TR200100797T2 - Naftiridin karboksilik asit türevi (metansülfonat seskihidrat) üretmek için yöntem - Google Patents

Naftiridin karboksilik asit türevi (metansülfonat seskihidrat) üretmek için yöntem

Info

Publication number
TR200100797T2
TR200100797T2 TR2001/00797T TR200100797T TR200100797T2 TR 200100797 T2 TR200100797 T2 TR 200100797T2 TR 2001/00797 T TR2001/00797 T TR 2001/00797T TR 200100797 T TR200100797 T TR 200100797T TR 200100797 T2 TR200100797 T2 TR 200100797T2
Authority
TR
Turkey
Prior art keywords
carboxylic acid
methanesulfonate
sesquhydrate
producing
acid derivative
Prior art date
Application number
TR2001/00797T
Other languages
English (en)
Inventor
Francis Hayes Jerome
Charles Walsgrove Timothy
Stephen Wells Andrew
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of TR200100797T2 publication Critical patent/TR200100797T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Abstract

Bu bulus, metansülfonat seskihidrat üretimi için iyilestirilmis bir yöntem ile ilgilidir ki söz konusu yöntem dogrudan tuz ve hidrat olusumu ile sonuçlanir. Bulusa göre, (7-(3-aminometil-4-syn-metoksiiminopirolidin-1-il) -1-siklopropil-6-floro-4-ogzo-1, 4-dihidro-1, 8-naftiridin-3-karboksilik asit metansülfonat seskihidrat üretmek içi, n, antibakteriyle faaliyete sahip formül (I)'in 7-(3-aminometil-1-syn-metoksiiminopirolidin-1-il) -1-siklopropil-6-floro-4-ogzo-1,4-dihidro-1, 8-naftiridin-3-karboksilik asidini, en az bir su ile karisabilir yardimci çözücü ve çözücüden maydana gelen bir çözücü madde içinde metansülfonik asit ile tepkimeye sokmak ve sonuçta elde edilen kati ürünü ayirmaktan meydana gelen bir yöntem saglanir.
TR2001/00797T 1998-09-18 1999-09-15 Naftiridin karboksilik asit türevi (metansülfonat seskihidrat) üretmek için yöntem TR200100797T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9820405.0A GB9820405D0 (en) 1998-09-18 1998-09-18 Process

Publications (1)

Publication Number Publication Date
TR200100797T2 true TR200100797T2 (tr) 2001-10-22

Family

ID=10839123

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00797T TR200100797T2 (tr) 1998-09-18 1999-09-15 Naftiridin karboksilik asit türevi (metansülfonat seskihidrat) üretmek için yöntem

Country Status (24)

Country Link
US (1) US6818771B1 (tr)
EP (1) EP1114050B1 (tr)
JP (1) JP2002526498A (tr)
KR (1) KR100679062B1 (tr)
CN (1) CN1315825C (tr)
AT (1) ATE337315T1 (tr)
AU (1) AU751060B2 (tr)
BR (1) BR9913858A (tr)
CA (1) CA2344439C (tr)
CY (1) CY1106171T1 (tr)
CZ (1) CZ297509B6 (tr)
DE (1) DE69932938T8 (tr)
DK (1) DK1114050T3 (tr)
ES (1) ES2272084T3 (tr)
GB (1) GB9820405D0 (tr)
HU (1) HU227068B1 (tr)
IL (2) IL141933A0 (tr)
NO (1) NO317997B1 (tr)
NZ (1) NZ510590A (tr)
PL (1) PL194707B1 (tr)
PT (1) PT1114050E (tr)
TR (1) TR200100797T2 (tr)
WO (1) WO2000017199A1 (tr)
ZA (1) ZA200102160B (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
CA2281817C (en) * 1999-06-29 2008-07-29 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against maxillary sinus pathogenic bacteria
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
KR20010091379A (ko) * 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
PT1412078E (pt) 2001-08-02 2009-01-08 Lg Life Sciences Ltd Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
TW200630368A (en) * 2004-10-18 2006-09-01 Neurocrine Biosciences Inc Hydrate of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and processes and methods related thereto
EP1891037A1 (en) * 2005-06-15 2008-02-27 Hetero Drugs Limited Gemifloxacin process and polymorphs

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57134482A (en) * 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
JPH0356479A (ja) * 1989-07-24 1991-03-12 Takeshi Yokota 水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
RU2049777C1 (ru) * 1989-08-16 1995-12-10 Пфайзер Инк. Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения
EP0688772B1 (en) 1994-06-16 1999-05-06 LG Chemical Limited Quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime) pyrrolidine substituents and processes for their preparation
US5776944A (en) 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
JP3449658B2 (ja) * 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
JP3145715B2 (ja) * 1995-06-06 2001-03-12 ファイザー・インコーポレーテッド 無水７−（［１α，５α，６α］−６−アミノ−３−アザビシクロ［３．１．０］ヘキサ−３−イル）−６−フルオロ−１−（２，４−ジフルオロフェニル）−１，４−ジヒドロ−４−オキソ−１，８−ナフチリディン−３−カルボン酸メタンスルホン酸塩の新規な結晶形態
ATE215072T1 (de) * 1995-08-11 2002-04-15 Pfizer (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4- phenylpiperidin-1-yl)-1-propanol-methansulfonat trihydrat
AR006439A1 (es) * 1996-03-29 1999-08-25 Smithkline Beecham Corp Dihidrato de eprosartano y un procedimiento para su produccion y formulacion
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
KR100286874B1 (ko) 1998-03-04 2001-04-16 성재갑 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
PT1082300E (pt) * 1998-05-29 2004-02-27 Upjohn Co Monometanossulfonato de 3-¬(1'-n-metilamino)etil-n-benzil|pirrolidina

Also Published As

Publication number Publication date
AU751060B2 (en) 2002-08-08
CZ2001978A3 (cs) 2002-01-16
NO20011290D0 (no) 2001-03-14
KR100679062B1 (ko) 2007-02-05
ATE337315T1 (de) 2006-09-15
IL141933A0 (en) 2002-03-10
BR9913858A (pt) 2001-06-12
CA2344439C (en) 2010-05-11
HU227068B1 (hu) 2010-06-28
ZA200102160B (en) 2002-06-26
JP2002526498A (ja) 2002-08-20
DK1114050T3 (da) 2006-10-09
PL194707B1 (pl) 2007-06-29
CN1318066A (zh) 2001-10-17
EP1114050B1 (en) 2006-08-23
NO20011290L (no) 2001-03-14
DE69932938D1 (de) 2006-10-05
CY1106171T1 (el) 2011-06-08
PL346656A1 (en) 2002-02-25
AU6328399A (en) 2000-04-10
EP1114050A1 (en) 2001-07-11
ES2272084T3 (es) 2007-04-16
GB9820405D0 (en) 1998-11-11
CN1315825C (zh) 2007-05-16
NO317997B1 (no) 2005-01-17
HUP0103914A3 (en) 2002-05-28
PT1114050E (pt) 2006-12-29
NZ510590A (en) 2003-05-30
DE69932938T2 (de) 2007-03-15
HK1038557A1 (en) 2002-03-22
WO2000017199A1 (en) 2000-03-30
CZ297509B6 (cs) 2007-01-03
US6818771B1 (en) 2004-11-16
KR20010075160A (ko) 2001-08-09
IL141933A (en) 2009-02-11
CA2344439A1 (en) 2000-03-30
DE69932938T8 (de) 2007-07-12
HUP0103914A2 (hu) 2002-03-28

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