TN2009000421A1 - Substituted sulphonamides, process for their preparation, pharmaceutical composition comprising thereof and their use - Google Patents

Substituted sulphonamides, process for their preparation, pharmaceutical composition comprising thereof and their use

Info

Publication number: TN2009000421A1
Authority: TN; Tunisia
Prior art keywords: preparation; pharmaceutical composition; prepared; substituted sulphonamides; aliphatic chain
Prior art date: 2007-04-20

Application number

TNP2009000421A

Other languages

English (en)

Inventor

Fridrich Gregan

Milan Remko

Elena Sluciakova

Jarmila Knapikova

Original Assignee

Unimed Pharma Spol Sro

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-20

Filing date

2009-10-13

Publication date

2011-03-31

2009-10-13 Application filed by Unimed Pharma Spol Sro filed Critical Unimed Pharma Spol Sro

2011-03-31 Publication of TN2009000421A1 publication Critical patent/TN2009000421A1/fr

Links

150000003456 sulfonamides Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
LLFQHNCOIPUFIJ-UHFFFAOYSA-N 4-sulfamoylbenzenesulfonyl chloride Chemical compound NS(=O)(=O)C1=CC=C(S(Cl)(=O)=O)C=C1 LLFQHNCOIPUFIJ-UHFFFAOYSA-N 0.000 abstract 1
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000007344 nucleophilic reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Ophthalmology & Optometry (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TNP2009000421A 2007-04-20 2009-10-13 Substituted sulphonamides, process for their preparation, pharmaceutical composition comprising thereof and their use TN2009000421A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SK54-2007A SK542007A3 (sk)	2007-04-20	2007-04-20	Substituované sulfónamidy, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
PCT/SK2008/050005 WO2008130332A1 (fr)	2007-04-20	2008-04-18	Sulfamides substitués, leur procédé de préparation, composition pharmaceutique en contenant et leur utilisation

Publications (1)

Publication Number	Publication Date
TN2009000421A1 true TN2009000421A1 (en)	2011-03-31

Family

ID=39671772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2009000421A TN2009000421A1 (en)	2007-04-20	2009-10-13	Substituted sulphonamides, process for their preparation, pharmaceutical composition comprising thereof and their use

Country Status (31)

Country	Link
US (1)	US8193184B2 (fr)
EP (1)	EP2142499B1 (fr)
JP (1)	JP5492764B2 (fr)
CN (1)	CN101663267A (fr)
AR (1)	AR065966A1 (fr)
AU (1)	AU2008241590B2 (fr)
BR (1)	BRPI0809728A2 (fr)
CA (1)	CA2684591C (fr)
CL (1)	CL2008001109A1 (fr)
DK (1)	DK2142499T3 (fr)
ES (1)	ES2528284T3 (fr)
HR (1)	HRP20141246T1 (fr)
HU (1)	HUE024552T2 (fr)
IL (1)	IL200952A0 (fr)
JO (1)	JO3206B1 (fr)
MA (1)	MA31364B1 (fr)
MX (1)	MX2009010528A (fr)
NZ (1)	NZ581302A (fr)
PE (1)	PE20090807A1 (fr)
PL (1)	PL2142499T3 (fr)
PT (1)	PT2142499E (fr)
RU (1)	RU2474574C2 (fr)
SA (1)	SA08290238B1 (fr)
SI (1)	SI2142499T1 (fr)
SK (1)	SK542007A3 (fr)
TN (1)	TN2009000421A1 (fr)
TW (1)	TWI392492B (fr)
UA (1)	UA99279C2 (fr)
UY (1)	UY31028A1 (fr)
WO (1)	WO2008130332A1 (fr)
ZA (1)	ZA200906305B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN115141128B (zh) *	2022-06-24	2024-09-13	沈阳药科大学	3-芳基-3-(磺胺苯甲酰胺基)丙(烯)酸衍生物及其制备方法及应用
CN118684601A (zh) *	2024-05-17	2024-09-24	北京颖泰嘉和生物科技股份有限公司	酰基氨磺酰胺苯甲酰胺的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2789938A (en)	1952-11-24	1957-04-23	Merck & Co Inc	Method of producing a diuretic effect with p-carboxybenzenesulfonamide
CH451142A (de) *	1965-01-19	1968-05-15	Sandoz Ag	Verfahren zur Herstellung neuer basisch substituierter Benzoesäureamide
GB1523631A (en) *	1975-07-08	1978-09-06	Leo Pharm Prod Ltd	Sulphonamide derivatives
EP0029090A3 (fr) *	1979-09-28	1981-07-01	American Cyanamid Company	Sulfonamides contenant un phénol stériquement empêché; composition stabilisée à base d'un polymère synthétique et des sulfonamides mentionnés
FR2504528A1 (fr) *	1981-04-23	1982-10-29	Choay Sa	Dialcoxy (2,4) benzenesulfonamides n-substitues
JPS5939867A (ja) *	1982-08-27	1984-03-05	Fuji Yakuhin Kogyo Kk	２−クロロスルホニル−４−ｎ−置換スルフアミル−クロロベンゼンの製造法
JPS6041071B2 (ja) *	1983-07-28	1985-09-13	ソシエテ・デチユ−デ・シヤンテイフイツク・エ・アンデユストリエル・ドウ・リル−ドウ−フランス	安息香酸誘導体
US4678855A (en) *	1985-10-09	1987-07-07	Merck & Co., Inc.	Substituted benzenesulfonamides
US4721809A (en) *	1986-09-18	1988-01-26	American Home Products Corporation	Alkylsulfonamido or perfluoroalkylsulfonamido benzenesulfonamides
DE69530683T2 (de) *	1994-03-11	2004-03-25	Pharmacopeia, Inc.	Sulfonamid derivate und deren verwendung
JP2001162950A (ja) *	1999-12-13	2001-06-19	Fuji Photo Film Co Ltd	感熱記録材料
JP4139712B2 (ja) *	2002-03-14	2008-08-27	ライオン株式会社	漂白活性化剤及び漂白剤組成物
AU2005269988B2 (en) *	2004-07-02	2012-02-02	Mati Therapeutics Inc.	Treatment medium delivery device and methods for delivery
SE0401969D0 (sv) *	2004-08-02	2004-08-02	Astrazeneca Ab	Piperidine derivatives
WO2008071421A1 (fr) *	2006-12-15	2008-06-19	Nicox S.A.	Esters de l'acide nitrique des inhibiteurs d'anhydrase carbonique

2007
- 2007-04-20 SK SK54-2007A patent/SK542007A3/sk unknown
2008
- 2008-03-11 TW TW097108546A patent/TWI392492B/zh not_active IP Right Cessation
- 2008-04-04 AR ARP080101430A patent/AR065966A1/es unknown
- 2008-04-17 JO JOP/2008/0180A patent/JO3206B1/ar active
- 2008-04-17 UY UY31028A patent/UY31028A1/es not_active Application Discontinuation
- 2008-04-18 CN CN200880012806A patent/CN101663267A/zh active Pending
- 2008-04-18 BR BRPI0809728A patent/BRPI0809728A2/pt not_active IP Right Cessation
- 2008-04-18 PE PE2008000680A patent/PE20090807A1/es not_active Application Discontinuation
- 2008-04-18 HU HUE08741979A patent/HUE024552T2/hu unknown
- 2008-04-18 CA CA2684591A patent/CA2684591C/fr not_active Expired - Fee Related
- 2008-04-18 PL PL08741979T patent/PL2142499T3/pl unknown
- 2008-04-18 MX MX2009010528A patent/MX2009010528A/es active IP Right Grant
- 2008-04-18 EP EP08741979.2A patent/EP2142499B1/fr active Active
- 2008-04-18 CL CL2008001109A patent/CL2008001109A1/es unknown
- 2008-04-18 RU RU2009134079/04A patent/RU2474574C2/ru not_active IP Right Cessation
- 2008-04-18 UA UAA200910016A patent/UA99279C2/ru unknown
- 2008-04-18 NZ NZ581302A patent/NZ581302A/en not_active IP Right Cessation
- 2008-04-18 HR HRP20141246AT patent/HRP20141246T1/hr unknown
- 2008-04-18 PT PT87419792T patent/PT2142499E/pt unknown
- 2008-04-18 WO PCT/SK2008/050005 patent/WO2008130332A1/fr not_active Ceased
- 2008-04-18 ES ES08741979.2T patent/ES2528284T3/es active Active
- 2008-04-18 JP JP2010504023A patent/JP5492764B2/ja not_active Expired - Fee Related
- 2008-04-18 DK DK08741979.2T patent/DK2142499T3/en active
- 2008-04-18 AU AU2008241590A patent/AU2008241590B2/en not_active Ceased
- 2008-04-18 SI SI200831379T patent/SI2142499T1/sl unknown
- 2008-04-19 SA SA08290238A patent/SA08290238B1/ar unknown
- 2008-04-20 US US12/596,820 patent/US8193184B2/en not_active Expired - Fee Related
2009
- 2009-09-10 ZA ZA200906305A patent/ZA200906305B/xx unknown
- 2009-09-15 IL IL200952A patent/IL200952A0/en not_active IP Right Cessation
- 2009-10-13 TN TNP2009000421A patent/TN2009000421A1/fr unknown
- 2009-11-05 MA MA32329A patent/MA31364B1/fr unknown

Also Published As

Publication number	Publication date
TW200843730A (en)	2008-11-16
RU2009134079A (ru)	2011-05-27
WO2008130332A1 (fr)	2008-10-30
MA31364B1 (fr)	2010-05-03
UA99279C2 (ru)	2012-08-10
EP2142499A1 (fr)	2010-01-13
MX2009010528A (es)	2011-01-28
CA2684591A1 (fr)	2008-10-30
TWI392492B (zh)	2013-04-11
SA08290238B1 (ar)	2012-06-23
ZA200906305B (en)	2010-05-26
PE20090807A1 (es)	2009-07-20
PL2142499T3 (pl)	2015-05-29
DK2142499T3 (en)	2015-01-12
HUE024552T2 (hu)	2016-02-29
NZ581302A (en)	2012-03-30
AR065966A1 (es)	2009-07-15
CL2008001109A1 (es)	2008-11-03
ES2528284T3 (es)	2015-02-06
CN101663267A (zh)	2010-03-03
AU2008241590B2 (en)	2012-06-21
CA2684591C (fr)	2016-11-01
US20100125076A1 (en)	2010-05-20
RU2474574C2 (ru)	2013-02-10
PT2142499E (pt)	2015-02-09
SK542007A3 (sk)	2008-11-06
IL200952A0 (en)	2010-05-17
WO2008130332B1 (fr)	2008-12-18
US8193184B2 (en)	2012-06-05
EP2142499B1 (fr)	2014-12-10
JP2010524929A (ja)	2010-07-22
UY31028A1 (es)	2008-11-28
AU2008241590A1 (en)	2008-10-30
JO3206B1 (ar)	2018-03-08
HRP20141246T1 (hr)	2015-02-13
BRPI0809728A2 (pt)	2016-10-18
SI2142499T1 (sl)	2015-04-30
JP5492764B2 (ja)	2014-05-14

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