TR200807263A2 - IgG'nin FcRn'ye bağlanmasını bloke eden peptidler - Google Patents
IgG'nin FcRn'ye bağlanmasını bloke eden peptidlerInfo
- Publication number
- TR200807263A2 TR200807263A2 TR200807263A TR200807263A TR200807263A2 TR 200807263 A2 TR200807263 A2 TR 200807263A2 TR 200807263 A TR200807263 A TR 200807263A TR 200807263 A TR200807263 A TR 200807263A TR 200807263 A2 TR200807263 A2 TR 200807263A2
- Authority
- TR
- Turkey
- Prior art keywords
- fcrn
- peptides
- igg binding
- methods
- blocking igg
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
Abstract
Bu buluş insan FcRn'sine bağlanan ve bir IgG'nin Fc bölümünün FcRn'ye bağlanmasını inhibe eden, böylece serum IgG seviyelerini modüle eden peptidlerle ilgilidir. Açıklanan bileşimler ve usuller örneğin oto-bağışıklık hastalıklarının ve enflamatuvar hastalıkların tedavisinde kullanılabilir. Buluş ayrıca buluşa göre olan peptidleri kullanma ve usulleri ve hazırlama usulleri ile ilgilidir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77485306P | 2006-02-17 | 2006-02-17 | |
| US80563406P | 2006-06-23 | 2006-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200807263A2 true TR200807263A2 (tr) | 2009-03-23 |
Family
ID=38291305
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR200807263A TR200807263A2 (tr) | 2006-02-17 | 2007-02-16 | IgG'nin FcRn'ye bağlanmasını bloke eden peptidler |
| TR200807263T TR200807263T1 (tr) | 2006-02-17 | 2007-02-16 | IgG'nin FcRn'ye bağlanmasını bloke eden peptidler |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR200807263T TR200807263T1 (tr) | 2006-02-17 | 2007-02-16 | IgG'nin FcRn'ye bağlanmasını bloke eden peptidler |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8101186B2 (tr) |
| EP (1) | EP1991572A2 (tr) |
| JP (1) | JP2009527499A (tr) |
| KR (1) | KR20080106432A (tr) |
| AU (1) | AU2007217042A1 (tr) |
| BR (1) | BRPI0707920A2 (tr) |
| CA (1) | CA2638867A1 (tr) |
| EA (1) | EA200870274A1 (tr) |
| IL (1) | IL193101A0 (tr) |
| ME (1) | MEP7408A (tr) |
| MX (1) | MX2008010327A (tr) |
| NO (1) | NO20083712L (tr) |
| RS (1) | RS20080362A (tr) |
| TR (2) | TR200807263A2 (tr) |
| TW (1) | TW200745163A (tr) |
| WO (1) | WO2007098420A2 (tr) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2449918B1 (de) * | 2003-04-22 | 2013-07-10 | Trisa Holding AG | Bürstenkopf für eine Elektrozahnbürste |
| TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| MX2010001363A (es) * | 2007-08-09 | 2010-03-09 | Syntonix Pharmaceuticals Inc | Peptidos inmunomoduladores. |
| WO2010014909A1 (en) * | 2008-08-01 | 2010-02-04 | Syntonix Pharmaceuticals, Inc. | Immunomodulatory peptides |
| WO2010141329A1 (en) | 2009-06-01 | 2010-12-09 | Medimmune, Llc | Molecules with extended half-lives and uses thereof |
| JP2013511554A (ja) * | 2009-11-23 | 2013-04-04 | パラティン テクノロジーズ,インコーポレイテッド | メラノコルチン−1受容体特異的線状ペプチド |
| RS67768B1 (sr) | 2010-11-30 | 2026-03-31 | Chugai Pharmaceutical Co Ltd | Terapijski agens koji indukuje citotoksičnost |
| CN104011207B (zh) | 2011-10-31 | 2018-09-18 | 中外制药株式会社 | 控制了重链与轻链的缔合的抗原结合分子 |
| SG10201805584YA (en) | 2012-02-24 | 2018-08-30 | Chugai Pharmaceutical Co Ltd | ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB |
| GB201208370D0 (en) * | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| ES2660912T3 (es) | 2013-03-15 | 2018-03-26 | Affibody Ab | Nuevos polipéptidos |
| WO2014205072A2 (en) | 2013-06-18 | 2014-12-24 | The Brigham And Women's Hospital, Inc. | FC RECEPTOR (FcRn) BINDING PEPTIDES AND USES THEREOF |
| GB201320066D0 (en) | 2013-11-13 | 2013-12-25 | Ucb Pharma Sa | Biological products |
| CN112142843B (zh) | 2013-12-24 | 2024-10-18 | 阿尔金克斯有限公司 | FcRn拮抗剂及使用方法 |
| CN118440206A (zh) | 2014-04-07 | 2024-08-06 | 中外制药株式会社 | 免疫活化抗原结合分子 |
| EP3144388B1 (en) | 2014-05-13 | 2020-07-01 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirecting antigen-binding molecule for cells having immunosuppression function |
| ES2743809T3 (es) | 2014-07-31 | 2020-02-20 | Amgen Res Munich Gmbh | Constructos de anticuerpo monocatenarios biespecificos específicos de especies cruzadas optimizados |
| SI3193930T1 (sl) | 2014-09-17 | 2019-10-30 | Affibody Ab | Novi polipeptidi |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| JP6781712B2 (ja) * | 2014-12-22 | 2020-11-04 | コンシッリョ ナツィオナーレ デッレ リチェルケConsiglio Nazionale Delle Ricerche | 心臓へ治療用/診断用化合物を送達するための生成物 |
| MY188761A (en) | 2015-03-09 | 2021-12-29 | Argenx Bvba | Method of reducing serum levels of fc-containing agents using fcrn antagonists |
| ES2945313T3 (es) | 2015-04-17 | 2023-06-30 | Amgen Res Munich Gmbh | Construcciones de anticuerpos biespecificos para CDH3 y CD3 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
| TWI717375B (zh) | 2015-07-31 | 2021-02-01 | 德商安美基研究(慕尼黑)公司 | Cd70及cd3抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI793062B (zh) | 2015-07-31 | 2023-02-21 | 德商安美基研究(慕尼黑)公司 | Dll3及cd3抗體構築體 |
| US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
| WO2017086419A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| CN108368166B (zh) | 2015-12-28 | 2023-03-28 | 中外制药株式会社 | 提高含fc区多肽纯化效率的方法 |
| EP3411404B1 (en) | 2016-02-03 | 2022-11-09 | Amgen Research (Munich) GmbH | Psma and cd3 bispecific t cell engaging antibody constructs |
| US11072666B2 (en) | 2016-03-14 | 2021-07-27 | Chugai Seiyaku Kabushiki Kaisha | Cell injury inducing therapeutic drug for use in cancer therapy |
| CN106771251B (zh) * | 2017-01-10 | 2019-03-15 | 柏荣诊断产品(上海)有限公司 | 兼顾特异性和灵敏度的免疫球蛋白G4亚型IgG4检测试剂盒 |
| DK3661954T3 (da) | 2017-08-03 | 2022-04-19 | Amgen Inc | Interleukin-21-muteiner og fremgangsmåder til behandling |
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| CN114126647A (zh) | 2019-06-07 | 2022-03-01 | 阿尔金克斯有限公司 | 适用于皮下施用的FcRn抑制剂的药物制剂 |
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| EP3819007B1 (en) | 2019-11-11 | 2024-07-10 | Amgen Research (Munich) GmbH | Dosing regimen for anti-bcma agents |
| EP4085144A4 (en) | 2019-12-19 | 2024-03-27 | The Trustees of The University of Pennsylvania | COMPOSITIONS FOR THE TREATMENT OF FRIEDREICH AAXIA |
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-
2007
- 2007-02-15 TW TW096105711A patent/TW200745163A/zh unknown
- 2007-02-16 US US11/676,148 patent/US8101186B2/en not_active Expired - Fee Related
- 2007-02-16 ME MEP7408 patent/MEP7408A/xx unknown
- 2007-02-16 WO PCT/US2007/062349 patent/WO2007098420A2/en not_active Ceased
- 2007-02-16 JP JP2008555527A patent/JP2009527499A/ja not_active Withdrawn
- 2007-02-16 KR KR20087022493A patent/KR20080106432A/ko not_active Withdrawn
- 2007-02-16 BR BRPI0707920-6A patent/BRPI0707920A2/pt not_active IP Right Cessation
- 2007-02-16 CA CA 2638867 patent/CA2638867A1/en not_active Abandoned
- 2007-02-16 TR TR200807263A patent/TR200807263A2/tr unknown
- 2007-02-16 AU AU2007217042A patent/AU2007217042A1/en not_active Abandoned
- 2007-02-16 RS RSP20080362 patent/RS20080362A/sr unknown
- 2007-02-16 EA EA200870274A patent/EA200870274A1/ru unknown
- 2007-02-16 MX MX2008010327A patent/MX2008010327A/es not_active Application Discontinuation
- 2007-02-16 EP EP07757148A patent/EP1991572A2/en not_active Withdrawn
- 2007-02-16 TR TR200807263T patent/TR200807263T1/tr unknown
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2008
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- 2008-08-28 NO NO20083712A patent/NO20083712L/no not_active Application Discontinuation
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2009
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| WO2007098420A8 (en) | 2009-09-11 |
| IL193101A0 (en) | 2009-02-11 |
| KR20080106432A (ko) | 2008-12-05 |
| TR200807263T1 (tr) | 2009-02-23 |
| MX2008010327A (es) | 2009-01-26 |
| TW200745163A (en) | 2007-12-16 |
| JP2009527499A (ja) | 2009-07-30 |
| EA200870274A1 (ru) | 2009-02-27 |
| US20110059889A1 (en) | 2011-03-10 |
| US9012603B2 (en) | 2015-04-21 |
| AU2007217042A2 (en) | 2009-04-23 |
| CA2638867A1 (en) | 2007-08-30 |
| RS20080362A (sr) | 2009-07-15 |
| MEP7408A (xx) | 2010-02-10 |
| WO2007098420A3 (en) | 2008-01-17 |
| US20070254831A1 (en) | 2007-11-01 |
| EP1991572A2 (en) | 2008-11-19 |
| US8101186B2 (en) | 2012-01-24 |
| WO2007098420A2 (en) | 2007-08-30 |
| BRPI0707920A2 (pt) | 2011-05-17 |
| AU2007217042A1 (en) | 2007-08-30 |
| NO20083712L (no) | 2008-10-20 |
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