TR199801613T2 - Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler. - Google Patents

Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler.

Info

Publication number
TR199801613T2
TR199801613T2 TR1998/01613T TR9801613T TR199801613T2 TR 199801613 T2 TR199801613 T2 TR 199801613T2 TR 1998/01613 T TR1998/01613 T TR 1998/01613T TR 9801613 T TR9801613 T TR 9801613T TR 199801613 T2 TR199801613 T2 TR 199801613T2
Authority
TR
Turkey
Prior art keywords
contrast agents
microbubbles
stabilized
product
dispersions
Prior art date
Application number
TR1998/01613T
Other languages
English (en)
Turkish (tr)
Inventor
Dugstad Harald
Klaveness Jo
Rongved Pal
Skurtveit Roald
Braenden Jorun
Original Assignee
Nycomed Imaging A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by Nycomed Imaging A/S filed Critical Nycomed Imaging A/S
Publication of TR199801613T2 publication Critical patent/TR199801613T2/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
TR1998/01613T 1996-02-19 1997-02-19 Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler. TR199801613T2 (xx)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents

Publications (1)

Publication Number Publication Date
TR199801613T2 true TR199801613T2 (xx) 1998-11-23

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01613T TR199801613T2 (xx) 1996-02-19 1997-02-19 Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler.

Country Status (24)

Country Link
US (4) US6221337B1 (2)
EP (2) EP0881915B1 (2)
JP (1) JP4418033B2 (2)
KR (1) KR100500334B1 (2)
CN (1) CN1278740C (2)
AP (1) AP890A (2)
AT (1) ATE238072T1 (2)
AU (1) AU726503B2 (2)
BG (1) BG102758A (2)
CA (1) CA2246779C (2)
CZ (1) CZ293986B6 (2)
DE (1) DE69721235T2 (2)
EA (1) EA001135B1 (2)
EE (1) EE04224B1 (2)
ES (1) ES2197986T3 (2)
HU (1) HU229090B1 (2)
IL (1) IL125748A (2)
NZ (1) NZ331509A (2)
OA (1) OA10839A (2)
PL (1) PL328406A1 (2)
PT (1) PT881915E (2)
SK (1) SK284200B6 (2)
TR (1) TR199801613T2 (2)
WO (1) WO1997029783A1 (2)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU784367B2 (en) * 1996-08-02 2006-03-16 Ge Healthcare As Improvements in or relating to contrast agents
MXPA99001053A (es) * 1996-08-02 2002-03-11 Nycomed Imaging As Mejoramientos en o que se relacionan con agentes de contraste.
ES2209167T3 (es) * 1997-08-12 2004-06-16 Bracco Research S.A. Composiciones administrables y metodo para produccion de imagenes por resonancia magnetica.
GB9717476D0 (en) * 1997-08-18 1997-10-22 Nycomed Imaging As Process
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9726773D0 (en) 1997-12-18 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonagraphy
EP1073716B1 (en) * 1998-04-28 2004-04-28 Amersham Health AS Improvements in or relating to separation processes
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US20030103960A1 (en) * 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
AU2001266696A1 (en) 2000-06-02 2001-12-11 Bracco Research Usa Compounds for targeting endothelial cells
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
KR100373712B1 (ko) * 2000-12-23 2003-02-25 사회복지법인삼성생명공익재단(삼성서울병원) 초음파 조영제 및 그의 제조방법
JP3819845B2 (ja) 2001-04-06 2006-09-13 ブラッコ・リサーチ・ソシエテ・アノニム 流体で充填された空洞内の局所物理パラメータの改善された測定方法
BR0307518A (pt) * 2002-02-01 2004-12-28 Shimoda Biotech Pty Ltd Composição farmacêutica
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
CA2666005C (en) 2002-03-01 2016-01-19 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
NO20024755D0 (no) * 2002-10-03 2002-10-03 Amersham Health As Metode
KR101280760B1 (ko) 2002-11-29 2013-07-05 지이 헬스케어 에이에스 초음파 조영 물질
JP4670083B2 (ja) * 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
PT2949658T (pt) 2003-03-03 2018-10-18 Bracco Suisse Sa Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos
EP1643972A4 (en) * 2003-06-27 2010-01-20 Smithkline Beecham Corp STABILIZED LIPOSOMAL TOPOTECAN COMPOSITION AND METHOD
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
NO20035401D0 (no) * 2003-12-04 2003-12-04 Amersham Health As Metode
CN100563718C (zh) * 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
JP2007515471A (ja) * 2003-12-22 2007-06-14 ブラッコ・リサーチ・ソシエテ・アノニム 造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
CN100574811C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用微粒类助剂及其应用
CN100427142C (zh) * 2005-01-10 2008-10-22 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用助剂及其筛选方法
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
JP5242408B2 (ja) 2005-12-09 2013-07-24 ブラッコ・スイス・ソシエテ・アノニム ターゲットベクター・リン脂質コンジュゲート
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
AR059193A1 (es) 2006-01-31 2008-03-12 Bayer Schering Pharma Ag Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
US7967753B2 (en) 2006-08-01 2011-06-28 Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan Pulse inversion sequences for nonlinear imaging
WO2008027520A2 (en) * 2006-08-30 2008-03-06 The Trustees Of Columbia University In The City Of New York Systems and methods for composite elastography and wave imaging
ATE469660T1 (de) 2006-09-05 2010-06-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
WO2011035312A1 (en) 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010014977A1 (en) * 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
WO2010030779A1 (en) * 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Isolation of microbubbles of selected size range from polydisperse microbubbles
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
EP2477550A4 (en) * 2009-09-15 2013-12-04 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR MICROBUBBLES
US9700640B2 (en) * 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
US9265483B2 (en) 2010-08-06 2016-02-23 The Trustees Of Columbia University In The City Of New York Medical imaging contrast devices, methods, and systems
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
AU2013255952B2 (en) 2012-04-30 2018-04-12 Ge Healthcare As Method for filling a container with a foamable composition
IN2014DN10714A (2) 2012-06-26 2015-09-04 Ge Healthcare As
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
WO2014142926A1 (en) 2013-03-14 2014-09-18 Empire Technology Development Llc Identification of surgical smoke
US10017551B2 (en) 2013-03-15 2018-07-10 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
EP3233136B8 (en) 2014-12-18 2019-04-10 Bracco Suisse SA Targeted gas-filled microvesicles formulation
EP3308779B1 (en) * 2015-06-10 2019-08-07 Teikyo University Theranostic bubble preparation (tb), and method for using same
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IN172208B (2) * 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9511488D0 (en) * 1995-06-07 1995-08-02 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

Also Published As

Publication number Publication date
ATE238072T1 (de) 2003-05-15
HUP9900813A2 (hu) 1999-07-28
DE69721235D1 (de) 2003-05-28
PT881915E (pt) 2003-09-30
KR19990082669A (ko) 1999-11-25
CZ262598A3 (cs) 1999-05-12
AU1884797A (en) 1997-09-02
AP9801319A0 (en) 1998-09-30
IL125748A0 (en) 1999-04-11
US6221337B1 (en) 2001-04-24
WO1997029783A1 (en) 1997-08-21
EP0881915A1 (en) 1998-12-09
NZ331509A (en) 2000-04-28
HU229090B1 (en) 2013-07-29
HK1014872A1 (en) 1999-10-08
AP890A (en) 2000-11-13
IL125748A (en) 2002-05-23
EP1331013A3 (en) 2004-03-24
SK112698A3 (en) 1999-04-13
EA001135B1 (ru) 2000-10-30
BG102758A (en) 1999-09-30
KR100500334B1 (ko) 2005-09-09
SK284200B6 (sk) 2004-10-05
AU726503B2 (en) 2000-11-09
CA2246779C (en) 2008-04-29
CZ293986B6 (cs) 2004-09-15
JP4418033B2 (ja) 2010-02-17
EE04224B1 (et) 2004-02-16
CN1213972A (zh) 1999-04-14
US20050201942A1 (en) 2005-09-15
CN1278740C (zh) 2006-10-11
DE69721235T2 (de) 2004-02-05
EA199800745A1 (ru) 1999-02-25
EP0881915B1 (en) 2003-04-23
PL328406A1 (en) 1999-01-18
US20010010811A1 (en) 2001-08-02
EE9800249A (et) 1999-02-15
ES2197986T3 (es) 2004-01-16
HUP9900813A3 (en) 1999-11-29
US20030202942A1 (en) 2003-10-30
JP2000511510A (ja) 2000-09-05
OA10839A (en) 2001-08-13
EP1331013A2 (en) 2003-07-30
CA2246779A1 (en) 1997-08-21

Similar Documents

Publication Publication Date Title
TR199801613T2 (xx) Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler.
Rosing et al. The role of activated human platelets in prothrombin and factor X activation
IL139112A0 (en) Improvements in or relating to diagnostic/therapeutic agents
Izgu et al. N-carboxyanhydride-mediated fatty acylation of amino acids and peptides for functionalization of protocell membranes
Griebel et al. Metabolism of poly-β-hydroxybutyrate: effect of mild alkaline extraction on native poly-β-hydroxybutyrate granules
Jain et al. Interfacial catalysis by phospholipase A2: monomeric enzyme is fully catalytically active at the bilayer interface
Tatulian et al. Structural changes in a secretory phospholipase A 2 Induced by membrane binding: a clue to interfacial activation?
AU3780497A (en) Improvements in or relating to contrast agents
BR9807043A (pt) Mistura estabilizada que compreende fibrinogênio
BR0012443A (pt) Lipolìmero neutro e composições de lipossoma contendo o mesmo
BR9808928A (pt) Complexo molecular e liberação controlada dealfa hidroxiácidos
van Dieijen et al. Assembly of the intrinsic factor X activating complex–interactions between factor IXa, factor VIIIa and phospholipid
Zhou et al. Allosteric activation of phosphatidylinositol-specific phospholipase C: specific phospholipid binding anchors the enzyme to the interface
Attwood et al. The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Reactivation of phospholipase A-inactivated enzyme by phospholipids and detergents
Bourin et al. Functional role of the polysaccharide component of rabbit thrombomodulin proteoglycan. Effects on inactivation of thrombin by antithrombin, cleavage of fibrinogen by thrombin and thrombin-catalysed activation of factor V
Hesler et al. Transverse-plane topography of long-chain acyl-CoA synthetase in the mitochondrial outer membrane.
Almeida et al. Effect of short-chain primary alcohols on fluidity and activity of sarcoplasmic reticulum membranes
ATE264340T1 (de) Stabilisierung von gefriergetrocknetem kuchen
Bazzi et al. Autophosphorylation of protein kinase C may require a high order of protein-phospholipid aggregates
GOVERS‐RIEMSLAG et al. Prothrombin activation on dioleoylphosphatidylcholine membranes
Lecompte et al. Membrane penetration of bovine factor V and Va detected by labeling with 5-iodonaphthalene-1-azide.
Dannenberg et al. Organization of microsomal UDP-glucuronosyltransferase. Activation by treatment at high pressure
Inoue et al. Miscibility of binary phospholipid mixtures under hydrated and unhydrated conditions. I. Phosphatidic acids with different acyl chain length
El Kirat et al. Transphosphatidylation activity of Streptomyces chromofuscus phospholipase D in biomimetic membranes
Weber et al. Modifications of bovine prothrombin fragment 1 in the presence and absence of Ca (II) ions. Loss of positive cooperativity in Ca (II) ion binding for the modified proteins.