TR199903218T2 - Metastaz karsiti etkiye sahip BIS-indol türevleri, bunlarin hazirlanmasi için yöntem ve bunlari içeren farmasötik bilesimler. - Google Patents

Metastaz karsiti etkiye sahip BIS-indol türevleri, bunlarin hazirlanmasi için yöntem ve bunlari içeren farmasötik bilesimler.

Info

Publication number
TR199903218T2
TR199903218T2 TR1999/03218T TR9903218T TR199903218T2 TR 199903218 T2 TR199903218 T2 TR 199903218T2 TR 1999/03218 T TR1999/03218 T TR 1999/03218T TR 9903218 T TR9903218 T TR 9903218T TR 199903218 T2 TR199903218 T2 TR 199903218T2
Authority
TR
Turkey
Prior art keywords
bis
indole derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
TR1999/03218T
Other languages
English (en)
Inventor
Livi Valeria
Menta Ernesto
Oliva Ambrogio
Grams Frank
Krell Hans-Willi
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR199903218T2 publication Critical patent/TR199903218T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Bu bulus, Formül (I) de verilen bis-indol türevlerinin kullanimlariyla alakalidir: Burada: R ve R' hidrojen, hidroksil, klorin, bromin, iodin, fluorin, (C1-C6) alkil, (C1-C4) alkoksi, (C1-C4) asiloksi, amino, mono-(C1-C4) alkilamino, di (C1-C4) alkilamino, -SH, (C1-C4)alkiltio, karboksi, (C1-C4) alkoksikarbonil gruplarindan bagimsiz olarak seçilirler.R1 ve R1' hidrojen, hidroksi,hidroksimetil, amino, karboksi, (C1-C4)alkil gruplarindan bagimsiz olarak seçilirler.
TR1999/03218T 1997-06-25 1998-06-23 Metastaz karsiti etkiye sahip BIS-indol türevleri, bunlarin hazirlanmasi için yöntem ve bunlari içeren farmasötik bilesimler. TR199903218T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97110336A EP0887348A1 (en) 1997-06-25 1997-06-25 Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
TR199903218T2 true TR199903218T2 (tr) 2000-07-21

Family

ID=8226954

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/03218T TR199903218T2 (tr) 1997-06-25 1998-06-23 Metastaz karsiti etkiye sahip BIS-indol türevleri, bunlarin hazirlanmasi için yöntem ve bunlari içeren farmasötik bilesimler.

Country Status (14)

Country Link
EP (2) EP0887348A1 (tr)
JP (1) JP2002507206A (tr)
KR (1) KR20010014215A (tr)
CN (1) CN1268134A (tr)
AR (1) AR016283A1 (tr)
AU (1) AU8629598A (tr)
BR (1) BR9810947A (tr)
CA (1) CA2294250A1 (tr)
CO (1) CO4940464A1 (tr)
HR (1) HRP980357A2 (tr)
MA (1) MA26513A1 (tr)
TR (1) TR199903218T2 (tr)
WO (1) WO1999000381A1 (tr)
ZA (1) ZA985482B (tr)

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* Cited by examiner, † Cited by third party
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ATE277010T1 (de) * 1998-07-08 2004-10-15 Harbor Branch Oceanographic Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
US7709520B2 (en) * 2000-10-06 2010-05-04 The Texas A&M University System Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
IT1317925B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
CN100352805C (zh) * 2000-11-08 2007-12-05 鲁汶天主教大学研究开发部 用作造影剂的取代的联吲哚衍生物、包含它们的药物组合物以及制造它们的中间体
GB2368843A (en) * 2000-11-08 2002-05-15 Leuven K U Res & Dev Non-porphyrin multipurpose contrast agents
WO2003032982A1 (en) * 2001-10-19 2003-04-24 Transtech Pharma, Inc. Bis-heteroaryl alkanes as therapeutic agents
JP4790594B2 (ja) 2003-02-25 2011-10-12 トポターゲット ユーケー リミテッド Ｈｄａｃインヒビターとしての、二環式ヘテロアリール基を含むヒドロキサム酸化合物
WO2005118539A1 (en) 2004-06-01 2005-12-15 F.Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitor
WO2006023891A2 (en) * 2004-08-23 2006-03-02 The Texas A & M University System Ligand-dependant activation of nur77 and uses thereof
CN100412058C (zh) * 2005-05-12 2008-08-20 苏州大学 一种双吲哚烷基化合物的合成方法
CN1332948C (zh) * 2005-05-12 2007-08-22 苏州大学 双吲哚烷基衍生物的合成方法
TW200716545A (en) * 2005-06-10 2007-05-01 Sigma Tau Ind Farmaceuti Indole derivatives having anti-tumor activity
EP1960355A1 (en) 2005-11-30 2008-08-27 F.Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
DE602006009138D1 (de) 2005-11-30 2009-10-22 Hoffmann La Roche 3-amino-2-arylpropylazaindole und anwendungen davon
ATE517086T1 (de) 2005-11-30 2011-08-15 Hoffmann La Roche Verfahren zur synthese von 3-amino-1- arylpropylindolen
WO2010086646A1 (en) * 2009-01-28 2010-08-05 Karus Therapeutics Limited Scriptaid isosteres and their use in therapy
CN101585800B (zh) * 2009-06-19 2011-06-15 中国科学院上海有机化学研究所 具有生物活性双吲哚甲烷类化合物
AU2012212323A1 (en) 2011-02-01 2013-09-12 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods using the same
IN2015DN03235A (tr) 2012-11-07 2015-10-02 Karus Therapeutics Ltd
PT2994465T (pt) 2013-05-10 2018-10-25 Karus Therapeutics Ltd Novos inibidores de histona desacetilase
CN103274987A (zh) * 2013-06-07 2013-09-04 华东师范大学 3,3-二取代氧化吲哚衍生物及其合成方法和应用
CN104030964B (zh) * 2014-06-05 2016-06-29 天津科技大学 双吲哚类化合物及合成方法
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
CN107698658B (zh) * 2015-06-23 2021-02-12 首都医科大学 双[3-(乙酰-Lys-AA-OBzl)-吲哚-2-基]乙烷,其制备,活性和应用
JP2020530477A (ja) * 2017-08-10 2020-10-22 ザ テキサス エーアンドエム ユニヴァーシティ システム Ｎｒ４ａ１リガンド、医薬組成物、及び関連する使用方法
US12285407B2 (en) 2018-11-21 2025-04-29 The University Of The West Indies Bis-indolylmethane derivatives and uses thereof
EP4110056B1 (en) * 2020-02-25 2025-08-27 The Texas A&M University System Nr4a1 modulators for use in the treatment of endometriosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866084A (en) * 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs

Also Published As

Publication number Publication date
MA26513A1 (fr) 2004-12-20
BR9810947A (pt) 2000-09-26
EP0887348A1 (en) 1998-12-30
AU8629598A (en) 1999-01-19
AR016283A1 (es) 2001-07-04
JP2002507206A (ja) 2002-03-05
CO4940464A1 (es) 2000-07-24
CA2294250A1 (en) 1999-01-07
KR20010014215A (ko) 2001-02-26
EP0991645A1 (en) 2000-04-12
WO1999000381A1 (en) 1999-01-07
CN1268134A (zh) 2000-09-27
ZA985482B (en) 1999-12-24
HRP980357A2 (en) 1999-02-28

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