PT1019426E - Agonistas e antagonistas do receptor de adenosina a1 - Google Patents

Agonistas e antagonistas do receptor de adenosina a1

Info

Publication number: PT1019426E
Authority: PT; Portugal
Prior art keywords: antagonists; agents; adenosin; receptor; compositions
Prior art date: 1995-12-29

Application number

PT96945316T

Other languages

English (en)

Inventor

Luiz Belardinelli

Ray Olsson

Peter J Scammells

Peter Gerard Milder

Jurg R Pfister

Stephen Baker

Original Assignee

Univ Florida

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-29

Filing date

1996-12-26

Publication date

2003-07-31

1996-12-26 Application filed by Univ Florida filed Critical Univ Florida

2003-07-31 Publication of PT1019426E publication Critical patent/PT1019426E/pt

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 3
239000005557 antagonist Substances 0.000 title 1
239000003795 chemical substances by application Substances 0.000 title 1
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
102000009346 Adenosine receptors Human genes 0.000 abstract 1
108050000203 Adenosine receptors Proteins 0.000 abstract 1
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
229960005305 adenosine Drugs 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
229940075420 xanthine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

PT96945316T 1995-12-29 1996-12-26 Agonistas e antagonistas do receptor de adenosina a1 PT1019426E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/581,655 US5736528A (en)	1993-10-28	1995-12-29	N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists

Publications (1)

Publication Number	Publication Date
PT1019426E true PT1019426E (pt)	2003-07-31

Family

ID=24326044

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96945316T PT1019426E (pt)	1995-12-29	1996-12-26	Agonistas e antagonistas do receptor de adenosina a1

Country Status (15)

Country	Link
US (2)	US5736528A (pt)
EP (1)	EP1019426B1 (pt)
JP (1)	JP2000502712A (pt)
KR (1)	KR19990076916A (pt)
CN (1)	CN1163502C (pt)
AT (1)	ATE234322T1 (pt)
AU (1)	AU728439B2 (pt)
BR (1)	BR9612324A (pt)
CA (1)	CA2238736C (pt)
DE (1)	DE69626705T2 (pt)
DK (1)	DK1019426T3 (pt)
ES (1)	ES2190487T3 (pt)
NZ (1)	NZ326608A (pt)
PT (1)	PT1019426E (pt)
WO (1)	WO1997024363A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5736528A (en) *	1993-10-28	1998-04-07	University Of Florida Research Foundation, Inc.	N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
US5789416B1 (en) *	1996-08-27	1999-10-05	Cv Therapeutics Inc	N6 mono heterocyclic substituted adenosine derivatives
IL127947A0 (en) *	1999-01-07	1999-11-30	Can Fite Technologies Ltd	Pharmaceutical use of adenosine agonists
US6790839B2 (en)	1999-01-07	2004-09-14	Can-Fite Biopharma Ltd.	Pharmaceutical administration of adenosine agonists
AU4138601A (en) *	1999-12-03	2001-06-12	Cv Therapeutics, Inc.	Method of identifying partial adenosine a1 receptor agonists and their use in the treatment of arrhythmias
US20030008841A1 (en) *	2000-08-30	2003-01-09	Rene Devos	Anti-HCV nucleoside derivatives
RU2248208C2 (ru) *	2000-09-08	2005-03-20	Си Ви Терапьютикс, Инк.	Пуринрибозиды в качестве антиаритмических средств
JP2004508336A (ja) *	2000-09-08	2004-03-18	スィーヴィー　セラピューティクス　インコーポレイテッド	抗不整脈薬としてのプリンリボシド
CA2347879A1 (en)	2001-05-11	2002-11-11	Vanderbilt University	Substituted dicinnamoylquinides and their use in augmentation of adenosine function
ATE418991T1 (de) *	2002-04-18	2009-01-15	Cv Therapeutics Inc	Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker
US20040121406A1 (en) *	2002-05-23	2004-06-24	Wilson Constance Neely	Methods and formulations for increasing the affinity of a1 adenosine receptor ligands for the a1 adenosine receptor
UA84404C2 (ru) *	2002-06-12	2008-10-27	Байоджен Айдек Ма Инк.	Способ лечения ишемического реперфузионного повреждения с помощью антагонистов рецептора аденозина
US20040229901A1 (en) *	2003-02-24	2004-11-18	Lauren Otsuki	Method of treatment of disease using an adenosine A1 receptor antagonist
EP1932529A1 (en)	2003-04-25	2008-06-18	Novacardia, Inc.	Method of improved diuresis in individuals with impaired renal function
CN1859913A (zh) *	2003-04-25	2006-11-08	美国诺华卡迪亚公司	改善肾功能损伤个体多尿症的方法
US20060293312A1 (en) *	2003-04-25	2006-12-28	Howard Dittrich	Method of improved diuresis in individuals with impaired renal function
US20050239759A1 (en) *	2004-04-16	2005-10-27	Lauren Otsuki	Method of treatment of disease using an adenosine A1 receptor antagonist and an aldosterone inhibitor
EP1809374A4 (en) *	2004-10-12	2008-09-10	Closed Loop Therapies Ltd	IMPLANTABLE METHODS AND DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS
ES2273599B1 (es) *	2005-10-14	2008-06-01	Universidad De Barcelona	Compuestos para el tratamiento de la fibrilacion auricular.
JP2009540003A (ja) *	2006-06-16	2009-11-19	ノヴァカーディア，インク．	Ａａ１ｒａの低頻度投与を含む腎機能の長期間にわたる改善
WO2008121882A1 (en) *	2007-03-29	2008-10-09	Novacardia, Inc.	Improved methods of administration of adenosine a1 receptor antagonists
WO2008121893A1 (en) *	2007-03-29	2008-10-09	Novacardia, Inc.	Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
DE102011005232A1 (de)	2011-03-08	2012-09-13	AristoCon GmbH & Co. KG	Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
TWI653227B (zh) *	2014-07-11	2019-03-11	Dow Agrosciences Llc	用於製備４－（１－（４－（全氟乙氧基）苯基）－１ｈ－１，２，４－三唑－３－基）苯甲醯疊氮化物之改良方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2460929A1 (de) *	1974-12-21	1976-06-24	Boehringer Sohn Ingelheim	Neue xanthinderivate, verfahren zu ihrer herstellung und ihre anwendung
US4364922A (en) *	1980-10-14	1982-12-21	University Of Virginia Alumni Patents Foundation	Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances
DE3138397A1 (de) *	1981-09-26	1983-04-07	Hoechst Ag, 6230 Frankfurt	"arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
US4980379A (en) *	1988-06-30	1990-12-25	The University Of Virginia	Use of adenosine antagonists in the treatment of bradyarrhythmias and hemodynamic depression associated with cardiopulmonary resucitation and/or cardiovascular collapse
DE3843117A1 (de) *	1988-12-22	1990-06-28	Boehringer Ingelheim Kg	Neue xanthinderivate mit adenosin-antagonistischer wirkung
JPH06102662B2 (ja) *	1989-09-01	1994-12-14	協和醗酵工業株式会社	キサンチン誘導体
DE4019892A1 (de) *	1990-06-22	1992-01-02	Boehringer Ingelheim Kg	Neue xanthinderivate
DE4205306B4 (de) *	1992-02-21	2005-11-24	Glüsenkamp, Karl-Heinz, Dr.	Säureamide, Arzneimittel mit denselben und Verfahren zur Herstellung von Säureamiden
US5288721A (en) *	1992-09-22	1994-02-22	Cell Therapeutics, Inc.	Substituted epoxyalkyl xanthines
WO1994016702A1 (fr) *	1993-01-26	1994-08-04	Kyowa Hakko Kogyo Co., Ltd.	Medicament contre l'elimination irreguliere des matieres fecales
US5446046A (en) *	1993-10-28	1995-08-29	University Of Florida Research Foundation	A1 adenosine receptor agonists and antagonists as diuretics
US5736528A (en) *	1993-10-28	1998-04-07	University Of Florida Research Foundation, Inc.	N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists

1995
- 1995-12-29 US US08/581,655 patent/US5736528A/en not_active Expired - Lifetime
1996
- 1996-12-26 DK DK96945316T patent/DK1019426T3/da active
- 1996-12-26 AT AT96945316T patent/ATE234322T1/de active
- 1996-12-26 EP EP96945316A patent/EP1019426B1/en not_active Expired - Lifetime
- 1996-12-26 CN CNB961993383A patent/CN1163502C/zh not_active Expired - Fee Related
- 1996-12-26 JP JP9524592A patent/JP2000502712A/ja not_active Ceased
- 1996-12-26 KR KR1019980705044A patent/KR19990076916A/ko not_active Ceased
- 1996-12-26 PT PT96945316T patent/PT1019426E/pt unknown
- 1996-12-26 AU AU15220/97A patent/AU728439B2/en not_active Ceased
- 1996-12-26 NZ NZ326608A patent/NZ326608A/xx not_active IP Right Cessation
- 1996-12-26 BR BR9612324-9A patent/BR9612324A/pt not_active IP Right Cessation
- 1996-12-26 ES ES96945316T patent/ES2190487T3/es not_active Expired - Lifetime
- 1996-12-26 WO PCT/US1996/020840 patent/WO1997024363A1/en not_active Ceased
- 1996-12-26 DE DE69626705T patent/DE69626705T2/de not_active Expired - Lifetime
- 1996-12-26 CA CA002238736A patent/CA2238736C/en not_active Expired - Fee Related
1998
- 1998-04-06 US US09/056,195 patent/US5998387A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NZ326608A (en)	2000-04-28
CN1163502C (zh)	2004-08-25
DK1019426T3 (da)	2003-07-14
KR19990076916A (ko)	1999-10-25
JP2000502712A (ja)	2000-03-07
DE69626705T2 (de)	2003-09-18
US5998387A (en)	1999-12-07
EP1019426B1 (en)	2003-03-12
CA2238736A1 (en)	1997-07-10
ES2190487T3 (es)	2003-08-01
WO1997024363A1 (en)	1997-07-10
EP1019426A1 (en)	2000-07-19
BR9612324A (pt)	1999-12-28
CN1206420A (zh)	1999-01-27
ATE234322T1 (de)	2003-03-15
US5736528A (en)	1998-04-07
CA2238736C (en)	2003-09-16
AU728439B2 (en)	2001-01-11
DE69626705D1 (de)	2003-04-17
AU1522097A (en)	1997-07-28

Publication	Publication Date	Title
DE69422191D1 (de)	2000-01-20	A1 adenosin rezeptor agonisten und antagonisten
DE69626705D1 (de)	2003-04-17	A1 adenosin rezeptor agonisten und antagonisten
TR200103607T2 (tr)	2002-10-21	Pürin Türevleri
ATE206432T1 (de)	2001-10-15	A3 -adenosin -rezeptor agonisten
BG101806A (bg)	1998-04-30	Индолови производни като антагонисти на 5-нт рецептори
PE20001225A1 (es)	2000-11-07	Derivados de adenina
TR200201001T2 (tr)	2002-09-23	Pürin türevleri
DK0760811T3 (da)	2010-01-25	Imidazolderivater som histaminreceptor H3-modulatorer
DE69719816D1 (de)	2003-04-17	N6-heterocyclisch substituierte Adenosin-Derivate
ES2196063T3 (es)	2003-12-16	Utilizacion de agentes antagonistas competitivos de progesterona para la preparacion de medicamentos destinados al tratamiento de hemorragias uterinas disfuncionales.
ES2175079T3 (es)	2002-11-16	Derivados de indol utiles como inhibidores de cgmp-pde.
TR200200985T2 (tr)	2002-10-21	Pürin türevleri
BR9707136A (pt)	1999-08-31	Derivados morfinóides condesados em heterociclo (ii)
WO1999064401A3 (en)	2003-04-17	Imidazolyl derivatives and their use as somatostatin receptor ligands
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DE69133135D1 (de)	2002-11-21	Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes
BR0015540A (pt)	2002-07-23	Antagonistas do receptor de adenosina e métodos de preparação e uso dos mesmos
IL79264A0 (en)	1986-09-30	Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors
ES2120025T3 (es)	1998-10-16	Derivados de xantina utilizados como antagonistas de receptores de adenosina a1.
DK0984963T3 (da)	2001-06-05	Hidtil ukendte forbindelser
NO911200D0 (no)	1991-03-25	Fremgangsmaate for fremstilling av selektive adenosin-receptor midler.
DE69933671D1 (de)	2006-11-30	Adenosin a1 antagonisten gegen männliche sterilität
BR0010216A (pt)	2002-03-19	Derivados de tio-oxindol
AR247200A1 (es)	1994-11-30	Procedimiento para preparar una nueva clase de agentes medicinales piperidinilicos, utiles como agentes antitromboticos y como antagonistas de los receptores de 5ht2 de serotonina.
ES2196820T3 (es)	2003-12-16	Derivados de pirido(2,3-b)indolizina y aza-analogos de la misma; ligandos especificos de crf 1.