SV2002000478A - Derivados de tiofeno utiles como anticancerosos ref. pc10795aagl/bb - Google Patents

Derivados de tiofeno utiles como anticancerosos ref. pc10795aagl/bb

Info

Publication number
SV2002000478A
SV2002000478A SV2001000478A SV2001000478A SV2002000478A SV 2002000478 A SV2002000478 A SV 2002000478A SV 2001000478 A SV2001000478 A SV 2001000478A SV 2001000478 A SV2001000478 A SV 2001000478A SV 2002000478 A SV2002000478 A SV 2002000478A
Authority
SV
El Salvador
Prior art keywords
formula
tiophene
banks
ref
derivatives
Prior art date
Application number
SV2001000478A
Other languages
English (en)
Inventor
Michael Joseph Luzzio
Matthew Arnold Marx
Bingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SV2002000478A publication Critical patent/SV2002000478A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

EL INVENTO SE REFIERE A COMPUESTOS DE FORMULA 1:VER FORMULA Y A SALES E HIDRATOS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, FORMULA EN LA QUE X, Y, R1, R2 Y R11 SON COMO AQUI SE DEFINEN. EL INVENTO SE REFIERE TAMBIEN A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS COMPUESTOS DE FORMULA 1, Y A METODOS PARA TRATAR TRASTORNOS HIPERPROLIFERATIVOS EN UN MAMIFERO MEDIANTE LA ADMINISTRACION DE LOS COMPUESTOS DE FORMULA 1.
SV2001000478A 2000-06-06 2001-06-05 Derivados de tiofeno utiles como anticancerosos ref. pc10795aagl/bb SV2002000478A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20968600P 2000-06-06 2000-06-06

Publications (1)

Publication Number Publication Date
SV2002000478A true SV2002000478A (es) 2002-07-03

Family

ID=22779830

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2001000478A SV2002000478A (es) 2000-06-06 2001-06-05 Derivados de tiofeno utiles como anticancerosos ref. pc10795aagl/bb

Country Status (23)

Country Link
US (1) US6964961B2 (es)
EP (1) EP1287001B1 (es)
JP (1) JP2003535867A (es)
AR (1) AR032621A1 (es)
AT (1) ATE277933T1 (es)
AU (1) AU2001252463A1 (es)
BR (1) BR0111377A (es)
CA (1) CA2411084A1 (es)
DE (1) DE60106022T2 (es)
DO (1) DOP2001000170A (es)
EC (1) ECSP014097A (es)
ES (1) ES2223827T3 (es)
GT (1) GT200100104A (es)
MX (1) MXPA02012034A (es)
PA (1) PA8518701A1 (es)
PE (1) PE20011373A1 (es)
PT (1) PT1287001E (es)
PY (1) PY0111330A (es)
SV (1) SV2002000478A (es)
TN (1) TNSN01082A1 (es)
TR (1) TR200402656T4 (es)
UY (1) UY26750A1 (es)
WO (1) WO2001094353A1 (es)

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DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
BR0306980A (pt) * 2002-02-01 2004-11-09 Novo Nordisk As Composto, uso de um composto, composição farmacêutica, e, método para o tratamento de distúrbios ou doenças relacionadas com o receptor de histamina h3
JP2005527511A (ja) * 2002-03-01 2005-09-15 ファイザー インコーポレイテッド 抗血管形成剤として有用なチエノピリジンのインドリル−尿素誘導体およびその使用法
CA2483890C (en) * 2002-06-06 2012-12-11 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7488823B2 (en) 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
CL2003002287A1 (es) 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
US7276519B2 (en) * 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
NZ541836A (en) 2003-02-27 2008-12-24 Palau Pharma Sa Pyrazolopyridine derivatives
EP1620094A4 (en) * 2003-05-06 2010-04-28 Glaxosmithkline Llc NEW CHEMICAL COMPOUNDS
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
JP4828421B2 (ja) 2003-08-14 2011-11-30 アレイ バイオファーマ、インコーポレイテッド 受容体チロシンキナーゼ阻害剤としてのキナゾリン誘導体
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
CA2573538C (en) 2004-07-30 2014-11-25 Methylgene Inc. Inhibitors of vegf receptor and hgf receptor signaling
ES2473341T3 (es) 2005-05-20 2014-07-04 Methylgene Inc Inhibidores de la se�alizaci�n del receptor del VEGF y del receptor del HGF
JP5148499B2 (ja) 2005-05-20 2013-02-20 メチルジーン インコーポレイテッド Ｖｅｇｆ受容体およびｈｇｆ受容体シグナル伝達の阻害剤
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
AR056200A1 (es) * 2005-09-27 2007-09-26 Wyeth Corp Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
CA2755268C (en) * 2005-11-15 2013-12-31 Array Biopharma, Inc. Erbb inhibitors
AR059246A1 (es) * 2006-01-30 2008-03-19 Array Biopharma Inc Compuestos heterobiciclicos de tiofeno y metodos de uso
MX2009010517A (es) 2007-04-05 2009-10-19 Amgen Inc Moduladores de cinasa aurora y metodos de uso.
WO2009109035A1 (en) 2008-03-05 2009-09-11 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
JP2011515401A (ja) 2008-03-20 2011-05-19 アムジエン・インコーポレーテツド オーロラキナーゼモジュレーターおよび使用方法
US9126935B2 (en) 2008-08-14 2015-09-08 Amgen Inc. Aurora kinase modulators and methods of use
CA2894860C (en) 2008-11-19 2018-11-06 Gerhard Koenig Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
JP5808319B2 (ja) * 2009-05-11 2015-11-10 フォルム ファーマシューティカルズ、インコーポレイテッド アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα７ニコチン酸受容体を用いた認知障害の治療
MX357676B (es) 2010-05-17 2018-07-18 Forum Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin- 3-il)benzo[b]tiofeno-2-carboxamida monohidratado.
EP3666272A1 (en) 2012-05-08 2020-06-17 Forum Pharmaceuticals Inc. Use of encenicline in the treatment of cognitive impairment, alzheimer's disease, memory deficit
FR3080620B1 (fr) * 2018-04-27 2021-11-12 Univ Paris Sud Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
CN113648307B (zh) * 2021-09-23 2022-09-30 河南大学 MII-tt-DTT及其在制备抗结直肠癌药物中的应用

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JPH02256667A (ja) * 1988-12-27 1990-10-17 Masatoshi Yamato 縮合キノリン系化合物およびその製造方法
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ZA986729B (en) * 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
WO1999024440A1 (en) * 1997-11-11 1999-05-20 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents

Also Published As

Publication number Publication date
EP1287001B1 (en) 2004-09-29
WO2001094353A1 (en) 2001-12-13
CA2411084A1 (en) 2001-12-13
US6964961B2 (en) 2005-11-15
JP2003535867A (ja) 2003-12-02
UY26750A1 (es) 2002-01-31
ES2223827T3 (es) 2005-03-01
DE60106022T2 (de) 2006-03-09
PA8518701A1 (es) 2002-09-17
AU2001252463A1 (en) 2001-12-17
MXPA02012034A (es) 2003-04-25
PE20011373A1 (es) 2002-01-18
ATE277933T1 (de) 2004-10-15
PY0111330A (es) 2003-11-03
TR200402656T4 (tr) 2004-11-22
EP1287001A1 (en) 2003-03-05
TNSN01082A1 (fr) 2005-11-10
US20020042409A1 (en) 2002-04-11
BR0111377A (pt) 2003-06-03
DOP2001000170A (es) 2002-05-15
ECSP014097A (es) 2003-02-06
PT1287001E (pt) 2004-12-31
GT200100104A (es) 2002-01-31
AR032621A1 (es) 2003-11-19
DE60106022D1 (de) 2004-11-04

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