TR200200100T2 - Kristalin 1-metilkarbapenem türevleri. - Google Patents

Kristalin 1-metilkarbapenem türevleri.

Info

Publication number
TR200200100T2
TR200200100T2 TR2002/00100T TR200200100T TR200200100T2 TR 200200100 T2 TR200200100 T2 TR 200200100T2 TR 2002/00100 T TR2002/00100 T TR 2002/00100T TR 200200100 T TR200200100 T TR 200200100T TR 200200100 T2 TR200200100 T2 TR 200200100T2
Authority
TR
Turkey
Prior art keywords
crystalline
methylcarbapenem derivatives
methylcarbapenem
derivatives
derivative
Prior art date
Application number
TR2002/00100T
Other languages
English (en)
Inventor
Kawamoto Isao
Shimoji Yasuo
Fukuhara Hiroshi
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of TR200200100T2 publication Critical patent/TR200200100T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Bu bulus, bir formül (I) 1-metilkarbapenem türevinin veya farmasötik olarak kabul edilebilir bir tuzunun kristalin formlarini saglamaktadir.
TR2002/00100T 1999-07-06 2000-07-06 Kristalin 1-metilkarbapenem türevleri. TR200200100T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19136899 1999-07-06

Publications (1)

Publication Number Publication Date
TR200200100T2 true TR200200100T2 (tr) 2002-05-21

Family

ID=16273433

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2002/00100T TR200200100T2 (tr) 1999-07-06 2000-07-06 Kristalin 1-metilkarbapenem türevleri.
TR2004/03436T TR200403436T2 (tr) 1999-07-06 2000-07-06 Kristalin 1-metilkarbapenem türevleri.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2004/03436T TR200403436T2 (tr) 1999-07-06 2000-07-06 Kristalin 1-metilkarbapenem türevleri.

Country Status (21)

Country Link
US (3) US20020128254A1 (tr)
EP (1) EP1193269A4 (tr)
JP (1) JP3476420B2 (tr)
KR (1) KR100750552B1 (tr)
CN (2) CN100360530C (tr)
AU (1) AU758190B2 (tr)
BR (1) BR0012253A (tr)
CA (1) CA2378483C (tr)
CZ (1) CZ20014731A3 (tr)
HK (1) HK1044768A1 (tr)
HU (1) HUP0202255A3 (tr)
IL (2) IL147214A0 (tr)
MX (1) MXPA02000061A (tr)
NO (1) NO327786B1 (tr)
NZ (1) NZ516310A (tr)
PL (1) PL352296A1 (tr)
RU (2) RU2214411C2 (tr)
TR (2) TR200200100T2 (tr)
TW (1) TWI250160B (tr)
WO (1) WO2001002401A1 (tr)
ZA (1) ZA200110413B (tr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL351898A1 (en) * 1999-04-06 2003-06-30 Sankyo Co O-substituted derivatives of carboxylic acids
US7041660B2 (en) * 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
HK1049480B (en) * 1999-09-30 2004-12-10 Otsuka Kagaku Kabushiki Kaisha 3-cephem derivative crystal and method for preparing the same
AU2001267011B2 (en) 2000-06-21 2006-02-02 Cubist Pharmaceuticals, Inc. Compositions and methods to improve the oral absorption of antimicrobial agents
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
EP1426376A4 (en) * 2001-08-13 2004-12-22 Eisai Co Ltd PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS
KR100628676B1 (ko) * 2001-09-26 2006-09-27 머크 앤드 캄파니 인코포레이티드 카바페넴 화합물의 제조방법
HRP20040264B1 (en) * 2001-09-26 2012-07-31 Merck@Sharp@@@Dohme@Corp Process for making carbapenem compounds
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
JP2005097278A (ja) * 2003-08-25 2005-04-14 Sankyo Co Ltd １−メチルカルバペネム化合物の結晶
BRPI0413842A (pt) 2003-08-25 2006-10-24 Sankyo Co composto de 1-metil-carbapenem ou um seu sal farmacologicamente aceitável, etanolato e tetra-hidrato de composto de 1-metil-carbapenem, processo para a preparação da forma cristalina, processo para a preparação de um tri-hidrato de etanolato de composto de 1-metil-carbapenem, tri-hidrato de etanolato de composto de 1-metil-carbapenem, composição farmacêutica para prevenir ou tratar infecções bacterianas, e, uso da forma cristalina
US20070249827A1 (en) * 2004-06-02 2007-10-25 Sandoz Ag Meropenem Intermediatein in Crystalling Form
KR20070112464A (ko) * 2005-03-22 2007-11-26 다이이찌 산쿄 가부시키가이샤 1-알킬피롤리딘 구조를 갖는 카르바페넴 유도체의 제조방법
NZ580951A (en) 2005-04-29 2011-06-30 Cubist Pharm Inc Therapeutic compositions
JPWO2006121151A1 (ja) * 2005-05-13 2008-12-18 第一三共株式会社 １−メチルカルバペネム化合物の結晶
CN101328179B (zh) * 2007-06-15 2011-01-12 山东轩竹医药科技有限公司 含有氧代氮杂环的巯基吡咯烷培南衍生物
CN101412717B (zh) * 2007-10-19 2011-01-12 山东轩竹医药科技有限公司 含有胍基烷酰胺基杂环的碳青霉烯衍生物
US20110054168A1 (en) * 2008-01-17 2011-03-03 Ayumu Kurimoto Method for preparing adenine compound
US20130079322A1 (en) * 2010-05-21 2013-03-28 Xuanzhu Pharama Co., Ltd. Crystalline of carbapenem derivative or its hydrate, preparation methods and uses thereof
CN103025733B (zh) * 2010-06-03 2015-11-25 山东轩竹医药科技有限公司 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途
EP2945929B1 (de) * 2013-01-15 2020-01-22 Merck Patent GmbH Acylguanidine zur behandlung von arthrose

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US4260543A (en) 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4748238A (en) 1984-03-14 1988-05-31 Merck & Co., Inc. Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid
US4713451A (en) 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
US4866171A (en) 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
CA2036163C (en) * 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
TW209220B (tr) * 1991-11-27 1993-07-11 Manyu Seiyaku Kk
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
ATE178066T1 (de) 1992-11-17 1999-04-15 Sankyo Co Krystallines carbapenemderivat
JPH06336483A (ja) * 1993-05-26 1994-12-06 Banyu Pharmaceut Co Ltd アミノアルキルピロリジニルチオカルバペネム誘導体
JPH07291973A (ja) * 1994-04-27 1995-11-07 Banyu Pharmaceut Co Ltd 新規な２−ピロリジニルチオカルバペネム誘導体
JPH09110869A (ja) * 1995-10-23 1997-04-28 Lederle Japan Ltd カルバペネム化合物
EP0882728B1 (en) * 1995-12-21 2002-09-04 Sankyo Company Limited 1-methylcarbapenem derivatives
JP2955276B2 (ja) * 1997-06-19 1999-10-04 三共株式会社 １−メチルカルバペネム誘導体を含有する抗菌剤

Also Published As

Publication number Publication date
NO20020030L (no) 2002-03-05
IL147214A0 (en) 2002-08-14
NO20020030D0 (no) 2002-01-04
HUP0202255A2 (en) 2002-10-28
RU2003118411A (ru) 2004-12-20
TWI250160B (en) 2006-03-01
TR200403436T2 (tr) 2005-03-21
CZ20014731A3 (cs) 2002-04-17
NO327786B1 (no) 2009-09-21
US6924279B2 (en) 2005-08-02
IL147214A (en) 2009-12-24
JP3476420B2 (ja) 2003-12-10
EP1193269A4 (en) 2003-05-28
CN101077869A (zh) 2007-11-28
EP1193269A1 (en) 2002-04-03
BR0012253A (pt) 2002-03-26
AU758190B2 (en) 2003-03-20
US20030158174A1 (en) 2003-08-21
MXPA02000061A (es) 2002-07-02
JP2001072681A (ja) 2001-03-21
KR20020022761A (ko) 2002-03-27
WO2001002401A1 (en) 2001-01-11
CN1372560A (zh) 2002-10-02
US20020128254A1 (en) 2002-09-12
PL352296A1 (en) 2003-08-11
HUP0202255A3 (en) 2003-10-28
CA2378483A1 (en) 2001-01-11
KR100750552B1 (ko) 2007-08-20
HK1044768A1 (en) 2002-11-01
US20030232803A1 (en) 2003-12-18
NZ516310A (en) 2004-05-28
CN100360530C (zh) 2008-01-09
CA2378483C (en) 2008-09-16
AU5848700A (en) 2001-01-22
RU2214411C2 (ru) 2003-10-20
ZA200110413B (en) 2003-03-19

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