NO990856L - Spirosykliske metallprotease-inhibitorer - Google Patents

Spirosykliske metallprotease-inhibitorer

Info

Publication number: NO990856L
Authority: NO; Norway
Prior art keywords: spirocyclic; protease inhibitors; metal protease; metal; inhibitors
Prior art date: 1996-08-28

Application number

NO990856A

Other languages

English (en)

Other versions

NO990856D0 (no

NO315373B1 (no

Inventor

Zhe Wang

Neil Gregory Almstead

Rimma Sandler Bradley

Michael George Natchus

Biswanath De

Stanislaw Pikul

Yetunde Olabisi Taiwo

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-28

Filing date

1999-02-23

Publication date

1999-04-28

1999-02-23 Application filed by Procter & Gamble filed Critical Procter & Gamble

1999-02-23 Publication of NO990856D0 publication Critical patent/NO990856D0/no

1999-04-28 Publication of NO990856L publication Critical patent/NO990856L/no

2003-08-25 Publication of NO315373B1 publication Critical patent/NO315373B1/no

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000002184 metal Substances 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Oncology (AREA)
Virology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Tropical Medicine & Parasitology (AREA)
Neurology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pregnancy & Childbirth (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)

NO19990856A 1996-08-28 1999-02-23 Spirosykliske metallprotease-inhibitorer NO315373B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2476696P	1996-08-28	1996-08-28
PCT/US1997/014557 WO1998008850A1 (en)	1996-08-28	1997-08-22	Spirocyclic metalloprotease inhibitors

Publications (3)

Publication Number	Publication Date
NO990856D0 NO990856D0 (no)	1999-02-23
NO990856L true NO990856L (no)	1999-04-28
NO315373B1 NO315373B1 (no)	2003-08-25

Family

ID=21822299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19990856A NO315373B1 (no)	1996-08-28	1999-02-23	Spirosykliske metallprotease-inhibitorer

Country Status (29)

Country	Link
US (1)	US6015912A (no)
EP (1)	EP0927183B1 (no)
JP (2)	JP3495376B2 (no)
KR (1)	KR100326611B1 (no)
CN (1)	CN1105723C (no)
AR (1)	AR009358A1 (no)
AT (1)	ATE272062T1 (no)
AU (1)	AU736238B2 (no)
BR (1)	BR9713178A (no)
CA (1)	CA2264044A1 (no)
CO (1)	CO4900045A1 (no)
CZ (1)	CZ63799A3 (no)
DE (1)	DE69730033T2 (no)
DK (1)	DK0927183T3 (no)
ES (1)	ES2225983T3 (no)
HU (1)	HUP9904694A3 (no)
ID (1)	ID19418A (no)
IL (1)	IL128667A (no)
NO (1)	NO315373B1 (no)
NZ (1)	NZ334257A (no)
PE (1)	PE107798A1 (no)
PL (1)	PL331920A1 (no)
PT (1)	PT927183E (no)
RU (1)	RU2203274C2 (no)
SK (1)	SK284041B6 (no)
TR (1)	TR199900429T2 (no)
TW (1)	TW581761B (no)
WO (1)	WO1998008850A1 (no)
ZA (1)	ZA977699B (no)

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US20030206874A1 (en) *	1996-11-21	2003-11-06	The Proctor & Gamble Company	Promoting whole body health
JP2001513484A (ja)	1997-07-31	2001-09-04	ザプロクターアンドギャンブルカンパニー	非環式メタロプロテアーゼ阻害剤
EP1053226A1 (en)	1998-02-04	2000-11-22	Novartis AG	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6410580B1 (en)	1998-02-04	2002-06-25	Novartis Ag	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6846478B1 (en)	1998-02-27	2005-01-25	The Procter & Gamble Company	Promoting whole body health
US6197974B1 (en) *	1998-10-26	2001-03-06	Abbott Laboratories	Enantioselective synthesis of 3-aminopyrrolidines
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1165530A2 (en)	1999-03-03	2002-01-02	The Procter & Gamble Company	Dihetero-substituted metalloprotease inhibitors
CN1349498A (zh)	1999-03-03	2002-05-15	宝洁公司	含有链烯基和炔基的金属蛋白酶抑制剂
US8283135B2 (en)	2000-06-30	2012-10-09	The Procter & Gamble Company	Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
CN1536989A (zh) *	2000-06-30	2004-10-13		促进全身健康
JP2004517038A (ja) *	2000-06-30	2004-06-10	ザ、プロクター、エンド、ギャンブル、カンパニー	全身の健康増進
FR2818643B1 (fr) *	2000-12-22	2003-02-07	Servier Lab	Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques que les contiennent
US6770647B2 (en)	2001-08-17	2004-08-03	Bristol-Myers Squibb Pharma Company	Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
AU2004233863B2 (en)	2003-04-24	2010-06-17	Incyte Holdings Corporation	Aza spiro alkane derivatives as inhibitors of metalloproteases
DE102004004974A1 (de) *	2004-01-31	2005-08-18	Aventis Pharma Deutschland Gmbh	Thieno-Iminosäure-Derivate als Inhibitoren von Matrix-Metalloproteinasen
MX341849B (es) *	2006-06-01	2016-09-05	Sanofi Aventis	Nitrilos espirociclicos como inhibidores de proteasa.
WO2008106058A2 (en) *	2007-02-27	2008-09-04	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
KR101571654B1 (ko) *	2007-02-28	2015-11-25	레오 파마 에이/에스	신규한 포스포디에스테라제 억제제
EP2473056A4 (en)	2009-09-04	2013-02-13	Glaxosmithkline Llc	CHEMICAL COMPOUNDS
WO2012123298A1 (en)	2011-03-11	2012-09-20	F. Hoffmann-La Roche Ag	Antiviral compounds
RU2523284C9 (ru) *	2012-05-31	2014-10-10	Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан"	Способ модификации макролидного антибиотика олигомицина а с помощью реакции [3+2]-диполярного циклоприсоединения азида и алкинов. 33-дезокис-33-(триазол-1-ил)-олигомицины а и их биологическая активность
UA119247C2 (uk)	2013-09-06	2019-05-27	РОЙВЕНТ САЙЕНСИЗ ҐмбГ	Спіроциклічні сполуки як інгібітори триптофангідроксилази
US9611201B2 (en)	2015-03-05	2017-04-04	Karos Pharmaceuticals, Inc.	Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
AR110150A1 (es) *	2016-11-09	2019-02-27	Roivant Sciences Gmbh	Procesos para la preparación de inhibidores de tph1

Family Cites Families (30)

* Cited by examiner, † Cited by third party
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JPH05125029A (ja) *	1991-11-06	1993-05-21	Yamanouchi Pharmaceut Co Ltd	新規なアミド化合物又はその塩
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1997
- 1997-08-22 WO PCT/US1997/014557 patent/WO1998008850A1/en not_active Ceased
- 1997-08-22 IL IL12866797A patent/IL128667A/en not_active IP Right Cessation
- 1997-08-22 CZ CZ99637A patent/CZ63799A3/cs unknown
- 1997-08-22 PT PT97939445T patent/PT927183E/pt unknown
- 1997-08-22 TR TR1999/00429T patent/TR199900429T2/xx unknown
- 1997-08-22 HU HU9904694A patent/HUP9904694A3/hu unknown
- 1997-08-22 AU AU41532/97A patent/AU736238B2/en not_active Ceased
- 1997-08-22 BR BR9713178-4A patent/BR9713178A/pt not_active IP Right Cessation
- 1997-08-22 CA CA002264044A patent/CA2264044A1/en not_active Abandoned
- 1997-08-22 NZ NZ334257A patent/NZ334257A/xx unknown
- 1997-08-22 KR KR1019997001652A patent/KR100326611B1/ko not_active Expired - Fee Related
- 1997-08-22 ES ES97939445T patent/ES2225983T3/es not_active Expired - Lifetime
- 1997-08-22 PL PL97331920A patent/PL331920A1/xx unknown
- 1997-08-22 CN CN97197542A patent/CN1105723C/zh not_active Expired - Fee Related
- 1997-08-22 AT AT97939445T patent/ATE272062T1/de not_active IP Right Cessation
- 1997-08-22 DE DE69730033T patent/DE69730033T2/de not_active Expired - Fee Related
- 1997-08-22 JP JP51171798A patent/JP3495376B2/ja not_active Expired - Fee Related
- 1997-08-22 DK DK97939445T patent/DK0927183T3/da active
- 1997-08-22 EP EP97939445A patent/EP0927183B1/en not_active Expired - Lifetime
- 1997-08-22 SK SK255-99A patent/SK284041B6/sk unknown
- 1997-08-22 RU RU99106587/04A patent/RU2203274C2/ru not_active IP Right Cessation
- 1997-08-26 US US08/918,328 patent/US6015912A/en not_active Expired - Fee Related
- 1997-08-27 ZA ZA9707699A patent/ZA977699B/xx unknown
- 1997-08-27 CO CO97049506A patent/CO4900045A1/es unknown
- 1997-08-27 AR ARP970103899A patent/AR009358A1/es unknown
- 1997-08-28 ID IDP972995A patent/ID19418A/id unknown
- 1997-08-28 PE PE1997000769A patent/PE107798A1/es not_active Application Discontinuation
1998
- 1998-02-03 TW TW087101299A patent/TW581761B/zh not_active IP Right Cessation
1999
- 1999-02-23 NO NO19990856A patent/NO315373B1/no unknown
2003
- 2003-08-13 JP JP2003292947A patent/JP2004002470A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP3495376B2 (ja)	2004-02-09
IL128667A0 (en)	2000-01-31
ID19418A (id)	1998-07-09
JP2000515168A (ja)	2000-11-14
ZA977699B (en)	1998-02-23
TW581761B (en)	2004-04-01
PL331920A1 (en)	1999-08-16
DK0927183T3 (da)	2004-11-29
WO1998008850A1 (en)	1998-03-05
NZ334257A (en)	2000-11-24
IL128667A (en)	2002-04-21
NO990856D0 (no)	1999-02-23
HK1021184A1 (en)	2000-06-02
SK284041B6 (sk)	2004-08-03
BR9713178A (pt)	2000-02-08
CN1105723C (zh)	2003-04-16
KR100326611B1 (ko)	2002-03-02
AU736238B2 (en)	2001-07-26
EP0927183A1 (en)	1999-07-07
AU4153297A (en)	1998-03-19
CA2264044A1 (en)	1998-03-05
CN1228779A (zh)	1999-09-15
SK25599A3 (en)	2000-05-16
AR009358A1 (es)	2000-04-12
KR20000035916A (ko)	2000-06-26
ES2225983T3 (es)	2005-03-16
JP2004002470A (ja)	2004-01-08
ATE272062T1 (de)	2004-08-15
RU2203274C2 (ru)	2003-04-27
DE69730033D1 (de)	2004-09-02
EP0927183B1 (en)	2004-07-28
HUP9904694A3 (en)	2001-12-28
NO315373B1 (no)	2003-08-25
DE69730033T2 (de)	2005-07-21
CZ63799A3 (cs)	1999-08-11
PE107798A1 (es)	1999-02-11
US6015912A (en)	2000-01-18
TR199900429T2 (xx)	1999-05-21
CO4900045A1 (es)	2000-03-27
HUP9904694A2 (hu)	2000-05-28
PT927183E (pt)	2004-12-31

Publication	Publication Date	Title
NO990856D0 (no)	1999-02-23	Spirosykliske metallprotease-inhibitorer
PT936912E (pt)	2004-06-30	Inibidores de cisteina protease
NO990759L (no)	1999-04-27	Heterocykliske metallproteaseinhibitorer
NO995433D0 (no)	1999-11-05	Protease-inhibitorer
NO990760D0 (no)	1999-02-18	1,4-heterocykliske metallproteaseinhibitorer
NO20006716D0 (no)	2000-12-29	Proteaseinhibitorer
NO20012980L (no)	2001-08-01	Proteaseinhibitorer
NO996578D0 (no)	1999-12-30	Urokinase-inhibitorer
DK1027332T3 (da)	2004-10-04	Hidtil ukendte lactametalloproteaseinhibitorer
NO992734L (no)	1999-08-02	Serin-protease inhibitorer
DK0958287T3 (da)	2003-01-20	Sulfamidmetalloprotease-inhibitorer
NO983688D0 (no)	1998-08-12	Serin-protease-inhibitorer
NO995435D0 (no)	1999-11-05	Protease-inhibitorer
NO995434D0 (no)	1999-11-05	Proteaseinhibitorer
NO995268D0 (no)	1999-10-28	Proteaseinhibitorer
DK0956294T3 (da)	2004-10-11	Thrombininhibitorer
ATE277074T1 (de)	2004-10-15	Serine-protease-inhibitoren
DE69714222D1 (de)	2002-08-29	Serine-protease-inhibitoren
BR9707086A (pt)	1999-04-13	Inibidores de proteinase aspartila
ATE282629T1 (de)	2004-12-15	Thrombininhibitoren
DE69720957T2 (de)	2004-01-29	Ace-hemmer
EP1007548A4 (en)	2002-07-03	THROMBIN INHIBITOR FROM TSE-TSE FLY
MA26429A1 (fr)	2004-12-20	Inhibiteurs de protease