TR200000764T2 - Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri. - Google Patents
Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri.Info
- Publication number
- TR200000764T2 TR200000764T2 TR2000/00764T TR200000764T TR200000764T2 TR 200000764 T2 TR200000764 T2 TR 200000764T2 TR 2000/00764 T TR2000/00764 T TR 2000/00764T TR 200000764 T TR200000764 T TR 200000764T TR 200000764 T2 TR200000764 T2 TR 200000764T2
- Authority
- TR
- Turkey
- Prior art keywords
- alkyl
- arylalkyl
- aryl
- hydrogen
- alkenyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000005681 phospholamban Human genes 0.000 title 1
- 108010059929 phospholamban Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93711997A | 1997-09-24 | 1997-09-24 | |
| US99015097A | 1997-12-12 | 1997-12-12 | |
| US10411498A | 1998-06-25 | 1998-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000764T2 true TR200000764T2 (tr) | 2001-03-21 |
Family
ID=27379660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00764T TR200000764T2 (tr) | 1997-09-24 | 1998-09-24 | Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1017691A1 (fr) |
| JP (1) | JP2003525838A (fr) |
| KR (1) | KR20010015607A (fr) |
| CN (1) | CN1143857C (fr) |
| AU (1) | AU735729B2 (fr) |
| BR (1) | BR9813216A (fr) |
| CA (1) | CA2304849A1 (fr) |
| EA (1) | EA003084B1 (fr) |
| EE (1) | EE04494B1 (fr) |
| HU (1) | HUP0003647A3 (fr) |
| ID (1) | ID24373A (fr) |
| IL (1) | IL134662A0 (fr) |
| NO (1) | NO20001569L (fr) |
| NZ (1) | NZ503044A (fr) |
| PL (1) | PL339493A1 (fr) |
| SK (1) | SK3902000A3 (fr) |
| TR (1) | TR200000764T2 (fr) |
| WO (1) | WO1999015523A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026491B2 (en) | 2000-07-21 | 2006-04-11 | Chugai Seiyaku Kabushiki Kaisha | Coumarin derivatives useful as TNFα inhibitors |
| GEP20053675B (en) * | 2001-03-30 | 2005-11-25 | Pfizer Prod Inc | Pyridazinone Aldose Reductase Inhibitors |
| US7572910B2 (en) | 2003-02-20 | 2009-08-11 | Pfizer, Inc. | Pyridazinone aldose reductase inhibitors |
| FR2970964B1 (fr) * | 2011-01-28 | 2013-12-13 | Univ Claude Bernard Lyon | Nouveaux derives d'azacoumarines presentant une activite inhibitrice des pompes mdr |
| KR20260021596A (ko) | 2023-04-05 | 2026-02-13 | 아이오니스 파마수티컬즈, 인코포레이티드 | Pln 발현을 감소시키는 화합물 및 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2543945A1 (de) * | 1975-10-02 | 1977-04-21 | Troponwerke Gmbh & Co Kg | 2-benzopyranonderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
| GB8630702D0 (en) * | 1986-12-23 | 1987-02-04 | Wellcome Found | Quinoline compound |
| EP0355583B1 (fr) * | 1988-08-10 | 1995-01-25 | Otsuka Pharmaceutical Co., Ltd. | Agents cardiotoniques |
| CA2022236A1 (fr) * | 1989-07-31 | 1991-02-01 | Hiroaki Yanagisawa | Derives de coumarin, leur preparation et leur utilisation pour le traitement des troubles cerebrovasculaires |
| DE4337906A1 (de) * | 1993-11-08 | 1995-05-11 | Cassella Ag | Verwendung von Cumarinderivaten |
-
1998
- 1998-09-24 CA CA002304849A patent/CA2304849A1/fr not_active Abandoned
- 1998-09-24 HU HU0003647A patent/HUP0003647A3/hu unknown
- 1998-09-24 JP JP2000512828A patent/JP2003525838A/ja active Pending
- 1998-09-24 WO PCT/FI1998/000755 patent/WO1999015523A1/fr not_active Ceased
- 1998-09-24 PL PL98339493A patent/PL339493A1/xx unknown
- 1998-09-24 ID IDW20000564A patent/ID24373A/id unknown
- 1998-09-24 SK SK390-2000A patent/SK3902000A3/sk unknown
- 1998-09-24 EP EP98946482A patent/EP1017691A1/fr not_active Withdrawn
- 1998-09-24 EA EA200000352A patent/EA003084B1/ru not_active IP Right Cessation
- 1998-09-24 TR TR2000/00764T patent/TR200000764T2/xx unknown
- 1998-09-24 KR KR1020007003094A patent/KR20010015607A/ko not_active Ceased
- 1998-09-24 AU AU93508/98A patent/AU735729B2/en not_active Ceased
- 1998-09-24 EE EEP200000179A patent/EE04494B1/xx not_active IP Right Cessation
- 1998-09-24 IL IL13466298A patent/IL134662A0/xx unknown
- 1998-09-24 NZ NZ503044A patent/NZ503044A/en unknown
- 1998-09-24 CN CNB98809438XA patent/CN1143857C/zh not_active Expired - Fee Related
- 1998-09-24 BR BR9813216-4A patent/BR9813216A/pt not_active IP Right Cessation
-
2000
- 2000-03-24 NO NO20001569A patent/NO20001569L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL134662A0 (en) | 2001-04-30 |
| NZ503044A (en) | 2001-08-31 |
| CN1143857C (zh) | 2004-03-31 |
| AU735729B2 (en) | 2001-07-12 |
| HUP0003647A3 (en) | 2002-12-28 |
| ID24373A (id) | 2000-07-13 |
| KR20010015607A (ko) | 2001-02-26 |
| SK3902000A3 (en) | 2000-12-11 |
| JP2003525838A (ja) | 2003-09-02 |
| BR9813216A (pt) | 2000-08-29 |
| EE200000179A (et) | 2001-04-16 |
| AU9350898A (en) | 1999-04-12 |
| HUP0003647A2 (hu) | 2001-08-28 |
| NO20001569D0 (no) | 2000-03-24 |
| CA2304849A1 (fr) | 1999-04-01 |
| EA200000352A1 (ru) | 2000-10-30 |
| EP1017691A1 (fr) | 2000-07-12 |
| CN1271357A (zh) | 2000-10-25 |
| PL339493A1 (en) | 2000-12-18 |
| WO1999015523A1 (fr) | 1999-04-01 |
| NO20001569L (no) | 2000-03-24 |
| EA003084B1 (ru) | 2002-12-26 |
| EE04494B1 (et) | 2005-06-15 |
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