TR200401026T4 - İndolokinazolinonlar - Google Patents

İndolokinazolinonlar

Info

Publication number: TR200401026T4
Authority: TR; Turkey
Prior art keywords: alkyl; cycloalkyl; cycloalkylamino; alkoxycarbonyl; alkylamino
Prior art date: 2000-07-17

Application number

TR2004/01026T

Other languages

English (en)

Turkish (tr)

Inventor

Zimmermann Kaspar

Portmann Robert

Dean Rigel Franklin

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-17

Filing date

2001-07-16

Publication date

2004-07-21

2001-07-16 Application filed by Novartis Ag filed Critical Novartis Ag

2004-07-21 Publication of TR200401026T4 publication Critical patent/TR200401026T4/xx

Links

125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
-1 cyano, tetrazolyl Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Virology (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Molecular Biology (AREA)

TR2004/01026T 2000-07-17 2001-07-16 İndolokinazolinonlar TR200401026T4 (tr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0017508.3A GB0017508D0 (en)	2000-07-17	2000-07-17	Antimicrobials

Publications (1)

Publication Number	Publication Date
TR200401026T4 true TR200401026T4 (tr)	2004-07-21

Family

ID=9895801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR2004/01026T TR200401026T4 (tr)	2000-07-17	2001-07-16	İndolokinazolinonlar

Country Status (18)

Country	Link
US (1)	US6964960B2 (2)
EP (1)	EP1303517B1 (2)
JP (1)	JP3939246B2 (2)
CN (1)	CN1183136C (2)
AR (1)	AR031379A1 (2)
AT (1)	ATE262530T1 (2)
AU (1)	AU2001279754A1 (2)
BR (1)	BR0112521A (2)
CA (1)	CA2415683C (2)
DE (1)	DE60102473T2 (2)
DK (1)	DK1303517T3 (2)
ES (1)	ES2218439T3 (2)
GB (1)	GB0017508D0 (2)
MY (1)	MY133969A (2)
PE (1)	PE20020210A1 (2)
PT (1)	PT1303517E (2)
TR (1)	TR200401026T4 (2)
WO (1)	WO2002006284A1 (2)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6956035B2 (en)	2001-08-31	2005-10-18	Inotek Pharmaceuticals Corporation	Isoquinoline derivatives and methods of use thereof
EP1603567A4 (en)	2003-02-28	2006-10-18	Inotek Pharmaceuticals Corp	TETRACYCLIC BENZAMIDE DERIVATIVES AND METHOD OF USE THEREOF
JP2008531562A (ja)	2005-02-25	2008-08-14	イノテックファーマシューティカルズコーポレイション	四環アミノ化合物および四環カルボキサミド化合物およびこれらの使用法
CN101316592A (zh)	2005-08-24	2008-12-03	伊诺泰克制药公司	茚并异喹啉酮类似物及其用法
EP2069351B1 (en)	2006-06-20	2015-10-28	AbbVie Inc.	Pyrazoloquinazolinones as parp inhibitors
GB0615809D0 (en) *	2006-08-09	2006-09-20	Istituto Di Ricerche D Biolog	Therapeutic compounds
GB0701273D0 (en) *	2007-01-24	2007-02-28	Angeletti P Ist Richerche Bio	New compounds
KR20090115879A (ko)	2007-02-28	2009-11-09	이노텍 파마슈티컬스 코포레이션	인데노이소퀴놀리논 유사체와 이의 이용 방법
CA2686848A1 (en)	2007-05-08	2008-11-20	Schering Corporation	Methods of treatment using intravenous formulations comprising temozolomide
ES2562903T3 (es)	2011-07-13	2016-03-09	Santen Pharmaceutical Co., Ltd	Nuevo compuesto que tiene actividad inhibidora de PARP
CN102766144B (zh) *	2012-07-10	2014-04-23	浙江大学	一种吲哚并[1,2-c]喹唑啉化合物的制备方法
AU2016296905B2 (en)	2015-07-23	2018-07-05	Centre National De La Recherche Scientifique	Use of a combination of Dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
WO2018162439A1 (en)	2017-03-08	2018-09-13	Onxeo	New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
CA3092779A1 (en)	2018-03-13	2019-09-19	Onxeo	A dbait molecule against acquired resistance in the treatment of cancer
KR20210097733A (ko) *	2018-11-30	2021-08-09	메르크 파텐트 게엠베하	전자 디바이스용 화합물
WO2020182779A1 (de) *	2019-03-12	2020-09-17	Merck Patent Gmbh	Materialien für organische elektrolumineszenzvorrichtungen
CN110357892B (zh) *	2019-07-10	2022-06-07	云南大学	四氢嘧啶并[1,2-a]吲哚衍生物及其合成方法与应用
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
CN114195789B (zh) *	2021-12-15	2022-09-09	广东海洋大学	一种无金属参与的多环吲哚衍生物的制备方法
CN121398822A (zh)	2023-06-21	2026-01-23	四方生物科学有限公司	用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3635966A (en)	1969-10-22	1972-01-18	Robins Co Inc A H	6-substituted-indolo(1 2-c)quinazolines
DE2237372C3 (de)	1972-07-29	1981-07-09	Basf Ag, 6700 Ludwigshafen	Heterocyclische Farbstoffe, ihre Herstellung und ihre Verwendung
US5441955A (en) *	1993-11-19	1995-08-15	Pathogenesis Corporation	Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof
GB9404485D0 (en) *	1994-03-09	1994-04-20	Cancer Res Campaign Tech	Benzamide analogues

2000
- 2000-07-17 GB GBGB0017508.3A patent/GB0017508D0/en not_active Ceased
2001
- 2001-07-12 PE PE2001000700A patent/PE20020210A1/es not_active Application Discontinuation
- 2001-07-13 MY MYPI20013343 patent/MY133969A/en unknown
- 2001-07-13 AR ARP010103339A patent/AR031379A1/es not_active Application Discontinuation
- 2001-07-16 AU AU2001279754A patent/AU2001279754A1/en not_active Abandoned
- 2001-07-16 DE DE60102473T patent/DE60102473T2/de not_active Expired - Lifetime
- 2001-07-16 CA CA002415683A patent/CA2415683C/en not_active Expired - Fee Related
- 2001-07-16 ES ES01957972T patent/ES2218439T3/es not_active Expired - Lifetime
- 2001-07-16 DK DK01957972T patent/DK1303517T3/da active
- 2001-07-16 EP EP01957972A patent/EP1303517B1/en not_active Expired - Lifetime
- 2001-07-16 WO PCT/EP2001/008192 patent/WO2002006284A1/en not_active Ceased
- 2001-07-16 AT AT01957972T patent/ATE262530T1/de not_active IP Right Cessation
- 2001-07-16 CN CNB018126995A patent/CN1183136C/zh not_active Expired - Fee Related
- 2001-07-16 BR BR0112521-4A patent/BR0112521A/pt not_active Application Discontinuation
- 2001-07-16 US US10/333,186 patent/US6964960B2/en not_active Expired - Fee Related
- 2001-07-16 JP JP2002512186A patent/JP3939246B2/ja not_active Expired - Fee Related
- 2001-07-16 PT PT01957972T patent/PT1303517E/pt unknown
- 2001-07-16 TR TR2004/01026T patent/TR200401026T4/xx unknown

Also Published As

Publication number	Publication date
CN1441803A (zh)	2003-09-10
WO2002006284A1 (en)	2002-01-24
MY133969A (en)	2007-11-30
DE60102473D1 (de)	2004-04-29
HK1056872A1 (en)	2004-03-05
AR031379A1 (es)	2003-09-24
BR0112521A (pt)	2003-07-01
CA2415683A1 (en)	2002-01-24
JP2004504323A (ja)	2004-02-12
AU2001279754A1 (en)	2002-01-30
DE60102473T2 (de)	2005-02-03
JP3939246B2 (ja)	2007-07-04
PE20020210A1 (es)	2002-04-04
GB0017508D0 (en)	2000-08-30
CN1183136C (zh)	2005-01-05
HK1055426A1 (en)	2004-01-09
ES2218439T3 (es)	2004-11-16
CA2415683C (en)	2009-12-29
US6964960B2 (en)	2005-11-15
DK1303517T3 (da)	2004-06-21
EP1303517B1 (en)	2004-03-24
ATE262530T1 (de)	2004-04-15
PT1303517E (pt)	2004-07-30
US20030199502A1 (en)	2003-10-23
EP1303517A1 (en)	2003-04-23

Publication	Publication Date	Title
TR200401026T4 (tr)	2004-07-21	İndolokinazolinonlar
TW200700393A (en)	2007-01-01	Novel cis-2,4,5-triaryl-imidazolines
TR199901847T2 (xx)	2000-06-21	Fosfolipaz az inhibit�r aktivitesi olan pirrolidin t�revleri.
TW200508177A (en)	2005-03-01	Quaternary ammonium salt, electrolyte and electrochemical device
TW200503621A (en)	2005-02-01	Pyrimidine compound and pests controlling composition containing the same
TR199902923T2 (xx)	2000-11-21	Yumu�ak kas h�cresi �o�almas� inhibit�rleri olarak (imidazol-5-il)metil-2-kuinolinon t�revleri.
PA8509301A1 (es)	2002-12-11	Inhibidores no peptidicos de la union celular dependiente de vla-4 utiles en enfermedades inflamatorias, autoinmunes y respiratorias
AP1555A (en)	2006-01-18	Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance
PL338339A1 (en)	2000-10-23	Novel derivatives of tetrazole
IN2012DN02609A (2)	2015-09-04
TR200200360T2 (tr)	2002-06-21	Antibakteriyel aktif maddeler.
DE60331344D1 (en)	2010-04-01	Biguanidderivate
EP1741714A4 (en)	2007-09-12	HETEROCYLIC COMPOUND AND ANTI-MALIGNANT TUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT
CO5611109A2 (es)	2006-02-28	Combinaciones de un ligando alfa-2-delta con un inhibidor selectivo de la ciclooxigenasa-2
MXPA03003942A (es)	2004-05-24	Compuestos bis-heterociclicos con actividad antitumoral y quimiosensibilizante.
ES8603809A1 (es)	1986-01-01	Un procedimiento para preparar un derivado de fluoralilamina
AU4513693A (en)	1994-02-14	Thiazoline derivative
IT1289979B1 (it)	1998-10-19	5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari
TW200514507A (en)	2005-05-01	Active compound combinations having insecticidal and acaricidal properties
UA93529C2 (ru)	2011-02-25	Соли и смеси 9-оксоакридин-10-уксусной кислоты c 1-алкиламино-1-дезоксиполиолами
TW330203B (en)	1998-04-21	1-Cycloalkenyltetrazolinones
DE60100539D1 (en)	2003-09-04	Tosylprolin-derivate als thymidylat-synthase inhibitoren
AR044822A1 (es)	2005-10-05	Derivados de fenoxifenilhidrazina con accion fungicida
TW356471B (en)	1999-04-21	Novel carbocyclic nucleoside agents useful as selective inhibitor of proinflammatory cytokines
TR199903249T2 (xx)	2000-09-21	�l-5 inhibit�rleri olarak 6-Azaurasil t�revleri.