TR200000669T2 - Büyüme etkinliğine sahip yeni bir protein-APRIL. - Google Patents

Büyüme etkinliğine sahip yeni bir protein-APRIL.

Info

Publication number
TR200000669T2
TR200000669T2 TR2000/00669T TR200000669T TR200000669T2 TR 200000669 T2 TR200000669 T2 TR 200000669T2 TR 2000/00669 T TR2000/00669 T TR 2000/00669T TR 200000669 T TR200000669 T TR 200000669T TR 200000669 T2 TR200000669 T2 TR 200000669T2
Authority
TR
Turkey
Prior art keywords
april
new protein
growth efficiency
growth
efficiency
Prior art date
Application number
TR2000/00669T
Other languages
English (en)
Inventor
Tschopp Jurg
Original Assignee
Apotech R & D Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotech R & D Sa filed Critical Apotech R & D Sa
Publication of TR200000669T2 publication Critical patent/TR200000669T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Tümör nekroz faktörü ailesinin (TNF) yeni bir üyesi olan APRIL, degistirilmis APRIL'ler ve bunlari ihtiva eden farmakolojik bilesimler.
TR2000/00669T 1997-09-12 1998-09-11 Büyüme etkinliğine sahip yeni bir protein-APRIL. TR200000669T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5878697P 1997-09-12 1997-09-12
US7938498P 1998-03-26 1998-03-26

Publications (1)

Publication Number Publication Date
TR200000669T2 true TR200000669T2 (tr) 2000-08-21

Family

ID=26738027

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00669T TR200000669T2 (tr) 1997-09-12 1998-09-11 Büyüme etkinliğine sahip yeni bir protein-APRIL.

Country Status (20)

Country Link
US (3) US20030138884A1 (tr)
EP (1) EP1027431A2 (tr)
JP (1) JP2001515712A (tr)
KR (1) KR100618492B1 (tr)
CN (1) CN1195849C (tr)
AU (1) AU759717B2 (tr)
BR (1) BR9812634A (tr)
CA (1) CA2303615A1 (tr)
CZ (1) CZ294615B6 (tr)
EA (1) EA005411B1 (tr)
EE (1) EE200000147A (tr)
HU (1) HUP0004611A3 (tr)
IL (1) IL134537A0 (tr)
IS (1) IS5378A (tr)
NO (1) NO20001242L (tr)
NZ (1) NZ503850A (tr)
PL (1) PL339463A1 (tr)
SK (1) SK3542000A3 (tr)
TR (1) TR200000669T2 (tr)
WO (1) WO1999012965A2 (tr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541224B2 (en) 1996-03-14 2003-04-01 Human Genome Sciences, Inc. Tumor necrosis factor delta polypeptides
US7217788B2 (en) 1996-03-14 2007-05-15 Human Genome Sciences, Inc. Human tumor necrosis factor delta polypeptides
AU5201399A (en) * 1997-09-30 1999-10-18 Pharmacia & Upjohn Company Tnf-related death ligand
WO1999026976A1 (en) * 1997-11-26 1999-06-03 Eli Lilly And Company Tnf ligand family gene
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
ATE515267T1 (de) 1999-01-25 2011-07-15 Biogen Idec Inc Verwendung eines antikörpers gegen wasserlöslich baff zur krebsbehandlung
US20030022233A1 (en) 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
PL211786B1 (pl) 1999-08-17 2012-06-29 Apoxis Sa Zastosowanie przeciwciała oraz polipeptydu
UA74798C2 (uk) * 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
WO2001025256A2 (en) * 1999-10-06 2001-04-12 University Of Utah Research Foundation Trdl-1-gamma, a novel tumor necrosis-like ligand
JP2003521931A (ja) 2000-02-11 2003-07-22 バイオジェン インコーポレイテッド Ｔｎｆファミリーの異種ポリペプチド
AU2048501A (en) * 2000-02-16 2001-08-27 Genentech Inc. Uses of agonists and antagonists to modulate activity of tnf-related molecules
AU2006201471B2 (en) * 2000-02-16 2009-07-23 Genentech, Inc. Uses of agonists and antagonists to modulate activity of TNF-related molecules
DE60128216T2 (de) * 2000-05-12 2008-01-10 Amgen Inc., Thousand Oaks Polypeptide zum Hemmen der April-vermittelten Proliferation von B- und T- Zellen
WO2001096528A2 (en) * 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
GB2370273A (en) * 2000-12-20 2002-06-26 Viaxxel Biotech Gmbh Compounds that affect CD83 expression
CA2446734A1 (en) 2001-05-24 2002-11-28 Human Genome Sciences, Inc. Antibodies against tumor necrosis factor delta (april)
EA010594B1 (ru) 2001-05-24 2008-10-30 Займодженетикс, Инк. Слитые белки taci-иммуноглобулина
JP2005530482A (ja) 2002-01-04 2005-10-13 ゼンコー・インコーポレイテッド ドミナントネガティブタンパク質およびそれらの用法
US7381792B2 (en) 2002-01-04 2008-06-03 Xencor, Inc. Variants of RANKL protein
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
WO2004089982A2 (en) * 2003-01-06 2004-10-21 Xencor April variants and methods thereof
AU2004233164B2 (en) 2003-03-28 2009-10-08 Biogen Ma Inc. Truncated BAFF receptors
EP1709072A1 (en) * 2004-01-29 2006-10-11 Genentech, Inc. Variants of the extracellular domain of bcma and uses thereof
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
WO2005113598A2 (en) * 2004-05-21 2005-12-01 Xencor, Inc. Tnf super family members with altered immunogenicity
US7947805B2 (en) 2004-12-23 2011-05-24 Merck Serono S.A. BCMA polypeptides and uses thereof
WO2007019573A2 (en) 2005-08-09 2007-02-15 Zymogenetics, Inc. Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
CN101262876A (zh) 2005-08-09 2008-09-10 酶遗传学股份有限公司 用taci-ig融合分子治疗b细胞恶性肿瘤的方法
AU2006298794B2 (en) * 2005-09-26 2012-05-10 Enzo Life Sciences, Inc. Antibodies against APRIL as biomarkers for early prognosis of lymphoma patients
CA2626082C (en) 2005-10-13 2017-04-11 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
US9726673B2 (en) 2005-11-23 2017-08-08 Genentech, Inc. Methods and compositions related to B cell assays
CN101489573B (zh) 2006-05-15 2013-05-22 阿雷斯贸易股份有限公司 用TACI-Ig融合分子治疗自身免疫疾病的方法
AU2010220421B9 (en) 2009-03-02 2015-03-05 Aduro Biotech Holdings, Europe B.V. Antibodies against a proliferating inducing ligand (APRIL)
WO2011109280A1 (en) 2010-03-05 2011-09-09 Lerner Research Institute Methods and compositions to treat immune-mediated disorders
WO2011108937A1 (en) * 2010-03-05 2011-09-09 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam B-cell stimulating fusion proteins of an antigen with baff or april
NL2011406C2 (en) * 2013-09-06 2015-03-10 Bionovion Holding B V Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides.
MX368931B (es) * 2013-09-23 2019-10-22 Regeneron Pharma Animales no humanos que tienen un gen de proteina reguladora de señal humanizado.
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
BR112016011004A2 (pt) * 2013-11-19 2017-12-05 Regeneron Pharma animal roedor geneticamente modificado, célula tronco embrionária de roedor, embrião de roedor, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo
NL2014108B1 (en) 2015-01-09 2016-09-30 Aduro Biotech Holdings Europe B V Altered april binding antibodies.
DK3380522T5 (da) 2015-11-25 2024-09-30 Visterra Inc Antistofmolekyler til april og anvendelser deraf
CA3199743A1 (en) 2020-10-29 2022-05-05 Industrial Polymers and Chemicals, Inc. Air filter with pathogen monitoring and inactivation
EP4384201A4 (en) 2021-08-11 2025-07-30 Akso Biopharmaceutical Inc METHODS FOR REDUCING THE PRODUCTION OF IGA, IGM AND/OR IGG IMMUNOGLOBULINS USING SBCMA VARIANTS AND THEIR FC FUSION PROTEINS
CN121263449A (zh) 2023-03-21 2026-01-02 拜格拉夫55公司 Cd19/cd38多特异性抗体
CN118909083A (zh) * 2024-07-30 2024-11-08 江苏省农业科学院 一种猪b细胞增殖诱导配体蛋白及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5176996A (en) * 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5256775A (en) * 1989-06-05 1993-10-26 Gilead Sciences, Inc. Exonuclease-resistant oligonucleotides
US5264564A (en) * 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
AU6166396A (en) * 1995-06-07 1996-12-30 Biogen, Inc. Complexes of modified lymphotoxins as pharmaceutical prepara tions
EP1362916A3 (en) * 1996-03-14 2004-02-18 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
US6509170B1 (en) * 1996-03-14 2003-01-21 Human Genome Sciences, Inc. Polynucleotides encoding human tumor necrosis factor delta
US6171787B1 (en) * 1997-06-26 2001-01-09 Abbott Laboratories Member of the TNF family useful for treatment and diagnosis of disease

Also Published As

Publication number Publication date
CZ294615B6 (cs) 2005-02-16
NZ503850A (en) 2002-12-20
US20050112596A1 (en) 2005-05-26
US20060084148A1 (en) 2006-04-20
CN1270632A (zh) 2000-10-18
NO20001242L (no) 2000-05-11
IS5378A (is) 2000-02-18
KR100618492B1 (ko) 2006-08-31
WO1999012965A2 (en) 1999-03-18
SK3542000A3 (en) 2000-08-14
IL134537A0 (en) 2001-04-30
US20030138884A1 (en) 2003-07-24
KR20010023893A (ko) 2001-03-26
CA2303615A1 (en) 1999-03-18
BR9812634A (pt) 2000-08-22
WO1999012965A3 (en) 1999-06-03
EE200000147A (et) 2001-02-15
JP2001515712A (ja) 2001-09-25
CN1195849C (zh) 2005-04-06
AU9316298A (en) 1999-03-29
EA005411B1 (ru) 2005-02-24
EP1027431A2 (en) 2000-08-16
PL339463A1 (en) 2000-12-18
AU759717B2 (en) 2003-04-17
HUP0004611A3 (en) 2002-04-29
NO20001242D0 (no) 2000-03-09
CZ2000869A3 (cs) 2000-09-13
HUP0004611A2 (hu) 2001-04-28
EA200000310A1 (ru) 2000-10-30

Similar Documents

Publication Publication Date Title
TR199902516T2 (tr) Kalsilitik bilesimleri.
TR200000654T2 (tr) KAY-Yeni bir bağışıklık sistemi proteini.
DE69807074D1 (de) Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden
TR199801179T2 (tr) Yeni taksoitler, bunlarin hazirlanmalari ve ilaç bilesimleri.
NO873175D0 (no) Tilbakereflekterende plate med forbedret lysstyrke.
DE69942515D1 (de) Stent mit verbesserter Zellkonfiguration
DE69000783D1 (de) Wasserhahn-einlassleitungsverbindung.
BG103251A (bg) Оксадиазоли, методи за получаването им и приложението им като лекарствени средства
EA200000310A1 (ru) April - новый белок, воздействующий на рост
NO995182L (no) Pattedyrcytokinlignende faktor 7
DE69108466D1 (de) Hochfrequenzleistungsverstärker mit hohem Wirkungsgrad.
DE69522299D1 (de) Mikrostreifenleiter-Antennen mit hohem Wirkungsgrad
TR199901393T2 (tr) Yeni bir endoglükanaz
BR9905905B1 (pt) prato oscilante de compressor do tipo prato oscilante.
FI961581A7 (fi) Elektroditon lamppu, jonka tehokkuutta on parannettu
TR200000697T2 (tr) İkame edilmiş 1,2,3,4,5,6-Heksahidro-2,6-Metano-3-Benzazosin-10-OL'ler, üretim yöntemleri ve farmasötik preparat olarak kullanımları.
FR2691527B3 (fr) Plaque de cuisson a grand rendement et a combustion amelioree.
TR199801102T2 (tr) Antineoplazmik peptitler
TR199700513A2 (tr) Reaktif aluminyumftalosiyanin boyar maddeleri, üretilmelerine mahsus usul ve bunlarin kullanilmasi.
FI945899A7 (fi) Kuiduttomat, lämpöä varastoivat liitoslevyt
DE69707786D1 (de) Methylsubstituierte Hexahydroindanole und ihre Verwendung als Riechstoffe
TR199600347A2 (tr) Yeni disazo boyarmaddeler.
IT1275742B1 (it) Centralino per l'alimentazione di energia elettrica, particolarmente per uso domestico
ATE301175T1 (de) Klebemittel und verwendung dieses klebemittels
DE69917934D1 (de) Brikettierung von pulverisiertem brennstoff