SV2002000512A - Interleuquina-2 estabilizada ref. msb-7267-sv - Google Patents
Interleuquina-2 estabilizada ref. msb-7267-svInfo
- Publication number
- SV2002000512A SV2002000512A SV2001000512A SV2001000512A SV2002000512A SV 2002000512 A SV2002000512 A SV 2002000512A SV 2001000512 A SV2001000512 A SV 2001000512A SV 2001000512 A SV2001000512 A SV 2001000512A SV 2002000512 A SV2002000512 A SV 2002000512A
- Authority
- SV
- El Salvador
- Prior art keywords
- interleuquina
- msb
- ref
- stabilized
- variant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Sub-Exchange Stations And Push- Button Telephones (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UNA PREPARACION FARMACEUTICA ESTABLE QUE COMPRENDE INTERLEUQUINA-2 HUMANA O UNA VARIANTE DE LA MISMA Y UNA CANTIDAD ESTABILIZANTE DE HISTIDINA. UNA FORMULACION PREFERIDA INCLUYE GLICINA Y SACAROSA Y UNA VARIANTE DE II-2 QUE TIENE UNA MUTACION SIMPLE, N88R. LA FORMULACION PREFERIDA ES EN FORMA LIOFILIZADA, QUE CON LA RECONSTITUCION CON UN DILUYENTE ACUOSO, PRODUCE UNA SOLUCION QUE TIENE UN PH QUE VARIA DESDE APROXIMADAMENTE 5,0 A 6,5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/605,577 US6689353B1 (en) | 2000-06-28 | 2000-06-28 | Stabilized interleukin 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2002000512A true SV2002000512A (es) | 2002-07-03 |
Family
ID=24424265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2001000512A SV2002000512A (es) | 2000-06-28 | 2001-06-27 | Interleuquina-2 estabilizada ref. msb-7267-sv |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6689353B1 (es) |
| EP (1) | EP1370280B1 (es) |
| JP (3) | JP5522878B2 (es) |
| KR (1) | KR100799402B1 (es) |
| CN (1) | CN1523997B (es) |
| AR (1) | AR029139A1 (es) |
| AU (1) | AU2001273063A1 (es) |
| BR (1) | BR0112101B1 (es) |
| CA (1) | CA2413334C (es) |
| CO (1) | CO5290308A1 (es) |
| CU (1) | CU23536A3 (es) |
| DE (1) | DE60142412D1 (es) |
| DO (1) | DOP2001000197A (es) |
| EC (1) | ECSP014106A (es) |
| ES (1) | ES2344729T3 (es) |
| HN (1) | HN2001000139A (es) |
| IL (2) | IL153587A0 (es) |
| MX (1) | MXPA03000046A (es) |
| MY (1) | MY128629A (es) |
| PE (1) | PE20020127A1 (es) |
| SV (1) | SV2002000512A (es) |
| TW (1) | TWI235063B (es) |
| UY (1) | UY26805A1 (es) |
| WO (1) | WO2002000243A2 (es) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8531276B2 (en) * | 2000-03-15 | 2013-09-10 | Logitech Europe S.A. | State-based remote control system |
| US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| JP5057648B2 (ja) * | 2002-09-26 | 2012-10-24 | 塩野義製薬株式会社 | 安定化されたタンパク組成物 |
| US20060099567A1 (en) * | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| AU2005245338B2 (en) | 2004-04-08 | 2011-11-17 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| SG160336A1 (en) | 2005-03-04 | 2010-04-29 | Dynavax Tech Corp | Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients |
| EP2001500A4 (en) * | 2006-03-10 | 2010-07-28 | Dyax Corp | FORMULATIONS FOR ECALLANTIDE |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| CN102838599A (zh) | 2006-05-04 | 2012-12-26 | 贝林格尔.英格海姆国际有限公司 | 多晶型 |
| EP2150537A4 (en) * | 2007-06-01 | 2010-09-22 | Acologix Inc | STABLE PEPTIDE FORMULATION AT HIGH TEMPERATURE |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
| EP2430195B1 (en) * | 2009-05-11 | 2019-01-23 | Biomatrica, INC. | Compositions and methods for biological sample storage |
| KR101853606B1 (ko) | 2009-07-06 | 2018-05-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 메티오닌을 함유하는 수성 인슐린 제제 |
| DK2498802T3 (en) | 2009-11-13 | 2015-04-13 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine |
| KR101337322B1 (ko) | 2009-11-13 | 2013-12-06 | 사노피-아벤티스 도이칠란트 게엠베하 | Glp-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
| NZ599298A (en) | 2009-11-27 | 2014-11-28 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
| WO2011138421A1 (en) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combination therapy |
| WO2012018639A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| ES2606554T3 (es) | 2010-08-30 | 2017-03-24 | Sanofi-Aventis Deutschland Gmbh | Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2 |
| KR102591732B1 (ko) | 2010-11-12 | 2023-10-19 | 넥타르 테라퓨틱스 | Il-2 부분 및 중합체의 접합체 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| WO2012075379A2 (en) * | 2010-12-02 | 2012-06-07 | Oncolytics Biotech Inc. | Liquid viral formulations |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| PL2750699T3 (pl) | 2011-08-29 | 2015-12-31 | Sanofi Aventis Deutschland | Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| US20130303554A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in sirs and/or sepsis |
| EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
| EP3249054A1 (en) | 2012-12-20 | 2017-11-29 | Biomatrica, INC. | Formulations and methods for stabilizing pcr reagents |
| CN103063829B (zh) * | 2012-12-21 | 2015-01-14 | 杭州茂天赛科技有限公司 | 一种冻存液 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| WO2015191632A1 (en) | 2014-06-10 | 2015-12-17 | Biomatrica, Inc. | Stabilization of thrombocytes at ambient temperatures |
| SI3482766T1 (sl) | 2014-08-11 | 2020-09-30 | Delinia, Inc. | Spremenjene variante IL-2, ki selektivno aktivirajo regulatorne T celice za zdravljenje avtoimunskih bolezni |
| AU2015359376B2 (en) | 2014-12-12 | 2021-09-09 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
| US9139653B1 (en) | 2015-04-30 | 2015-09-22 | Kymab Limited | Anti-human OX40L antibodies and methods of treatment |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
| MA47290A (fr) | 2015-10-08 | 2019-11-27 | Nektar Therapeutics | Combinaison d'un agoniste sélectif de l'il-2rbeta et d'un agoniste de l'il-15 à action prolongée |
| KR102589056B1 (ko) | 2015-12-08 | 2023-10-12 | 바이오매트리카 인코포레이티드 | 적혈구 침강 속도의 감소 |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗pd-l1およびil-2サイトカイン |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| SG11201903882VA (en) | 2016-11-08 | 2019-05-30 | Delinia Inc | Il-2 variants for the treatment of autoimmune diseases |
| JP7165717B2 (ja) | 2017-03-15 | 2022-11-04 | パンディオン・オペレーションズ・インコーポレイテッド | 標的免疫寛容 |
| AU2018273914A1 (en) | 2017-05-24 | 2019-11-14 | Pandion Operations, Inc. | Targeted immunotolerance |
| PH12020550661A1 (en) | 2017-11-21 | 2021-04-19 | Univ Leland Stanford Junior | Partial agonists of interleukin-2 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CN119504973A (zh) | 2018-03-28 | 2025-02-25 | 阿森迪斯药物肿瘤股份有限公司 | Il-2缀合物 |
| CA3141327A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Operations, Inc. | Madcam targeted immunotolerance |
| CN114867749A (zh) | 2019-12-17 | 2022-08-05 | 安进公司 | 用于疗法中的双重白介素-2/tnf受体激动剂 |
| IL293978A (en) | 2019-12-20 | 2022-08-01 | Regeneron Pharma | New il2 agonists and methods of using them |
| JP2023514010A (ja) | 2020-01-10 | 2023-04-05 | ブライト ピーク セラピューティクス エージー | 修飾il-2ポリペプチドおよびその使用 |
| EP4090674A4 (en) | 2020-01-14 | 2024-01-24 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| IL298642A (en) | 2020-06-03 | 2023-01-01 | Ascendis Pharma Oncology Div A/S | il-2 sequences and uses thereof |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| CA3201446A1 (en) * | 2020-11-13 | 2022-05-19 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising human interleukin 2 variant or derivative thereof and use thereof |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0158487B1 (en) * | 1984-04-09 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Stable composition of interleukin-2 |
| JPS60215631A (ja) * | 1984-04-09 | 1985-10-29 | Takeda Chem Ind Ltd | インタ−ロイキン−2組成物 |
| JPH0645551B2 (ja) * | 1986-01-07 | 1994-06-15 | 塩野義製薬株式会社 | インタ−ロイキン−2組成物 |
| JPH0229016A (ja) * | 1989-06-09 | 1990-01-31 | Alpine Electron Inc | イコライザ装置 |
| US5358708A (en) | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
| US5656730A (en) * | 1995-04-07 | 1997-08-12 | Enzon, Inc. | Stabilized monomeric protein compositions |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| JP2001511437A (ja) * | 1997-07-31 | 2001-08-14 | ロディア・シミ | 官能化されたポリオルガノシロキサンを含む化粧品組成物 |
| DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
-
2000
- 2000-06-28 US US09/605,577 patent/US6689353B1/en not_active Expired - Lifetime
-
2001
- 2001-06-14 AR ARP010102841A patent/AR029139A1/es active IP Right Grant
- 2001-06-26 MY MYPI20013006A patent/MY128629A/en unknown
- 2001-06-26 DO DO2001000197A patent/DOP2001000197A/es unknown
- 2001-06-26 CO CO01050546A patent/CO5290308A1/es not_active Application Discontinuation
- 2001-06-27 ES ES01952296T patent/ES2344729T3/es not_active Expired - Lifetime
- 2001-06-27 CA CA2413334A patent/CA2413334C/en not_active Expired - Lifetime
- 2001-06-27 BR BRPI0112101A patent/BR0112101B1/pt not_active IP Right Cessation
- 2001-06-27 CN CN018144454A patent/CN1523997B/zh not_active Expired - Fee Related
- 2001-06-27 EC EC2001004106A patent/ECSP014106A/es unknown
- 2001-06-27 IL IL15358701A patent/IL153587A0/xx active IP Right Grant
- 2001-06-27 DE DE60142412T patent/DE60142412D1/de not_active Expired - Lifetime
- 2001-06-27 WO PCT/US2001/020675 patent/WO2002000243A2/en not_active Ceased
- 2001-06-27 SV SV2001000512A patent/SV2002000512A/es unknown
- 2001-06-27 JP JP2002505024A patent/JP5522878B2/ja not_active Expired - Lifetime
- 2001-06-27 UY UY26805A patent/UY26805A1/es not_active IP Right Cessation
- 2001-06-27 AU AU2001273063A patent/AU2001273063A1/en not_active Abandoned
- 2001-06-27 EP EP01952296A patent/EP1370280B1/en not_active Expired - Lifetime
- 2001-06-27 KR KR1020027017859A patent/KR100799402B1/ko not_active Expired - Fee Related
- 2001-06-27 MX MXPA03000046A patent/MXPA03000046A/es active IP Right Grant
- 2001-06-28 HN HN2001000139A patent/HN2001000139A/es unknown
- 2001-06-28 PE PE2001000639A patent/PE20020127A1/es not_active Application Discontinuation
- 2001-06-28 TW TW090115670A patent/TWI235063B/zh not_active IP Right Cessation
-
2002
- 2002-12-23 IL IL153587A patent/IL153587A/en unknown
- 2002-12-24 CU CU20020334A patent/CU23536A3/es not_active IP Right Cessation
-
2012
- 2012-06-21 JP JP2012139913A patent/JP2012211166A/ja active Pending
-
2014
- 2014-09-08 JP JP2014182175A patent/JP5989728B2/ja not_active Expired - Fee Related
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