TH102403A - A purinone derivative, which is HM74A agonist. - Google Patents

Abstract

DC60 (05/11/51) This invention relates to purunone derivatives, i.e., agonists of the HM74a receptor, hereafter supplied, namely the composition and methods of use of the compounds, and their pharmacologically acceptable salts for therapeutic use. This invention relates to purunone derivatives, i.e., agonists of the HM74a receptor, hereafter supplied, namely the composition and methods of use of the compounds, and their pharmacologically acceptable salts for therapeutic use.

Claims (70)

1. Compounds according to formula I: (chemical formula) I or their salts or pro-drugs that are pharmacologically acceptable, where: dashed lines indicate alternative bonds; X is N, CR3a, CR4aR5a, or NR6a; Y is N, CR3b, CR4bR5b, or NR6b; L is -(C1-6 alkylene)-(Q1)m(C1-6 The alkylene)p-(Q2)q-(C1-6 alkylene)r- is selectively substituted by 1, 2, 3, 4, or 5 RL1, where if both m and q are 1, then p is 1; R1 is H, C1-10 alkyl, C2-10 alkynyl, C2-10 alkynyl, or Cy, where such C1-10 alkyl, C2-10 alkynyl, or C2-10 alkynyl are selectively substituted by 1, 2, 3, 4, or 5 RL2; R2 is halo, cyano, C1-3 haloalkyl, Z, SRA, or moity with the formula: R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 Haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd, where these C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyls can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd; R4a, R4b, R5a, and R5b are independently selected from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where the aforementioned C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, R6a and R6b are selected independently from H, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl are used. Selective substitution is possible with 1, 2, or 3 substitutes which are independently selected from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; RL1 and RL2 are independently selected from Halo, C1-6 Alkyl, C2-6 Alkinil, C2-6 Alkinil, C1-6 Haloalkyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)NRc2Rd2, NRc2C(O)ORa2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, NRc2S(O)2Rb2, and S(O)2NRc2Rd2; R2a is H, C1-6 alkyl, C2-6 alkynyl, C2-10 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy4, CN, NO2, C(O)Rb6, C(O)NRc6Rd6, or C(O)ORa6; Cy is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will It can be selectively replaced by 1, 2, 3, 4 or 5 substitutes chosen from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; Cy1 and Cy2 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl. Each of these can be selectively replaced by 1, 2, 3, 4, or 5 substitutes, which are independently selected from Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4, and S(O)2NRc4Rd4; And Cy3, where C1-4 alkynil, C2-4 alkynil, or C2-4 alkynils are selectively replaced by 1, 2, or 3 substitutes, where Independently selected from CN, NO2, halo, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)NRc4Rd4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, NRc4S(O)2Rb4, S(O)2NRc4Rd4 and Cy3; Cy3 and Cy4 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes. Independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6; Z is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will Can be selectively replaced by 1, 2, 3, 4 or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rb6, S(O)2Rb6, and S(O)2NRc6Rd6; RA is H or C1-4 alkyl; Q1 and Q2 are independently selected from O, S, NH, CH2, CO, CS, SO, SO2, OCH2, SCH2, NHCH2, CH2CH2, COCH2, CONH, COO, SOCH2, SONH, SO2CH2, and SO2NH; Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, Ra and Ra1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, and Cy2, where the aforementioned C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, and C2-6 alkynyl are Selective substitution is possible with 1, 2, 3, 4, or 5 substitutes chosen from Halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or, such heterocycloalkyl alkyls can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rb and Rb1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl are selectively substituted by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rb2, Rb3, Rb4, Rb5, and Rb6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or heterocycloalkyl alkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or such heterocycloalkyl alkyl can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, OC(O)Ra5, C(O)ORb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc and Rd together with N atoms where they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc1 and Rd1. Independently selected substitutes will be made from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc1 and Rd1 together with the N atoms to which they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc2 and Rd2. They will be independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc2 and Rd2 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc3 and Rd3 are independently selectable from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where such C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl are selectively replaced by OH, amino, Halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc3 and Rd3 together with an N atom where they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc4 and Rd4 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc4 and Rd4 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc5 and Rd5 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc5 and Rd5 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; And Rc6 and Rd6 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc6 and Rd6 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; And m, p, q, and r are independently selected from 0 and 1, provided that: (a) when is CR4aR5a (formula) CR4bR5b, then R2 is something other than halo, C1-3 haloalkyl, Z or SRA; (b) when is , then R2 is something other than Z; (c) when is , and R3b is H or unreplaced aryl, then R2 is something other than unreplaced aryl; (d) when is , then R2 is something other than aryl; and (e) when is , and -L-R1 is something other than methyl. 2. The compounds according to claim 1, or their salts that are pharmaceutically acceptable, where X is N. 3. The compounds according to claim 1, or their salts that are pharmaceutically acceptable, where X is CH₃. 4. Any of the compounds under the preceding claims, or their salts, that are pharmaceutically acceptable, where Y is CR3b. 5. Any of the compounds listed in the preceding claims, or their salts, that are pharmaceutically acceptable, where Y is CH₃. 6. Any of the compounds listed in the preceding claims, or their salts, that are pharmaceutically acceptable, where Y is C-Me. 7. Any of the compounds listed in the preceding claims, or their salts, are pharmaceutically acceptable, where X is CH and Y is N. 8. Any compound under any of the preceding claims, or their salts, are acceptable. In pharmaceuticals, where R3a and R3b are independently selected from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, Cy1, ORa, SRa, C(O)Rb, S(O)2Rb, and NRcRd, where the aforementioned C1-6 alkyl, C2-6 alkinyl, and C2-6 alkinyls can be selectively replaced by 1, 2, or 3 substitutes which are independently selected from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd; 9. Any of the preceding claims, or their salts, are pharmacologically acceptable, whereby R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, Cy1, ORa, SRa, and NRcRd, whereby such C1-6 alkyl and C2-6 alkinyl are selectively substituted by 1, 2, or 3 selected substitutes. Independent of each other from Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRb, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd 10. Any of the preceding claims, or their salts, are pharmacologically acceptable, whereby R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, Cy1, ORa, SRa, and NRcRd, whereby the C1-6 alkyl, C2-6 alkynyl, and C2-6 alkinyl compounds are selectively substituted by 1, 2, or 3 substitutes which are independently selectable from Cy1, C(O)NRcRd, C(O)ORa, and NRcC(O)Rb. 11. Any of the preceding claims, or their salts, are pharmacopoeias where R3a and R3b are independently selectable from H, C1-6 alkyl, C1-6 haloalkyl, Cy1, halo, ORa, SRa, S(O)Rb, S(O)2Rb, and NRcRd, where such C1-6 alkyls are selectively substituted by 1, 2, or 3 substitutes which are independently selectable from Cy1, C(O)NRcRd, C(O)ORa, halo, ORa, NRcRd, NRcC(O)NRcRd, and NRcC(O)Rb. 12. Any compound under any of the preceding claims, or their salts, are acceptable. In pharmaceuticals, where: at least one R3a and R3b are selected from Cy1; Cy1 is selected from aryls, heteroaryls, cycloalkyls, and heterocycloalkyls, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes which are selected from halo, C1-4 alkyls, C2-4 alkynyls, C2-4 alkinyls, C1-4 haloalkyls, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, and C(O)ORa4, and Cy3, where C1-4 alkyls, C2-4 alkinyls and C2-4 alkinyls can be selectively replaced by 1, 2, or 3 substitutes which are independently selected from halo, ORa4 and Cy3; And Cy3 is independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes which are independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, CN, NO2, NRc6Rd6, ORa6, and SRa6; 13. Any of the compounds under the preceding claims, or their salts, are pharmacopoeias where at least one of R3a and R3b is selected from C1-6 alkyls and C1-63 haloalkyls, where such C1-6 alkyls are selectively substituted by 1, 2, or 3 substitutes which are independently selected from C(O)NRcRd, C(O)ORa, NRcRd, NRcC(O)NRcRd, and NRcC(O)Rb. 14. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, whereby: at least one of R3a and R3b is selected from C1-3 alkyls, such C1-3 alkyls are selectively substituted by Cy1 and are selectively substituted by 1 or 2 selected substitutes. Independently from Halo, ORa, and SRa; Cy1 is selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4, or 5 substitutes selected from Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, C(O)ORb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4. S(O)2NRc4R4d and Cy3, where C1-4 alkyl, C2-4 alkynyl and C2-4 alkynyl are selectively substituted by 1, 2, or 3 substitutes which are independently selected from ORa4 and Cy3; And Cy3 will be selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 independently selected substitutes from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6 and S(O)2NRc6Rd6 15. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, whereby: at least one of R3a and R3b is selected from C1-3 alkyls, such C1-3 alkyls are selectively substituted by Cy1 and are selectively substituted by 1 or 2 selected substitutes. Independently selected from halo, ORa, and SRa; Cy1 is selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4, or 5 substitutes which are independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, and Cy3, where C1-4 alkyl, C2-4 alkynyl, and C2-4 alkynyl can be selectively replaced by 1, 2, or 3 substitutes which are independently selected from ORa4 and Cy3; And Cy3 will be selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes which are selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, CN, NO2, NRc6Rd6, ORa6 and SRa6. 16. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, whereby: at least one of R3a and R3b is selected from C1-3 alkyls, whereby such C1-3 alkyls are selectively substituted by Cy1 and are selectively substituted by 1 or 2 substitutes which are selected. Independently from Halo, ORa, and SRa; Cy1 is selected from Ayril, HeteroAyril, Cycloalkyl, and HeteroCycloalkyl, each of which is replaced by 1 or 2 R7 and selectively replaced by 1, 2, or 3 R8; R7, at each appearance, is selected independently from Cy3 and C1-4 alkyl, where C1-4 alkyl is selectively replaced by 1 or 2 Cy3 and selectively replaced by 1 or 2 substitutes which are independently selected from Halo and ORa4; R8, at each appearance, is selected independently from Halo, C1-4 alkyl, C2-4 alkynil, C2-4 alkynil, C1-4 Haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, and C(O)ORa4; and Cy3 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which is independently substituted by 1, 2, 3, 4 or 5 substitutes which are independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, CN, NO2, NRc6Rd6, ORa6 and SRa6. 17. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, whereby R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl and C1-6 haloalkyl. 18. Any of the compounds under the preceding claims, or their salts, are pharmaceutically acceptable, whereby R3a and R3b are independently selectable from aryls, heteroaryls, cycloalkyls, and heterocycloalkyls. 19. Any of the preceding claims, or their salts, are pharmacopoeiaworthy, whereby R3b is a heteroaryl selectively substituted by 1, 2, 3, 4 or 5 independently selected substitutes of aryl, cycloalkyl, and heterocycloalkyl, each of which is selectively substituted by 1, 2, 3, 4 or 5 independently selected substitutes of halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkinyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6 and SRa6. 20. Any of the compounds under the preceding claims, or their salts, are pharmacopoeiaworthy, where R3b is thiazolyl selectively substituted by phenyl, where such phenyl is selectively substituted by 1, 2, 3, 4 or 5 substitutes chosen from OH and halo. 21. Any compound under any of the preceding claims, or their salts, are acceptable. In pharmaceuticals, Cy1 is selectively substituted from aryls, heteroaryls, cycloalkyls, and heterocycloalkyls, each of which can be selectively replaced by 1, 2, 3, 4, or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkinyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4, S(O)2NRc4Rd4, and Cy3, where C1-4 alkyl, C2-4 alkynyl, and C2-4 alkynyl can be selectively replaced by 1, 2, or 3 substitutes which are selected independently of ORa4 and Cy3. 22. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where m and q are 0. 23. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R1 is H or C1-10 alkyl. 24. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where -L-R1 is C1-10 alkyl. 25. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, whereby -L-R1 is a C4-7 alkyl selectively substituted by 1, 2, 3, 4 or 5 substitutes independently selected from halo, , OH, and CN. 26. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where -L-R1 is butyl or pentyl. 27. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R2 is a halo, cyano, C1 haloalkyl, Z, SRA, or moity having the formula (chemical formula). 28. Compounds according to claim 1, or their salts that are pharmacologically acceptable, where R2 is halo, cyano, C1 haloalkyl, Z, or SRA, 29. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R2 is a halo, cyano, or C1 haloalkyl. 30. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R2 is halo, or C1 is haloalkyl. 31. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R2 is Cl, Br, or CF3. 32. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R2 is Cl or Br. 33. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R2 is Br. 34. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, where R2 is the molecule with the formula: (chemical formula). 35. Any of the compounds under the preceding claims, or their salts, are pharmaceutically acceptable, where R2 is S-Me. 36. Any of the compounds under the preceding claims, or their salts, are pharmacologically acceptable, whereby R2 shall be selected from aryls, heteroaryls, cycloalkyls, and heterocycloalkyls, each of which is selectively substituted by 1, 2, 3, 4 or 5 substitutes which are selected from halo, C1-4 alkyls, C2-4 alkinyls, C2-4 alkinyls, C1-4 haloalkyls, and ORa4. 37. The compounds according to claim 1, or their salts that are pharmacologically acceptable, having the formula: (chemical formula) II 38. Compounds according to claim 37, or their pharmacologically acceptable salts, where R3b is selected from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, Cy1, ORa, SRa, S(O)Rb, S(O)2Rb, and NRcRd, where such C1-6 alkyl, C2-6 alkinyl, and C2-6 alkinyl are selectively substituted by 1, 2, or 3 substitutes which are independently selected from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd. 39. The compounds according to claim 37, or their salts that are pharmacologically acceptable, where R3b is selected from H, C1-6 alkyl, C1-6 haloalkyl, Cy1, ORa, SRa, S(O)Rb, S(O)2Rb, and NRcRd, where such C1-6 alkyls are selectively substituted by 1, 2, or 3 substitutes which are independently selected from Cy1, C(O)NRcRd, C(O)ORa, halo, ORa, NRcRd, NRcC(O)NRcRd, and NRcC(O)Rb. 40. Compounds according to claim 37, or their salts that are pharmacologically acceptable, where R3b is Cy1; Cy1 is selected from aryls, heteroaryls, cycloalkyls, and heterocycloalkyls, each of which is selectively substituted by 1, 2, 3, 4 or 5 substitutes which are independently selected from halo, C1-4 alkyls, C2-4 alkynyls, C2-4 alkinyls, C1-4 haloalkyls, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, and Cy3, where C1-4 alkyls, C2-4 alkinyls, and C2-4 alkinyls are selectively substituted by 1, 2, or 3 substitutes which are independently selected from ORa4 and Cy3; and Cy3 will be selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, CN, NO2, NRc6Rd6, ORa6 and SRa6. 41. Compounds according to claim 37, or their salts that are pharmacologically acceptable, where R3b is a C1-6 alkyl or C1-6 haloalkyl, where such C1-6 alkyl is selectively substituted by 1, 2 or 3 substitutes which are independently selected from C(O)NRcRd, C(O)ORa, NRcRd, NRcC(O)ORaRd, and NRcC(O)Rb. 42. Compounds according to claim 37, or their salts that are pharmacologically acceptable, where: R3b is selected from C1-3 alkyls, where such C1-3 alkyls are replaced by Cy1 and are selectively replaced by 1 or 2 substitutes which are independently selected from ORa, and SRa; Cy1 is selected from aryls, heteroaryls, cycloalkyls, and heterocycloalkyls, where each is replaced by 1 or 2 R7 and are selectively replaced by 1, 2, or 3 R8; R7, at each appearance, is independently selected from Cy3 and C1-4 alkyls, where such C1-4 alkyls are replaced by 1 or 2 Cy3 and are selectively replaced by 1 or 2 substitutes which Independently selected from Halo and ORa4; R8, at each appearance, is independently selected from Halo, C1-4 Alkyl, C2-4 Alkinil, C2-4 Alkinil, C1-4 Haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, and C(O)ORa4; And Cy3 will be selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes which are selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, CN, NO2, NRc6Rd6, ORa6, and SRa6. 43. Any of the compounds under Claims 37-42 or their salts are pharmacologically acceptable, where L is a C1-6 alkylene; R1 is H, C1-3 alkyl, where such C1-3 alkyl is selectively substituted by 1, 2, 3, 4, or 5RL2; and RL2, at each appearance, is independently selectable from halo, CN, NO2, and ORa2; 44. Any of the compounds under Claims 37-42 or their salts are pharmacologically acceptable, where R2 is a halo or C1-3 haloalkyl. 45. Any of the compounds under Claims 37-44 or their salts that are pharmacologically acceptable, where R2 is Br. 46. Any of the compounds under Claims 37-45 or their salts are pharmacologically acceptable, where: L is C1-6 alkylene; R3b is H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, Cy1, ORa, SRa, or NRcRd, where the aforementioned C1-6 alkyl, C2-6 alkinyl, and C2-6 alkinyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb. NRcS(O)2Rb, and S(O)2NRcRd; and R2 is halo, cyano, C1 haloalkyl, Z, SRA, or moity which has the formula (chemical formula). 47. Any of the compounds under Claims 37-46, or their salts, are pharmacologically acceptable, where: L is C1-18 alkylene; R3b is H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, Cy1, ORa, SRa, or NRcRd, where such C1-6 alkyl, C2-6 alkynyl, and C2-6 alkinyl are selectively substituted by 1, 2, or 3 substitutes which are independently selected from Cy1, C(O)NRcRd, C(O)ORa, and NRcC(O)Rb; and R2 is halo, cyano, C1 haloalkyl, Z, or SRA. 48. Any of the compounds under claims 37-47, or their salts, are pharmacologically acceptable, where: L is C1-18 alkylene; R3b is a heteroaryl selectively substituted by 1, 2, 3, 4 or 5 substitutes which are independently selected from aryls, cycloalkyl, and heterocycloalkyl, each substituted. One, two, three, four, or five selected representatives can be chosen from the following: halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkinyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, and SRa6, and R2 is halo, cyano, C1 haloalkyl, Z, SRA, or moity with the formula (chemical formula). 49. Any of the compounds under claims 37-48, or their salts, are pharmacologically acceptable, where: L is C1-18 alkylene; R3b is thiazolyl selectively replaceable by phenyl, where such phenyl is selectively replaceable by 1, 2, 3, 4 or 5 independent substitutes of OH and halo; and R2 is halo, cyano, C1 haloalkyl, Z, SRA, or moity having the formula (chemical formula). 50. Any of the compounds under Claims 37-49, or their salts, are pharmacologically acceptable, where: L is C1-18 alkylene; R3b is H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl or C1-6 haloalkyl; and R2 is halo, cyano or C1 haloalkyl. 51. Any of the compounds under Claims 37-50, or their salts, are pharmacologically acceptable, where: R3b is a C1-6 alkyl, C1-6 haloalkyl, or Cy1, where such C1-6 alkyl is selectively substituted by 1, 2, or 3 substitutes which are independently selected from Cy1, C(O)NRcRd, C(O)ORa, halo, ORa, SRa, NRcRd, NRcC(O)NRcRd, and NRcC(O)Rb; L is a C1-6 alkylene selectively substituted by 1, 2, 3, 4, or 5RL1; R1 is H or a C1-3 alkyl, where such C1-3 alkyl is selectively substituted by 1, 2, 3, 4, or 5RL2. RL1 and RL2, at each appearance, They will be selected independently from Halo, CN, NO2, and ORa2; and R2 is Halo or C1-3 Haloalkyl. 52. Any of the compounds in Claim 37-51, where: -L-R1 is a C2-7 alkyl selectively substituted by 1, 2, 3, 4 or 5 halo; R2 is a halo. 53. Compounds according to claim 37, or their salts that are pharmacologically acceptable, whereby: the compound shall have the formula IIa: (chemical formula) IIa; and LA is a C1-3 alkylene selectively substituted by one or two substitutes which are independently selected from halo, ORa, and SRa. 54. Compounds according to claim 37, or their salts that are pharmacologically acceptable, where: the compound shall have the formula IIb: (chemical formula) IIb; LA is a C1-3 alkylene selectively substituted by 1 or 2 substitutes independently selected from halo, ORa, and SRa; LB is a C1-4 alkylene selectively substituted by 1 or 2 substitutes independently selected from halo, and ORa4; and t1 is 0 or 1. 55. The compounds according to claim 1, or their salts, which are pharmaceutically acceptable, having the formula III: (chemical formula) III. 56. The compounds according to claim 1, or their salts that are pharmaceutically acceptable, having the formula IV: (chemical formula) IV. 57. Selected compounds according to claim 1 from: 3-methyl-9-pentyl-7-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 9-butyl-3-methyl-7-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 9-pentyl-7-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 9-butyl-7-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-methyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-methyl-9-butyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-chloro-3-methyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; and 7-chloro-3-methyl-9-butyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; or their pharmacologically acceptable salts. 58. Selected compounds according to claim 1 from: 7-bromo-3-(methylthio)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(methylsulfinyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-hydroxy-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-butyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-butyl-3-(methoxymethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-phenyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-pyridin-3-yl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-pyridin-4-yl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-pyridin-2-yl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(1,3-thiazol-2-yl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-propyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-[(dimethylamino)methyl]-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-9-pentyl-7-(1,3-thiazol-2-yl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-7-(methylthio)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-9-pentyl-7-phenyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-9-pentyl-7-pyridin-4-yl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-(3,5-dimethylisooxazol-4-yl)-3-methyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-cyclopropyl-3-methyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-7-(1-methyl-1H-pyrazol-4-yl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-9-pentyl-7-(4H-1,2,4-triazol-4-yl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-9-pentyl-7-(1H-1,2,4-triazol-4-yl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-cyclobutyl-3-methyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(4-methoxyphenyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(4-trifluoromethyl)phenyl)-6,9-dihydro-5H-[1,2,4]triazolo [4,3-a]purine-5-one; 7-bromo-3-(4-methoxybenzyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-(3-bromobenzyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-(3-pyrimidin-5-ylbenzyl)-6,9-dihydro-5H-[1,2,4]triazolo [4,3-a]purine-5-one; 7-bromo-9-pentyl-3-pyrimidin-4-il-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-pyrazin-2-il-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-cyclopropyl-9-pentyl,-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(dimethylamino)-9-pentyl,-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(3,3,3-trifluoropropyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(2-phenylethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(pyridine-4-ylmethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a] purine-5-one; 7-bromo-9-pentyl-3-(2-pyridine-3-ylmethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a] purine-5-one; 7-bromo-9-pentyl-3-(1-phenylcyclopropyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a] purine-5-one; 7-bromo-3-(2-methylpyridin-4-yl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(3-fluoropyridin-4-yl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(3-fluorobenzyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(3-methoxybenzyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a] purine-5-one; 7-bromo-3-(1,3-oxazol-4-yl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a] purine-5-one; 7-bromo-3-isooxazol-3-yl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a] purine-5-one; 7-bromo-3-(1-methyl-1H-imidazol-2-yl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo [4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(3-pyridin-4-ilbenzyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(2-methoxybenzyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 1-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-il) cyclopropane carboxamide; 1-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-il) cyclopropane carboxylic acid; 7-bromo-9-pentyl-3-[1-(trifluoromethyl)cyclopropyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-(2,3-dihydro-1,4-benzodioxin-6-ilmethyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-[(3-oxo-3,4-dihydro-2H-1,4-benzoxacin-6-yl)methyl])-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-benzyl-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 6-bromo-4-pentyl-4,7-dihydro-8H-terazolo[1,5-a]purin-8-one; 3-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-il) propanoic acid; 7-bromo-3-(3-morpholin-4-il-3-oxopropyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; N-benzyl-3-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-il)propanamide; 7-bromo-3-(3-oxo-3-pyrrolidin-1-ylpropyl)-9-pentyl-6,9-dihydro-5H-pyrrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 3-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-pyrrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-3-yl)-N-methylpropanamide; 3-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)-N-(2-phenylethyl)propanamide; 3-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-il)-N-(pyridin-4-ilmethyl)propanamide; 3-[2-(3-benzyl-1,2,4-oxadiasol-5-il)ethyl]-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-{2-[3-(2-thienylmethyl)-1,2,4-oxadiazol-5-yl]ethyl}-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-(2-{3-[4-(trifluoromethyl)benzyl]-1,2,4-oxadiazol-5-yl}ethyl)-6,9-dihydro-5H-pyrrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-3-{2-[3-(4-fluorobenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-{2-[3-(4-methoxybenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-6,9-dihydro-5H-pyrrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-9-pentyl-3-{2-[3-(pyridine-4-ilmethyl)-1,2,4-oxadiazol-5-il]ethyl}-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-(2-{3-[3-(trifluoromethyl)benzyl]-1,2,4-oxadiazol-5-il}ethyl)-6,9-dihydro-5H-pyrrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidine-5-one; 7-bromo-9-pentyl-3-{2-[3-(pyridine-3-ilmethyl)-1,2,4-oxadiazol-5-il]ethyl}- 6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-{2-(3-phenyl-1,2,4-oxadiazol-5-il)ethyl}-6,9-dihydro-5H- [1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(3-fluorobenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{2-[3-(4-chlorobenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-[2-(3-benzyl-1,2,4-oxadiazol-5-yl)ethyl]-7-chloro-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{2-[3-(2-fluorobenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{2-[3-(2-methoxybenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-pyrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-3-[2-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]-9-pentyl-6,9-dihydro-5H-pyrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-3-{2-[3-(3-methylbenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-pyrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-3-{2-[3-(3-methylbenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-pyrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-3-{2-[3-(2,4-difluorobenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl- 6,9-dihydro-5H-pyrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-3-{2-[3-(3,5-difluorobenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl- 6,9-dihydro-5H-pyrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-9-pentyl-3-{2-[3-(3-(thienylmethyl)-1,2,4-oxadiazol-5-yl]ethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-{2-[3-(1-phenylcyclopropyl)-1,2,4-oxadiazol-5-yl]ethyl}- 6,9-dihydro-5H-pyrrolo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one; 7-bromo-9-pentyl-3-{2-[3-(pyridine-2-ilmethyl)-1,2,4-oxadiazol-5-il]ethyl}-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrimidine-5-one; 3-[(2R)-2-(3-benzyl-1,2,4-oxadiazol-5-il)propyl]-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-(2-{3-[(4-methyl-1,3-thiazol-2-yl)methyl]-1,2,4-oxadiazol-5-yl} ethyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(2-methylbenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-(2-{3-[hydroxy(phenyl)methyl]-1,2,4-oxadiazol-5-yl}ethyl)-9-pentyl- 6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(2,5-difluorobenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl- 6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-{2-[3-(pyrimidin-5-ilmethyl)-1,2,4-oxadiazol-5-il]ethyl}-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-{2-[3-(2-fluorobenzyl)-1,2,4-oxadiazol-5-il]ethyl}-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 3-[2-(3-benzyl-1,2,4-oxadiazol-5-yl)ethyl]-9-pentyl-7-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-[2-(3-benzyl-1,2,4-oxadiazol-5-yl)ethyl]-7-cyclopropyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-methyl-9-pentyl-7-[1-(trifluoromethyl)cyclopropyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-(2,2-difluorocyclopropyl)-3-methyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-(1-hydroxycyclopropyl)-3-methyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[2-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-[2-(5-benzyl-1,3,4-oxadiazol-2-il)ethyl]-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; N-[(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-il) methyl]benzamide; N-[(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-il) methyl]acetamide; 3-(1-benzylpiperidin-4-yl)-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-[3-(3-benzyl-1,2,4-oxadiazol-5-yl)propyl]-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 2-bromo-4-pentyl-1,4-dihydro-9H-[1,2,4]triazolo[1,5-a]purin-9-one; 3-methyl-9-pentyl-7-(1,3-thiazol-4-il)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-[2-(3-pyrazin-2-il-1,2,4-oxadiazol-5-il)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one trifluoroacetate; 7-bromo-9-pentyl-3-[2-(3-pyrazin-3-il-1,2,4-oxadiazol-5-il)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one trifluoroacetate Hydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one trifluoroacetate; 7-bromo-9-pentyl-3-[2-(3-pyrazin-2-il-1,2,4-oxadiazol-5-il)ethyl]-6,9-di Hydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one trifluoroacetate; 7-bromo-9-pentyl-3-[2-(3-pyridin-4-il-1,2,4-oxadiazol-5-il)ethyl]-6,9-di Hydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one trifluoroacetate; 7-bromo-9-pentyl-3-{2-[3-(2-thienyl)1,2,4-oxadiaxol-5-yl)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-(1,3-benzodioxol-5-ylmethyl)-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; and 7-bromo-9-pentyl-3-pyrimidin-5-yl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; or their pharmaceutically acceptable salts. 59. Selected compound of claim 1 from: 7-bromo-9-pentyl-3-[3-(3-phenyl-1,2,4-oxadiazol-5-il)propyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[2-(3-pyridin-2-il-1,2,4-oxadiazol-5-il)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[2-(3-pyridin-4-il-1,2,4-oxadiazol-5-il)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one Hydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-{2-[3-(2-thienyl)-1,2,4-oxadiazol-5-il)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-(1,3-benzodioxol-5-ilmethyl)-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-pyrimidin-5-il-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[3-(3-phenyl-1,2,4-oxadiazol-5-il)propyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[3-(3-pyrimidin-2-il-1,2,4-oxadiazol-5-il)propyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[3-(3-pyridin-3-il-1,2,4-oxadiazol-5-il)propyl]-6,9- dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[3-(3-pyridin-4-il-1,2,4-oxadiazol-5-il)propyl]-6,9- dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)propyl]-6,9- dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-{3-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]propyl}-6,9- dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-{3-[3-(3-thienyl)-1,2,4-oxadiazol-5-yl]propyl}-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-(3-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}propyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[3-(3-pyrimidin-2-il-1,2,4-oxadiazol-5-il]propyl}-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(4-ethinylphenyl)-1,2,4-oxadiazol-5-yl]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(1H-indol-5-il)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(1H-indol-3-il)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(6-methoxypyridin-3-il)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-{3-[3-(4-aminopyrimidin-5-il)-1,2,4-oxadiazol-5-il]propyl}-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]propyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(2-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(3-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]propyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{2-[3-(4-hydroxybenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{2-[3-(2-hydroxybenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(3-hydroxybenzyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-9-pentyl-3-[3-(4-phenyl-1H-pyrazol-1-il)propyl]-6,9-dihydro-5H-[1,2,4] triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[3-(4-phenyl-1H-imidazol-1-il)propyl]-6,9-dihydro-5H-[1,2,4] triazolo[4,3-a]purin-5-one; 7-bromo-3-3-[4-(5-fluoro-2-hydroxyphenyl)-1H-pyrazol-1-il]propyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-2-[5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-2-[5-(4-hydroxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-2-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-2-[5-(3-hydroxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-2-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-2-[5-(2-hydroxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-2-[5-(2-chloro-4-methoxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-2-[5-(2-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-il]ethyl-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[2-(5-pyridin-4-il-1,2,4-oxadiazol-3-il)ethyl]-6,9- dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[2-(5-pyridin-3-il-1,2,4-oxadiazol-3-il)ethyl]-6,9- dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-pentyl-3-[2-(5-pyridin-2-il-1,2,4-oxadiazol-3-il)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-3-il]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-3-il]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-il]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(3-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; 7-bromo-3-{2-[3-(2-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{2-[3-(2-chloro-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{2-[3-(2-chloro-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]ethyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 3-[2-(5-benzyl-1,2,4-oxadiazol-3-yl)ethyl]-7-bromo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(2-chloro-4-methoxyphenyl)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-{3-[3-(2-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-5-il]propyl}-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]-4-methoxybenzamide; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]benzamide; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]isonicotinamide; 7-bromo-9-pentyl-3-[2-(pyrimidine-2-ylamino)ethyl]-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-5-one; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-3-yl)ethyl]nicotinamide; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purine-3-yl)ethyl]pyridine-2-carboxamide; 3-amino-N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]isonicotinamide; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]-2-methylisonicotinamide; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]-N'-phenylurea; N-[2-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]-4-hydroxybenzamide; 3-methyl-7-(pentafluoroethyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-methyl-9-(4,4,4-trifluorobutyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-3-methyl-9-(5,5,5-trifluorobutyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; 7-bromo-9-(4-fluorobutyl)-3-methyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; and 7-bromo-9-(4-fluoropentyl)-3-methyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one; or their pharmacologically acceptable salts. 60. A composition consisting of any of the compounds listed in Paragraphs 1 to 59, or their pharmaceutically acceptable salts, and at least one pharmaceutically acceptable carrier. 61. The use of compounds with formula I: (chemical formula) I or their salts or pro-drugs that are pharmacologically acceptable for therapeutic purposes, where: dashed lines indicate alternative bonds; X is N, CR3a, CR4aR5a, or NR6a; Y is N, CR3b, CR4bR5b, or NR6b; L is -(C1-6 alkylene)-(Q1)m(C1-6 Alkylene)p-(Q2)q-(C1-6 alkylene)r- is selectively substituted by 1, 2, 3, 4, or 5 RL1, where if both m and q are 1, then p is 1; R1 is H, C1-10 alkyl, C2-10 alkynyl, C2-10 alkynyl, or Cy, where such C1-10 alkyl, C2-10 alkynyl, or C2-10 alkynyl are selectively substituted by 1, 2, 3, 4, or 5 RL2; R2 is halo, cyano, C1-3 haloalkyl, Z, SRA, or moity with the formula: (chemical formula); R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd, where such C1-6 alkyl, C2-6 alkynyl, or C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd; R4a, R4b, R5a, and R5b are selected independently from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where the aforementioned C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; R6a and R6b are selected independently from H, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl are Selective substitution is possible with 1, 2, or 3 substitutes which are independently selected from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; RL1 and RL2 are independently selected from Halo, C1-6 Alkyl, C2-6 Alkinil, C2-6 Alkinil, C1-6 Haloalkyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)NRc2Rd2, NRc2C(O)ORa2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, NRc2S(O)2Rb2, and S(O)2NRc2Rd2; R2a is H, C1-6 alkyl, C2-6 alkynyl, C2-10 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy4, CN, NO2, C(O)Rb6, C(O)NRc6Rd6, or C(O)ORa6; Cy is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will It can be selectively replaced by 1, 2, 3, 4 or 5 substitutes chosen from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; Cy1 and Cy2 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl. Each of these can be selectively replaced by 1, 2, 3, 4, or 5 substitutes, which are independently selected from Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4,OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4, and S(O)2NRc4Rd4; And Cy3, where C1-4 alkynil, C2-4 alkynil, or C2-4 alkynils are selectively replaced by 1, 2, or 3 substitutes, where Independently selected from CN, NO2, halo, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)NRc4Rd4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, NRc4S(O)2Rb4, S(O)2NRc4Rd4 and Cy3; Cy3 and Cy4 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes. Independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6; Z is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will Can be selectively replaced by 1, 2, 3, 4 or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rb6, S(O)2Rb6, and S(O)2NRc6Rd6; RA is H or C1-4 alkyl; Q1 and Q2 are independently selected from O, S, NH, CH2, CO, CS, SO, SO2, OCH2, SCH2, NHCH2, CH2CH2, COCH2, CONH, COO, SOCH2, SONH, SO2CH2, and SO2NH; Ra and Ra1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where the aforementioned C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, and C2-6 alkinyl are Selective substitution is possible with 1, 2, 3, 4, or 5 substitutes chosen from Halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or, such heterocycloalkyl alkyls can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rb and Rb1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl are selectively substituted by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rb2, Rb3, Rb4, Rb5, and Rb6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or heterocycloalkyl alkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or such heterocycloalkyl alkyl can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, OC(O)Ra5, C(O)ORb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc and Rd together with N atoms where they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc1 and Rd1. Independently selected substitutes will be made from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc1 and Rd1 together with the N atoms to which they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc2 and Rd2. They will be independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc2 and Rd2 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc3 and Rd3 are independently selectable from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where such C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl are selectively replaced by OH, amino, Halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc3 and Rd3 together with an N atom where they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc4 and Rd4 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc4 and Rd4 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc5 and Rd5 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc5 and Rd5 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; And Rc and Rd6 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. They can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc6 and Rd6 together with an N atom at which they are bonded to form 4-, 5-, 6-, or 7-membered heterocycloalkyl groups; and m, p, q, and r are independently selectable from 0 and 1. 62. Use under claim 61 where the treatment consists of agonizing the MH74a receptor. 63. The use of compounds with formula I: (chemical formula) I or their salts or pro-drugs that are pharmacologically acceptable for the treatment of diseases associated with the MH74a receptor, where: dashed lines indicate alternative bonds; X is N, CR3a, CR4aR5a, or NR6a; Y is N, CR3b, CR4bR5b, or NR6b; L is -(C1-6 alkylene)-(Q1)m(C1-6 The alkylene)p-(Q2)q-(C1-6 alkylene)r- is selectively substituted by 1, 2, 3, 4, or 5 RL1, where if both m and q are 1, then p is 1; R1 is H, C1-10 alkyl, C2-10 alkynyl, C2-10 alkynyl, or Cy, where such C1-10 alkyl, C2-10 alkynyl, or C2-10 alkynyl are selectively substituted by 1, 2, 3, 4, or 5 RL2; R2 is halo, cyano, C1-3 haloalkyl, Z, SRA, or moity with the formula: R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 Haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd, where such C1-6 alkyl, C2-6 alkynyl, or C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd; R4a, R4b, R5a, and R5b are independently selected from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where the aforementioned C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; R6a and R6b are selected independently from H, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl are used. Selective substitution is possible with 1, 2, or 3 substitutes which are independently selected from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; RL1 and RL2 are independently selected from Halo, C1-6 Alkyl, C2-6 Alkinil, C2-6 Alkinil, C1-6 Haloalkyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)NRc2Rd2, NRc2C(O)ORa2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, NRc2S(O)2Rb2, and S(O)2NRc2Rd2; R2a is H, C1-6 alkyl, C2-6 alkynyl, C2-10 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy4, CN, NO2, C(O)Rb6, C(O)NRc6Rd6, or C(O)ORa6; Cy is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will It can be selectively replaced by 1, 2, 3, 4 or 5 substitutes chosen from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; Cy1 and Cy2 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl. Each of these can be selectively replaced by 1, 2, 3, 4, or 5 substitutes, which are independently selected from Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4, and S(O)2NRc4Rd4; And Cy3, where C1-4 alkynil, C2-4 alkynil, or C2-4 alkynils are selectively replaced by 1, 2, or 3 substitutes, where Independently selected from CN, NO2, halo, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)NRc4Rd4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, NRc4S(O)2Rb4, S(O)2NRc4Rd4 and Cy3; Cy3 and Cy4 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes. Independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6; Z is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will Can be selectively replaced by 1, 2, 3, 4 or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rb6, S(O)2Rb6, and S(O)2NRc6Rd6; RA is H or C1-4 alkyl; Q1 and Q2 are independently selected from O, S, NH, CH2, CO, CS, SO, SO2, OCH2, SCH2, NHCH2, CH2CH2, COCH2, CONH, COO, SOCH2, SONH, SO2CH2, and SO2NH; Ra and Ra1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where the aforementioned C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, and C2-6 alkinyl are Selective substitution is possible with 1, 2, 3, 4, or 5 substitutes chosen from Halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or, such heterocycloalkyl alkyls can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rb and Rb1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl are selectively substituted by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rb2, Rb3, Rb4, Rb5, and Rb6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or heterocycloalkyl alkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or such heterocycloalkyl alkyl can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, OC(O)Ra5, C(O)ORb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc and Rd together with N atoms where they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc1 and Rd1. Independently selected substitutes will be made from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc1 and Rd1 together with the N atoms to which they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc2 and Rd2. They will be independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc2 and Rd2 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc3 and Rd3 are independently selectable from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where such C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl are selectively replaced by OH, amino, Halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc3 and Rd3 together with an N atom where they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc4 and Rd4 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc4 and Rd4 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc5 and Rd5 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc5 and Rd5 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; And Rc6 and Rd6 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. They can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc6 and Rd6 together with an N atom at which they are bonded to form 4-, 5-, 6-, or 7-membered heterocycloalkyl groups; and m, p, q, and r are independently selectable from 0 and 1. 64. Use under claim 63 where the disease is associated with higher plasma FFAs. 65. Use under claim 63 where the disease is: dyslipidemia, high-activity antiretroviral therapy (HAART) lipodystrophy, insulin resistance, diabetes mellitus, metabolic syndrome, atherosclerosis, coronary heart disease, epilepsy, obesity, increased body mass index (BMI), increased waist circumference, non-alcoholic fatty liver disease, hepatolipidemia, or hypertension. 66. Pharmaceutically acceptable uses of compounds with formula I: (chemical formula) I or their salts or pro-drugs in the treatment of dyslipidemia, lipodystrophy associated with high-activity antiretroviral therapy (HAART), insulin resistance, diabetes mellitus, metabolic syndrome, atherosclerosis, coronary heart disease, epilepsy, obesity, increased body mass index (BMI), increased waist circumference, non-alcoholic fatty liver disease, hepatolipidemia, or hypertension, where: dashed lines indicate alternative bonds; X is N, CR3a, CR4aR5a, or NR6a; Y is N, CR3b, CR4bR5b, or NR6b; L is -(C1-6 alkylene)-(Q1)m(C1-6 Alkylene)p-(Q2)q-(C1-6 alkylene)r- is selectively substituted by 1, 2, 3, 4, or 5 RL1, where if both m and q are 1, then p is 1; R1 is H, C1-10 alkyl, C2-10 alkynyl, C2-10 alkynyl, or Cy, where such C1-10 alkyl, C2-10 alkynyl, or C2-10 alkynyl are selectively substituted by 1, 2, 3, 4, or 5 RL2; R2 is halo, cyano, C1-3 haloalkyl, Z, SRA, or moity with the formula: (chemical formula); R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd, where such C1-6 alkyl, C2-6 alkynyl, or C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd; R4a, R4b, R5a, and R5b are selected independently from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where the aforementioned C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, R6a and R6b are selected independently from H, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl are used. Selective substitution is possible with 1, 2, or 3 substitutes which are independently selected from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; RL1 and RL2 are independently selected from Halo, C1-6 Alkyl, C2-6 Alkinil, C2-6 Alkinil, C1-6 Haloalkyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)NRc2Rd2, NRc2C(O)ORa2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, NRc2S(O)2Rb2, and S(O)2NRc2Rd2; R2a is H, C1-6 alkyl, C2-6 alkynyl, C2-10 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy4, CN, NO2, C(O)Rb6, C(O)NRc6Rd6, or C(O)ORa6; Cy is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will It can be selectively replaced by 1, 2, 3, 4 or 5 substitutes chosen from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; Cy1 and Cy2 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl. Each of these can be selectively replaced by 1, 2, 3, 4, or 5 substitutes, which are independently selected from Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4, and S(O)2NRc4Rd4; And Cy3, where C1-4 alkynil, C2-4 alkynil, or C2-4 alkynils are selectively replaced by 1, 2, or 3 substitutes, where Independently selected from CN, NO2, halo, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)NRc4Rd4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, NRc4S(O)2Rb4, S(O)2NRc4Rd4 and Cy3; Cy3 and Cy4 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes. Independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6; Z is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will Can be selectively replaced by 1, 2, 3, 4 or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rb6, S(O)2Rb6, and S(O)2NRc6Rd6; RA is H or C1-4 alkyl; Q1 and Q2 are independently selected from O, S, NH, CH2, CO, CS, SO, SO2, OCH2, SCH2, NHCH2, CH2CH2, COCH2, CONH, COO, SOCH2, SONH, SO2CH2, and SO2NH; Ra and Ra1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where the aforementioned C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, and C2-6 alkinyl are Selective substitution is possible with 1, 2, 3, 4, or 5 substitutes chosen from Halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or, such heterocycloalkyl alkyls can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rb and Rb1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl are selectively substituted by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rb2, Rb3, Rb4, Rb5, and Rb6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or heterocycloalkyl alkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or such heterocycloalkyl alkyl can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, OC(O)Ra5, C(O)ORb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc and Rd together with N atoms where they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc1 and Rd1. Independently selected substitutes will be made from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc1 and Rd1 together with the N atoms to which they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc2 and Rd2. They will be independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc2 and Rd2 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc3 and Rd3 are independently selectable from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where such C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl are selectively replaced by OH, amino, Halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc3 and Rd3 together with an N atom where they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc4 and Rd4 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc4 and Rd4 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc5 and Rd5 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc5 and Rd5 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; And Rc6 and Rd6 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. They can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc6 and Rd6 together with an N atom at which they are bonded to form 4-, 5-, 6-, or 7-membered heterocycloalkyl groups; and m, p, q, and r are independently selectable from 0 and 1. 67. Pharmaceutically acceptable use of compounds with formula I: (chemical formula) I or their salts or pro-drugs in the preparation of pharmaceuticals for therapeutic purposes related to the MH74a receptor, where: dashed lines indicate alternative bonds; X is N, CR3a, CR4aR5a, or NR6a; Y is N, CR3b, CR4bR5b, or NR6b; L is -(C1-6 alkylene)-(Q1)m(C1-6 The alkylene)p-(Q2)q-(C1-6 alkylene)r- is selectively substituted by 1, 2, 3, 4, or 5 RL1, where if both m and q are 1, then p is 1; R1 is H, C1-10 alkyl, C2-10 alkynyl, C2-10 alkynyl, or Cy, where such C1-10 alkyl, C2-10 alkynyl, or C2-10 alkynyl are selectively substituted by 1, 2, 3, 4, or 5 RL2; R2 is halo, cyano, C1-3 haloalkyl, Z, SRA, or moity with the formula: R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 Haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd, where such C1-6 alkyl, C2-6 alkynyl, or C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd; R4a, R4b, R5a, and R5b are independently selected from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where the aforementioned C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; R6a and R6b are selected independently from H, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl are used. Selective substitution is possible with 1, 2, or 3 substitutes which are independently selected from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; RL1 and RL2 are independently selected from Halo, C1-6 Alkyl, C2-6 Alkinil, C2-6 Alkinil, C1-6 Haloalkyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)NRc2Rd2, NRc2C(O)ORa2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, NRc2S(O)2Rb2, and S(O)2NRc2Rd2; R2a is H, C1-6 alkyl, C2-6 alkynyl, C2-10 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy4, CN, NO2, C(O)Rb6, C(O)NRc6Rd6, or C(O)ORa6; Cy is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will It can be selectively replaced by 1, 2, 3, 4 or 5 substitutes chosen from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; Cy1 and Cy2 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl. Each of these can be selectively replaced by 1, 2, 3, 4, or 5 substitutes, which are independently selected from Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4, and S(O)2NRc4Rd4; And Cy3, where C1-4 alkynil, C2-4 alkynil, or C2-4 alkynils are selectively replaced by 1, 2, or 3 substitutes, where Independently selected from CN, NO2, halo, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)NRc4Rd4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, NRc4S(O)2Rb4, S(O)2NRc4Rd4 and Cy3; Cy3 and Cy4 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes. Independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6; Z is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will Can be selectively replaced by 1, 2, 3, 4 or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rb6, S(O)2Rb6, and S(O)2NRc6Rd6; RA is H or C1-4 alkyl; Q1 and Q2 are independently selected from O, S, NH, CH2, CO, CS, SO, SO2, OCH2, SCH2, NHCH2, CH2CH2, COCH2, CONH, COO, SOCH2, SONH, SO2CH2, and SO2NH; Ra and Ra1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where the aforementioned C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, and C2-6 alkinyl are Selective substitution is possible with 1, 2, 3, 4, or 5 substitutes chosen from Halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or, such heterocycloalkyl alkyls can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rb and Rb1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl are selectively substituted by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rb2, Rb3, Rb4, Rb5, and Rb6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or heterocycloalkyl alkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or such heterocycloalkyl alkyl can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, OC(O)Ra5, C(O)ORb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc and Rd together with N atoms where they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc1 and Rd1. Independently selected substitutes will be made from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl are substituted by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc1 and Rd1 together with the N atoms to which they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc2 and Rd2. They will be independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc2 and Rd2 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc3 and Rd3 are independently selectable from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where such C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl are selectively replaced by OH, amino, Halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc3 and Rd3 together with an N atom where they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc4 and Rd4 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc4 and Rd4 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc5 and Rd5 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc5 and Rd5 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; And Rc6 and Rd6 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. They can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc6 and Rd6 together with an N atom at which they are bonded to form 4-, 5-, 6-, or 7-membered heterocycloalkyl groups; and m, p, q, and r are independently selectable from 0 and 1. 68. Use under claim 67 where the disease is associated with higher plasma FFAs. 69. Use under claim 67 where the disease is: dyslipidemia, high-activity antiretroviral therapy (HAART) lipodystrophy, insulin resistance, diabetes mellitus, metabolic syndrome, atherosclerosis, coronary heart disease, epilepsy, obesity, increased body mass index (BMI), increased waist circumference, non-alcoholic fatty liver disease, hepatolipidemia, or hypertension. 70. Pharmaceutically acceptable uses of compounds with formula I: (chemical formula) I or their salts or pro-drugs for pharmaceutical preparations for the treatment of dyslipidemia, highly antiretroviral therapy-associated lipodystrophy (HAART), insulin resistance, diabetes mellitus, metabolic syndrome, atherosclerosis, coronary heart disease, epilepsy, obesity, increased body mass index (BMI), increased waist circumference, non-alcoholic fatty liver disease, hepatolipidemia, or hypertension, where: dashed lines indicate alternative bonds; X is N, CR3a, CR4aR5a, or NR6a; Y is N, CR3b, CR4bR5b, or NR6b; L is -(C1-6 alkylene)-(Q1)m(C1-6). Alkylene)p-(Q2)q-(C1-6 alkylene)r- is selectively substituted by 1, 2, 3, 4, or 5 RL1, where if both m and q are 1, then p is 1; R1 is H, C1-10 alkyl, C2-10 alkynyl, C2-10 alkynyl, or Cy, where such C1-10 alkyl, C2-10 alkynyl, or C2-10 alkynyl are selectively substituted by 1, 2, 3, 4, or 5 RL2; R2 is halo, cyano, C1-3 haloalkyl, Z, SRA, or moity with the formula: (chemical formula); R3a and R3b are independently selectable from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd, where such C1-6 alkyl, C2-6 alkynyl, or C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy1, CN, NO2, halo, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb, and S(O)2NRcRd; R4a, R4b, R5a, and R5b are selected independently from H, halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where the aforementioned C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl can be selectively replaced by 1, 2, or 3 independently selected substitutes from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, R6a and R6b are selected independently from H, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1, where C1-6 alkyl, C2-6 alkynyl, and C2-6 alkynyl are used. Selective substitution is possible with 1, 2, or 3 substitutes which are independently selected from Cy2, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)NRc1Rd1, NRc1C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, NRc1S(O)2Rb1, and S(O)2NRc1Rd1; RL1 and RL2 are independently selected from Halo, C1-6 Alkyl, C2-6 Alkinil, C2-6 Alkinil, C1-6 Haloalkyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)NRc2Rd2, NRc2C(O)ORa2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, NRc2S(O)2Rb2, and S(O)2NRc2Rd2; R2a is H, C1-6 alkyl, C2-6 alkynyl, C2-10 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy4, CN, NO2, C(O)Rb6, C(O)NRc6Rd6, or C(O)ORa6; Cy is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will It can be selectively replaced by 1, 2, 3, 4 or 5 substitutes chosen from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; Cy1 and Cy2 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl. Each of these can be selectively replaced by 1, 2, 3, 4, or 5 substitutes, which are independently selected from Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rb4, S(O)2Rb4, and S(O)2NRc4Rd4; And Cy3, where C1-4 alkynil, C2-4 alkynil, or C2-4 alkynils are selectively replaced by 1, 2, or 3 substitutes, where Independently selected from CN, NO2, halo, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)NRc4Rd4, NRc4C(O)ORa4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, NRc4S(O)2Rb4, S(O)2NRc4Rd4 and Cy3; Cy3 and Cy4 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which can be selectively replaced by 1, 2, 3, 4 or 5 substitutes. Independently selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6; Z is aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each of which will Can be selectively replaced by 1, 2, 3, 4 or 5 substitutes selected from halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, S(O)Rb6, S(O)NRc6Rb6, S(O)2Rb6, and S(O)2NRc6Rd6; RA is H or C1-4 alkyl; Q1 and Q2 are independently selected from O, S, NH, CH2, CO, CS, SO, SO2, OCH2, SCH2, NHCH2, CH2CH2, COCH2, CONH, COO, SOCH2, SONH, SO2CH2, and SO2NH; Ra and Ra1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where the aforementioned C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, and C2-6 alkinyl are Selective substitution is possible with 1, 2, 3, 4, or 5 substitutes chosen from Halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or, such heterocycloalkyl alkyls can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rb and Rb1 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl are selectively substituted by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rb2, Rb3, Rb4, Rb5, and Rb6 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, Or heterocycloalkyl alkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or such heterocycloalkyl alkyl can be selectively replaced by OH, cyano, amino, halo, C1-6 alkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl; Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, OC(O)Ra5, C(O)ORb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc and Rd together with N atoms where they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc1 and Rd1. Independently selected substitutes will be made from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, and Cy2, where C1-6 alkyl, C1-6 haloalkyl, C2-6 alkinyl, or C2-6 alkinyl can be selectively replaced by 1, 2, 3, 4, or 5 independently selected substitutes from halo, C1-6 alkyl, C2-6 alkinyl, C2-6 alkinyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5. OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; or Rc1 and Rd1 together with the N atoms to which they are bonded form 4-, 5-, 6- or 7-membered heterocycloalkyl groups that are selectively substituted by 1, 2, or 3 substitutes. Independently selected from halo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, Cy2, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5d5, NRc5C(O)ORa5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, and S(O)2NRc5Rd5; Rc2 and Rd2. They will be independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc2 and Rd2 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc3 and Rd3 are independently selectable from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where such C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl are selectively replaced by OH, amino, Halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc3 and Rd3 together with an N atom where they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc4 and Rd4 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc4 and Rd4 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; Rc5 and Rd5 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, heteroaryl cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. It can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc5 and Rd5 together with an N atom at which they are bonded to form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; And Rc6 and Rd6 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloal, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, and heterocycloalkyl alkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl alkyl, heteroaryl alkyl, cycloalkyl alkyl, or the aforementioned heterocycloalkyl alkyl. They can be selectively replaced by OH, amino, halo, C1-6 alkyl, C1-10 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or heterocycloalkyl; or Rc6 and Rd6 together with an N atom at which they are bonded to form 4-, 5-, 6-, or 7-membered heterocycloalkyl groups; and m, p, q, and r are independently selectable from 0 and 1.