TR200101032T2 - Healing active proteins in plants. - Google Patents

Healing active proteins in plants.

Info

Publication number
TR200101032T2
TR200101032T2 TR2001/01032T TR200101032T TR200101032T2 TR 200101032 T2 TR200101032 T2 TR 200101032T2 TR 2001/01032 T TR2001/01032 T TR 2001/01032T TR 200101032 T TR200101032 T TR 200101032T TR 200101032 T2 TR200101032 T2 TR 200101032T2
Authority
TR
Turkey
Prior art keywords
plants
active proteins
host
healing active
present
Prior art date
Application number
TR2001/01032T
Other languages
Turkish (tr)
Inventor
Bernard Heifetz Peter
Arthur Goff Stephen
Bloom Tuttle Annmarie
Else Griot-Wenk Monika
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of TR200101032T2 publication Critical patent/TR200101032T2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214Plastid transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pain & Pain Management (AREA)

Abstract

Mevcut bulus, sagaltici yönden aktif proteinleri, tercihen plastit genomundan ya da vaküole hedefleyerek ekspresyona tabi tutan transjenik bitkileri ifsa eder. Mevcut bulus, ayrica bu gibi transjenik bitkilerin ihtiyaç halindeki bir konakçiya hastaliklarin önlenmesi ya da tedavi edilmesi için tatbik edilmesini tarif eder. Tercih edilen bir bulus biçimi itibariyla, bu gibi bitkiler ya da bunlardan türetilen maddeler bir konakçiya oral yoldan tatbik edilir.The present invention discloses transgenic plants that target expressing active proteins, preferably from the plastid genome or vacuole. The present invention also describes the application of such transgenic plants to a host in need to prevent or treat diseases. As a preferred form of invention, such plants or substances derived therefrom are administered orally to a host.

TR2001/01032T 1998-10-07 1999-10-05 Healing active proteins in plants. TR200101032T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16736298A 1998-10-07 1998-10-07
US16823198A 1998-10-07 1998-10-07

Publications (1)

Publication Number Publication Date
TR200101032T2 true TR200101032T2 (en) 2001-10-22

Family

ID=26863095

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01032T TR200101032T2 (en) 1998-10-07 1999-10-05 Healing active proteins in plants.

Country Status (14)

Country Link
EP (1) EP1117817A2 (en)
JP (1) JP2002526116A (en)
KR (1) KR20010085901A (en)
CN (1) CN1330718A (en)
AR (1) AR020717A1 (en)
AU (2) AU758817B2 (en)
BR (1) BR9915919A (en)
CA (1) CA2344269A1 (en)
HU (1) HUP0103616A3 (en)
IL (1) IL142041A0 (en)
PL (1) PL347904A1 (en)
RU (2) RU2001111881A (en)
TR (1) TR200101032T2 (en)
WO (1) WO2000020612A2 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US7361331B2 (en) * 1996-10-18 2008-04-22 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Plant bioreactors
WO2001007590A2 (en) * 1999-07-27 2001-02-01 Syngenta Participations Ag Chimeric genes for plastid expression
US7572466B1 (en) 1999-10-13 2009-08-11 Health Research, Inc. Oral immunology using plant product containing a non-enteric pathogen antigen
EP1268832A4 (en) * 2000-02-29 2003-04-02 Univ Auburn Production of antibodies in transgenic plastids
WO2001077353A2 (en) * 2000-04-05 2001-10-18 Syngenta Participations Ag Expression of pollen allergens in plastids
FR2809413B1 (en) * 2000-05-29 2004-10-22 Tabacs & Allumettes Ind PRODUCTION OF RECOMBINANT ALLERGENS IN PLANT CELLS
JP2002017186A (en) * 2000-06-30 2002-01-22 Hayashibara Biochem Lab Inc Transgenic plants
GB2364705A (en) * 2000-07-14 2002-02-06 Icgeb Fusion protein expression in plastids
JP2004506427A (en) 2000-08-11 2004-03-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト Method for stable transformation of plants
CA2441699A1 (en) * 2001-04-13 2002-10-24 Boyce Thompson Institute For Plant Research Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives
US20040014174A1 (en) * 2002-04-23 2004-01-22 Mayfield Stephen P. Expression of polypeptides in chloroplasts, and compositions and methods for expressing same
FR2841906B1 (en) * 2002-07-05 2006-08-18 Stallergenes Sa NUCLEIC ACID MOLECULE ENCODING AN ALLERGENE PREPROPROTEIN OF A MITER OF THE GENUS DERMATOPHAGOIDES OR EUROGLYPHUS AND USE THEREOF FOR THE PRODUCTION OF SAID ALLERGEN IN PLANTS
WO2004035734A2 (en) 2002-10-15 2004-04-29 Syngenta Participations Ag Plastid transformation
ES2531125T3 (en) 2003-02-03 2015-03-10 Ibio Inc System for gene expression in plants
WO2004074491A2 (en) * 2003-02-18 2004-09-02 Syngeta Participations Ag Expression in plants of antibodies against enterotoxigenic escherichia coli
GB0307989D0 (en) * 2003-04-07 2003-05-14 Mcewen Lab Ltd Therapeutic composition
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
WO2005026375A2 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
RU2259846C1 (en) * 2004-06-10 2005-09-10 Федоскова Татьяна Германовна Method and means for carrying out specific immunotherapy of allergic disease patients having sensitization to gnat stings
DE602005023332D1 (en) 2004-09-29 2010-10-14 Collplant Ltd COLLAGENPRODUZIERENDE PLANTS AND METHOD FOR THE PRODUCTION AND THEIR USE
EP2484768A3 (en) * 2005-07-18 2012-11-21 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
AU2012241058B2 (en) * 2005-07-18 2014-04-17 Protalix Ltd. Mucosal or Enteral Administration of Biologically Active Macromolecules
JP2009502207A (en) 2005-08-03 2009-01-29 フラウンホーファー ユーエスエー, インコーポレイテッド Compositions and methods for the production of immunoglobulins
BRPI0707733B1 (en) 2006-02-13 2019-12-31 Ibio, Inc. isolated antigen, vaccine composition, use of said composition and method for producing an antigen protein
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
AU2008246928B2 (en) 2007-05-07 2014-04-17 Protalix Ltd. Large scale disposable bioreactor
GB2449466B (en) * 2007-05-23 2009-11-18 Algentech Ltd Production of proteins in plant tissue
WO2009009759A2 (en) 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
US20090297550A1 (en) * 2007-10-31 2009-12-03 Henry Daniell Chloroplast-derived human vaccine antigens against malaria
BRPI0913983A2 (en) * 2008-06-30 2015-10-20 Orf Liftaekni Hf cosmetic and / or therapeutic composition, and method for making a topical skin care product
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US9175300B2 (en) 2008-11-27 2015-11-03 Vanga Siva Reddy Method of expressing foreign protein in plastids
US9551005B2 (en) * 2009-07-16 2017-01-24 Kenneth John Piller Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin
US8784819B2 (en) 2009-09-29 2014-07-22 Ibio Inc. Influenza hemagglutinin antibodies, compositions and related methods
US20120309092A1 (en) * 2009-11-18 2012-12-06 Agriculture Victoria Services Pty Ltd Angiogenin Expression in Plants
WO2012170678A1 (en) 2011-06-07 2012-12-13 Fraunhofer Usa, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
JP2013040138A (en) * 2011-08-17 2013-02-28 Univ Of Tsukuba Method of producing activated recombinant pollen allergen
CN104754954B (en) * 2012-08-23 2018-08-28 特郎萨格以色列有限公司 Transgenic microalgae and their use for oral delivery of proteins
EP3104885A4 (en) 2014-02-12 2017-08-30 Transalgae (Israel) Ltd Algal based edible vaccines
EA035092B1 (en) * 2014-05-14 2020-04-27 Барбара Бурвинкель Synthesis of double-stranded nucleic acids
FR3021328B1 (en) * 2014-05-23 2018-01-05 Angany Inc. COMMERCIAL PRODUCTION OF ALLERGEN AMB A1 BY TRANSIENT EXPRESSION IN PLANTS
CN104561353B (en) * 2015-01-29 2017-01-11 中国农业科学院蔬菜花卉研究所 InDel marker in close linkage with cabbage fertility as well as detection method and application of InDel marker
WO2017165320A1 (en) * 2016-03-20 2017-09-28 The Trustees Of The University Of Pennsylvania Codon optimization and ribosome profiling for increasing transgene expression in chloroplasts of higher plants

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451513A (en) * 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
GB9319429D0 (en) * 1993-09-21 1993-11-03 London Health Ass Methods and products for controlling immune responses in mammals
US5576198A (en) * 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
FR2736930B1 (en) * 1995-07-17 1997-09-19 Biocem PROCESS FOR THE PRODUCTION, BY PLANT CELLS, OF HEMINIC PROTEINS, PROTEINS THUS OBTAINED AND PRODUCTS CONTAINING THE SAME
ZA965786B (en) * 1995-07-19 1997-01-27 Kimberly Clark Co Nonwoven barrier and method of making the same
WO1997004123A1 (en) * 1995-07-19 1997-02-06 Gel Tech Group Inc. Collagen compound production in plants
DE69632403T2 (en) * 1995-08-10 2005-05-19 Rutgers University CELL CORE-CODED TRANSCRIPTION SYSTEM PLASTIC OF HIGHER PLANTS
DE69733881T2 (en) * 1996-03-06 2006-05-24 Rutgers University PLASTIC TRANSFORMATION IN ARABIDOPSIS THALIANA
WO1998006862A1 (en) * 1996-08-09 1998-02-19 Calgene Llc Methods for producing carotenoid compounds and speciality oils in plant seeds
WO1998006861A2 (en) * 1996-08-15 1998-02-19 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
CN1552849B (en) * 1996-09-12 2013-08-14 辛根塔参与股份公司 Transgenic plants expressing cellulolytic enzymes
USRE39350E1 (en) * 1997-01-17 2006-10-17 The Scripps Research Institute RNA binding protein and binding site useful for expression of recombinant molecules
NZ502742A (en) * 1997-08-07 2004-04-30 Univ Auburn Universal chloroplast integration and expression vectors, transformed plants and products thereof
JP2002520019A (en) * 1998-07-10 2002-07-09 カルジーン エルエルシー Expression of eukaryotic peptides in plant plastids

Also Published As

Publication number Publication date
AR020717A1 (en) 2002-05-22
AU2003200126A9 (en) 2003-04-17
HUP0103616A2 (en) 2002-01-28
AU758817B2 (en) 2003-04-03
CA2344269A1 (en) 2000-04-13
HUP0103616A3 (en) 2003-07-28
WO2000020612A2 (en) 2000-04-13
PL347904A1 (en) 2002-04-22
RU2003131696A (en) 2005-04-20
KR20010085901A (en) 2001-09-07
IL142041A0 (en) 2002-03-10
JP2002526116A (en) 2002-08-20
BR9915919A (en) 2001-08-21
RU2001111881A (en) 2003-06-20
AU2003200126A1 (en) 2003-04-17
EP1117817A2 (en) 2001-07-25
AU6334099A (en) 2000-04-26
WO2000020612A3 (en) 2000-07-06
CN1330718A (en) 2002-01-09

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