TR200201470T2 - N6 heterosiklik 8-modifiye adenosin türevleri. - Google Patents

N6 heterosiklik 8-modifiye adenosin türevleri.

Info

Publication number
TR200201470T2
TR200201470T2 TR2002/01470T TR200201470T TR200201470T2 TR 200201470 T2 TR200201470 T2 TR 200201470T2 TR 2002/01470 T TR2002/01470 T TR 2002/01470T TR 200201470 T TR200201470 T TR 200201470T TR 200201470 T2 TR200201470 T2 TR 200201470T2
Authority
TR
Turkey
Prior art keywords
heterocyclic
adenosine derivatives
modified adenosine
modifying
partial
Prior art date
Application number
TR2002/01470T
Other languages
English (en)
Inventor
A. Zablocki Jeff
P. Palle Venkata
N. Ibrahim Prahba
Belardinelli Luiz
Original Assignee
Cv Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics, Inc. filed Critical Cv Therapeutics, Inc.
Publication of TR200201470T2 publication Critical patent/TR200201470T2/tr

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Seçici, kismi veya tam adenosin A1 reseptörü kismi veya tam agonistleri olan N6 heterosiklik 8 modifiye adenosin türevleri memelilerde, ve özellikle insanlarda, kalp aktivitesinin modifiye edilmesinde, adiposit fonksiyonunun modifiye edilmesinde, merkezi sinir sistemi rahatsizliklarinin tedavi edilmesinde ve diyabetik rahatsizliklarin ve obezitenin tedavi edilmesinde yararlidir.
TR2002/01470T 1999-12-03 2000-11-29 N6 heterosiklik 8-modifiye adenosin türevleri. TR200201470T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/454,485 US6294522B1 (en) 1999-12-03 1999-12-03 N6 heterocyclic 8-modified adenosine derivatives

Publications (1)

Publication Number Publication Date
TR200201470T2 true TR200201470T2 (tr) 2002-12-23

Family

ID=23804799

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01470T TR200201470T2 (tr) 1999-12-03 2000-11-29 N6 heterosiklik 8-modifiye adenosin türevleri.

Country Status (20)

Country Link
US (2) US6294522B1 (tr)
EP (1) EP1237898B1 (tr)
JP (1) JP4021196B2 (tr)
KR (1) KR100484987B1 (tr)
CN (1) CN1195772C (tr)
AR (1) AR029198A1 (tr)
AT (1) ATE292140T1 (tr)
AU (1) AU771242B2 (tr)
CA (1) CA2394861C (tr)
DE (1) DE60019164T2 (tr)
ES (1) ES2236044T3 (tr)
HK (1) HK1051695B (tr)
IL (2) IL149651A0 (tr)
MX (1) MXPA02005318A (tr)
NO (1) NO323138B1 (tr)
NZ (1) NZ518736A (tr)
TR (1) TR200201470T2 (tr)
TW (1) TWI268923B (tr)
WO (1) WO2001042265A2 (tr)
ZA (1) ZA200204379B (tr)

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US20040161844A1 (en) * 1996-06-06 2004-08-19 Baker Brenda F. Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation
US20040171030A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
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USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
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US6605597B1 (en) * 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
CA2671940A1 (en) * 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
US6995148B2 (en) * 2001-04-05 2006-02-07 University Of Pittsburgh Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy
JP2005527502A (ja) * 2002-02-19 2005-09-15 シーブイ・セラピューティクス・インコーポレイテッド Ａ１アデノシン受容体の部分的および全アゴニスト
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AU2003291755A1 (en) * 2002-11-05 2004-06-07 Isis Pharmaceuticals, Inc. Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
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US20070161582A1 (en) * 2003-08-08 2007-07-12 Dusan Mijikovic Pharmaceutical compositions and methods for metabolic modulation
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US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
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WO2006030803A1 (ja) * 2004-09-17 2006-03-23 Kissei Pharmaceutical Co., Ltd. ８位修飾プリンヌクレオシド誘導体及びその医薬用途
KR20070083714A (ko) 2004-10-20 2007-08-24 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ 아데노신 수용체 작용제의 용도
DK2444079T3 (en) 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
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CA2655310A1 (en) * 2006-06-22 2008-05-29 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
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US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
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Also Published As

Publication number Publication date
DE60019164T2 (de) 2006-02-02
CN1195772C (zh) 2005-04-06
HK1051695A1 (en) 2003-08-15
WO2001042265A2 (en) 2001-06-14
US20020045595A1 (en) 2002-04-18
NO20022573D0 (no) 2002-05-30
DE60019164D1 (de) 2005-05-04
KR100484987B1 (ko) 2005-04-22
ATE292140T1 (de) 2005-04-15
IL149651A0 (en) 2002-11-10
CA2394861C (en) 2007-01-30
JP4021196B2 (ja) 2007-12-12
ZA200204379B (en) 2003-06-25
AU4510101A (en) 2001-06-18
TWI268923B (en) 2006-12-21
IL149651A (en) 2006-08-20
WO2001042265A3 (en) 2002-01-03
EP1237898B1 (en) 2005-03-30
NO20022573L (no) 2002-05-30
EP1237898A2 (en) 2002-09-11
MXPA02005318A (es) 2002-12-11
CN1402732A (zh) 2003-03-12
ES2236044T3 (es) 2005-07-16
NZ518736A (en) 2004-02-27
KR20030032906A (ko) 2003-04-26
NO323138B1 (no) 2007-01-08
CA2394861A1 (en) 2001-06-14
US6294522B1 (en) 2001-09-25
HK1051695B (en) 2005-06-03
AU771242B2 (en) 2004-03-18
AR029198A1 (es) 2003-06-18
JP2003516413A (ja) 2003-05-13

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