TR200200054T2 - Vitamin D3 analogları. - Google Patents

Vitamin D3 analogları.

Info

Publication number
TR200200054T2
TR200200054T2 TR2002/00054T TR200200054T TR200200054T2 TR 200200054 T2 TR200200054 T2 TR 200200054T2 TR 2002/00054 T TR2002/00054 T TR 2002/00054T TR 200200054 T TR200200054 T TR 200200054T TR 200200054 T2 TR200200054 T2 TR 200200054T2
Authority
TR
Turkey
Prior art keywords
alkyl
analogs
vitamin
fluoroalkyl
hydroxy
Prior art date
Application number
TR2002/00054T
Other languages
English (en)
Inventor
David Batcho Andrew
Michael Hennessy Bernard
Radoje Uskokovic Milan
Original Assignee
F.Hoffmann-La Proche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Proche Ag filed Critical F.Hoffmann-La Proche Ag
Publication of TR200200054T2 publication Critical patent/TR200200054T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Meme kanseri, prostat kanseri, miyeloid lösemi iyi huylu prostat büyümesi, kellik ve osteropoz tedavisinde faydali oaln, R1'in hidrojen veya bir alkil grubu oldugu; R2'nin hidrojen veya alkil grubu oldugu; veya R1'in, R2'nin ve C20'nin hep birlikte siklopropil oldugu; A'nin a, b, c veya d oldugu; R3'ün alkil, hidroksi-alkil veya floroalkil oldugu; ve R4'ün alkil, hidroksi-alkil veya floroalkil oldugu, formül (I) bilesikleridir.
TR2002/00054T 1999-07-12 2000-07-06 Vitamin D3 analogları. TR200200054T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14341399P 1999-07-12 1999-07-12

Publications (1)

Publication Number Publication Date
TR200200054T2 true TR200200054T2 (tr) 2002-06-21

Family

ID=22503954

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00054T TR200200054T2 (tr) 1999-07-12 2000-07-06 Vitamin D3 analogları.

Country Status (36)

Country Link
US (1) US6331642B1 (tr)
EP (1) EP1200399B1 (tr)
JP (1) JP3803579B2 (tr)
KR (1) KR100477161B1 (tr)
CN (1) CN1174964C (tr)
AR (1) AR024695A1 (tr)
AT (1) ATE262508T1 (tr)
AU (1) AU779408B2 (tr)
BR (1) BR0012419A (tr)
CA (1) CA2378803C (tr)
CO (1) CO5190683A1 (tr)
DE (1) DE60009303T2 (tr)
DK (1) DK1200399T3 (tr)
EG (1) EG23909A (tr)
ES (1) ES2215707T3 (tr)
GC (1) GC0000198A (tr)
HK (1) HK1047578B (tr)
HR (1) HRP20020007A2 (tr)
HU (1) HUP0202157A3 (tr)
IL (2) IL147254A0 (tr)
JO (1) JO2255B1 (tr)
MA (1) MA26808A1 (tr)
MX (1) MXPA02000313A (tr)
MY (1) MY122633A (tr)
NO (1) NO20020161D0 (tr)
NZ (1) NZ516339A (tr)
PE (1) PE20010328A1 (tr)
PL (1) PL201877B1 (tr)
PT (1) PT1200399E (tr)
RS (1) RS50229B (tr)
RU (1) RU2235721C2 (tr)
TR (1) TR200200054T2 (tr)
TW (1) TWI268276B (tr)
UY (1) UY26239A1 (tr)
WO (1) WO2001004089A1 (tr)
ZA (1) ZA200110487B (tr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013832A1 (fr) * 2000-08-17 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Agent therapeutique destine au traitement de l'osteoporose
AU2001296542B2 (en) 2000-10-02 2007-10-25 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
EP1430026A1 (en) * 2001-09-21 2004-06-23 F. Hoffmann-La Roche Ag 3-desoxy-vitamin d3 analog esters
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
CA2524026A1 (en) * 2003-04-30 2004-11-18 Bioxell S.P.A. Gemini vitamin d3 compounds and methods of use thereof
US20050113348A1 (en) * 2003-06-12 2005-05-26 Yanchun Li Vitamin D and vitamin D analogs or derivatives as new anti-hypertensive agents
US7332482B2 (en) * 2003-09-24 2008-02-19 Bioxell S.P.A. Method for treating benign prostatic hyperplasia
JP2007506780A (ja) * 2003-09-24 2007-03-22 ビオエクセル エスピーエー 膀胱機能障害の治療方法
GB2407499B (en) * 2003-11-03 2008-02-27 Bioxell Spa Vitamin D3 analogue for use in the treatment of BPH
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
EP1797033A4 (en) * 2004-09-24 2010-04-28 Bioxell Spa 20-CYCLOALKYL-26,27-ALKYL / HALOGENALKYL-VITAMIN-D3 COMPOUNDS AND METHODS FOR THEIR APPLICATION
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
ES2544819T3 (es) * 2007-05-30 2015-09-04 Opko IP Holdings II, Inc. Proceso para la producción de precursores de la vitamina D de óxido de fosfina
TWI700293B (zh) 2008-04-11 2020-08-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗體
EP2682386B1 (en) * 2011-03-02 2016-08-17 Nihon University Novel vitamin d receptor modulator with partial agonist activity
KR102523660B1 (ko) 2016-09-26 2023-04-19 (주)하이플 박스용 테두리 부재보강부재와 에셈블리컨테이너 원터치크립이 포함된 박스

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749710A (en) 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6040300A (en) * 1995-04-07 2000-03-21 Arch Development Corporation Method of preventing colon cancer with vitamin D3 analogues
AU708679B2 (en) 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives

Also Published As

Publication number Publication date
CN1174964C (zh) 2004-11-10
KR100477161B1 (ko) 2005-03-18
HRP20020007A2 (en) 2003-04-30
TWI268276B (en) 2006-12-11
YU92701A (sh) 2004-09-03
EP1200399A1 (en) 2002-05-02
NO20020161L (no) 2002-01-11
ZA200110487B (en) 2003-03-20
PT1200399E (pt) 2004-06-30
KR20020033728A (ko) 2002-05-07
JP2003504354A (ja) 2003-02-04
DE60009303D1 (de) 2004-04-29
AR024695A1 (es) 2002-10-23
WO2001004089A1 (en) 2001-01-18
JO2255B1 (en) 2004-10-07
HK1047578B (zh) 2005-04-29
CN1360572A (zh) 2002-07-24
JP3803579B2 (ja) 2006-08-02
US6331642B1 (en) 2001-12-18
HUP0202157A2 (en) 2002-10-28
PL201877B1 (pl) 2009-05-29
PE20010328A1 (es) 2001-03-22
NZ516339A (en) 2003-07-25
NO20020161D0 (no) 2002-01-11
HUP0202157A3 (en) 2004-04-28
PL356124A1 (en) 2004-06-14
AU6689400A (en) 2001-01-30
IL147254A0 (en) 2002-08-14
GC0000198A (en) 2006-03-29
MXPA02000313A (es) 2002-06-21
EP1200399B1 (en) 2004-03-24
ATE262508T1 (de) 2004-04-15
CA2378803C (en) 2009-01-27
ES2215707T3 (es) 2004-10-16
RS50229B (sr) 2009-07-15
RU2235721C2 (ru) 2004-09-10
HK1047578A1 (en) 2003-02-28
AU779408B2 (en) 2005-01-20
UY26239A1 (es) 2000-10-31
CO5190683A1 (es) 2002-08-29
EG23909A (en) 2007-12-30
BR0012419A (pt) 2002-03-26
MA26808A1 (fr) 2004-12-20
IL147254A (en) 2006-07-05
MY122633A (en) 2006-04-29
DK1200399T3 (da) 2004-07-19
CA2378803A1 (en) 2001-01-18
DE60009303T2 (de) 2005-02-24

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