TR200200310T2 - Interlökin-5 inhibe eden 6-azaurasil türevleri. - Google Patents

Interlökin-5 inhibe eden 6-azaurasil türevleri.

Info

Publication number
TR200200310T2
TR200200310T2 TR2002/00310T TR200200310T TR200200310T2 TR 200200310 T2 TR200200310 T2 TR 200200310T2 TR 2002/00310 T TR2002/00310 T TR 2002/00310T TR 200200310 T TR200200310 T TR 200200310T TR 200200310 T2 TR200200310 T2 TR 200200310T2
Authority
TR
Turkey
Prior art keywords
derivatives
inhibit interleukin
azauracil
azauracil derivatives
methods
Prior art date
Application number
TR2002/00310T
Other languages
English (en)
Inventor
Fernand Armand Lacrampe Jean
Jean Edgard Freyne Eddy
Dirk Deroose Freder�K
Michel Claude Fortin J�r�me
Coesemans Erwin
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR200200310T2 publication Critical patent/TR200200310T2/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0461—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Mevcut bulus eozinofile bagimli enflamatuar hastaliklari tedavisinde faydali IL-5 inhibe eden 6-azaurasil türevlerine, bunlarin hazirlanmasina mahsus yöntemlere ve aramaddelere ve ayni zamanda söz konusu türevleri ihtiva eden farmasötik bilesimlere iliskindir. Ayrica bu tür türevlerin bir ilaç olarak kullanimina ve söz konusu türevleri kullanarak bir reseptörü isaretlemeye veya bir organi görüntülemeye mahsus yöntemlere iliskindir.
TR2002/00310T 1999-08-06 2000-07-31 Interlökin-5 inhibe eden 6-azaurasil türevleri. TR200200310T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99870170 1999-08-06
EP99126035 1999-12-27

Publications (1)

Publication Number Publication Date
TR200200310T2 true TR200200310T2 (tr) 2002-08-21

Family

ID=26153219

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00310T TR200200310T2 (tr) 1999-08-06 2000-07-31 Interlökin-5 inhibe eden 6-azaurasil türevleri.

Country Status (30)

Country Link
US (1) US6911444B2 (tr)
EP (1) EP1206471B1 (tr)
JP (1) JP2003506451A (tr)
KR (1) KR100795484B1 (tr)
CN (1) CN1188410C (tr)
AR (1) AR025046A1 (tr)
AT (1) ATE318811T1 (tr)
AU (1) AU780047B2 (tr)
BG (1) BG106367A (tr)
BR (1) BR0013014A (tr)
CA (1) CA2380759A1 (tr)
CO (1) CO5050264A1 (tr)
CZ (1) CZ2002356A3 (tr)
DE (1) DE60026312T2 (tr)
EA (1) EA004740B1 (tr)
EE (1) EE200200057A (tr)
ES (1) ES2260031T3 (tr)
HK (1) HK1048634B (tr)
HR (1) HRP20020096A2 (tr)
HU (1) HUP0202692A3 (tr)
IL (1) IL147976A0 (tr)
MX (1) MXPA02001343A (tr)
MY (1) MY133512A (tr)
NO (1) NO322386B1 (tr)
NZ (1) NZ516506A (tr)
PL (1) PL353475A1 (tr)
SK (1) SK1642002A3 (tr)
TR (1) TR200200310T2 (tr)
TW (1) TWI271404B (tr)
WO (1) WO2001010866A1 (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1486490A1 (en) 2002-02-28 2004-12-15 Takeda Chemical Industries, Ltd. Azole compounds
MXPA06013924A (es) * 2004-05-29 2007-07-18 7Tm Pharma As Acidos tiazolaceticos sustituidos como ligandos crth2.
CA2735521A1 (en) 2008-09-04 2010-03-11 Boehringer Ingelheim International Gmbh Indolizine inhibitors of leukotriene production
JP4743340B1 (ja) 2009-10-28 2011-08-10 セントラル硝子株式会社 保護膜形成用薬液
JP5690839B2 (ja) 2009-12-04 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のベンゾイミダゾール阻害薬
PH12013500301A1 (en) 2010-08-16 2013-03-25 Boehringer Ingelheim Int Oxadiazole inhibitors of leukotriene production
US8580829B2 (en) 2010-08-26 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EA201300389A1 (ru) 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена
WO2012040137A1 (en) 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EP2632915B1 (en) 2010-10-29 2015-08-12 Boehringer Ingelheim International GmbH Benzimidazole inhibitors of leukotriene production
US8772304B2 (en) 2010-11-01 2014-07-08 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
EP2651930B1 (en) 2010-12-16 2015-10-28 Boehringer Ingelheim International GmbH Biarylamide inhibitors of leukotriene production
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US42416A (en) * 1864-04-19 Improvement in harvesters
US10177A (en) * 1853-11-01 Improved pen and pencil case
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4631278A (en) 1984-08-01 1986-12-23 Janssen Pharmaceutica N.V. Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
CA1244024A (en) 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
BR9811678A (pt) * 1997-07-10 2000-09-19 Janssen Pharmaceutica Nv Derivados de 6-azauracila de inibição de il-5
CA2294533A1 (en) * 1997-07-10 1999-01-21 Janssen Pharmaceutica N.V. 6-azauracil derivatives as il-5 inhibitors
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives

Also Published As

Publication number Publication date
EE200200057A (et) 2003-04-15
MY133512A (en) 2007-11-30
EA004740B1 (ru) 2004-08-26
TWI271404B (en) 2007-01-21
BR0013014A (pt) 2002-04-16
HK1048634A1 (en) 2003-04-11
CN1368972A (zh) 2002-09-11
EA200200232A1 (ru) 2002-08-29
HRP20020096A2 (en) 2005-10-31
WO2001010866A1 (en) 2001-02-15
DE60026312D1 (de) 2006-04-27
CZ2002356A3 (cs) 2002-06-12
US6911444B2 (en) 2005-06-28
NZ516506A (en) 2004-02-27
CN1188410C (zh) 2005-02-09
NO20020565D0 (no) 2002-02-05
EP1206471B1 (en) 2006-03-01
AR025046A1 (es) 2002-11-06
HUP0202692A3 (en) 2003-01-28
HUP0202692A2 (hu) 2002-12-28
BG106367A (bg) 2002-09-30
CO5050264A1 (es) 2001-06-27
AU780047B2 (en) 2005-02-24
IL147976A0 (en) 2002-09-12
KR20020012317A (ko) 2002-02-15
NO322386B1 (no) 2006-09-25
HK1048634B (zh) 2005-09-30
PL353475A1 (en) 2003-11-17
MXPA02001343A (es) 2002-07-22
AU6160900A (en) 2001-03-05
NO20020565L (no) 2002-03-26
KR100795484B1 (ko) 2008-01-16
SK1642002A3 (en) 2003-03-04
JP2003506451A (ja) 2003-02-18
CA2380759A1 (en) 2001-02-15
ES2260031T3 (es) 2006-11-01
DE60026312T2 (de) 2006-12-21
US20030114453A1 (en) 2003-06-19
ATE318811T1 (de) 2006-03-15
EP1206471A1 (en) 2002-05-22

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