TR200101664T2 - Fenilendiamin grubu i‡eren herpesviruslarìn heteroksiklik karboksamid i‡eren tiore inhibit”rleri - Google Patents

Fenilendiamin grubu i‡eren herpesviruslarìn heteroksiklik karboksamid i‡eren tiore inhibit”rleri

Info

Publication number
TR200101664T2
TR200101664T2 TR2001/01664T TR200101664T TR200101664T2 TR 200101664 T2 TR200101664 T2 TR 200101664T2 TR 2001/01664 T TR2001/01664 T TR 2001/01664T TR 200101664 T TR200101664 T TR 200101664T TR 200101664 T2 TR200101664 T2 TR 200101664T2
Authority
TR
Turkey
Prior art keywords
carbon atoms
inhibitors
herpesviruses
thio
heterocyclic carboxamide
Prior art date
Application number
TR2001/01664T
Other languages
English (en)
Inventor
David Bloom Jonathan
Joseph Curran Kevin
Joseph Digrandi Martin
George Dushin Rusell
Richard Jones Thomas
Albert Lang Stanley
Antonia Ross Adma
Anthony Terefenko Eugene
Mark O'hara Bryan
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of TR200101664T2 publication Critical patent/TR200101664T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Formülü (I) olan ve , G'nin monosiklik heteroaril olduGu; X'in bir baG, -NH, 1 ila 6 karbon atomlu alkil, 1 ila 6 karbon atomlu alkenil, 1 ila 6 karbon atomlu alkoksi, 1 ila 6 karbon atomlu tioalkil, 1 ila 6 karbon atomlu alkilamino, veya (CH)J olduGu; J'nin 1 ila 6 karbon atomlu alkil, 3 ila 7 karbon atomlu sikloalkil fenil veya benzil; ve n'nin 1 ila 6 aras nda bir tam say olduGu ve insan sitomegalovirus, herpes simplex viruslar , Epstein-Barr virusu, varicella-zoster virusu,insan herpes viruslar -6 ve -7, ve Kaposi herpesvirusu dahil olmak üzere herpes viruslar ile ilgili hastal klar n tedavisinde yararl olan bir bileçik.
TR2001/01664T 1998-12-09 1999-12-06 Fenilendiamin grubu i‡eren herpesviruslarìn heteroksiklik karboksamid i‡eren tiore inhibit”rleri TR200101664T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20855998A 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
TR200101664T2 true TR200101664T2 (tr) 2002-03-21

Family

ID=22775044

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01664T TR200101664T2 (tr) 1998-12-09 1999-12-06 Fenilendiamin grubu i‡eren herpesviruslarìn heteroksiklik karboksamid i‡eren tiore inhibit”rleri

Country Status (18)

Country Link
EP (1) EP1144397A3 (tr)
JP (1) JP2002531554A (tr)
CN (1) CN1348446A (tr)
AU (1) AU1934700A (tr)
BG (1) BG105581A (tr)
BR (1) BR9916046A (tr)
CA (1) CA2350767A1 (tr)
CZ (1) CZ20011956A3 (tr)
EA (1) EA200100631A1 (tr)
HU (1) HUP0200232A2 (tr)
ID (1) ID30158A (tr)
IL (1) IL143182A0 (tr)
NO (1) NO20012832L (tr)
PL (1) PL349217A1 (tr)
SK (1) SK7682001A3 (tr)
TR (1) TR200101664T2 (tr)
WO (1) WO2000034258A2 (tr)
ZA (1) ZA200104377B (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
EP2077995B1 (en) 2006-11-02 2012-02-08 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
EP2914592B1 (en) 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
US9284310B2 (en) 2012-11-03 2016-03-15 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN110565100B (zh) * 2019-07-12 2021-05-07 西北工业大学 一种二茂钴阳离子基缓蚀剂及制备方法和使用方法
WO2023011574A1 (zh) 2021-08-05 2023-02-09 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和用途
EP4433479A1 (en) 2021-11-19 2024-09-25 Basf Se Bicyclic compounds for the control of invertebrate pests
CN115433093A (zh) * 2022-09-26 2022-12-06 无锡双启科技有限公司 一种3-氯-4-三氟甲基苯胺的制备方法
CN115710190A (zh) * 2022-11-16 2023-02-24 常州佳德医药科技有限公司 4-甲氧基-2-氨基-n,n-二甲基苯胺、制备方法及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69811062T2 (de) * 1997-04-10 2003-07-17 Pharmacia & Upjohn Co., Kalamazoo Polyaromatische antivirale zusammensetzungen

Also Published As

Publication number Publication date
HUP0200232A2 (hu) 2002-05-29
EP1144397A3 (en) 2002-09-11
SK7682001A3 (en) 2002-07-02
CA2350767A1 (en) 2000-06-15
WO2000034258A2 (en) 2000-06-15
PL349217A1 (en) 2002-07-01
NO20012832D0 (no) 2001-06-08
ZA200104377B (en) 2002-12-20
IL143182A0 (en) 2002-04-21
JP2002531554A (ja) 2002-09-24
CN1348446A (zh) 2002-05-08
BR9916046A (pt) 2001-10-02
EP1144397A2 (en) 2001-10-17
ID30158A (id) 2001-11-08
WO2000034258A3 (en) 2001-11-29
CZ20011956A3 (cs) 2001-10-17
AU1934700A (en) 2000-06-26
BG105581A (en) 2001-12-31
NO20012832L (no) 2001-08-07
EA200100631A1 (ru) 2002-02-28

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