TN2013000362A1 - Benzodioxane inhibitors of leukotriene production - Google Patents

Benzodioxane inhibitors of leukotriene production

Info

Publication number: TN2013000362A1
Authority: TN; Tunisia
Prior art keywords: compounds; inhibitors; formula; leukotriene production; benzodioxane
Prior art date: 2011-03-14

Application number

TNP2013000362A

Other languages

English (en)

Inventor

Abeywardane Ashita

j burke Michael

Martin Kirrane Thomas Jr

Russel Netherton Matthew

Kumar Padyana Anil

Louise Smith Keenan Lana

Takahashi Hidenori

Robert Turner Michael

Zhang Qiang

Zhang Qing

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-03-14

Filing date

2013-09-12

Publication date

2015-01-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45922814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2013000362(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-09-12 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2015-01-20 Publication of TN2013000362A1 publication Critical patent/TN2013000362A1/fr

Links

239000003112 inhibitor Substances 0.000 title abstract 2
150000002617 leukotrienes Chemical class 0.000 title 1
LYKMMUBOEFYJQG-UHFFFAOYSA-N piperoxan Chemical compound C1OC2=CC=CC=C2OC1CN1CCCCC1 LYKMMUBOEFYJQG-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
102100022118 Leukotriene A-4 hydrolase Human genes 0.000 abstract 3
108010072713 leukotriene A4 hydrolase Proteins 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
208000037765 diseases and disorders Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

TNP2013000362A 2011-03-14 2013-09-12 Benzodioxane inhibitors of leukotriene production TN2013000362A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161452329P	2011-03-14	2011-03-14
PCT/US2012/028843 WO2012125598A1 (fr)	2011-03-14	2012-03-13	Inhibiteurs benzodioxanes de production de leucotriènes

Publications (1)

Publication Number	Publication Date
TN2013000362A1 true TN2013000362A1 (en)	2015-01-20

Family

ID=45922814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2013000362A TN2013000362A1 (en)	2011-03-14	2013-09-12	Benzodioxane inhibitors of leukotriene production

Country Status (29)

Country	Link
US (2)	US8551982B2 (fr)
EP (1)	EP2686310B1 (fr)
JP (1)	JP5640162B2 (fr)
KR (1)	KR101893756B1 (fr)
CN (1)	CN103415513B (fr)
AP (1)	AP3339A (fr)
AU (1)	AU2012229172B2 (fr)
BR (1)	BR112013023517B1 (fr)
CA (1)	CA2835617C (fr)
CL (1)	CL2013002546A1 (fr)
CO (1)	CO6771439A2 (fr)
DK (1)	DK2686310T5 (fr)
EA (1)	EA023876B1 (fr)
EC (1)	ECSP13012958A (fr)
ES (1)	ES2660493T3 (fr)
GE (1)	GEP20156347B (fr)
HU (1)	HUE036408T2 (fr)
IL (1)	IL227805A (fr)
MA (1)	MA35089B1 (fr)
MX (1)	MX355309B (fr)
PE (1)	PE20140976A1 (fr)
PH (1)	PH12013501912A1 (fr)
PL (1)	PL2686310T3 (fr)
SG (1)	SG193454A1 (fr)
TN (1)	TN2013000362A1 (fr)
TR (1)	TR201802550T4 (fr)
TW (1)	TWI551593B (fr)
UY (1)	UY33950A (fr)
WO (1)	WO2012125598A1 (fr)

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CA2835617C (fr)	2011-03-14	2020-07-21	Boehringer Ingelheim International Gmbh	Inhibiteurs benzodioxanes de production de leucotrienes
EP2734516B1 (fr)	2011-07-19	2015-06-17	Boehringer Ingelheim International GmbH	Éthers d'arylpyrazole en tant qu'inhibiteurs de leucotriène a4 hydrolase
NZ628587A (en) *	2012-03-06	2016-07-29	Boehringer Ingelheim Int	Benzodioxanes in combination with other actives for inhibiting leukotriene production
TW201350474A (zh) *	2012-03-06	2013-12-16	Boehringer Ingelheim Int	白三烯素生成之苯并二噁烷抑制劑
US9233089B2 (en) *	2012-03-23	2016-01-12	The Board Of Trustees Of The Leland Stanford Junior University	Treatment of pulmonary hypertension with leukotriene inhibitors
US9403830B2 (en)	2012-07-17	2016-08-02	Boehringer Ingelheim International Gmbh	Inhibitors of leukotriene production
EA032649B1 (ru)	2013-01-29	2019-06-28	Аптиникс Инк.	Спиролактамные модуляторы nmda-рецептора и их применение
ES2864862T3 (es)	2013-03-12	2021-10-14	Celltaxis Llc	Métodos de inhibición de la leucotrieno A4 hidrolasa
WO2014152536A2 (fr) *	2013-03-14	2014-09-25	Celtaxsys, Inc.	Inhibiteurs de la leucotriène a4 hydrolase
MX2015011677A (es)	2013-03-14	2016-07-08	Celtaxsys Inc	Inhibidores de leucotrieno a4 hidrolasa.
WO2014151761A1 (fr) *	2013-03-15	2014-09-25	Ariad Pharmaceuticals, Inc.	Nouveaux inhibiteurs de choline kinase
JP2016523982A (ja)	2013-07-15	2016-08-12	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ロイコトリエン生成の阻害剤
JP6353899B2 (ja) *	2013-07-15	2018-07-04	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ロイコトリエン生成の阻害剤
JP6749002B2 (ja) *	2014-10-08	2020-09-02	国立研究開発法人理化学研究所	植物成長促進剤及び植物成長促進方法
EP3275433A1 (fr)	2016-07-29	2018-01-31	Som Innovation Biotech S.L.	Composition à libération prolongée comprenant du tolcapone micronisé
SG10202101055VA (en) *	2016-08-01	2021-03-30	Aptinyx Inc	Spiro-lactam nmda receptor modulators and uses thereof
JP2019527232A (ja)	2016-08-01	2019-09-26	アプティニックスインコーポレイテッド	スピロ−ラクタムｎｍｄａ修飾因子及びこれを用いた方法
MX385336B (es)	2016-08-01	2025-03-18	Aptinyx Inc	Moduladores del receptor nmda espiro-lactam y uso de los mismos.
CN106866692A (zh) *	2017-03-30	2017-06-20	毛阿龙	具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法
CN112204031B (zh)	2018-01-31	2024-05-24	元羿生物科技(香港)有限公司	螺-内酰胺nmda受体调节剂及其用途
EP3801559B1 (fr)	2018-05-31	2025-01-01	Celltaxis, LLC	Procédé de réduction d'exacerbations pulmonaires chez des patients atteints d'une maladie respiratoire
MX2023001725A (es)	2020-08-14	2023-02-22	Novartis Ag	Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmaceuticos de los mismos.
AU2022376563A1 (en)	2021-11-01	2023-12-07	Alkahest, Inc.	Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

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2012
- 2012-03-13 CA CA2835617A patent/CA2835617C/fr active Active
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- 2012-03-13 PE PE2013002044A patent/PE20140976A1/es not_active Application Discontinuation
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Also Published As

Publication number	Publication date
BR112013023517B1 (pt)	2021-08-31
AP2013007044A0 (en)	2013-08-31
US20130345195A1 (en)	2013-12-26
PL2686310T3 (pl)	2018-06-29
SG193454A1 (en)	2013-10-30
JP2014511826A (ja)	2014-05-19
ES2660493T3 (es)	2018-03-22
EP2686310B1 (fr)	2017-12-13
AU2012229172A1 (en)	2013-08-29
EP2686310A1 (fr)	2014-01-22
DK2686310T3 (en)	2018-02-26
MA35089B1 (fr)	2014-05-02
CL2013002546A1 (es)	2014-04-04
PE20140976A1 (es)	2014-08-28
UY33950A (es)	2012-09-28
MX2013010457A (es)	2013-10-28
KR20140021600A (ko)	2014-02-20
HUE036408T2 (hu)	2018-07-30
KR101893756B1 (ko)	2018-09-03
US20130196973A1 (en)	2013-08-01
BR112013023517A2 (pt)	2016-12-06
IL227805A0 (en)	2013-09-30
GEP20156347B (en)	2015-08-10
ECSP13012958A (es)	2013-11-29
CA2835617A1 (fr)	2012-09-20
EA201301019A1 (ru)	2014-03-31
CN103415513A (zh)	2013-11-27
WO2012125598A1 (fr)	2012-09-20
AU2012229172B2 (en)	2017-02-09
US9133146B2 (en)	2015-09-15
CN103415513B (zh)	2016-01-20
TR201802550T4 (tr)	2018-03-21
JP5640162B2 (ja)	2014-12-10
TWI551593B (zh)	2016-10-01
PH12013501912A1 (en)	2013-10-14
TW201302723A (zh)	2013-01-16
EA023876B1 (ru)	2016-07-29
AP3339A (en)	2015-07-31
CA2835617C (fr)	2020-07-21
DK2686310T5 (en)	2018-07-09
US8551982B2 (en)	2013-10-08
NZ614109A (en)	2015-01-30
CO6771439A2 (es)	2013-10-15
IL227805A (en)	2017-06-29
MX355309B (es)	2018-04-16

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