TR200100159T2 - Antitrombotik maddeler olarak bispiperidinler - Google Patents

Antitrombotik maddeler olarak bispiperidinler

Info

Publication number
TR200100159T2
TR200100159T2 TR2001/00159T TR200100159T TR200100159T2 TR 200100159 T2 TR200100159 T2 TR 200100159T2 TR 2001/00159 T TR2001/00159 T TR 2001/00159T TR 200100159 T TR200100159 T TR 200100159T TR 200100159 T2 TR200100159 T2 TR 200100159T2
Authority
TR
Turkey
Prior art keywords
antithrombotic agents
bispiperidines
compounds
platle
fibrinogen
Prior art date
Application number
TR2001/00159T
Other languages
English (en)
Inventor
Yue Christophe
Henry Martuerite
Giboulot Thierry
Lesur Brigitte
Original Assignee
Laboratoire L. Lafon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L. Lafon filed Critical Laboratoire L. Lafon
Publication of TR200100159T2 publication Critical patent/TR200100159T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Bulus, (I) formülü bilesiklerine iliskindir, bu formülde, R1,R2,R3,Z1,Z2 istem 1'de tanimlandigi gibidir. Bahsedilen bilesikler, fibrinojenin Gp IIb/IIIa platle reseptörleri üzerinde sabitlenmesini engellemektedir ve terapide antitrombotik maddeler olarak yararlidir.
TR2001/00159T 1998-07-17 1999-07-16 Antitrombotik maddeler olarak bispiperidinler TR200100159T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9809166A FR2781223B1 (fr) 1998-07-17 1998-07-17 Bispiperidines et leurs applications therapeutiques

Publications (1)

Publication Number Publication Date
TR200100159T2 true TR200100159T2 (tr) 2001-06-21

Family

ID=9528732

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00159T TR200100159T2 (tr) 1998-07-17 1999-07-16 Antitrombotik maddeler olarak bispiperidinler

Country Status (25)

Country Link
US (1) US6333338B1 (tr)
EP (1) EP1098878B1 (tr)
JP (1) JP2002520393A (tr)
KR (1) KR100584032B1 (tr)
CN (1) CN1286812C (tr)
AT (1) ATE256661T1 (tr)
AU (1) AU761655B2 (tr)
BR (1) BR9912835A (tr)
CA (1) CA2337776A1 (tr)
DE (1) DE69913701T2 (tr)
DK (1) DK1098878T3 (tr)
EA (1) EA003674B1 (tr)
ES (1) ES2212576T3 (tr)
FR (1) FR2781223B1 (tr)
HU (1) HUP0103623A3 (tr)
IL (2) IL140581A0 (tr)
NO (1) NO318963B1 (tr)
NZ (1) NZ509170A (tr)
PL (1) PL193804B1 (tr)
PT (1) PT1098878E (tr)
SK (1) SK152001A3 (tr)
TR (1) TR200100159T2 (tr)
UA (1) UA65631C2 (tr)
WO (1) WO2000003986A1 (tr)
ZA (1) ZA200100238B (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047874A1 (en) * 1999-12-24 2001-07-05 Smithkline Beecham P.L.C. (hetero)bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives
CA2529486A1 (en) * 2003-06-18 2004-12-23 Nst Neurosurvival Technologies Ltd. Method for selective targeting of apoptotic cells and small molecule ligands used thereof
AU2020300002A1 (en) 2019-07-01 2022-02-24 Tonix Pharma Limited Anti-CD154 antibodies and uses thereof
US20240059781A1 (en) 2021-01-06 2024-02-22 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.

Also Published As

Publication number Publication date
EP1098878A1 (fr) 2001-05-16
EA200100150A1 (ru) 2001-08-27
DE69913701T2 (de) 2004-10-21
AU4629099A (en) 2000-02-07
IL140581A (en) 2006-12-31
DK1098878T3 (da) 2004-02-16
PL345418A1 (en) 2001-12-17
WO2000003986A1 (fr) 2000-01-27
BR9912835A (pt) 2001-10-09
CN1312799A (zh) 2001-09-12
NO20010252D0 (no) 2001-01-15
ES2212576T3 (es) 2004-07-16
HUP0103623A2 (hu) 2002-02-28
IL140581A0 (en) 2002-02-10
CA2337776A1 (en) 2000-01-27
EP1098878B1 (fr) 2003-12-17
PT1098878E (pt) 2004-04-30
NO318963B1 (no) 2005-05-30
HUP0103623A3 (en) 2003-01-28
CN1286812C (zh) 2006-11-29
KR20010071925A (ko) 2001-07-31
DE69913701D1 (de) 2004-01-29
FR2781223A1 (fr) 2000-01-21
FR2781223B1 (fr) 2000-10-13
NO20010252L (no) 2001-03-19
US6333338B1 (en) 2001-12-25
SK152001A3 (en) 2001-11-06
EA003674B1 (ru) 2003-08-28
KR100584032B1 (ko) 2006-05-29
AU761655B2 (en) 2003-06-05
PL193804B1 (pl) 2007-03-30
ZA200100238B (en) 2001-11-21
UA65631C2 (en) 2004-04-15
JP2002520393A (ja) 2002-07-09
ATE256661T1 (de) 2004-01-15
NZ509170A (en) 2004-01-30

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