TNSN01032A1 - Une composition pour la prevention et/ou le traitement des effets cytotoxiques induits par l'utilisation d'agents immunosuppressifs - Google Patents
Une composition pour la prevention et/ou le traitement des effets cytotoxiques induits par l'utilisation d'agents immunosuppressifsInfo
- Publication number
- TNSN01032A1 TNSN01032A1 TNTNSN01032A TNSN01032A TNSN01032A1 TN SN01032 A1 TNSN01032 A1 TN SN01032A1 TN TNSN01032 A TNTNSN01032 A TN TNSN01032A TN SN01032 A TNSN01032 A TN SN01032A TN SN01032 A1 TNSN01032 A1 TN SN01032A1
- Authority
- TN
- Tunisia
- Prior art keywords
- prevention
- treatment
- composition
- immunosuppressive agents
- cytotoxic effects
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940125721 immunosuppressive agent Drugs 0.000 title abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 231100000331 toxic Toxicity 0.000 abstract 2
- 230000002588 toxic effect Effects 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- DHMQDGOQFOQNFH-CNRUNOGKSA-N 2-amino-2-tritioacetic acid Chemical compound [3H]C(N)C(O)=O DHMQDGOQFOQNFH-CNRUNOGKSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- -1 L-CARNITINE PROPIONYL Chemical class 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UNE COMPOSITION EST REVELEE ET QUI EST CONVENABLE POUR LA PREVENTION ET/OU LE TRAITEMENT DES ANOMALIES CELLULAIRES ET TISSULAIRES D’ORIGINE EXOGENE, TOXIQUE OU METABOLIQUE, ET CONVENABLE EGALEMENT POUR LA REDUCTION DES EFFETS TOXIQUES DE LA CYCLOSPORINE – A ET DES AUTRES AGENTS IMMUNOSUPPRESSIFS, LAQUELLE PEUT PRENDRE LA FORME D’UN SUPPLEMENT ALIMENTAIRE OU D’UN MEDICAMENT EFFECTIF, CONTENANT COMME INGREDIENTS ACTIFS EN COMBINAISON OU CONDITIONNES SEPAREMENT : i) LE PROPIONYL L- CARNITINE OU L'UN DE SES SELS ACCEPTABLES SUR LE PLAN PHARMACOLOGIQUES, ET ii) UN ACIDE AMINE CHOISI PARMI LE GROUPE CONSISTANT DE GLYCINE, SERINE, ALANINE ET ARGININE, OU DES MELANGES DE CES DERNIERS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000107A IT1316998B1 (it) | 2000-03-02 | 2000-03-02 | Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN01032A1 true TNSN01032A1 (fr) | 2005-11-10 |
Family
ID=11454493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN01032A TNSN01032A1 (fr) | 2000-03-02 | 2001-02-27 | Une composition pour la prevention et/ou le traitement des effets cytotoxiques induits par l'utilisation d'agents immunosuppressifs |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7897641B2 (fr) |
| EP (1) | EP1267863B1 (fr) |
| AR (1) | AR027963A1 (fr) |
| AT (1) | ATE335476T1 (fr) |
| AU (2) | AU4103101A (fr) |
| CA (1) | CA2400728C (fr) |
| CY (1) | CY1106169T1 (fr) |
| CZ (1) | CZ20022759A3 (fr) |
| DE (1) | DE60122120T2 (fr) |
| DK (1) | DK1267863T3 (fr) |
| ES (1) | ES2269356T3 (fr) |
| HU (1) | HUP0300083A3 (fr) |
| IT (1) | IT1316998B1 (fr) |
| MX (1) | MXPA02008531A (fr) |
| PL (1) | PL202682B1 (fr) |
| PT (1) | PT1267863E (fr) |
| SK (1) | SK11892002A3 (fr) |
| TN (1) | TNSN01032A1 (fr) |
| WO (1) | WO2001064204A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106232114B (zh) * | 2014-04-22 | 2022-03-18 | 味之素株式会社 | 周围神经病变的预防或改善用组合物 |
| CN115469026B (zh) * | 2022-07-14 | 2023-10-20 | 中日友好医院(中日友好临床医学研究所) | 用于检测环孢素a肾毒性相关标志物的检测试剂、试剂盒及其用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1120033B (it) * | 1979-10-05 | 1986-03-19 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale |
| US5290538A (en) * | 1988-12-22 | 1994-03-01 | Skrezek Christian | Nephro protective infusion solutions |
| JPH0662547B2 (ja) * | 1989-01-10 | 1994-08-17 | 田辺製薬株式会社 | グリシン誘導体 |
| IT1248323B (it) * | 1991-05-16 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti |
| IT1245869B (it) | 1991-06-05 | 1994-10-25 | Sigma Tau Ind Farmaceuti | Impiego di propionil l-carnitina per il recupero del tono muscolare in soggetti immobilizzati |
| US5763408A (en) * | 1992-06-03 | 1998-06-09 | Fuji Photo Film Co., Ltd. | Amino acid derivatives and application thereof |
| US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| IT1277147B1 (it) * | 1995-01-20 | 1997-11-04 | Sigma Tau Ind Farmaceuti | Uso della carnitina e i suoi derivati per ridurre gli effetti tossici della ciclosporina-a e di altri farmaci immunosoppressivi. |
| DK0793962T3 (da) * | 1996-03-04 | 2000-05-22 | Sigma Tau Ind Farmaceuti | Lægemiddel indeholdende et carnitinderivat til behandling af arteriosclerosis obliterans |
| US6348495B1 (en) * | 1996-06-06 | 2002-02-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Method for treating celiac disease |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| IT1291127B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
| US5922766A (en) * | 1997-07-02 | 1999-07-13 | Acosta; Phyllis J. B. | Palatable elemental medical food |
| IT1302863B1 (it) | 1998-11-13 | 2000-10-10 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un |
| IT1306130B1 (it) * | 1999-04-16 | 2001-05-30 | Sigma Tau Healthscience Spa | Composizione comprendente una carnitina e glutatione, atta adaumentare l'assorbimento del glutatione sinergizzandone gli effetti. |
| IT1306173B1 (it) * | 1999-07-23 | 2001-05-30 | Sigma Tau Healthscience Spa | Composizione per la prevenzione degli affaticamenti muscolari e permigliorare il rendimento energetico muscolare. |
| IT1306722B1 (it) * | 1999-10-08 | 2001-10-02 | Sigma Tau Healthscience Spa | Composizione per la prevenzione e/o il trattamento di disfunzionicircolatorie, comprendente derivati della l-carnitina ed estratti di |
| IT1307278B1 (it) * | 1999-11-18 | 2001-10-30 | Sigma Tau Healthscience Spa | Composizione per la prevenzione e/o il trattamento di disturbi dovutiad un alterato metabolismo dei lipidi, che comprende propionil |
| IT1317062B1 (it) * | 2000-07-14 | 2003-05-26 | Sigma Tau Healthscience Spa | Integratore alimentare utile per prevenire le disfunzioni epatiche ebiliari comprendente una alcanoil l-carnitina. |
| ITRM20010155A1 (it) * | 2001-03-23 | 2002-09-23 | Biosalts Srl | Sale di creatina ad aumentato valore nutrizionale e terapeutico e composizioni che lo contengono. |
-
2000
- 2000-03-02 IT IT2000RM000107A patent/IT1316998B1/it active
-
2001
- 2001-02-20 US US10/220,185 patent/US7897641B2/en not_active Expired - Fee Related
- 2001-02-20 MX MXPA02008531A patent/MXPA02008531A/es active IP Right Grant
- 2001-02-20 AT AT01912114T patent/ATE335476T1/de active
- 2001-02-20 DK DK01912114T patent/DK1267863T3/da active
- 2001-02-20 WO PCT/IT2001/000082 patent/WO2001064204A2/fr not_active Ceased
- 2001-02-20 ES ES01912114T patent/ES2269356T3/es not_active Expired - Lifetime
- 2001-02-20 HU HU0300083A patent/HUP0300083A3/hu unknown
- 2001-02-20 CA CA002400728A patent/CA2400728C/fr not_active Expired - Fee Related
- 2001-02-20 PT PT01912114T patent/PT1267863E/pt unknown
- 2001-02-20 PL PL358267A patent/PL202682B1/pl unknown
- 2001-02-20 DE DE60122120T patent/DE60122120T2/de not_active Expired - Lifetime
- 2001-02-20 SK SK1189-2002A patent/SK11892002A3/sk unknown
- 2001-02-20 AU AU4103101A patent/AU4103101A/xx active Pending
- 2001-02-20 CZ CZ20022759A patent/CZ20022759A3/cs unknown
- 2001-02-20 AU AU2001241031A patent/AU2001241031B8/en not_active Ceased
- 2001-02-20 EP EP01912114A patent/EP1267863B1/fr not_active Expired - Lifetime
- 2001-02-27 AR ARP010100885A patent/AR027963A1/es unknown
- 2001-02-27 TN TNTNSN01032A patent/TNSN01032A1/fr unknown
-
2006
- 2006-09-25 CY CY20061101374T patent/CY1106169T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60122120D1 (de) | 2006-09-21 |
| EP1267863A2 (fr) | 2003-01-02 |
| PL202682B1 (pl) | 2009-07-31 |
| CY1106169T1 (el) | 2011-06-08 |
| WO2001064204A3 (fr) | 2002-03-28 |
| CA2400728A1 (fr) | 2001-09-07 |
| AU2001241031B8 (en) | 2005-12-01 |
| ITRM20000107A1 (it) | 2001-09-02 |
| CZ20022759A3 (cs) | 2003-02-12 |
| HUP0300083A3 (en) | 2004-07-28 |
| PL358267A1 (en) | 2004-08-09 |
| AR027963A1 (es) | 2003-04-16 |
| ES2269356T3 (es) | 2007-04-01 |
| WO2001064204A2 (fr) | 2001-09-07 |
| DE60122120T2 (de) | 2007-02-08 |
| ATE335476T1 (de) | 2006-09-15 |
| EP1267863B1 (fr) | 2006-08-09 |
| HUP0300083A2 (hu) | 2003-06-28 |
| CA2400728C (fr) | 2009-04-28 |
| AU4103101A (en) | 2001-09-12 |
| IT1316998B1 (it) | 2003-05-26 |
| US7897641B2 (en) | 2011-03-01 |
| US20030144354A1 (en) | 2003-07-31 |
| DK1267863T3 (da) | 2006-12-04 |
| PT1267863E (pt) | 2006-10-31 |
| AU2001241031B2 (en) | 2005-10-27 |
| ITRM20000107A0 (it) | 2000-03-02 |
| MXPA02008531A (es) | 2003-02-12 |
| SK11892002A3 (sk) | 2003-02-04 |
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