TR199900486T2 - Aziniloksi ve fenoksi-diaril-karbonasit türevleri. - Google Patents

Aziniloksi ve fenoksi-diaril-karbonasit türevleri.

Info

Publication number
TR199900486T2
TR199900486T2 TR1999/00486T TR9900486T TR199900486T2 TR 199900486 T2 TR199900486 T2 TR 199900486T2 TR 1999/00486 T TR1999/00486 T TR 1999/00486T TR 9900486 T TR9900486 T TR 9900486T TR 199900486 T2 TR199900486 T2 TR 199900486T2
Authority
TR
Turkey
Prior art keywords
azinyloxy
diaryl
phenoxy
carboxylic acid
acid derivatives
Prior art date
Application number
TR1999/00486T
Other languages
English (en)
Inventor
Amberg Wilhelm
Jansen Rolf
Kling Andreas
Klinge Dagmar
Riechers Hartmut
Hergenr�Der Stefan
Raschack Manfred
Unger Liliane
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR199900486T2 publication Critical patent/TR199900486T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Mevcut bulus formül (I)'e göre olan karbonasit türevleri ve bunlarin fizyolojik kabul edilebilir tuzlari ve saf enantiomer ve diastereoizamer formlari, bunlarin üretimi ve ETA/ETB- reseptör antagonist karisimlari olarak kullanimlari ile ilgilidir.Formül (I).
TR1999/00486T 1996-09-05 1997-09-02 Aziniloksi ve fenoksi-diaril-karbonasit türevleri. TR199900486T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19636046A DE19636046A1 (de) 1996-09-05 1996-09-05 Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten

Publications (1)

Publication Number Publication Date
TR199900486T2 true TR199900486T2 (tr) 1999-06-21

Family

ID=7804712

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00486T TR199900486T2 (tr) 1996-09-05 1997-09-02 Aziniloksi ve fenoksi-diaril-karbonasit türevleri.

Country Status (22)

Country Link
US (1) US6670367B1 (tr)
EP (1) EP0929529A2 (tr)
JP (1) JP2000517329A (tr)
KR (1) KR20000068446A (tr)
CN (1) CN1236362A (tr)
AR (1) AR009543A1 (tr)
AU (1) AU736414B2 (tr)
BG (1) BG103258A (tr)
BR (1) BR9711693A (tr)
CA (1) CA2265504A1 (tr)
CO (1) CO4900070A1 (tr)
DE (1) DE19636046A1 (tr)
HU (1) HUP0000664A3 (tr)
ID (1) ID19417A (tr)
IL (1) IL128743A0 (tr)
NO (1) NO312674B1 (tr)
NZ (1) NZ334548A (tr)
PL (1) PL331998A1 (tr)
SK (1) SK25999A3 (tr)
TR (1) TR199900486T2 (tr)
WO (1) WO1998009953A2 (tr)
ZA (1) ZA977946B (tr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030975A (en) * 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
IL134276A0 (en) * 1997-09-04 2001-04-30 Basf Ag Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists
CA2304712C (en) * 1997-09-26 2008-04-29 Knoll Aktiengesellschaft Endothelin antagonist and a renin-angiotensin system inhibitor as a combined preparation
DE19743143A1 (de) 1997-09-30 1999-04-01 Knoll Ag Pharmazeutische Kombinationspräparate
AU742506B2 (en) * 1997-10-17 2002-01-03 Eurogene Limited The use of inhibitors of the renin-angiotensin system
DE19809144A1 (de) * 1998-03-04 1999-09-09 Basf Ag Neue unsymmetrisch substituierte Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶LAMBDA¶/ET¶B¶-Rezeptorantagonisten
DE19836044A1 (de) * 1998-08-10 2000-02-17 Basf Ag Neue Carbonsäurederivate, die Ketoseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
DE19933164A1 (de) * 1999-07-20 2001-01-25 Basf Ag Neue Carbonsäurederivate mit 5,6 substituiertem Pyrimidinring, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
DE19951671A1 (de) * 1999-10-27 2001-05-03 Basf Ag 2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als Endothelinantagonist
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
JP4155561B2 (ja) * 2000-12-26 2008-09-24 国立大学法人佐賀大学 アレルギー性疾患検査方法
DE60120104T2 (de) 2001-03-20 2006-09-21 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
DK1243263T3 (da) 2001-03-21 2003-03-17 Sanol Arznei Schwarz Gmbh Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte
AU2005232395B2 (en) 2004-04-16 2010-09-09 Schwarz Pharma Ag Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
EA014055B1 (ru) 2004-08-27 2010-08-30 Шварц Фарма Аг Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами
MX2008011844A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Formulaciones de sitaxsentano de sodio.
MX2008011842A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Procedimientos y composiciones para el tratamiento de insuficiencia cardiaca diastolica.
EA019757B1 (ru) 2006-06-15 2014-06-30 ЮСиБи ФАРМА ГМБХ Фармацевтическая композиция с синергетическим противосудорожным эффектом
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
CN103709106A (zh) * 2013-12-06 2014-04-09 石家庄博策生物科技有限公司 一种立体选择性制备安立生坦的方法
CN103739557B (zh) * 2013-12-30 2015-10-21 黄河三角洲京博化工研究院有限公司 一种4,6-二甲基-2-甲磺酰基嘧啶的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313413A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryloxy(thio)-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4313412A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4335950A1 (de) 1993-10-21 1995-04-27 Basf Ag Derivate von 3-Hydroxycarbonsäuren, deren Herstellung und Verwendung
DE4411225A1 (de) 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19536891A1 (de) 1995-10-04 1997-04-10 Basf Ag Neue Aminosäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
CA2265504A1 (en) 1998-03-12
BG103258A (en) 2000-12-29
HUP0000664A3 (en) 2001-07-30
WO1998009953A3 (de) 1998-10-29
EP0929529A2 (de) 1999-07-21
CO4900070A1 (es) 2000-03-27
DE19636046A1 (de) 1998-03-12
AR009543A1 (es) 2000-04-26
US6670367B1 (en) 2003-12-30
WO1998009953A2 (de) 1998-03-12
AU4552497A (en) 1998-03-26
JP2000517329A (ja) 2000-12-26
NO991079L (no) 1999-05-04
NZ334548A (en) 2000-09-29
SK25999A3 (en) 1999-09-10
CN1236362A (zh) 1999-11-24
BR9711693A (pt) 1999-08-24
ZA977946B (en) 1999-03-04
AU736414B2 (en) 2001-07-26
NO991079D0 (no) 1999-03-04
ID19417A (id) 1998-07-09
NO312674B1 (no) 2002-06-17
HUP0000664A2 (hu) 2001-04-28
PL331998A1 (en) 1999-08-16
IL128743A0 (en) 2000-01-31
KR20000068446A (ko) 2000-11-25

Similar Documents

Publication Publication Date Title
TR199900486T2 (tr) Aziniloksi ve fenoksi-diaril-karbonasit türevleri.
TR200102800T2 (tr) Yeni bileşikler.
TR200101398T2 (tr) Pirolidin türevleri-CCR-3 reseptörü antagonistleri.
TR199700844T1 (tr) Pirazolil-Benzoil Türevleri.
TR200201874T2 (tr) Proteaz inhibitörleri olarak yeni bileşikler ve bileşimler.
EE9900217A (et) Sulfiinhappe derivaadid, nende valmistamine ja kasutamine
TR199800436A2 (tr) Primidin türevlerinin kanserin önlenmesi için kullanilmasi.
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
TR200401029T4 (tr) Asilfenil-üre türevleri, imalat yöntemleri ve ilaç maddesi olarak kullanımları
FI93831B (fi) Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita
SE9504661D0 (sv) New compounds
TR199901305T2 (tr) Calpain-önleyicileri olarak ketonbenzamidler
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
TR200002542T2 (tr) Meta-azasiklik amino benzoik asit bileşikleri ve bunların integrin antagonistleri olan türevleri
ATE219073T1 (de) Benzopyran derivate mit leukotrien- antagonistischer wirkung
TR200000737T2 (tr) İkame edilmiş kroman türevleri.
BG102623A (bg) Нови производни на бензоилгуанидина, методи за тяхното получаване и приложението им за производството на ле- карствени средства
TR200001452T2 (tr) Bifenilamidin türevleri.
TR199700206A2 (tr) Floralkil- ve floralkoksi ikame edilmis heterosiklik bradikinin-antagonistleri, bunlarin imal edilmesine mahsus usul ve bunlarin kullanilmalari.
TR200001909T2 (tr) Matris metaloprotez inhibitörleri.
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
BG104232A (bg) Заместени 1,2,3,4,5,6-хексахидро-2,6-метано-3-бензазоцин- 10-оли, метод за тяхното получаване и приложението им като лекарствени средства
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
ES466850A1 (es) Procedimiento para la preparacion de 2-bromo-6-fluor-n-imi- dazolidinilidenbenzamina.
SE9604582D0 (sv) Novel compounds