TR200002146T2 - (-)Cis-3-hidroksi-1-metil-4- (2,4,6-Trimetoksifenil)-piperidin üretim yöntemi. - Google Patents
(-)Cis-3-hidroksi-1-metil-4- (2,4,6-Trimetoksifenil)-piperidin üretim yöntemi.Info
- Publication number
- TR200002146T2 TR200002146T2 TR2000/02146T TR200002146T TR200002146T2 TR 200002146 T2 TR200002146 T2 TR 200002146T2 TR 2000/02146 T TR2000/02146 T TR 2000/02146T TR 200002146 T TR200002146 T TR 200002146T TR 200002146 T2 TR200002146 T2 TR 200002146T2
- Authority
- TR
- Turkey
- Prior art keywords
- methyl
- trimethoxyphenyl
- cis
- hydroxy
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
(-)Cis-3-hidroksi-1-metil-4- (2,4,6-Trimetoksifenil)-piperidin (II) üretimine yönelik bir yöntem tarif edilmis olup, söz konusu yöntemin özelligi 1-metil-piperidin-4-on' un hidrobromür' e aktarilmasi, daha sonra brom ile birlikte 3(R,S)-brom-1-metil- 4-okso-piperidin-hidrobromür haline ve yine 1,3,5-trimetoksibenzol ile 3(R,S) -brom-1-metil-4- (2,4,6-trimetoksifenil) -1,2,3,6-tetrahidro- piridin-hidrobromüre dönüstürülmesidir. Tepkime çözeltisinin organik bir çözücüye aktarilmasina bagli olarak ilk önce 3(R,S)-brom-1-metil-4- (2,4,6-trimetoksifenil) -1,2,3,6-tetrahidro- piridin-hidrobromür kati madde olarak izole edilir ve daha sonra bu ürün su ile tepkimeye sokulur ve karistirma yoluyla 3(R,S)-hidroksi-1-metil-4- (2,4,6-trimetoksifenil) -1,2,3,6-tetrahidro-piridin haline dönüstürülür. Bunu takiben baska islemlerden geçirilen ürün katalitik olarak rasemik 3,4-cis-alkol haline hidratize edilir ve son olarak da siral yardimci tepkiyenlerle rasemat ayrismasi (DEVAMI VAR).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19802449A DE19802449A1 (de) | 1998-01-23 | 1998-01-23 | Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200002146T2 true TR200002146T2 (tr) | 2000-12-21 |
Family
ID=7855418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/02146T TR200002146T2 (tr) | 1998-01-23 | 1998-12-18 | (-)Cis-3-hidroksi-1-metil-4- (2,4,6-Trimetoksifenil)-piperidin üretim yöntemi. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6225473B1 (tr) |
| EP (1) | EP1049674B1 (tr) |
| JP (1) | JP4585116B2 (tr) |
| KR (1) | KR100567941B1 (tr) |
| CN (1) | CN1137096C (tr) |
| AR (1) | AR015218A1 (tr) |
| AT (1) | ATE355270T1 (tr) |
| AU (1) | AU762407B2 (tr) |
| BR (1) | BR9814774B1 (tr) |
| CA (1) | CA2318946C (tr) |
| CY (1) | CY1106511T1 (tr) |
| CZ (1) | CZ298852B6 (tr) |
| DE (2) | DE19802449A1 (tr) |
| DK (1) | DK1049674T3 (tr) |
| ES (1) | ES2281943T3 (tr) |
| HU (1) | HU227928B1 (tr) |
| IL (1) | IL137422A (tr) |
| NO (1) | NO321933B1 (tr) |
| NZ (1) | NZ505897A (tr) |
| PL (1) | PL190790B1 (tr) |
| PT (1) | PT1049674E (tr) |
| RU (1) | RU2265595C2 (tr) |
| SK (1) | SK285883B6 (tr) |
| TR (1) | TR200002146T2 (tr) |
| WO (1) | WO1999037615A1 (tr) |
| ZA (1) | ZA99477B (tr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6437136B2 (en) * | 1998-01-23 | 2002-08-20 | Aventis Pharma Deutschland Gmbh | Process for the preparation of (−)cis-3-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)piperidine |
| DE19809649A1 (de) * | 1998-03-06 | 1999-09-09 | Hoechst Marion Roussel De Gmbh | Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester |
| EP3611506B1 (en) | 2015-04-20 | 2021-11-17 | Sumitomo Dainippon Pharma Oncology, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| PL3298021T3 (pl) | 2015-05-18 | 2019-11-29 | Tolero Pharmaceuticals Inc | Proleki alvocidibu o zwiększonej biodostępności |
| WO2017024073A1 (en) | 2015-08-03 | 2017-02-09 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| KR20190099260A (ko) | 2016-12-19 | 2019-08-26 | 톨레로 파마수티컬스, 인크. | 프로파일링 펩티드 및 감도 프로파일링을 위한 방법 |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| JP2022511029A (ja) | 2018-12-04 | 2022-01-28 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | がんの処置のための薬剤としての使用のためのｃｄｋ９インヒビターおよびその多形 |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置 |
| CN110577974B (zh) * | 2019-09-10 | 2021-07-20 | 杭州澳赛诺生物科技有限公司 | 手性3-羟基-1,2,3,6-四氢吡啶的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN164232B (tr) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
| DE3836676A1 (de) | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
| US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| US5908934A (en) * | 1996-09-26 | 1999-06-01 | Bristol-Myers Squibb Company | Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs |
-
1998
- 1998-01-23 DE DE19802449A patent/DE19802449A1/de not_active Withdrawn
- 1998-12-18 SK SK1097-2000A patent/SK285883B6/sk not_active IP Right Cessation
- 1998-12-18 CA CA002318946A patent/CA2318946C/en not_active Expired - Lifetime
- 1998-12-18 PT PT98966836T patent/PT1049674E/pt unknown
- 1998-12-18 AU AU25135/99A patent/AU762407B2/en not_active Expired
- 1998-12-18 AT AT98966836T patent/ATE355270T1/de active
- 1998-12-18 NZ NZ505897A patent/NZ505897A/xx not_active IP Right Cessation
- 1998-12-18 ES ES98966836T patent/ES2281943T3/es not_active Expired - Lifetime
- 1998-12-18 DK DK98966836T patent/DK1049674T3/da active
- 1998-12-18 KR KR1020007007959A patent/KR100567941B1/ko not_active Expired - Lifetime
- 1998-12-18 JP JP2000528539A patent/JP4585116B2/ja not_active Expired - Lifetime
- 1998-12-18 DE DE59813924T patent/DE59813924D1/de not_active Expired - Lifetime
- 1998-12-18 EP EP98966836A patent/EP1049674B1/de not_active Expired - Lifetime
- 1998-12-18 BR BRPI9814774-9A patent/BR9814774B1/pt not_active IP Right Cessation
- 1998-12-18 PL PL342064A patent/PL190790B1/pl unknown
- 1998-12-18 CN CNB988132311A patent/CN1137096C/zh not_active Expired - Lifetime
- 1998-12-18 IL IL13742298A patent/IL137422A/xx not_active IP Right Cessation
- 1998-12-18 RU RU2000122151/04A patent/RU2265595C2/ru active
- 1998-12-18 WO PCT/EP1998/008327 patent/WO1999037615A1/de not_active Ceased
- 1998-12-18 HU HU0100649A patent/HU227928B1/hu unknown
- 1998-12-18 TR TR2000/02146T patent/TR200002146T2/tr unknown
- 1998-12-18 CZ CZ20002665A patent/CZ298852B6/cs not_active IP Right Cessation
- 1998-12-18 US US09/600,775 patent/US6225473B1/en not_active Expired - Lifetime
-
1999
- 1999-01-21 AR ARP990100242A patent/AR015218A1/es active IP Right Grant
- 1999-01-22 ZA ZA9900477A patent/ZA99477B/xx unknown
-
2000
- 2000-07-04 NO NO20003454A patent/NO321933B1/no not_active IP Right Cessation
-
2007
- 2007-04-12 CY CY20071100513T patent/CY1106511T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2036581T3 (es) | Generacion catalitica de hidrogeno a partir de hidrocarburos. | |
| ATE642T1 (de) | Verfahren zur herstellung von urethanen. | |
| EP0345776A3 (en) | Assays utilizing sensitizer-induced production of detectable signals | |
| DE69108600D1 (de) | Verfahren zur Herstellung von e-Caprolacton. | |
| Shapley et al. | Thermal carbon-oxygen bond scission in a. mu. 3-. eta. 2-coordinated acyl. Structural characterization of a doubly bridging four-electron oxo ligand | |
| CY1106511T1 (el) | Μεθοδος για την παρασκευη (-)cis-3-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-πιπεριδινης | |
| Suzuki et al. | (o‐Phenylenediamino) borylstannanes: Efficient Reagents for Borylation of Various Alkyl Radical Precursors | |
| SE8104359L (sv) | Elektrokemiskt forfarande for syntes av organiska foreningar | |
| TR199901565A2 (tr) | Lityum titanil oksalat katalizörle polyester çogulyogusmasi | |
| DE3889041D1 (de) | Herstellung von Immunonähe-Katalysatoren. | |
| IT8719830A0 (it) | Procedimento per la realizzazione di reazioni enzimatiche entro un solvente organico. | |
| KR960017629A (ko) | 직접 반응에 의한 비산화성 산의 귀금속 염의 제조방법 | |
| DE59510633D1 (de) | Verfahren zur herstellung von cyclischen lactamen | |
| DE68904350D1 (de) | Herstellung von 3,5,6-trichlorpyridin-2-ol und zwischenprodukte dafuer. | |
| KR920703452A (ko) | 염화 칼슘과 아세틸렌의 제조를 위한 2-단 공정 | |
| KR880000409A (ko) | 환상요소 제조방법 | |
| MY133750A (en) | Process for preparing diaryl carbonate | |
| KR880000434A (ko) | 3,7-디히드로-3-n-프로필-1H-푸린-2,6-디온(엔프로필린)의 신규의 제조방법 | |
| Bartels et al. | C (6)-alkylation of 3-hydroxypiperidine via reductive and homolytic cleavage of N, S-Acetals | |
| TR200000424T2 (tr) | 3-İzopropil-1H-2,1,3-Benzotiadiazin-4(3H)-ON-2,2,-Dioksit üretim yöntemi. | |
| KR850003712A (ko) | 올레핀 유도체 제조용 질소산화물 유도체의 분해방법 | |
| MOORE | Biomass energy production. Citations from the International Aerospace Abstracts data base[Progress Report, 1975- Apr. 1980] | |
| Hellberg et al. | Umpolung of the 5‐Alkyl‐2‐dimethylamino‐1, 3‐dithiolium‐4‐thiolate Mesoion and Its Application in the Synthesis of Some New Tetrathiafulvalenes | |
| ClOC | I””” C02Me | |
| ES8604961A1 (es) | Procedimiento de obtencion de la 3,7-dihidro-3-metil-1-(5- oxohexil)-7-propil-1h-purina-2,6-diona |