1977-04-15
DE2336401C3 (de)	1980-03-13
IE37913B1 (en)	1977-11-09
YU36037B (en)	1981-11-13
AU474015B2 (en)	1976-07-08
ES417377A1 (es)	1976-02-16
NO137941B (no)	1978-02-13
BE802981A (fr)	1973-11-16
US3893999A (en)	1975-07-08
YU203073A (en)	1981-04-30
NO137941C (no)	1978-05-31
IL42764A0 (en)	1974-01-14
PL87381B1 (2)	1976-06-30
FR2194425A1 (2)	1974-03-01
FI52466B (2)	1977-05-31
AT341684B (de)	1978-02-27
DK131868C (da)	1976-03-08
ATA664173A (de)	1977-06-15
GB1425384A (en)	1976-02-18
AU5868073A (en)	1975-01-30
CS195254B2 (en)	1980-01-31
FR2194425B1 (2)	1976-04-09
DK131868B (da)	1975-09-15
RO63451A (fr)	1978-07-15
DD107461A5 (2)	1974-08-05
DE2336401A1 (de)	1974-02-14

Publication	Publication Date	Title
SU646915A3 (ru)	1979-02-05	Способ получени три -п- толуолсульфоната -аденозил- -метионина
US5102791A (en)	1992-04-07	Stable sulpho-adendoyl-l-methionine (same) salts, particlarly suitable for parenteral use
SU628822A3 (ru)	1978-10-15	Способ получени хлоргидрата 4 -эпи-6 оксиадриамицина
DE69302938T2 (de)	1996-10-17	Erythromycinderivate, Herstellung und Verwendung davon
US3707536A (en)	1972-12-26	Process for the isolation and purification of s-adenosyl methionine and ethionine and novel sulfates thereof
Baddiley et al.	1948	Synthesis of adenosine triphosphate
EP0131942B1 (de)	1987-11-11	Anthracyclin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Cytostatika
SU489316A3 (ru)	1975-10-25	Способ получени производных фузидовой кислоты
NAWA	1951	Rhodexin A and B, New Cardiac Glycosides of Rhodea japonica, Roth
Fujino et al.	1965	On glumamycin, a new antibiotic. V. The steric configuration of α, β-diaminobutyric acid
SU776562A3 (ru)	1980-10-30	Способ получени антрациклинов
DE2233535C3 (de)	1982-05-06	Verfahren zur Herstellung von α-L-Aspartyl-L-phenylalanin-C↓1↓- bis C↓3↓-alkylestern
DE2427976C2 (de)	1985-12-12	Proscillaridinäther, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
SU434657A3 (ru)	1974-06-30	Способ получения производных рифамицина sv
US3384631A (en)	1968-05-21	Isolation of bacitracin from dilute solutions thereof by precipitation as a complex with a divalent metal and an organic sulfate or sulfonate
CH449006A (de)	1967-12-31	Verfahren zur Herstellung von Fusidinsäure- und Dihydrofusidinsäurederivaten
JPS6241237B2 (2)	1987-09-02
Zechmeister et al.	1955	Bisdehydro-carotenes
SU576922A3 (ru)	1977-10-15	Способ получени двойных солей -аденозил- -метионина
DE1595937A1 (de)	1970-04-16	Kristalline 5'-Guanylsaeure und Verfahren zu deren Gewinnung
GB672510A (en)	1952-05-21	Improvements in or relating to the purification of aureomycin
SU569566A1 (ru)	1977-08-25	Способ получени о-нитрофенилсульфениламинокислот
SU558533A1 (ru)	1981-09-07	Способ получени реумицина
SU574144A3 (ru)	1977-09-25	Способ получени производных -изонитрозоацетофенона
SU331544A1 (ru)		Способ получения бяс-мочевинного аддукта антибиотика