TR200102423T2 - Peptid ligandları yoluyla bağlı birden fazla imünojenik bileşeni olan HBV çekirdek antijeni parçacıkları - Google Patents

Peptid ligandları yoluyla bağlı birden fazla imünojenik bileşeni olan HBV çekirdek antijeni parçacıkları

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Publication number
TR200102423T2
TR200102423T2 TR2001/02423T TR200102423T TR200102423T2 TR 200102423 T2 TR200102423 T2 TR 200102423T2 TR 2001/02423 T TR2001/02423 T TR 2001/02423T TR 200102423 T TR200102423 T TR 200102423T TR 200102423 T2 TR200102423 T2 TR 200102423T2
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TR
Turkey
Prior art keywords
hbv
hbv core
particles
peptide ligands
core
Prior art date
Application number
TR2001/02423T
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English (en)
Inventor
Murray Kenneth
Original Assignee
Biogen, Inc.
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Publication date
Application filed by Biogen, Inc. filed Critical Biogen, Inc.
Publication of TR200102423T2 publication Critical patent/TR200102423T2/tr

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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Abstract

Bu bulus birden fazla imünojen özellikleri ile ayirt edilen hepti B virüsü (HBV) ile ilgilidir. Daha özel olarak, bulus, HBV çekirdeki proteinine seçici olarak baglananan HBV kapsid-baglama peptidleri olan ligandlarla çapraz baglanmis imünojenler, epitoplar veya baska ilgili yapilar içeren HBC çekirdek antijen parçaciklar ile ilgilidir. Bu tip parçaciklar,HBV çekirdek proteini ve HBV yüzey proteinleri arasindaki etkilesimi bloke ederek avantajli sekilde HBV virüsü bilesimini de inhibe eden ve önleyen HBV kapsid-baglama peptidleri dahil, çesitli imünojenik epitoplar için iletim sistemleri olarak kullanilabilir. Farkli imünojenlerin ve/veya HBV kapsid-baglama peptidi ligandlarinin karisimlari ayni HBV çekirdegi parçacigina çarpaz baglanabilir. Olusan bu tip çok bilesenli veya çok-degerli HBV çekirdek parçaciklari avantajli olarak tedavi edici ve önleyici asilarda ve bilesimlerde, ve ayni zamanda teshis bilesimlerinde ve bularin kullanim yöntemlerinde kullanilabilir.
TR2001/02423T 1998-12-04 1999-12-03 Peptid ligandları yoluyla bağlı birden fazla imünojenik bileşeni olan HBV çekirdek antijeni parçacıkları TR200102423T2 (tr)

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US11091198P 1998-12-04 1998-12-04

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TR200102423T2 true TR200102423T2 (tr) 2002-02-21

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TR2001/02423T TR200102423T2 (tr) 1998-12-04 1999-12-03 Peptid ligandları yoluyla bağlı birden fazla imünojenik bileşeni olan HBV çekirdek antijeni parçacıkları

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EP (3) EP2351768B1 (tr)
JP (2) JP2002532387A (tr)
KR (1) KR100715954B1 (tr)
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PL (1) PL348766A1 (tr)
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