TR199900429T2 - Spirosiklik metaloproteaz inhibitörleri. - Google Patents

Spirosiklik metaloproteaz inhibitörleri.

Info

Publication number
TR199900429T2
TR199900429T2 TR1999/00429T TR9900429T TR199900429T2 TR 199900429 T2 TR199900429 T2 TR 199900429T2 TR 1999/00429 T TR1999/00429 T TR 1999/00429T TR 9900429 T TR9900429 T TR 9900429T TR 199900429 T2 TR199900429 T2 TR 199900429T2
Authority
TR
Turkey
Prior art keywords
compounds
spirosiklik
rleri
metalloproteaz
inhibit
Prior art date
Application number
TR1999/00429T
Other languages
English (en)
Inventor
Wang Zhe
Gregory Almstead Neil
Sandler Bradley Rimma
George Natchus Michael
De Biswanath
Pikul Stanislaw
Olabisi Taiwo Yetunde
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Publication of TR199900429T2 publication Critical patent/TR199900429T2/tr

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/10—Spiro-condensed systems

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Abstract

Bulus, istemlerde tarif edildigi haliyle (I) formülü bilesiklerini, ya da bu bilesiklerin bir optik izomeri, diastereomeri ya da enantiomeri, ya da farmasötik açidan kabul edilebilir bir tuzunu ya da biyo-hidrolize-edilebilir amidi, esteri ya da imidini temin etmektedir, bu maddeler metaloproteazlarin inhibitörleri olarak yararlidir. Ayni zamanda, metaloproteaz etkinligi ile vasiflanan hastaliklar, bozukluklar ve durumlarin, bu bilesikler ya da bu bilesikleri ihtiva eden farmasötik bilesim kullanilarak tedavi edilmesi için yöntemler ve farmasötik bilesimler de anlatilmistir.
TR1999/00429T 1996-08-28 1997-08-22 Spirosiklik metaloproteaz inhibitörleri. TR199900429T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2476696P 1996-08-28 1996-08-28

Publications (1)

Publication Number Publication Date
TR199900429T2 true TR199900429T2 (tr) 1999-05-21

Family

ID=21822299

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00429T TR199900429T2 (tr) 1996-08-28 1997-08-22 Spirosiklik metaloproteaz inhibitörleri.

Country Status (29)

Country Link
US (1) US6015912A (tr)
EP (1) EP0927183B1 (tr)
JP (2) JP3495376B2 (tr)
KR (1) KR100326611B1 (tr)
CN (1) CN1105723C (tr)
AR (1) AR009358A1 (tr)
AT (1) ATE272062T1 (tr)
AU (1) AU736238B2 (tr)
BR (1) BR9713178A (tr)
CA (1) CA2264044A1 (tr)
CO (1) CO4900045A1 (tr)
CZ (1) CZ63799A3 (tr)
DE (1) DE69730033T2 (tr)
DK (1) DK0927183T3 (tr)
ES (1) ES2225983T3 (tr)
HU (1) HUP9904694A3 (tr)
ID (1) ID19418A (tr)
IL (1) IL128667A (tr)
NO (1) NO315373B1 (tr)
NZ (1) NZ334257A (tr)
PE (1) PE107798A1 (tr)
PL (1) PL331920A1 (tr)
PT (1) PT927183E (tr)
RU (1) RU2203274C2 (tr)
SK (1) SK284041B6 (tr)
TR (1) TR199900429T2 (tr)
TW (1) TW581761B (tr)
WO (1) WO1998008850A1 (tr)
ZA (1) ZA977699B (tr)

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CA2298617A1 (en) 1997-07-31 1999-02-11 Yetunde Olabisi Taiwo Acyclic metalloprotease inhibitors
JP4750272B2 (ja) 1998-02-04 2011-08-17 ノバルティス アーゲー マトリックス分解メタロプロテイナーゼを阻害するスルホニルアミノ誘導体
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6846478B1 (en) 1998-02-27 2005-01-25 The Procter & Gamble Company Promoting whole body health
US6197974B1 (en) * 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
BR0008716A (pt) 1999-03-03 2002-09-24 Procter & Gamble Inibidores de metaloprotease contendo alquenil ou alquinil
MXPA01008857A (es) 1999-03-03 2002-07-02 Procter & Gamble Inhibidores de metaloproteasa dihetero sustituidos.
MXPA03000043A (es) * 2000-06-30 2003-10-15 Procter & Gamble Promocion de la salud en todo el cuerpo.
US8283135B2 (en) * 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
JP2004517038A (ja) * 2000-06-30 2004-06-10 ザ、プロクター、エンド、ギャンブル、カンパニー 全身の健康増進
FR2818643B1 (fr) * 2000-12-22 2003-02-07 Servier Lab Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques que les contiennent
WO2003016248A2 (en) 2001-08-17 2003-02-27 Bristol-Myers Squibb Company Patent Department Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace)
EP1622569B1 (en) 2003-04-24 2015-12-02 Incyte Corporation Aza spiro alkane derivatives as inhibitors of metallproteases
DE102004004974A1 (de) * 2004-01-31 2005-08-18 Aventis Pharma Deutschland Gmbh Thieno-Iminosäure-Derivate als Inhibitoren von Matrix-Metalloproteinasen
UA100669C2 (ru) * 2006-06-01 2013-01-25 Санофі-Авентіс Спироциклические нитрилы как ингибиторы протеазы, способ их получения (варианты) и лекарственное средство на их основе
JP2010519329A (ja) * 2007-02-27 2010-06-03 バーテックス ファーマシューティカルズ インコーポレイテッド セリンプロテアーゼ阻害剤
RS53407B (sr) * 2007-02-28 2014-10-31 Leo Pharma A/S Novi inhibitori fosfodiesteraze
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ATE272062T1 (de) 2004-08-15
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