ATE316531T1 - Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1 - Google Patents

Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1

Info

Publication number
ATE316531T1
ATE316531T1 AT00968314T AT00968314T ATE316531T1 AT E316531 T1 ATE316531 T1 AT E316531T1 AT 00968314 T AT00968314 T AT 00968314T AT 00968314 T AT00968314 T AT 00968314T AT E316531 T1 ATE316531 T1 AT E316531T1
Authority
AT
Austria
Prior art keywords
dihydrocinolinone
condensed
derivatives
mrp1
inhibiting mrp1
Prior art date
Application number
AT00968314T
Other languages
English (en)
Inventor
Rosanne Bonjouklian
Douglas Webb Johnson
Peter Ambrose Lander
Mark Christopher Lohman
Vinod Francis Patel
Sreenivasarao Vepachedu
Yongping Xie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE316531T1 publication Critical patent/ATE316531T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00968314T 1999-10-07 2000-09-22 Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1 ATE316531T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15817599P 1999-10-07 1999-10-07
US16978499P 1999-12-09 1999-12-09

Publications (1)

Publication Number Publication Date
ATE316531T1 true ATE316531T1 (de) 2006-02-15

Family

ID=26854809

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00968314T ATE316531T1 (de) 1999-10-07 2000-09-22 Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1

Country Status (7)

Country Link
US (2) US6670373B1 (de)
EP (1) EP1224189B1 (de)
AT (1) ATE316531T1 (de)
AU (1) AU7824900A (de)
DE (1) DE60025744D1 (de)
PE (1) PE20010751A1 (de)
WO (1) WO2001027116A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7430257B1 (en) * 1998-02-12 2008-09-30 Lot 41 Acquisition Foundation, Llc Multicarrier sub-layer for direct sequence channel and multiple-access coding
ES2243709T3 (es) * 2001-04-09 2005-12-01 Eli Lilly And Company Compuestos y procedimientos para inhibir la mrp1.
CN1281210C (zh) * 2003-11-29 2006-10-25 胡汛 五味子乙素在制备治疗肿瘤药物中的应用
WO2005118583A1 (en) * 2004-05-28 2005-12-15 Millennium Pharmaceuticals, Inc. 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors
WO2006074207A2 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Inhibitors of checkpoint kinases
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
EP2605652B1 (de) 2010-08-18 2017-11-08 Samumed, LLC Diketone und hydroxyketone as cateninsignalweg-aktivatoren
BR112013018740A2 (pt) 2011-01-28 2019-01-08 Sanofi Sa anticorpos humanos para pcsk9 para uso em métodos de tratamento de grupos específicos de indivíduos
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
WO2013059548A1 (en) 2011-10-19 2013-04-25 Sanofi Compositions and methods for treating cancer using jak2 inhibitor
JO3370B1 (ar) 2011-11-10 2019-03-13 Regeneron Pharma طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
ES2709824T3 (es) 2013-02-22 2019-04-17 Samumed Llc Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
WO2015116852A1 (en) 2014-01-29 2015-08-06 Regeneron Pharmaceuticals, Inc. Methods for treating rheumatoid arthritis by administering an il-6r antibody
DK3206686T3 (da) 2014-08-20 2019-12-16 Samumed Llc Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker
JP2018523684A (ja) 2015-08-18 2018-08-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗ｐｃｓｋ９阻害抗体
EP3495351A1 (de) * 2017-12-08 2019-06-12 Solvay Sa Oxidation einer pyrazolylketon verbindung zur entsprechenden carboxysäure
CN112955222A (zh) 2018-08-29 2021-06-11 里珍纳龙药品有限公司 用于治疗患有类风湿性关节炎的个体的方法和组合物
TW202521583A (zh) 2019-01-31 2025-06-01 法商賽諾菲生物技術公司 用於治療幼年原發性關節炎之組成物及方法
MA55760A (fr) 2019-04-24 2022-03-02 Regeneron Pharma Procédés de diagnostic et de traitement de la polyarthrite rhumatoïde
JP2022534794A (ja) 2019-06-04 2022-08-03 サノフィ・バイオテクノロジー 関節リウマチを有する対象における疼痛を治療するための組成物および方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
US5717092A (en) 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
JP2002510625A (ja) * 1998-04-08 2002-04-09 イーライ・リリー・アンド・カンパニー Ｍｒｐ１の阻害方法

Also Published As

Publication number Publication date
WO2001027116A2 (en) 2001-04-19
EP1224189A2 (de) 2002-07-24
AU7824900A (en) 2001-04-23
EP1224189B1 (de) 2006-01-25
PE20010751A1 (es) 2001-07-18
US20040077675A1 (en) 2004-04-22
US6670373B1 (en) 2003-12-30
DE60025744D1 (de) 2006-04-13
WO2001027116A3 (en) 2001-11-22

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