SU908092A1 - Способ получени рибофлавина - Google Patents

Способ получени рибофлавина Download PDF

Info

Publication number: SU908092A1
Authority: SU; USSR - Soviet Union
Prior art keywords: riboflavin; fermentation; vniigenetika; source; producing
Prior art date: 1980-09-04

Application number

SU802981423A

Other languages

English (en)

Russian (ru)

Inventor

А.Я. Куканова

В.Г. Жданов

А.И. Степанов

В.А. Панова

Original Assignee

Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-04

Filing date

1980-09-04

Publication date

1984-12-30

1980-09-04 Application filed by Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов filed Critical Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов

1980-09-04 Priority to SU802981423A priority Critical patent/SU908092A1/ru

1981-09-01 Priority to YU210281A priority patent/YU210281A/xx

1981-09-04 Priority to HU256281A priority patent/HU185652B/hu

1981-09-11 Priority to CS816727A priority patent/CS237777B1/cs

1984-12-30 Application granted granted Critical

1984-12-30 Publication of SU908092A1 publication Critical patent/SU908092A1/ru

Links

AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title claims abstract description 46
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title claims abstract description 23
235000019192 riboflavin Nutrition 0.000 title claims abstract description 23
229960002477 riboflavin Drugs 0.000 title claims abstract description 23
239000002151 riboflavin Substances 0.000 title claims abstract description 23
238000000034 method Methods 0.000 title claims abstract description 16
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 10
229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 9
239000011707 mineral Substances 0.000 claims abstract description 9
235000015097 nutrients Nutrition 0.000 claims abstract description 9
150000003839 salts Chemical class 0.000 claims abstract description 9
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 8
229910052799 carbon Inorganic materials 0.000 claims abstract description 8
244000063299 Bacillus subtilis Species 0.000 claims abstract description 7
235000013379 molasses Nutrition 0.000 claims abstract description 7
229940041514 candida albicans extract Drugs 0.000 claims abstract description 6
235000000346 sugar Nutrition 0.000 claims abstract description 6
239000012138 yeast extract Substances 0.000 claims abstract description 6
241000193830 Bacillus <bacterium> Species 0.000 claims abstract description 5
244000005700 microbiome Species 0.000 claims abstract description 5
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
229940088594 vitamin Drugs 0.000 claims abstract description 5
239000011782 vitamin Substances 0.000 claims abstract description 5
235000014469 Bacillus subtilis Nutrition 0.000 claims abstract description 4
238000005273 aeration Methods 0.000 claims abstract description 4
239000003102 growth factor Substances 0.000 claims abstract description 4
239000012141 concentrate Substances 0.000 claims abstract description 3
239000003630 growth substance Substances 0.000 claims abstract description 3
238000004519 manufacturing process Methods 0.000 claims description 3
244000285963 Kluyveromyces fragilis Species 0.000 claims description 2
235000014663 Kluyveromyces fragilis Nutrition 0.000 claims description 2
238000012258 culturing Methods 0.000 claims 1
235000013305 food Nutrition 0.000 abstract description 3
240000004808 Saccharomyces cerevisiae Species 0.000 abstract description 2
238000000855 fermentation Methods 0.000 description 26
230000004151 fermentation Effects 0.000 description 26
239000002609 medium Substances 0.000 description 26
235000010755 mineral Nutrition 0.000 description 7
239000000203 mixture Substances 0.000 description 7
239000001888 Peptone Substances 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
239000008103 glucose Substances 0.000 description 5
108010080698 Peptones Proteins 0.000 description 4
239000012531 culture fluid Substances 0.000 description 4
235000019319 peptone Nutrition 0.000 description 4
229920001817 Agar Polymers 0.000 description 3
240000008042 Zea mays Species 0.000 description 3
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
235000002017 Zea mays subsp mays Nutrition 0.000 description 3
239000008272 agar Substances 0.000 description 3
235000005822 corn Nutrition 0.000 description 3
239000000463 material Substances 0.000 description 3
238000009331 sowing Methods 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
244000061456 Solanum tuberosum Species 0.000 description 2
235000002595 Solanum tuberosum Nutrition 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
239000005018 casein Substances 0.000 description 2
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
235000021240 caseins Nutrition 0.000 description 2
238000011109 contamination Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000000284 extract Substances 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
239000002054 inoculum Substances 0.000 description 2
230000002906 microbiologic effect Effects 0.000 description 2
244000005706 microflora Species 0.000 description 2
230000035772 mutation Effects 0.000 description 2
150000003212 purines Chemical class 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
150000003722 vitamin derivatives Chemical class 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 description 1
LPXQRXLUHJKZIE-UHFFFAOYSA-N 8-azaguanine Chemical compound NC1=NC(O)=C2NN=NC2=N1 LPXQRXLUHJKZIE-UHFFFAOYSA-N 0.000 description 1
229960005508 8-azaguanine Drugs 0.000 description 1
241000235349 Ascomycota Species 0.000 description 1
239000002028 Biomass Substances 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
108010058643 Fungal Proteins Proteins 0.000 description 1
241000233866 Fungi Species 0.000 description 1
229910021380 Manganese Chloride Inorganic materials 0.000 description 1
GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
ZRKWMRDKSOPRRS-UHFFFAOYSA-N N-Methyl-N-nitrosourea Chemical compound O=NN(C)C(N)=O ZRKWMRDKSOPRRS-UHFFFAOYSA-N 0.000 description 1
IGQLDUYTWDABFK-UHFFFAOYSA-N Roseoflavin Natural products OCC(O)C(O)C(O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(N(C)C)C(C)=C2 IGQLDUYTWDABFK-UHFFFAOYSA-N 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
229930003270 Vitamin B Natural products 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
239000003674 animal food additive Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
238000007865 diluting Methods 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
-1 for example Substances 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000011565 manganese chloride Substances 0.000 description 1
235000002867 manganese chloride Nutrition 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
231100000219 mutagenic Toxicity 0.000 description 1
230000003505 mutagenic effect Effects 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
150000003017 phosphorus Chemical class 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
235000012015 potatoes Nutrition 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
IGQLDUYTWDABFK-GUTXKFCHSA-N roseoflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(N(C)C)C(C)=C2 IGQLDUYTWDABFK-GUTXKFCHSA-N 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
AYTGUZPQPXGYFS-UHFFFAOYSA-N urea nitrate Chemical class NC(N)=O.O[N+]([O-])=O AYTGUZPQPXGYFS-UHFFFAOYSA-N 0.000 description 1
235000019156 vitamin B Nutrition 0.000 description 1
239000011720 vitamin B Substances 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SU802981423A 1980-09-04 1980-09-04 Способ получени рибофлавина SU908092A1 (ru)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
SU802981423A SU908092A1 (ru)	1980-09-04	1980-09-04	Способ получени рибофлавина
YU210281A YU210281A (en)	1980-09-04	1981-09-01	Process for obtaining riboflavin
HU256281A HU185652B (en)	1980-09-04	1981-09-04	Process for producing riboflavine with microbiological method
CS816727A CS237777B1 (en)	1980-09-04	1981-09-11	Processing of riboflavine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SU802981423A SU908092A1 (ru)	1980-09-04	1980-09-04	Способ получени рибофлавина

Publications (1)

Publication Number	Publication Date
SU908092A1 true SU908092A1 (ru)	1984-12-30

Family

ID=20917508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU802981423A SU908092A1 (ru)	1980-09-04	1980-09-04	Способ получени рибофлавина

Country Status (4)

Country	Link
CS (1)	CS237777B1 (cs)
HU (1)	HU185652B (cs)
SU (1)	SU908092A1 (cs)
YU (1)	YU210281A (cs)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3940071A1 (en)	2020-07-15	2022-01-19	Chifeng Pharmaceutical Co., Ltd	5-methylfolate producing microorganism
WO2022013663A1 (en)	2020-07-15	2022-01-20	Chifeng Pharmaceutical Co., Ltd.	5-methylfolate producing microorganism
EP4006139A1 (en)	2020-11-26	2022-06-01	Acies Bio d.o.o.	Genetically engineered bacterium capable of producing cytokinins with isoprenoid side chains

1980
- 1980-09-04 SU SU802981423A patent/SU908092A1/ru active
1981
- 1981-09-01 YU YU210281A patent/YU210281A/xx unknown
- 1981-09-04 HU HU256281A patent/HU185652B/hu unknown
- 1981-09-11 CS CS816727A patent/CS237777B1/cs unknown

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
14 Авторское свидетельство СССР № 389132, кл. С 12 D 5/04, 1969. 2. Патент US № 3900368, кл. , опублик. 1976. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3940071A1 (en)	2020-07-15	2022-01-19	Chifeng Pharmaceutical Co., Ltd	5-methylfolate producing microorganism
WO2022013663A1 (en)	2020-07-15	2022-01-20	Chifeng Pharmaceutical Co., Ltd.	5-methylfolate producing microorganism
EP4006139A1 (en)	2020-11-26	2022-06-01	Acies Bio d.o.o.	Genetically engineered bacterium capable of producing cytokinins with isoprenoid side chains
WO2022112509A1 (en)	2020-11-26	2022-06-02	Acies Bio D.O.O.	Genetically engineered bacterium capable of producing cytokinins with isoprenoid side chains

Also Published As

Publication number	Publication date
CS672781A1 (en)	1984-11-19
CS237777B1 (en)	1985-10-16
YU210281A (en)	1983-06-30
HU185652B (en)	1985-03-28

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US20090197305A1 (en)	2009-08-06	Process for the preparation of polymyxin b employing (paeni) bacillus polymyxa
US3375173A (en)	1968-03-26	Fermentation process for the production of l-threonine
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SU908092A1 (ru)	1984-12-30	Способ получени рибофлавина
SU974817A1 (ru)	1990-08-23	Способ получени L-треонина
FR2546907A1 (fr)	1984-12-07	Procede de production de la riboflavine
SU751829A1 (ru)	1980-07-30	Штамм вниигенетика-10-89-продуцент изолейцина
RU2084520C1 (ru)	1997-07-20	Штамм бактерий brevibacterium flavum - продуцент l-глутамина (варианты)
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US20060270004A1 (en)	2006-11-30	Fermentation processes with low concentrations of carbon-and nitrogen-containing nutrients
RU2835689C1 (ru)	2025-03-03	Способ получения рибофлавина
BE890917A (fr)	1982-04-29	Procede microbiologique d'obtention de la riboflavine et riboflavine ainsi obtenue
SI9600120A (en)	1997-12-31	New and improved fermentative procedure for the production of clavulanic acid and its salts
RU2103349C1 (ru)	1998-01-27	Способ обогащения растительного сырья микробным белком
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RU2065878C1 (ru)	1996-08-27	Штамм streptomyces fradiae - продуцент тилозина
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SU1735369A1 (ru)	1992-05-23	Способ получени аминогликозидного антибиотического комплекса
SU1509402A1 (ru)	1989-09-23	Штамм гриба @ продуцент @ -галактозидазы
SU1479509A1 (ru)	1989-05-15	Способ получени белковой биомассы
RU2059726C1 (ru)	1996-05-10	Штамм бактерий corynebacterium sp. - продуцент l-лейцина