SV2017005545A - Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y metodos para usar los mismos - Google Patents
Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y metodos para usar los mismosInfo
- Publication number
- SV2017005545A SV2017005545A SV2017005545A SV2017005545A SV2017005545A SV 2017005545 A SV2017005545 A SV 2017005545A SV 2017005545 A SV2017005545 A SV 2017005545A SV 2017005545 A SV2017005545 A SV 2017005545A SV 2017005545 A SV2017005545 A SV 2017005545A
- Authority
- SV
- El Salvador
- Prior art keywords
- iii
- mesotheline
- methods
- growth factor
- epidermic
- Prior art date
Links
- 102000009465 Growth Factor Receptors Human genes 0.000 title 1
- 108010009202 Growth Factor Receptors Proteins 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102400001368 Epidermal growth factor Human genes 0.000 abstract 1
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 229940116977 epidermal growth factor Drugs 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001104—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
- A61K39/001168—Mesothelin [MSLN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
EN EL PRESENTE DOCUMENTO SE PROPORCIONAN COMPOSICIONES Y MÉTODOS PARA DESENCADENAR UNA RESPUESTA INMUNITARIA EN UN SUJETO. EN PARTICULAR, LA PRESENTE DIVULGACIÓN SE REFIERE A PROTEÍNAS DE FUSIÓN QUE COMPRENDEN UN POLIPÉPTIDO DE LA VARIANTE III DEL RECEPTOR DE FACTOR DE CRECIMIENTO EPIDÉRMICO (EGFRVIII) Y UN POLIPÉPTIDO DE MESOTELINA, Y A MÉTODOS PARA DESENCADENAR UNA RESPUESTA INMUNITARIA USANDO CELULAS HOSPEDADORAS QUE COMPRENDEN MOLÉCULAS DE ÁCIDO NUCLEICO QUE CODIFICAN DICHAS PROTEINAS DE FUSIÓN. EN ALGUNAS REALIZACIONES, LAS MOLÉCULAS DE ÁCIDO NUCLEICO PUEDEN CODIFICAR UNA PROTEÍNA DE FUSIÓN EGFRVLLL-MESOTELINA QUE COMPRENDE UNA SECUENCIA DE AMINOÁCIDOS QUE ES AL MENOS I) UN 90% IDÉNTICA, II) UN 95% IDÉNTICA, O III) UN 99% IDÉNTICA A EGFR~IILX5-MESOTELINA3~T-A~L 2C~O MO SE EXPONE EN LA SEQ ID NO: 8
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562146559P | 2015-04-13 | 2015-04-13 | |
| US201562243397P | 2015-10-19 | 2015-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2017005545A true SV2017005545A (es) | 2018-05-11 |
Family
ID=55809232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2017005545A SV2017005545A (es) | 2015-04-13 | 2017-10-13 | Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y metodos para usar los mismos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10105427B2 (es) |
| EP (1) | EP3283509A1 (es) |
| JP (1) | JP6782253B2 (es) |
| KR (1) | KR20180002640A (es) |
| CN (1) | CN107750256A (es) |
| AU (1) | AU2016247887A1 (es) |
| BR (1) | BR112017022076A2 (es) |
| CA (1) | CA2982533A1 (es) |
| CO (1) | CO2017011431A2 (es) |
| CR (1) | CR20170507A (es) |
| EA (1) | EA201792274A1 (es) |
| EC (1) | ECSP17075380A (es) |
| HK (2) | HK1250992A1 (es) |
| IL (1) | IL254957A0 (es) |
| MA (1) | MA44379A (es) |
| MX (1) | MX2017013174A (es) |
| PH (1) | PH12017502080A1 (es) |
| SG (1) | SG11201708360TA (es) |
| SV (1) | SV2017005545A (es) |
| TW (1) | TW201710285A (es) |
| UY (1) | UY36616A (es) |
| WO (1) | WO2016168198A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY36616A (es) | 2015-04-13 | 2016-10-31 | Aduro Biotech Inc | Fusiones de variante iii del receptor de factor de crecimiento epidérmico-mesotelina y métodos para usar los mismos |
| JP2018512165A (ja) | 2015-04-13 | 2018-05-17 | アデュロ バイオテック，インコーポレイテッド | 癌の治療のための免疫原性融合タンパク質 |
| RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
| KR20260039788A (ko) | 2017-10-10 | 2026-03-20 | 시애틀 프로젝트 코포레이션 | 핫스팟을 이용한 신생항원 동정 |
| CA3083097A1 (en) | 2017-11-22 | 2019-05-31 | Gritstone Oncology, Inc. | Reducing junction epitope presentation for neoantigens |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| WO2001072329A1 (en) | 2000-03-29 | 2001-10-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| CA2206343C (en) | 1994-11-28 | 2009-04-07 | Thomas Jefferson University | Reagents and processes for targeting mutant epidermal growth factor receptors |
| EP1575500A4 (en) | 2002-07-12 | 2007-01-03 | Univ Johns Hopkins | MESOTHELIN VACCINE AND MODEL SYSTEMS |
| JP2006514823A (ja) | 2002-08-20 | 2006-05-18 | ミレニアム ファーマスーティカルズ インク | 子宮頸癌の同定、評価、予防および治療を行うための組成物、キットおよび方法 |
| KR101192652B1 (ko) | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
| US7833775B2 (en) | 2003-02-06 | 2010-11-16 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| AU2004249254B2 (en) | 2003-06-17 | 2010-07-08 | Mannkind Corporation | Combinations of tumor-associated antigens for the treatment of various types of cancers |
| WO2007117371A2 (en) | 2006-03-01 | 2007-10-18 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
| WO2007103225A2 (en) | 2006-03-01 | 2007-09-13 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| RS57630B1 (sr) * | 2010-11-17 | 2018-11-30 | Aduro Biotech Inc | Metode i sastavi za uzrokovanje imunog odgovora na egfrviii |
| WO2014106123A1 (en) | 2012-12-27 | 2014-07-03 | Aduro Biotech, Inc. | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
| CN104211814A (zh) | 2013-05-29 | 2014-12-17 | 三星电子株式会社 | 用于消耗靶膜蛋白的组合物 |
| UY36616A (es) | 2015-04-13 | 2016-10-31 | Aduro Biotech Inc | Fusiones de variante iii del receptor de factor de crecimiento epidérmico-mesotelina y métodos para usar los mismos |
| JP2018512165A (ja) | 2015-04-13 | 2018-05-17 | アデュロ バイオテック，インコーポレイテッド | 癌の治療のための免疫原性融合タンパク質 |
-
2016
- 2016-04-12 UY UY0001036616A patent/UY36616A/es not_active Application Discontinuation
- 2016-04-12 TW TW105111337A patent/TW201710285A/zh unknown
- 2016-04-12 WO PCT/US2016/027136 patent/WO2016168198A1/en not_active Ceased
- 2016-04-12 HK HK18110280.8A patent/HK1250992A1/zh unknown
- 2016-04-12 US US15/097,178 patent/US10105427B2/en not_active Expired - Fee Related
- 2016-04-12 CN CN201680028967.8A patent/CN107750256A/zh active Pending
- 2016-04-12 JP JP2017554395A patent/JP6782253B2/ja not_active Expired - Fee Related
- 2016-04-12 EP EP16718812.7A patent/EP3283509A1/en not_active Withdrawn
- 2016-04-12 BR BR112017022076-8A patent/BR112017022076A2/pt not_active Application Discontinuation
- 2016-04-12 CR CR20170507A patent/CR20170507A/es unknown
- 2016-04-12 HK HK18110071.1A patent/HK1250730A1/zh unknown
- 2016-04-12 SG SG11201708360TA patent/SG11201708360TA/en unknown
- 2016-04-12 CA CA2982533A patent/CA2982533A1/en not_active Abandoned
- 2016-04-12 AU AU2016247887A patent/AU2016247887A1/en not_active Abandoned
- 2016-04-12 EA EA201792274A patent/EA201792274A1/ru unknown
- 2016-04-12 MX MX2017013174A patent/MX2017013174A/es unknown
- 2016-04-12 MA MA044379A patent/MA44379A/fr unknown
- 2016-04-12 KR KR1020177031486A patent/KR20180002640A/ko not_active Withdrawn
-
2017
- 2017-10-09 IL IL254957A patent/IL254957A0/en unknown
- 2017-10-13 SV SV2017005545A patent/SV2017005545A/es unknown
- 2017-11-07 CO CONC2017/0011431A patent/CO2017011431A2/es unknown
- 2017-11-13 EC ECIEPI201775380A patent/ECSP17075380A/es unknown
- 2017-11-16 PH PH12017502080A patent/PH12017502080A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180002640A (ko) | 2018-01-08 |
| JP6782253B2 (ja) | 2020-11-11 |
| TW201710285A (zh) | 2017-03-16 |
| JP2018512166A (ja) | 2018-05-17 |
| HK1250992A1 (zh) | 2019-01-18 |
| EP3283509A1 (en) | 2018-02-21 |
| MX2017013174A (es) | 2018-04-11 |
| CO2017011431A2 (es) | 2018-01-16 |
| PH12017502080A1 (en) | 2018-05-07 |
| BR112017022076A2 (pt) | 2018-08-14 |
| SG11201708360TA (en) | 2017-11-29 |
| US10105427B2 (en) | 2018-10-23 |
| UY36616A (es) | 2016-10-31 |
| EA201792274A1 (ru) | 2018-02-28 |
| US20160346369A1 (en) | 2016-12-01 |
| CA2982533A1 (en) | 2016-10-20 |
| ECSP17075380A (es) | 2018-02-28 |
| CN107750256A (zh) | 2018-03-02 |
| WO2016168198A1 (en) | 2016-10-20 |
| HK1250730A1 (zh) | 2019-01-11 |
| CR20170507A (es) | 2018-02-13 |
| MA44379A (fr) | 2019-01-23 |
| AU2016247887A1 (en) | 2017-11-02 |
| IL254957A0 (en) | 2017-12-31 |
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