TR200102730T2 - New method for the production of doxazosin mesylate in crystal modification. - Google Patents
New method for the production of doxazosin mesylate in crystal modification.Info
- Publication number
- TR200102730T2 TR200102730T2 TR2001/02730T TR200102730T TR200102730T2 TR 200102730 T2 TR200102730 T2 TR 200102730T2 TR 2001/02730 T TR2001/02730 T TR 2001/02730T TR 200102730 T TR200102730 T TR 200102730T TR 200102730 T2 TR200102730 T2 TR 200102730T2
- Authority
- TR
- Turkey
- Prior art keywords
- production
- doxazosin
- new method
- crystal modification
- doxazosin mesylate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000013078 crystal Substances 0.000 title abstract 2
- 229960000220 doxazosin mesylate Drugs 0.000 title abstract 2
- VJECBOKJABCYMF-UHFFFAOYSA-N doxazosin mesylate Chemical compound [H+].CS([O-])(=O)=O.C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 VJECBOKJABCYMF-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000004048 modification Effects 0.000 title abstract 2
- 238000012986 modification Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 1
- 229960001389 doxazosin Drugs 0.000 abstract 1
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A modifikasyonunda doksazosin-mesilatin üretimine yönelik bir yöntem olup, doksazosinin, metansulfonik asit ile birlikte aprotik, polar organik bir çözücü ve metanolden meydana gelen bir karisim içerisinde çözülmesi ve bu islem sirasinda çökelen çözeltinin gerektiginde bulanikliginin giderilmesi ve bu islem sirasinda çökelen berrak çözeltinin gerektiginde A formunun doksazosin-mesilat kristalleri ile asilanmasi, isitilmasi, olusan ürün sogutulduktan sonra izole edilmesi, organik bir çözücü ile yikanmasi ve kurutulmasi islemlerinden ibarettir.A method for the production of doxazosin-meslatin in modification A, where doxazosin is dissolved together with methanesulfonic acid in a mixture consisting of an aprotic, polar organic solvent and methanol, and the solution of the solution precipitated during this process is required and the clear solution precipitated during this process is required. It consists of hanging, heating with doxazosin-mesylate crystals, isolating the product after cooling, washing and drying with an organic solvent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19912063A DE19912063A1 (en) | 1999-03-18 | 1999-03-18 | New process for the preparation of doxazosin mesylate in a crystal modification called Form A. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200102730T2 true TR200102730T2 (en) | 2002-06-21 |
Family
ID=7901411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/02730T TR200102730T2 (en) | 1999-03-18 | 2000-03-06 | New method for the production of doxazosin mesylate in crystal modification. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1165548A1 (en) |
| JP (1) | JP2002540109A (en) |
| KR (1) | KR20010113753A (en) |
| CN (1) | CN1352643A (en) |
| AU (1) | AU3960800A (en) |
| CA (1) | CA2367903A1 (en) |
| CZ (1) | CZ20013347A3 (en) |
| DE (1) | DE19912063A1 (en) |
| HU (1) | HUP0200663A2 (en) |
| IL (1) | IL144944A0 (en) |
| PL (1) | PL350088A1 (en) |
| TR (1) | TR200102730T2 (en) |
| WO (1) | WO2000056731A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19912573A1 (en) * | 1999-03-19 | 2000-09-21 | Knoll Ag | Medicament containing doxazosin mesylate of crystal modification D |
| RU2186779C1 (en) * | 2001-01-31 | 2002-08-10 | Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Method of doxazosin methanesulfonate preparing |
| NZ585558A (en) * | 2007-12-24 | 2011-08-26 | Cipla Ltd | Crystalline polymorph of doxazosin mesylate (form iv) and process for preparation thereof |
| CN109988158A (en) * | 2018-01-03 | 2019-07-09 | 合肥立方制药股份有限公司 | X crystal form, doxazosin mesylate containing X crystal form and its preparation method and application |
| CN111303130B (en) * | 2018-12-11 | 2021-09-14 | 合肥立方制药股份有限公司 | Doxazosin mesylate crystal form, and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1287588B1 (en) * | 1996-12-13 | 1998-08-06 | Alfa Chem Ital | CRYSTALLINE FORM OF MESILATE DOXAZOSIN AND PROCESS FOR ITS PRODUCTION |
| PT849266E (en) * | 1996-12-20 | 2007-03-30 | Heumann Pcs Gmbh | Novel polymorphic form of doxazosin mesylate (form iii) |
| DE19800214A1 (en) * | 1998-01-06 | 1999-07-15 | Knoll Ag | Process for the preparation of doxazosin mcsylate in a crystal modification referred to as Form A and an intermediate therefor |
-
1999
- 1999-03-18 DE DE19912063A patent/DE19912063A1/en not_active Withdrawn
-
2000
- 2000-03-06 IL IL14494400A patent/IL144944A0/en unknown
- 2000-03-06 TR TR2001/02730T patent/TR200102730T2/en unknown
- 2000-03-06 EP EP00918763A patent/EP1165548A1/en not_active Withdrawn
- 2000-03-06 HU HU0200663A patent/HUP0200663A2/en unknown
- 2000-03-06 JP JP2000606592A patent/JP2002540109A/en active Pending
- 2000-03-06 CZ CZ20013347A patent/CZ20013347A3/en unknown
- 2000-03-06 CA CA002367903A patent/CA2367903A1/en not_active Abandoned
- 2000-03-06 CN CN00805209A patent/CN1352643A/en active Pending
- 2000-03-06 PL PL00350088A patent/PL350088A1/en unknown
- 2000-03-06 KR KR1020017011780A patent/KR20010113753A/en not_active Withdrawn
- 2000-03-06 AU AU39608/00A patent/AU3960800A/en not_active Abandoned
- 2000-03-06 WO PCT/EP2000/001939 patent/WO2000056731A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU3960800A (en) | 2000-10-09 |
| DE19912063A1 (en) | 2000-09-21 |
| JP2002540109A (en) | 2002-11-26 |
| CA2367903A1 (en) | 2000-09-28 |
| KR20010113753A (en) | 2001-12-28 |
| PL350088A1 (en) | 2002-11-04 |
| CZ20013347A3 (en) | 2002-01-16 |
| IL144944A0 (en) | 2002-06-30 |
| WO2000056731A1 (en) | 2000-09-28 |
| CN1352643A (en) | 2002-06-05 |
| EP1165548A1 (en) | 2002-01-02 |
| HUP0200663A2 (en) | 2002-08-28 |
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