SU791220A3 - Способ получени производных ароилфенилнафталинов или их фармацевтически приемлемых кислотно-аддитивных солей - Google Patents

Способ получени производных ароилфенилнафталинов или их фармацевтически приемлемых кислотно-аддитивных солей Download PDF

Info

Publication number: SU791220A3
Authority: SU; USSR - Soviet Union
Prior art keywords: compounds; formula; hydrogen; pharmaceutically acceptable; derivatives
Prior art date: 1975-10-28

Application number

SU762414461A

Other languages

English (en)

Russian (ru)

Inventor

Суареш Тулио

Дэвид Джонс Чарльз

Original Assignee

Эли Лилли Энд Компани (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-10-28

Filing date

1976-10-26

Publication date

1980-12-23

1976-10-26 Application filed by Эли Лилли Энд Компани (Фирма) filed Critical Эли Лилли Энд Компани (Фирма)

1980-12-23 Application granted granted Critical

1980-12-23 Publication of SU791220A3 publication Critical patent/SU791220A3/ru

Links

150000003839 salts Chemical class 0.000 title claims abstract description 6
238000000034 method Methods 0.000 title claims description 3
239000000654 additive Substances 0.000 title description 2
239000002253 acid Substances 0.000 claims abstract description 7
239000001257 hydrogen Substances 0.000 claims abstract description 6
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 12
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 6
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
XHLHPRDBBAGVEG-UHFFFAOYSA-N 1-tetralone Chemical class C1=CC=C2C(=O)CCCC2=C1 XHLHPRDBBAGVEG-UHFFFAOYSA-N 0.000 claims description 2
ANRQGKOBLBYXFM-UHFFFAOYSA-M phenylmagnesium bromide Chemical compound Br[Mg]C1=CC=CC=C1 ANRQGKOBLBYXFM-UHFFFAOYSA-M 0.000 claims description 2
150000001875 compounds Chemical class 0.000 abstract description 23
241001465754 Metazoa Species 0.000 abstract description 14
230000035558 fertility Effects 0.000 abstract description 4
229940124558 contraceptive agent Drugs 0.000 abstract description 3
239000003433 contraceptive agent Substances 0.000 abstract description 3
241000124008 Mammalia Species 0.000 abstract description 2
239000003814 drug Substances 0.000 abstract description 2
230000002401 inhibitory effect Effects 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
VKPPFDPXZWFDFA-UHFFFAOYSA-N 2-chloroethanamine Chemical compound NCCCl VKPPFDPXZWFDFA-UHFFFAOYSA-N 0.000 abstract 1
241000607479 Yersinia pestis Species 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
150000002790 naphthalenes Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
239000000203 mixture Substances 0.000 description 12
241000700159 Rattus Species 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
239000000126 substance Substances 0.000 description 6
241000271566 Aves Species 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
230000000694 effects Effects 0.000 description 5
230000035935 pregnancy Effects 0.000 description 5
238000012360 testing method Methods 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
241000282421 Canidae Species 0.000 description 4
230000002254 contraceptive effect Effects 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 3
239000011230 binding agent Substances 0.000 description 3
239000003921 oil Substances 0.000 description 3
235000019198 oils Nutrition 0.000 description 3
239000007787 solid Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
238000005303 weighing Methods 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
RTEXIPZMMDUXMR-UHFFFAOYSA-N benzene;ethyl acetate Chemical compound CCOC(C)=O.C1=CC=CC=C1 RTEXIPZMMDUXMR-UHFFFAOYSA-N 0.000 description 2
230000037396 body weight Effects 0.000 description 2
238000009395 breeding Methods 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
239000013078 crystal Substances 0.000 description 2
230000006378 damage Effects 0.000 description 2
210000002257 embryonic structure Anatomy 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
210000003754 fetus Anatomy 0.000 description 2
238000001914 filtration Methods 0.000 description 2
-1 for example Chemical class 0.000 description 2
239000012458 free base Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
HFVMEOPYDLEHBR-UHFFFAOYSA-N (2-fluorophenyl)-phenylmethanol Chemical compound C=1C=CC=C(F)C=1C(O)C1=CC=CC=C1 HFVMEOPYDLEHBR-UHFFFAOYSA-N 0.000 description 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
QISOBCMNUJQOJU-UHFFFAOYSA-N 4-bromo-1h-pyrazole-5-carboxylic acid Chemical compound OC(=O)C=1NN=CC=1Br QISOBCMNUJQOJU-UHFFFAOYSA-N 0.000 description 1
QJPJQTDYNZXKQF-UHFFFAOYSA-N 4-bromoanisole Chemical compound COC1=CC=C(Br)C=C1 QJPJQTDYNZXKQF-UHFFFAOYSA-N 0.000 description 1
PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
206010007134 Candida infections Diseases 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
241000272161 Charadriiformes Species 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
241000272201 Columbiformes Species 0.000 description 1
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
208000007027 Oral Candidiasis Diseases 0.000 description 1
YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
241000287182 Sturnidae Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
241000287411 Turdidae Species 0.000 description 1
DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
239000003513 alkali Substances 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000002585 base Substances 0.000 description 1
MDHYEMXUFSJLGV-UHFFFAOYSA-N beta-phenethyl acetate Natural products CC(=O)OCCC1=CC=CC=C1 MDHYEMXUFSJLGV-UHFFFAOYSA-N 0.000 description 1
201000003984 candidiasis Diseases 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
239000011651 chromium Substances 0.000 description 1
238000013329 compounding Methods 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
RBWRWAUAVRMBAC-UHFFFAOYSA-M magnesium;methoxybenzene;bromide Chemical compound [Mg+2].[Br-].COC1=CC=[C-]C=C1 RBWRWAUAVRMBAC-UHFFFAOYSA-M 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Pyrrole Compounds (AREA)

SU762414461A 1975-10-28 1976-10-26 Способ получени производных ароилфенилнафталинов или их фармацевтически приемлемых кислотно-аддитивных солей SU791220A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US62599175A	1975-10-28	1975-10-28

Publications (1)

Publication Number	Publication Date
SU791220A3 true SU791220A3 (ru)	1980-12-23

Family

ID=24508491

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SU762414461A SU791220A3 (ru)	1975-10-28	1976-10-26	Способ получени производных ароилфенилнафталинов или их фармацевтически приемлемых кислотно-аддитивных солей
SU782641053A SU818476A3 (ru)	1975-10-28	1978-07-25	Способ получени производныхАРОилфЕНилНАфТАлиНОВ

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SU782641053A SU818476A3 (ru)	1975-10-28	1978-07-25	Способ получени производныхАРОилфЕНилНАфТАлиНОВ

Country Status (30)

Country	Link
JP (1)	JPS6045191B2 (da)
AR (1)	AR214622A1 (da)
AT (1)	AT346321B (da)
AU (1)	AU509372B2 (da)
BE (1)	BE847716A (da)
BG (1)	BG27555A3 (da)
CA (1)	CA1078834A (da)
CH (2)	CH624398A5 (da)
CS (1)	CS235057B2 (da)
DD (1)	DD127460A5 (da)
DE (1)	DE2646213C2 (da)
DK (1)	DK484776A (da)
ES (1)	ES452735A1 (da)
FR (1)	FR2329264A1 (da)
GB (1)	GB1561687A (da)
GR (1)	GR61816B (da)
HU (1)	HU175227B (da)
IE (1)	IE43641B1 (da)
IL (1)	IL50772A (da)
MX (1)	MX4291E (da)
NL (1)	NL187164C (da)
NZ (1)	NZ182421A (da)
PH (1)	PH14538A (da)
PL (2)	PL111987B1 (da)
PT (1)	PT65752B (da)
RO (1)	RO70755A (da)
SE (1)	SE428689B (da)
SU (2)	SU791220A3 (da)
YU (1)	YU262276A (da)
ZA (1)	ZA766439B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4179558A (en) *	1978-01-30	1979-12-18	E. R. Squibb & Sons, Inc.	Naphthalenone derivatives and analogs
DE3121175A1 (de) *	1981-05-27	1982-12-16	Klinge Pharma GmbH, 8000 München	Erythro-1,2,3-triphenyl-1-pentanon-derivate sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4410553A (en)	1981-08-28	1983-10-18	Mcginty James	Method and apparatus for cooking particulate foodstuffs
JPH0717589B2 (ja) *	1990-01-22	1995-03-01	ファイザー製薬株式会社	新規１，３―ジカルボニル化合物およびその組成物
US6391892B1 (en) *	1995-03-10	2002-05-21	Eli Lilly And Company	Naphthyl pharmaceutical compounds

1976
- 1976-10-13 DE DE2646213A patent/DE2646213C2/de not_active Expired
- 1976-10-20 MX MX764988U patent/MX4291E/es unknown
- 1976-10-21 NZ NZ182421A patent/NZ182421A/xx unknown
- 1976-10-21 CA CA263,896A patent/CA1078834A/en not_active Expired
- 1976-10-22 PH PH19030A patent/PH14538A/en unknown
- 1976-10-22 GB GB43884/76A patent/GB1561687A/en not_active Expired
- 1976-10-25 GR GR52004A patent/GR61816B/el unknown
- 1976-10-25 PT PT65752A patent/PT65752B/pt unknown
- 1976-10-26 PL PL1976211453A patent/PL111987B1/pl unknown
- 1976-10-26 JP JP51129305A patent/JPS6045191B2/ja not_active Expired
- 1976-10-26 SU SU762414461A patent/SU791220A3/ru active
- 1976-10-26 ES ES452735A patent/ES452735A1/es not_active Expired
- 1976-10-26 AU AU19004/76A patent/AU509372B2/en not_active Expired
- 1976-10-26 RO RO7688227A patent/RO70755A/ro unknown
- 1976-10-26 PL PL1976193264A patent/PL104551B1/pl unknown
- 1976-10-27 IL IL50772A patent/IL50772A/xx unknown
- 1976-10-27 DK DK484776A patent/DK484776A/da not_active Application Discontinuation
- 1976-10-27 IE IE2371/76A patent/IE43641B1/en unknown
- 1976-10-27 CH CH1355476A patent/CH624398A5/de not_active IP Right Cessation
- 1976-10-27 ZA ZA00766439A patent/ZA766439B/xx unknown
- 1976-10-27 SE SE7611953A patent/SE428689B/xx not_active IP Right Cessation
- 1976-10-27 HU HU76EI716A patent/HU175227B/hu unknown
- 1976-10-27 YU YU02622/76A patent/YU262276A/xx unknown
- 1976-10-28 AT AT800576A patent/AT346321B/de not_active IP Right Cessation
- 1976-10-28 FR FR7632511A patent/FR2329264A1/fr active Granted
- 1976-10-28 DD DD195507A patent/DD127460A5/xx unknown
- 1976-10-28 AR AR265274A patent/AR214622A1/es active
- 1976-10-28 NL NLAANVRAGE7611974,A patent/NL187164C/xx not_active IP Right Cessation
- 1976-10-28 BG BG034552A patent/BG27555A3/xx unknown
- 1976-10-28 BE BE1007722A patent/BE847716A/xx not_active IP Right Cessation
- 1976-10-28 CS CS766971A patent/CS235057B2/cs unknown
1978
- 1978-07-25 SU SU782641053A patent/SU818476A3/ru active
1980
- 1980-08-28 CH CH648780A patent/CH624376A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE7611953L (sv)	1977-04-29
IE43641L (en)	1977-04-28
DK484776A (da)	1977-04-29
JPS5253845A (en)	1977-04-30
GB1561687A (en)	1980-02-27
FR2329264B1 (da)	1978-11-17
BG27555A3 (en)	1979-11-12
CH624398A5 (en)	1981-07-31
CH624376A5 (en)	1981-07-31
ATA800576A (de)	1978-03-15
CS235057B2 (en)	1985-04-16
GR61816B (en)	1979-01-22
IL50772A (en)	1980-11-30
JPS6045191B2 (ja)	1985-10-08
AU1900476A (en)	1978-05-04
DD127460A5 (da)	1977-09-28
AR214622A1 (es)	1979-07-13
PT65752A (en)	1976-11-01
BE847716A (fr)	1977-04-28
NZ182421A (en)	1978-11-13
AT346321B (de)	1978-11-10
NL187164B (nl)	1991-01-16
IL50772A0 (en)	1976-12-31
MX4291E (es)	1982-03-17
NL187164C (nl)	1991-06-17
DE2646213A1 (de)	1977-05-12
IE43641B1 (en)	1981-04-22
PH14538A (en)	1981-09-24
PT65752B (en)	1978-04-20
YU262276A (en)	1982-05-31
HU175227B (hu)	1980-06-28
RO70755A (ro)	1981-01-30
SE428689B (sv)	1983-07-18
CA1078834A (en)	1980-06-03
DE2646213C2 (de)	1987-02-12
NL7611974A (nl)	1977-05-02
SU818476A3 (ru)	1981-03-30
ES452735A1 (es)	1978-01-01
PL104551B1 (pl)	1979-08-31
AU509372B2 (en)	1980-05-08
FR2329264A1 (fr)	1977-05-27
PL111987B1 (en)	1980-09-30
ZA766439B (en)	1978-06-28

Publication	Publication Date	Title
US4230862A (en)	1980-10-28	Antifertility compounds
US4133814A (en)	1979-01-09	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US3875229A (en)	1975-04-01	Substituted carboxanilides
JPS6028836B2 (ja)	1985-07-06	５−メチル−イソフラボン誘導体の製造方法
US4323707A (en)	1982-04-06	Antifertility compounds
CS196328B2 (en)	1980-03-31	Method of preparing novel derivatives of 2-aroyl-3-phenyl-benzothiophene
WO2008003378A1 (de)	2008-01-10	Sulfamat-benzothiophen-derivate
DE69635852T2 (de)	2006-09-14	Verbindungen mit Stickstoff enthaltenden, nichtbasischen Seitenketten und diese enthaltende Zubereitungen
SU791220A3 (ru)	1980-12-23	Способ получени производных ароилфенилнафталинов или их фармацевтически приемлемых кислотно-аддитивных солей
CA1096869A (en)	1981-03-03	Pyridine derivative, its preparation and use
US3987182A (en)	1976-10-19	Novel benzimidazoles useful as anti-androgens
US4113777A (en)	1978-09-12	2- OR 4-Hydroxy-3,5-dihalo-benzylamines and salts thereof
GB2107714A (en)	1983-05-05	Phenyl ketones
JPH01250316A (ja)	1989-10-05	抗脂血剤
US4473583A (en)	1984-09-25	Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
US4075223A (en)	1978-02-21	Novel antifertility agents
NO155056B (no)	1986-10-27	Sprengstoff.
US4400543A (en)	1983-08-23	3-Phenyl-4-benzoyl-1,2-dihydronaphthalenes
US3979468A (en)	1976-09-07	4'-Chloro-4-ethynylbiphenyl and method of preparing same
DE2551879A1 (de)	1976-05-26	Neue heterozyklische verbindungen, verfahren zu deren herstellung und dieselben enthaltende pharmazeutische praeparate
KR800000943B1 (ko)	1980-09-15	아로일-페닐나프탈렌 유도체의 제조방법
JPH0356473A (ja)	1991-03-12	シクロオキシゲナーゼと５―リポキシゲナーゼの二重阻害剤である新規な７―アローイル―４―ヒドロキシ―３―メチル―ベンゾフラン
WO2003099269A1 (en)	2003-12-04	Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease
US4065571A (en)	1977-12-27	Antiviral 5-(substituted benzal) hydantoins
US4283404A (en)	1981-08-11	Aroylethenylpiperidinobutyrophenone antipsychotic agents