ES2154191A1 - Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. - Google Patents

Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.

Info

Publication number
ES2154191A1
ES2154191A1 ES009802460A ES9802460A ES2154191A1 ES 2154191 A1 ES2154191 A1 ES 2154191A1 ES 009802460 A ES009802460 A ES 009802460A ES 9802460 A ES9802460 A ES 9802460A ES 2154191 A1 ES2154191 A1 ES 2154191A1
Authority
ES
Spain
Prior art keywords
alkyl
tetrazol
ylmethyl
biphenyl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009802460A
Other languages
English (en)
Other versions
ES2154191B1 (es
Inventor
Ambros Rafael Foguet
Burniol Lluis Anglada
Munoz Aurelio Sacristan
Barenys Josep Maria Castello
Hernandez Jose A Ortiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Priority to ES009802460A priority Critical patent/ES2154191B1/es
Priority to ARP990105909A priority patent/AR021343A1/es
Priority to AU12728/00A priority patent/AU1272800A/en
Priority to PCT/EP1999/008991 priority patent/WO2000031071A1/en
Priority to PA19998485801A priority patent/PA8485801A1/es
Publication of ES2154191A1 publication Critical patent/ES2154191A1/es
Application granted granted Critical
Publication of ES2154191B1 publication Critical patent/ES2154191B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nuevos acetales derivados de los 2-alquil-5-halo-3-[2''-(tetrazol- 5-il)-bifenil-4-ilmetil]-3H-imidazol-4-carbaldehidos. Consiste en los nuevos acetales derivados de los 2-alquil-5-halo-3-[2''- (tetrazol-5-il)bifenil-4-ilmetil]-3H-imidazol-4-carbaldehidos de fórmula general (I) así como sus sales de sustitución farmacéuticamente aceptables. Estos compuestos se pueden emplear como antihipertensivos. La presente invención también describe el procedimiento para su obtención y una composición farmacéutica que los contiene.
ES009802460A 1998-11-24 1998-11-24 Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. Expired - Lifetime ES2154191B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES009802460A ES2154191B1 (es) 1998-11-24 1998-11-24 Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
ARP990105909A AR021343A1 (es) 1998-11-24 1999-11-19 Nuevos acetales derivados de los 2-alquil-5-halo-3-[2'-(tetrazol-5-il)-bifenil-4-ilmetil]-3h-imidazol-4-carbaldehidos
AU12728/00A AU1272800A (en) 1998-11-24 1999-11-22 2-alkyl-5-halo-3-(2'-(tetrazol-5-YL)-biphenyl-4-ylmethyl)-3H imidazole-4-carboxaldehyde acetal derivatives, their preparation and use
PCT/EP1999/008991 WO2000031071A1 (en) 1998-11-24 1999-11-22 2-alkyl-5-halo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-imidazole-4-carboxaldehyde acetal derivatives, their preparation and use
PA19998485801A PA8485801A1 (es) 1998-11-24 1999-11-24 Nuevos acetales derivados 2-alquil-5-halo-3-[2'-(tetrazol-5-il)-bifenil-4-ilmetil]-3h-imidazol-4-carbaldehidos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802460A ES2154191B1 (es) 1998-11-24 1998-11-24 Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.

Publications (2)

Publication Number Publication Date
ES2154191A1 true ES2154191A1 (es) 2001-03-16
ES2154191B1 ES2154191B1 (es) 2001-10-16

Family

ID=8305894

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009802460A Expired - Lifetime ES2154191B1 (es) 1998-11-24 1998-11-24 Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.

Country Status (5)

Country Link
AR (1) AR021343A1 (es)
AU (1) AU1272800A (es)
ES (1) ES2154191B1 (es)
PA (1) PA8485801A1 (es)
WO (1) WO2000031071A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2242543A1 (es) * 2004-04-30 2005-11-01 Universidad De Alcala Derivados de losartan con propiedades antioxidantes.

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0102252B1 (pt) 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5225428A (en) * 1991-10-01 1993-07-06 Bayer Aktiengesellschaft Cyclic-substituted imidazolyl-propenoic acid derivatives
US5264581A (en) * 1992-05-29 1993-11-23 E. I. Du Pont De Nemours And Company Radioiodinated angiotensin receptor antagonists
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
US5468764A (en) * 1992-07-01 1995-11-21 Hoechst Aktiengesellschaft Angiotensin II receptor antagonists for the treatment of disturbances in cardiac rhythm
WO1995032198A1 (en) * 1994-05-21 1995-11-30 Korea Research Institute Of Chemical Technology Imidazole derivatives and processes for the preparation thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
WO1998034922A1 (en) * 1997-02-05 1998-08-13 Sankyo Company, Limited Prophylactic or therapeutic agent for diabetic complication

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5225428A (en) * 1991-10-01 1993-07-06 Bayer Aktiengesellschaft Cyclic-substituted imidazolyl-propenoic acid derivatives
US5264581A (en) * 1992-05-29 1993-11-23 E. I. Du Pont De Nemours And Company Radioiodinated angiotensin receptor antagonists
US5468764A (en) * 1992-07-01 1995-11-21 Hoechst Aktiengesellschaft Angiotensin II receptor antagonists for the treatment of disturbances in cardiac rhythm
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
WO1995032198A1 (en) * 1994-05-21 1995-11-30 Korea Research Institute Of Chemical Technology Imidazole derivatives and processes for the preparation thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2242543A1 (es) * 2004-04-30 2005-11-01 Universidad De Alcala Derivados de losartan con propiedades antioxidantes.
ES2242543B1 (es) * 2004-04-30 2006-12-01 Universidad De Alcala Derivados de losartan con propiedades antioxidantes.

Also Published As

Publication number Publication date
PA8485801A1 (es) 2000-09-29
AU1272800A (en) 2000-06-13
WO2000031071A1 (en) 2000-06-02
ES2154191B1 (es) 2001-10-16
AR021343A1 (es) 2002-07-17

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