TR200102729T2 - Platelet yapışmasını bloke etme amaçlı protein - Google Patents

Platelet yapışmasını bloke etme amaçlı protein

Info

Publication number
TR200102729T2
TR200102729T2 TR2001/02729T TR200102729T TR200102729T2 TR 200102729 T2 TR200102729 T2 TR 200102729T2 TR 2001/02729 T TR2001/02729 T TR 2001/02729T TR 200102729 T TR200102729 T TR 200102729T TR 200102729 T2 TR200102729 T2 TR 200102729T2
Authority
TR
Turkey
Prior art keywords
protein
collagen
cells
platelet adhesion
naturally occurring
Prior art date
Application number
TR2001/02729T
Other languages
English (en)
Inventor
Strittmatter Wolfgang
G�Ssow Dettlef
Hofmann Uwe
Hemberger J�Rgen
Fotev Zisi
Scheuble Bernhard
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of TR200102729T2 publication Critical patent/TR200102729T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Tibbi sülük Hirudo medicinalis'in tükürügünden izole edilen, dogal yoldan olusan ve güçlü sekilde kolajene baglanan ve böylelikle kalojene dogal platelet yapismasini önleyici olarak hareket eden protein tarif edilir.Protein, yaklasik 12000 moleküler agirliga, bir asidik izoelektrik noktaya sahiptir ve alti sistein içerir. Protein sekanslandi ve gen, H.medicinalis cDNA-kütüphanesinden klonlandi. Yeniden birlestirici tekniklerle böyle polipeptidin üretilmesi prosedürü açiklanir. Yeniden birlestirici ve dogal yoldan olusan proteinler, kolajene bagimli platelet yapismasinin güçlü önleyicileridir ve bu nedenle kalp hastaliklari ve dolasim sistemi hastaliklariyla ilgili çesitli durumlarin terapötik tedavisinde yararlidirlar. Ayrica protein, dogal veya suni kolajen yüzeylerin hücreler için yapiskan olmamalarini saglamak ve hücrelerin aktiflestirlmesini önlemek amaciyla bu yüzeylerin kaplanmasinda yaralidir.
TR2001/02729T 1999-03-18 2000-03-10 Platelet yapışmasını bloke etme amaçlı protein TR200102729T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99105530 1999-03-18
EP99109503 1999-05-12

Publications (1)

Publication Number Publication Date
TR200102729T2 true TR200102729T2 (tr) 2002-04-22

Family

ID=26152935

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02729T TR200102729T2 (tr) 1999-03-18 2000-03-10 Platelet yapışmasını bloke etme amaçlı protein

Country Status (27)

Country Link
US (3) US6774107B1 (tr)
EP (1) EP1161530B1 (tr)
JP (1) JP4805461B2 (tr)
KR (1) KR100788219B1 (tr)
CN (1) CN1185344C (tr)
AR (1) AR023099A1 (tr)
AT (1) ATE295883T1 (tr)
AU (1) AU767172B2 (tr)
BR (1) BR0009074A (tr)
CA (1) CA2367457C (tr)
CO (1) CO5241328A1 (tr)
CZ (1) CZ301524B6 (tr)
DE (1) DE60020220T2 (tr)
DK (1) DK1161530T3 (tr)
ES (1) ES2240067T3 (tr)
HK (1) HK1045330B (tr)
HU (1) HU228068B1 (tr)
MX (1) MXPA01009363A (tr)
MY (1) MY123371A (tr)
NO (1) NO330769B1 (tr)
PL (1) PL200384B1 (tr)
PT (1) PT1161530E (tr)
RU (1) RU2292351C2 (tr)
SI (1) SI1161530T1 (tr)
SK (1) SK287496B6 (tr)
TR (1) TR200102729T2 (tr)
WO (1) WO2000056885A1 (tr)

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PL200384B1 (pl) 1999-03-18 2008-12-31 Merck Patent Gmbh Polipeptyd blokujący adhezję płytek krwi, sposób jego otrzymywania, zastosowanie i zawierający go preparat farmaceutyczny
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen
WO2003008454A2 (en) * 2001-07-18 2003-01-30 Merck Patent Gmbh Glycoprotein vi fusion proteins
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KR101340580B1 (ko) * 2004-10-12 2013-12-11 보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티 플로로글루시놀의 생합성 및 이로부터1,3-디하이드록시벤젠의 합성
CA2611102A1 (en) * 2005-05-26 2006-11-30 Thomas Jefferson University Method to treat and prevent posterior capsule opacification
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
CA2623565A1 (en) * 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20080015145A1 (en) 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
EP2379084B1 (en) * 2008-10-15 2017-11-22 Ionis Pharmaceuticals, Inc. Modulation of factor 11 expression
WO2012003461A2 (en) 2010-07-02 2012-01-05 Draths Corporation Phloroglucinol synthases and methods of making and using the same
WO2012006244A1 (en) 2010-07-06 2012-01-12 Draths Corporation Method for producing phloroglucinol and dihydrophloroglucinol
WO2012006245A1 (en) 2010-07-06 2012-01-12 Draths Corporation Phloroglucinol reductase and methods of making and using the same
WO2012024650A2 (en) 2010-08-19 2012-02-23 Abbott Laboratories Anti-ngf antibodies and their use
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
DE202012012998U1 (de) 2011-08-31 2014-06-13 Daniel Elias Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels
JP6629069B2 (ja) 2012-06-06 2020-01-15 ゾエティス・エルエルシー イヌ化抗ｎｇｆ抗体およびその方法
CN104854128A (zh) 2012-07-19 2015-08-19 硕腾有限责任公司 牛流感病毒组合物
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
WO2018035199A1 (en) 2016-08-17 2018-02-22 Pharmaq As Sea lice vaccine
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
MX2020009526A (es) 2018-03-12 2020-10-28 Zoetis Services Llc Anticuerpos anti-ngf y metodos de estos.
WO2019178601A1 (en) 2018-03-16 2019-09-19 Zoetis Services Llc Peptide vaccines against interleukin-31
KR20250026872A (ko) 2018-03-16 2025-02-25 조에티스 서비시즈 엘엘씨 수의학적 용도를 위한 인터류킨-31 단클론성 항체
JP7438135B2 (ja) 2018-05-09 2024-02-26 アイオーニス ファーマシューティカルズ， インコーポレーテッド Ｆｘｉの発現を低下させるための化合物及び方法
BR112022004488A2 (pt) 2019-09-11 2022-05-31 Zoetis Services Llc Herpesvírus recombinante de vetores de peru que expressam antígenos de patógenos aviários e seus usos
US20220119513A1 (en) 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
US12440556B2 (en) 2020-06-15 2025-10-14 Zoetis Services Llc Genetically modified cell line for production of Marek's disease virus vaccine and methods of making and using the same
CA3254914A1 (en) 2020-10-07 2026-03-02 Zoetis Services Llc Anti-ngf antibodies and methods of use thereof
TW202607038A (zh) 2020-10-19 2026-02-16 美商碩騰服務公司 犬及貓抑瘤素Ｍ受體β之抗體及其用途
AU2022349693A1 (en) 2021-09-27 2024-03-14 Zoetis Services Llc ANTI- TGFβ1,2,3 ANTIBODIES AND THERAPEUTIC USES THEREOF

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DE4136513A1 (de) * 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
ES2169080T3 (es) * 1993-07-01 2002-07-01 Merck Patent Gmbh Inhibidor de la agregacion de plaquetas estimulada por colageno.
ES2255477T5 (es) * 1993-07-29 2010-04-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Uso de paclitaxel y sus derivados en la fabricacion de un medicamento para el tratamiento de reestenosis.
RO117971B1 (ro) * 1994-09-12 2002-11-29 Schering Ag Procedeu de obtinere a unei proteine asp pallidipin recombinanta, proteina obtinuta si compozitie farmaceutica cu aceasta
EP0789764B1 (en) * 1994-10-28 2002-01-09 Vitaleech Bioscience N.V. A novel family of protease inhibitors, and other biologic active substances
PL200384B1 (pl) 1999-03-18 2008-12-31 Merck Patent Gmbh Polipeptyd blokujący adhezję płytek krwi, sposób jego otrzymywania, zastosowanie i zawierający go preparat farmaceutyczny
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen

Also Published As

Publication number Publication date
ATE295883T1 (de) 2005-06-15
PL350147A1 (en) 2002-11-04
BR0009074A (pt) 2002-01-02
AR023099A1 (es) 2002-09-04
CA2367457A1 (en) 2000-09-28
US6774107B1 (en) 2004-08-10
RU2292351C2 (ru) 2007-01-27
PL200384B1 (pl) 2008-12-31
NO20014506D0 (no) 2001-09-17
EP1161530A1 (en) 2001-12-12
CZ301524B6 (cs) 2010-03-31
CO5241328A1 (es) 2003-01-31
AU3166200A (en) 2000-10-09
HK1045330A1 (en) 2002-11-22
CZ20013341A3 (cs) 2002-01-16
US20060094079A1 (en) 2006-05-04
MY123371A (en) 2006-05-31
MXPA01009363A (es) 2002-06-04
WO2000056885A1 (en) 2000-09-28
AU767172B2 (en) 2003-11-06
ES2240067T3 (es) 2005-10-16
US20050065084A1 (en) 2005-03-24
PT1161530E (pt) 2005-09-30
SI1161530T1 (en) 2005-10-31
NO20014506L (no) 2001-11-16
KR20020008131A (ko) 2002-01-29
JP4805461B2 (ja) 2011-11-02
DK1161530T3 (da) 2005-08-08
HUP0200353A2 (hu) 2002-05-29
JP2002539788A (ja) 2002-11-26
DE60020220D1 (de) 2005-06-23
CA2367457C (en) 2010-09-21
CN1344318A (zh) 2002-04-10
HK1045330B (zh) 2005-09-09
KR100788219B1 (ko) 2007-12-26
SK12902001A3 (sk) 2002-03-05
NO330769B1 (no) 2011-07-11
US7090986B2 (en) 2006-08-15
DE60020220T2 (de) 2006-05-24
CN1185344C (zh) 2005-01-19
SK287496B6 (sk) 2010-12-07
EP1161530B1 (en) 2005-05-18
HUP0200353A3 (en) 2003-12-29
US6962801B2 (en) 2005-11-08
HU228068B1 (en) 2012-09-28

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