TR200000598T2 - Kemik metabolizması bozukluklarının tedavisi için bir arginin mimetiği içeren peptitler, bunların üretimi ve sözkonusu bileşikleri içeren ilaçlar. - Google Patents
Kemik metabolizması bozukluklarının tedavisi için bir arginin mimetiği içeren peptitler, bunların üretimi ve sözkonusu bileşikleri içeren ilaçlar.Info
- Publication number
- TR200000598T2 TR200000598T2 TR2000/00598T TR200000598T TR200000598T2 TR 200000598 T2 TR200000598 T2 TR 200000598T2 TR 2000/00598 T TR2000/00598 T TR 2000/00598T TR 200000598 T TR200000598 T TR 200000598T TR 200000598 T2 TR200000598 T2 TR 200000598T2
- Authority
- TR
- Turkey
- Prior art keywords
- compounds
- amino acid
- question
- treatment
- production
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000004475 Arginine Substances 0.000 title 1
- 208000018083 Bone metabolism disease Diseases 0.000 title 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000001151 peptidyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Genel formül (I)'in bilesikleri, bunlarin totomerleri, optik izomerleri, farmasötik açidan kabul edilebilir tuzlari ve ön ilaçlarina iliskindir. R1,R2,R3 ve X ayni veya farkli olabilirler. Burada R1,R2 hidrojeni, bir amino asit, peptidil, alkil veya aril kisim; R3 hidroksi, düsük alkoksiyi veya bir -NR31R32 kismi; ( R31, R32 bagimsiz olarak hidrojen, amino asit, peptil, alkil veya aril kisimdir); X bir amino asit veya bir peptit; R4 hidrojen, hidroksi, amino asit veya C1-C4-alkil; m 0 ile 5 arasinda bir sayi; R5, bir veya daha çok heteroatom içerebilen, tercihen ikameli, doymus veya doymamis mono veya bisiklik parçasini, ikame veya ara heteroatomlari olabilen C1-C11 alkil grubudur.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97115402A EP0902036A1 (en) | 1997-09-05 | 1997-09-05 | Peptide containing an arginine mimetic for the treatment of osteoporosis, their production, and drugs containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000598T2 true TR200000598T2 (tr) | 2000-07-21 |
Family
ID=8227319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00598T TR200000598T2 (tr) | 1997-09-05 | 1998-09-02 | Kemik metabolizması bozukluklarının tedavisi için bir arginin mimetiği içeren peptitler, bunların üretimi ve sözkonusu bileşikleri içeren ilaçlar. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6429288B1 (tr) |
| EP (2) | EP0902036A1 (tr) |
| JP (1) | JP2001515919A (tr) |
| KR (1) | KR20010023656A (tr) |
| CN (1) | CN1269806A (tr) |
| AR (1) | AR013462A1 (tr) |
| AU (1) | AU9439398A (tr) |
| BR (1) | BR9812056A (tr) |
| CA (1) | CA2301969A1 (tr) |
| TR (1) | TR200000598T2 (tr) |
| WO (1) | WO1999012970A1 (tr) |
| ZA (1) | ZA988095B (tr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004522705A (ja) * | 2000-10-30 | 2004-07-29 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | アミジノ−尿素セロトニン受容体リガンドおよび組成物、その医薬的使用およびその合成方法 |
| US6946562B2 (en) * | 2001-12-12 | 2005-09-20 | Eastman Kodak Company | Synthesis of peptoid substituted azole compounds |
| US8775997B2 (en) | 2003-09-15 | 2014-07-08 | Nvidia Corporation | System and method for testing and configuring semiconductor functional circuits |
| US8732644B1 (en) | 2003-09-15 | 2014-05-20 | Nvidia Corporation | Micro electro mechanical switch system and method for testing and configuring semiconductor functional circuits |
| US8775112B2 (en) | 2003-09-15 | 2014-07-08 | Nvidia Corporation | System and method for increasing die yield |
| US8711161B1 (en) | 2003-12-18 | 2014-04-29 | Nvidia Corporation | Functional component compensation reconfiguration system and method |
| US8723231B1 (en) | 2004-09-15 | 2014-05-13 | Nvidia Corporation | Semiconductor die micro electro-mechanical switch management system and method |
| US8711156B1 (en) | 2004-09-30 | 2014-04-29 | Nvidia Corporation | Method and system for remapping processing elements in a pipeline of a graphics processing unit |
| US8021193B1 (en) | 2005-04-25 | 2011-09-20 | Nvidia Corporation | Controlled impedance display adapter |
| US7793029B1 (en) | 2005-05-17 | 2010-09-07 | Nvidia Corporation | Translation device apparatus for configuring printed circuit board connectors |
| US8412872B1 (en) | 2005-12-12 | 2013-04-02 | Nvidia Corporation | Configurable GPU and method for graphics processing using a configurable GPU |
| US8417838B2 (en) * | 2005-12-12 | 2013-04-09 | Nvidia Corporation | System and method for configurable digital communication |
| US8724483B2 (en) | 2007-10-22 | 2014-05-13 | Nvidia Corporation | Loopback configuration for bi-directional interfaces |
| US8687639B2 (en) * | 2009-06-04 | 2014-04-01 | Nvidia Corporation | Method and system for ordering posted packets and non-posted packets transfer |
| US9176909B2 (en) | 2009-12-11 | 2015-11-03 | Nvidia Corporation | Aggregating unoccupied PCI-e links to provide greater bandwidth |
| US9331869B2 (en) * | 2010-03-04 | 2016-05-03 | Nvidia Corporation | Input/output request packet handling techniques by a device specific kernel mode driver |
| US9330031B2 (en) | 2011-12-09 | 2016-05-03 | Nvidia Corporation | System and method for calibration of serial links using a serial-to-parallel loopback |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| WO1992010511A1 (en) * | 1990-12-13 | 1992-06-25 | The University Of Melbourne | Compounds and compositions which inhibit bone resorption |
| DK0591392T3 (da) | 1991-06-21 | 1996-09-30 | Genetics Inst | Farmaceutiske formuleringer af osteogene proteiner |
| WO1993020859A1 (en) | 1992-04-20 | 1993-10-28 | Board Of Regents Of The University Of Washington | Sustained release compositions for delivery of growth factors |
| CA2093836A1 (en) | 1992-04-24 | 1993-10-25 | Wayne Gombotz | Biodegradable tgf-.beta. delivery system for bone regeneration |
| CA2119090A1 (en) | 1993-03-26 | 1994-09-27 | Wayne R. Gombotz | Compositions for controlled release of biologically active tgf-.beta. |
| CA2158762A1 (en) | 1993-04-08 | 1994-10-27 | Hans Rink | Cyclic compounds and compositions which inhibit bone resorption |
| AU1192097A (en) * | 1995-12-09 | 1997-07-03 | Boehringer Mannheim Gmbh | 3-aminoethyl-n-amidino-2,5-dihydropyrrole derivatives having arginine mimetic properties |
-
1997
- 1997-09-05 EP EP97115402A patent/EP0902036A1/en not_active Withdrawn
-
1998
- 1998-09-02 JP JP2000510775A patent/JP2001515919A/ja active Pending
- 1998-09-02 EP EP98947498A patent/EP1009770A1/en not_active Withdrawn
- 1998-09-02 AU AU94393/98A patent/AU9439398A/en not_active Abandoned
- 1998-09-02 CN CN98808822A patent/CN1269806A/zh active Pending
- 1998-09-02 US US09/486,679 patent/US6429288B1/en not_active Expired - Fee Related
- 1998-09-02 KR KR1020007002308A patent/KR20010023656A/ko not_active Withdrawn
- 1998-09-02 BR BR9812056-5A patent/BR9812056A/pt not_active IP Right Cessation
- 1998-09-02 TR TR2000/00598T patent/TR200000598T2/tr unknown
- 1998-09-02 CA CA002301969A patent/CA2301969A1/en not_active Abandoned
- 1998-09-02 WO PCT/EP1998/005547 patent/WO1999012970A1/en not_active Ceased
- 1998-09-03 AR ARP980104401A patent/AR013462A1/es unknown
- 1998-09-04 ZA ZA9808095A patent/ZA988095B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0902036A1 (en) | 1999-03-17 |
| CA2301969A1 (en) | 1999-03-18 |
| AU9439398A (en) | 1999-03-29 |
| KR20010023656A (ko) | 2001-03-26 |
| AR013462A1 (es) | 2000-12-27 |
| BR9812056A (pt) | 2000-09-26 |
| WO1999012970A1 (en) | 1999-03-18 |
| US6429288B1 (en) | 2002-08-06 |
| ZA988095B (en) | 2000-03-22 |
| EP1009770A1 (en) | 2000-06-21 |
| JP2001515919A (ja) | 2001-09-25 |
| CN1269806A (zh) | 2000-10-11 |
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