TR200002804T2 - MRP1 inhibe etmek için yöntemler - Google Patents

MRP1 inhibe etmek için yöntemler

Info

Publication number
TR200002804T2
TR200002804T2 TR2000/02804T TR200002804T TR200002804T2 TR 200002804 T2 TR200002804 T2 TR 200002804T2 TR 2000/02804 T TR2000/02804 T TR 2000/02804T TR 200002804 T TR200002804 T TR 200002804T TR 200002804 T2 TR200002804 T2 TR 200002804T2
Authority
TR
Turkey
Prior art keywords
methods
mrp1
inhibit
inhibit mrp1
wholly
Prior art date
Application number
TR2000/02804T
Other languages
English (en)
Inventor
Michael Gruber Joseph
Hurst Norman Bryan
Patrick Hollinshead Sean
Wendell Wilson Joseph
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR200002804T2 publication Critical patent/TR200002804T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mevcut bulus, direncin kismen veya bütünüyle MRP1'den kaynaklandigi dirençli neoplazmalarin inhibe edilmesi için yararli olan bir formül (I) bilesigi ile ilgilidir.
TR2000/02804T 1998-04-08 1999-04-07 MRP1 inhibe etmek için yöntemler TR200002804T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8108898P 1998-04-08 1998-04-08

Publications (1)

Publication Number Publication Date
TR200002804T2 true TR200002804T2 (tr) 2001-02-21

Family

ID=22162031

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02804T TR200002804T2 (tr) 1998-04-08 1999-04-07 MRP1 inhibe etmek için yöntemler

Country Status (17)

Country Link
US (1) US6221876B1 (tr)
EP (1) EP1067932A4 (tr)
JP (1) JP2002510632A (tr)
KR (1) KR20010042481A (tr)
CN (1) CN1296410A (tr)
AU (1) AU3550299A (tr)
BR (1) BR9909446A (tr)
CA (1) CA2327452A1 (tr)
EA (1) EA200001035A1 (tr)
HU (1) HUP0102548A2 (tr)
ID (1) ID26804A (tr)
IL (1) IL138393A0 (tr)
NO (1) NO20005041L (tr)
PL (1) PL343320A1 (tr)
SK (1) SK14992000A3 (tr)
TR (1) TR200002804T2 (tr)
WO (1) WO1999051236A1 (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE315033T1 (de) 1998-08-07 2006-02-15 Chiron Corp Subtituierte isoxazole derivate als estrogen rezeptor modulatore
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
ES2233487T3 (es) * 1999-12-22 2005-06-16 Eli Lilly And Company Procedimientos y compuestos para la inhibicion de mrp1.
EP1301518A1 (en) 2000-06-14 2003-04-16 Eli Lilly And Company Tricyclic compounds as mrp1-inhibitors
US7064131B2 (en) 2001-04-09 2006-06-20 Eli Lilly And Company Compounds and methods for inhibiting MRP1
CN1281210C (zh) * 2003-11-29 2006-10-25 胡汛 五味子乙素在制备治疗肿瘤药物中的应用
EP1753422B1 (en) * 2004-05-14 2008-05-28 The Cleveland Clinic Foundation Small molecule inhibitors for mrp1 and other multidrug transporters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
US6221876B1 (en) 2001-04-24
CN1296410A (zh) 2001-05-23
KR20010042481A (ko) 2001-05-25
HUP0102548A2 (hu) 2001-11-28
NO20005041D0 (no) 2000-10-06
IL138393A0 (en) 2001-10-31
BR9909446A (pt) 2000-12-12
WO1999051236A1 (en) 1999-10-14
SK14992000A3 (sk) 2001-06-11
CA2327452A1 (en) 1999-10-14
ID26804A (id) 2001-02-08
JP2002510632A (ja) 2002-04-09
NO20005041L (no) 2000-10-06
AU3550299A (en) 1999-10-25
EP1067932A1 (en) 2001-01-17
EP1067932A4 (en) 2001-11-14
PL343320A1 (en) 2001-08-13
EA200001035A1 (ru) 2001-04-23

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