NO991079L - Azinyloksy- og fenoksy-diaryl-karboksylsyre-derivater, deres fremstilling og deres anvendelse som blandede ETA/ETB-endotelin-reseptor-antagonister - Google Patents
Azinyloksy- og fenoksy-diaryl-karboksylsyre-derivater, deres fremstilling og deres anvendelse som blandede ETA/ETB-endotelin-reseptor-antagonisterInfo
- Publication number
- NO991079L NO991079L NO991079A NO991079A NO991079L NO 991079 L NO991079 L NO 991079L NO 991079 A NO991079 A NO 991079A NO 991079 A NO991079 A NO 991079A NO 991079 L NO991079 L NO 991079L
- Authority
- NO
- Norway
- Prior art keywords
- azinyloxy
- diaryl
- phenoxy
- preparation
- carboxylic acid
- Prior art date
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19636046A DE19636046A1 (de) | 1996-09-05 | 1996-09-05 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
| PCT/EP1997/004688 WO1998009953A2 (de) | 1996-09-05 | 1997-09-02 | Azinyloxy- und phenoxy-diaryl-carbonsäure derivate, deren herstellung und deren verwendung als gemischte eta/etb endothelin-rezeptorantagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991079D0 NO991079D0 (no) | 1999-03-04 |
| NO991079L true NO991079L (no) | 1999-05-04 |
| NO312674B1 NO312674B1 (no) | 2002-06-17 |
Family
ID=7804712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991079A NO312674B1 (no) | 1996-09-05 | 1999-03-04 | Azinyloksy- og fenoksy-diaryl-karboksylsyre-derivater, deres fremstilling og deres anvendelse, og farmasöytisk preparatinneholdende dem |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6670367B1 (no) |
| EP (1) | EP0929529A2 (no) |
| JP (1) | JP2000517329A (no) |
| KR (1) | KR20000068446A (no) |
| CN (1) | CN1236362A (no) |
| AR (1) | AR009543A1 (no) |
| AU (1) | AU736414B2 (no) |
| BG (1) | BG103258A (no) |
| BR (1) | BR9711693A (no) |
| CA (1) | CA2265504A1 (no) |
| CO (1) | CO4900070A1 (no) |
| DE (1) | DE19636046A1 (no) |
| HU (1) | HUP0000664A3 (no) |
| ID (1) | ID19417A (no) |
| IL (1) | IL128743A0 (no) |
| NO (1) | NO312674B1 (no) |
| NZ (1) | NZ334548A (no) |
| PL (1) | PL331998A1 (no) |
| SK (1) | SK25999A3 (no) |
| TR (1) | TR199900486T2 (no) |
| WO (1) | WO1998009953A2 (no) |
| ZA (1) | ZA977946B (no) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6030975A (en) * | 1997-03-14 | 2000-02-29 | Basf Aktiengesellschaft | Carboxylic acid derivatives, their preparation and use in treating cancer |
| KR20010023615A (ko) * | 1997-09-04 | 2001-03-26 | 스타르크, 카르크 | 신규 카르복실산 유도체, 그 제조 및 혼합 ｅｔａ/ｅｔｂ엔도텔린 수용체 길항제로서의 용도 |
| ES2214734T3 (es) * | 1997-09-26 | 2004-09-16 | ABBOTT GMBH & CO. KG | Antagonista de la endotelina e inhibidor del sistema renina-angiotensina como preparado de combinacion. |
| DE19743143A1 (de) * | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
| KR100523112B1 (ko) * | 1997-10-17 | 2005-10-19 | 유로진 리미티드 | 레닌-안지오텐신계 억제제의 사용 |
| DE19809144A1 (de) * | 1998-03-04 | 1999-09-09 | Basf Ag | Neue unsymmetrisch substituierte Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶LAMBDA¶/ET¶B¶-Rezeptorantagonisten |
| DE19836044A1 (de) * | 1998-08-10 | 2000-02-17 | Basf Ag | Neue Carbonsäurederivate, die Ketoseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten |
| US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
| DE19933164A1 (de) * | 1999-07-20 | 2001-01-25 | Basf Ag | Neue Carbonsäurederivate mit 5,6 substituiertem Pyrimidinring, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
| DE19951671A1 (de) * | 1999-10-27 | 2001-05-03 | Basf Ag | 2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als Endothelinantagonist |
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| JP4155561B2 (ja) * | 2000-12-26 | 2008-09-24 | 国立大学法人佐賀大学 | アレルギー性疾患検査方法 |
| DK1243262T3 (da) | 2001-03-20 | 2006-10-02 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter |
| ES2185606T3 (es) | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma. |
| KR20070007931A (ko) | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
| EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| PL1781276T3 (pl) | 2004-08-27 | 2010-11-30 | Ucb Pharma Gmbh | Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy |
| CA2644784A1 (en) * | 2006-03-13 | 2007-09-20 | Jinling Chen | Formulations of sitaxsentan sodium |
| JP2009530284A (ja) * | 2006-03-13 | 2009-08-27 | エンサイシブ・ファーマシューティカルズ・インコーポレイテッド | 拡張期心不全を治療するための方法と組成物 |
| WO2007144195A2 (en) | 2006-06-15 | 2007-12-21 | Schwarz Pharma Ag | Pharmaceutical composition with synergistic anticonvulsant effect |
| US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
| CN103709106A (zh) * | 2013-12-06 | 2014-04-09 | 石家庄博策生物科技有限公司 | 一种立体选择性制备安立生坦的方法 |
| CN103739557B (zh) * | 2013-12-30 | 2015-10-21 | 黄河三角洲京博化工研究院有限公司 | 一种4,6-二甲基-2-甲磺酰基嘧啶的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4313413A1 (de) * | 1993-04-23 | 1994-10-27 | Basf Ag | 3-(Het)aryloxy(thio)-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung |
| DE4313412A1 (de) * | 1993-04-23 | 1994-10-27 | Basf Ag | 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung |
| DE4335950A1 (de) | 1993-10-21 | 1995-04-27 | Basf Ag | Derivate von 3-Hydroxycarbonsäuren, deren Herstellung und Verwendung |
| DE4411225A1 (de) | 1994-03-31 | 1995-10-05 | Basf Ag | Verwendung von Carbonsäurederivaten als Arzneimittel |
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19536891A1 (de) | 1995-10-04 | 1997-04-10 | Basf Ag | Neue Aminosäurederivate, ihre Herstellung und Verwendung |
-
1996
- 1996-09-05 DE DE19636046A patent/DE19636046A1/de not_active Withdrawn
-
1997
- 1997-03-02 US US09/254,137 patent/US6670367B1/en not_active Expired - Fee Related
- 1997-09-02 CN CN97199458A patent/CN1236362A/zh active Pending
- 1997-09-02 CA CA002265504A patent/CA2265504A1/en not_active Abandoned
- 1997-09-02 EP EP97943819A patent/EP0929529A2/de not_active Withdrawn
- 1997-09-02 PL PL97331998A patent/PL331998A1/xx unknown
- 1997-09-02 JP JP10512203A patent/JP2000517329A/ja active Pending
- 1997-09-02 KR KR1019997001815A patent/KR20000068446A/ko not_active Ceased
- 1997-09-02 SK SK259-99A patent/SK25999A3/sk unknown
- 1997-09-02 WO PCT/EP1997/004688 patent/WO1998009953A2/de not_active Ceased
- 1997-09-02 HU HU0000664A patent/HUP0000664A3/hu unknown
- 1997-09-02 TR TR1999/00486T patent/TR199900486T2/xx unknown
- 1997-09-02 BR BR9711693A patent/BR9711693A/pt not_active IP Right Cessation
- 1997-09-02 IL IL12874397A patent/IL128743A0/xx unknown
- 1997-09-02 AU AU45524/97A patent/AU736414B2/en not_active Ceased
- 1997-09-02 NZ NZ334548A patent/NZ334548A/xx unknown
- 1997-09-04 ZA ZA977946A patent/ZA977946B/xx unknown
- 1997-09-04 CO CO97051479A patent/CO4900070A1/es unknown
- 1997-09-05 AR ARP970104059A patent/AR009543A1/es not_active Application Discontinuation
- 1997-09-05 ID IDP973110A patent/ID19417A/id unknown
-
1999
- 1999-03-04 NO NO19991079A patent/NO312674B1/no not_active IP Right Cessation
- 1999-03-16 BG BG103258A patent/BG103258A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0000664A2 (hu) | 2001-04-28 |
| JP2000517329A (ja) | 2000-12-26 |
| NO991079D0 (no) | 1999-03-04 |
| KR20000068446A (ko) | 2000-11-25 |
| US6670367B1 (en) | 2003-12-30 |
| CA2265504A1 (en) | 1998-03-12 |
| EP0929529A2 (de) | 1999-07-21 |
| DE19636046A1 (de) | 1998-03-12 |
| AU736414B2 (en) | 2001-07-26 |
| ID19417A (id) | 1998-07-09 |
| NZ334548A (en) | 2000-09-29 |
| AR009543A1 (es) | 2000-04-26 |
| PL331998A1 (en) | 1999-08-16 |
| WO1998009953A3 (de) | 1998-10-29 |
| CN1236362A (zh) | 1999-11-24 |
| BG103258A (en) | 2000-12-29 |
| CO4900070A1 (es) | 2000-03-27 |
| ZA977946B (en) | 1999-03-04 |
| IL128743A0 (en) | 2000-01-31 |
| SK25999A3 (en) | 1999-09-10 |
| BR9711693A (pt) | 1999-08-24 |
| WO1998009953A2 (de) | 1998-03-12 |
| AU4552497A (en) | 1998-03-26 |
| HUP0000664A3 (en) | 2001-07-30 |
| NO312674B1 (no) | 2002-06-17 |
| TR199900486T2 (xx) | 1999-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |