TR200101032T2 - Healing active proteins in plants. - Google Patents
Healing active proteins in plants.Info
- Publication number
- TR200101032T2 TR200101032T2 TR2001/01032T TR200101032T TR200101032T2 TR 200101032 T2 TR200101032 T2 TR 200101032T2 TR 2001/01032 T TR2001/01032 T TR 2001/01032T TR 200101032 T TR200101032 T TR 200101032T TR 200101032 T2 TR200101032 T2 TR 200101032T2
- Authority
- TR
- Turkey
- Prior art keywords
- plants
- active proteins
- host
- healing active
- present
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000035876 healing Effects 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000002706 plastid Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 210000003934 vacuole Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8214—Plastid transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Pain & Pain Management (AREA)
Abstract
Mevcut bulus, sagaltici yönden aktif proteinleri, tercihen plastit genomundan ya da vaküole hedefleyerek ekspresyona tabi tutan transjenik bitkileri ifsa eder. Mevcut bulus, ayrica bu gibi transjenik bitkilerin ihtiyaç halindeki bir konakçiya hastaliklarin önlenmesi ya da tedavi edilmesi için tatbik edilmesini tarif eder. Tercih edilen bir bulus biçimi itibariyla, bu gibi bitkiler ya da bunlardan türetilen maddeler bir konakçiya oral yoldan tatbik edilir.The present invention discloses transgenic plants that target expressing active proteins, preferably from the plastid genome or vacuole. The present invention also describes the application of such transgenic plants to a host in need to prevent or treat diseases. As a preferred form of invention, such plants or substances derived therefrom are administered orally to a host.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16736298A | 1998-10-07 | 1998-10-07 | |
| US16823198A | 1998-10-07 | 1998-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200101032T2 true TR200101032T2 (en) | 2001-10-22 |
Family
ID=26863095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/01032T TR200101032T2 (en) | 1998-10-07 | 1999-10-05 | Healing active proteins in plants. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1117817A2 (en) |
| JP (1) | JP2002526116A (en) |
| KR (1) | KR20010085901A (en) |
| CN (1) | CN1330718A (en) |
| AR (1) | AR020717A1 (en) |
| AU (2) | AU758817B2 (en) |
| BR (1) | BR9915919A (en) |
| CA (1) | CA2344269A1 (en) |
| HU (1) | HUP0103616A3 (en) |
| IL (1) | IL142041A0 (en) |
| PL (1) | PL347904A1 (en) |
| RU (2) | RU2001111881A (en) |
| TR (1) | TR200101032T2 (en) |
| WO (1) | WO2000020612A2 (en) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
| US7361331B2 (en) * | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
| WO2001007590A2 (en) * | 1999-07-27 | 2001-02-01 | Syngenta Participations Ag | Chimeric genes for plastid expression |
| US7572466B1 (en) | 1999-10-13 | 2009-08-11 | Health Research, Inc. | Oral immunology using plant product containing a non-enteric pathogen antigen |
| EP1268832A4 (en) * | 2000-02-29 | 2003-04-02 | Univ Auburn | Production of antibodies in transgenic plastids |
| WO2001077353A2 (en) * | 2000-04-05 | 2001-10-18 | Syngenta Participations Ag | Expression of pollen allergens in plastids |
| FR2809413B1 (en) * | 2000-05-29 | 2004-10-22 | Tabacs & Allumettes Ind | PRODUCTION OF RECOMBINANT ALLERGENS IN PLANT CELLS |
| JP2002017186A (en) * | 2000-06-30 | 2002-01-22 | Hayashibara Biochem Lab Inc | Transgenic plants |
| GB2364705A (en) * | 2000-07-14 | 2002-02-06 | Icgeb | Fusion protein expression in plastids |
| JP2004506427A (en) | 2000-08-11 | 2004-03-04 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | Method for stable transformation of plants |
| CA2441699A1 (en) * | 2001-04-13 | 2002-10-24 | Boyce Thompson Institute For Plant Research | Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives |
| US20040014174A1 (en) * | 2002-04-23 | 2004-01-22 | Mayfield Stephen P. | Expression of polypeptides in chloroplasts, and compositions and methods for expressing same |
| FR2841906B1 (en) * | 2002-07-05 | 2006-08-18 | Stallergenes Sa | NUCLEIC ACID MOLECULE ENCODING AN ALLERGENE PREPROPROTEIN OF A MITER OF THE GENUS DERMATOPHAGOIDES OR EUROGLYPHUS AND USE THEREOF FOR THE PRODUCTION OF SAID ALLERGEN IN PLANTS |
| WO2004035734A2 (en) | 2002-10-15 | 2004-04-29 | Syngenta Participations Ag | Plastid transformation |
| ES2531125T3 (en) | 2003-02-03 | 2015-03-10 | Ibio Inc | System for gene expression in plants |
| WO2004074491A2 (en) * | 2003-02-18 | 2004-09-02 | Syngeta Participations Ag | Expression in plants of antibodies against enterotoxigenic escherichia coli |
| GB0307989D0 (en) * | 2003-04-07 | 2003-05-14 | Mcewen Lab Ltd | Therapeutic composition |
| US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| WO2005026375A2 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| RU2259846C1 (en) * | 2004-06-10 | 2005-09-10 | Федоскова Татьяна Германовна | Method and means for carrying out specific immunotherapy of allergic disease patients having sensitization to gnat stings |
| DE602005023332D1 (en) | 2004-09-29 | 2010-10-14 | Collplant Ltd | COLLAGENPRODUZIERENDE PLANTS AND METHOD FOR THE PRODUCTION AND THEIR USE |
| EP2484768A3 (en) * | 2005-07-18 | 2012-11-21 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
| AU2012241058B2 (en) * | 2005-07-18 | 2014-04-17 | Protalix Ltd. | Mucosal or Enteral Administration of Biologically Active Macromolecules |
| JP2009502207A (en) | 2005-08-03 | 2009-01-29 | フラウンホーファー ユーエスエー, インコーポレイテッド | Compositions and methods for the production of immunoglobulins |
| BRPI0707733B1 (en) | 2006-02-13 | 2019-12-31 | Ibio, Inc. | isolated antigen, vaccine composition, use of said composition and method for producing an antigen protein |
| GB0604938D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Proteins, nucleic acids and medicaments |
| GB0604964D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Protein folding |
| GB0604966D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
| GB0617816D0 (en) * | 2006-09-11 | 2006-10-18 | Renovo Ltd | Nucleic acids and methods of protein expression |
| AU2008246928B2 (en) | 2007-05-07 | 2014-04-17 | Protalix Ltd. | Large scale disposable bioreactor |
| GB2449466B (en) * | 2007-05-23 | 2009-11-18 | Algentech Ltd | Production of proteins in plant tissue |
| WO2009009759A2 (en) | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| US20090297550A1 (en) * | 2007-10-31 | 2009-12-03 | Henry Daniell | Chloroplast-derived human vaccine antigens against malaria |
| BRPI0913983A2 (en) * | 2008-06-30 | 2015-10-20 | Orf Liftaekni Hf | cosmetic and / or therapeutic composition, and method for making a topical skin care product |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| US9175300B2 (en) | 2008-11-27 | 2015-11-03 | Vanga Siva Reddy | Method of expressing foreign protein in plastids |
| US9551005B2 (en) * | 2009-07-16 | 2017-01-24 | Kenneth John Piller | Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin |
| US8784819B2 (en) | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| US20120309092A1 (en) * | 2009-11-18 | 2012-12-06 | Agriculture Victoria Services Pty Ltd | Angiogenin Expression in Plants |
| WO2012170678A1 (en) | 2011-06-07 | 2012-12-13 | Fraunhofer Usa, Inc. | In vivo de-glycosylation of recombinant proteins by co-expression with pngase f |
| JP2013040138A (en) * | 2011-08-17 | 2013-02-28 | Univ Of Tsukuba | Method of producing activated recombinant pollen allergen |
| CN104754954B (en) * | 2012-08-23 | 2018-08-28 | 特郎萨格以色列有限公司 | Transgenic microalgae and their use for oral delivery of proteins |
| EP3104885A4 (en) | 2014-02-12 | 2017-08-30 | Transalgae (Israel) Ltd | Algal based edible vaccines |
| EA035092B1 (en) * | 2014-05-14 | 2020-04-27 | Барбара Бурвинкель | Synthesis of double-stranded nucleic acids |
| FR3021328B1 (en) * | 2014-05-23 | 2018-01-05 | Angany Inc. | COMMERCIAL PRODUCTION OF ALLERGEN AMB A1 BY TRANSIENT EXPRESSION IN PLANTS |
| CN104561353B (en) * | 2015-01-29 | 2017-01-11 | 中国农业科学院蔬菜花卉研究所 | InDel marker in close linkage with cabbage fertility as well as detection method and application of InDel marker |
| WO2017165320A1 (en) * | 2016-03-20 | 2017-09-28 | The Trustees Of The University Of Pennsylvania | Codon optimization and ribosome profiling for increasing transgene expression in chloroplasts of higher plants |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451513A (en) * | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
| GB9319429D0 (en) * | 1993-09-21 | 1993-11-03 | London Health Ass | Methods and products for controlling immune responses in mammals |
| US5576198A (en) * | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
| FR2736930B1 (en) * | 1995-07-17 | 1997-09-19 | Biocem | PROCESS FOR THE PRODUCTION, BY PLANT CELLS, OF HEMINIC PROTEINS, PROTEINS THUS OBTAINED AND PRODUCTS CONTAINING THE SAME |
| ZA965786B (en) * | 1995-07-19 | 1997-01-27 | Kimberly Clark Co | Nonwoven barrier and method of making the same |
| WO1997004123A1 (en) * | 1995-07-19 | 1997-02-06 | Gel Tech Group Inc. | Collagen compound production in plants |
| DE69632403T2 (en) * | 1995-08-10 | 2005-05-19 | Rutgers University | CELL CORE-CODED TRANSCRIPTION SYSTEM PLASTIC OF HIGHER PLANTS |
| DE69733881T2 (en) * | 1996-03-06 | 2006-05-24 | Rutgers University | PLASTIC TRANSFORMATION IN ARABIDOPSIS THALIANA |
| WO1998006862A1 (en) * | 1996-08-09 | 1998-02-19 | Calgene Llc | Methods for producing carotenoid compounds and speciality oils in plant seeds |
| WO1998006861A2 (en) * | 1996-08-15 | 1998-02-19 | Agrivax Incorporated | Delivery of tolerogenic antigens via edible plants or plant-derived products |
| CN1552849B (en) * | 1996-09-12 | 2013-08-14 | 辛根塔参与股份公司 | Transgenic plants expressing cellulolytic enzymes |
| USRE39350E1 (en) * | 1997-01-17 | 2006-10-17 | The Scripps Research Institute | RNA binding protein and binding site useful for expression of recombinant molecules |
| NZ502742A (en) * | 1997-08-07 | 2004-04-30 | Univ Auburn | Universal chloroplast integration and expression vectors, transformed plants and products thereof |
| JP2002520019A (en) * | 1998-07-10 | 2002-07-09 | カルジーン エルエルシー | Expression of eukaryotic peptides in plant plastids |
-
1999
- 1999-10-05 BR BR9915919-8A patent/BR9915919A/en not_active IP Right Cessation
- 1999-10-05 IL IL14204199A patent/IL142041A0/en unknown
- 1999-10-05 CN CN99813154A patent/CN1330718A/en active Pending
- 1999-10-05 TR TR2001/01032T patent/TR200101032T2/en unknown
- 1999-10-05 HU HU0103616A patent/HUP0103616A3/en unknown
- 1999-10-05 AU AU63340/99A patent/AU758817B2/en not_active Ceased
- 1999-10-05 AR ARP990105036A patent/AR020717A1/en unknown
- 1999-10-05 WO PCT/EP1999/007414 patent/WO2000020612A2/en not_active Ceased
- 1999-10-05 KR KR1020017004448A patent/KR20010085901A/en not_active Ceased
- 1999-10-05 RU RU2001111881/13A patent/RU2001111881A/en not_active Application Discontinuation
- 1999-10-05 PL PL99347904A patent/PL347904A1/en not_active Application Discontinuation
- 1999-10-05 CA CA002344269A patent/CA2344269A1/en not_active Abandoned
- 1999-10-05 JP JP2000574707A patent/JP2002526116A/en active Pending
- 1999-10-05 EP EP99950626A patent/EP1117817A2/en not_active Withdrawn
-
2003
- 2003-01-15 AU AU2003200126A patent/AU2003200126A1/en not_active Abandoned
- 2003-10-27 RU RU2003131696/13A patent/RU2003131696A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR020717A1 (en) | 2002-05-22 |
| AU2003200126A9 (en) | 2003-04-17 |
| HUP0103616A2 (en) | 2002-01-28 |
| AU758817B2 (en) | 2003-04-03 |
| CA2344269A1 (en) | 2000-04-13 |
| HUP0103616A3 (en) | 2003-07-28 |
| WO2000020612A2 (en) | 2000-04-13 |
| PL347904A1 (en) | 2002-04-22 |
| RU2003131696A (en) | 2005-04-20 |
| KR20010085901A (en) | 2001-09-07 |
| IL142041A0 (en) | 2002-03-10 |
| JP2002526116A (en) | 2002-08-20 |
| BR9915919A (en) | 2001-08-21 |
| RU2001111881A (en) | 2003-06-20 |
| AU2003200126A1 (en) | 2003-04-17 |
| EP1117817A2 (en) | 2001-07-25 |
| AU6334099A (en) | 2000-04-26 |
| WO2000020612A3 (en) | 2000-07-06 |
| CN1330718A (en) | 2002-01-09 |
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