TR201713643A2 - COASERVAT PRODUCTION METHOD WITH THE COASERVATION METHOD AND THE COASERVATS OBTAINED BY THIS PRODUCTION METHOD AND THEIR USE OF THESE AS TISSUE SCAFFOLD - Google Patents

COASERVAT PRODUCTION METHOD WITH THE COASERVATION METHOD AND THE COASERVATS OBTAINED BY THIS PRODUCTION METHOD AND THEIR USE OF THESE AS TISSUE SCAFFOLD Download PDF

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Publication number
TR201713643A2
TR201713643A2 TR2017/13643A TR201713643A TR201713643A2 TR 201713643 A2 TR201713643 A2 TR 201713643A2 TR 2017/13643 A TR2017/13643 A TR 2017/13643A TR 201713643 A TR201713643 A TR 201713643A TR 201713643 A2 TR201713643 A2 TR 201713643A2
Authority
TR
Turkey
Prior art keywords
production method
production
tissue scaffold
coaservats
coaservation
Prior art date
Application number
TR2017/13643A
Other languages
Turkish (tr)
Inventor
Torun Köse Gamze
Başak Kayitmazer Büyükokutan Ayşe
Karabiyik Acar Özge
Original Assignee
Univ Yeditepe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yeditepe filed Critical Univ Yeditepe
Priority to TR2017/13643A priority Critical patent/TR201713643A2/en
Priority to PCT/TR2018/050489 priority patent/WO2019054971A2/en
Publication of TR201713643A2 publication Critical patent/TR201713643A2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Bu buluş, kitosan (KT) ve hiyalüronik asit (HA) polimerleri ile kompleks koaservasyon tekniği kullanılarak doku mühendisliğine yönelik hücre enkapsüle edebilme (makro-enkapsülasyon) kapasitesine sahip doku iskelesi üretimi ile ilgilidir. Buluşun amacı, biyobozunur, biyouyumlu ve elastik özelliklere sahip, tamamen doğal polimerlerden oluşan ve hiçbir çapraz bağlayıcı veya organik solvent kullanılmadığı için toksik etkisi bulunmayan ve hücre yaşamasına, çoğalmasına ve eğer ki kök hücre kullanılıyor ise arzu edilen hücre tipine özelleşmesine elverişli bir ortam sağlayacak gözenekli yüzeye sahip olan doku iskelelerinin oluşturulmasını sağlayan bir üretim gerçekleştirmektir (Şekil 7).The present invention relates to the production of tissue scaffold capable of cell encapsulation (macro-encapsulation) for tissue engineering using the complex coacervation technique with chitosan (KT) and hyaluronic acid (HA) polymers. The aim of the invention is to provide a porous surface that is biodegradable, biocompatible and has elastic properties, consists entirely of natural polymers and has no toxic effects since no crosslinker or organic solvent is used, and that will provide an environment conducive to cell survival, proliferation and, if stem cells, to be tailored to the desired cell type. It is to realize a production that enables the creation of tissue scaffolds that have a

TR2017/13643A 2017-09-15 2017-09-15 COASERVAT PRODUCTION METHOD WITH THE COASERVATION METHOD AND THE COASERVATS OBTAINED BY THIS PRODUCTION METHOD AND THEIR USE OF THESE AS TISSUE SCAFFOLD TR201713643A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TR2017/13643A TR201713643A2 (en) 2017-09-15 2017-09-15 COASERVAT PRODUCTION METHOD WITH THE COASERVATION METHOD AND THE COASERVATS OBTAINED BY THIS PRODUCTION METHOD AND THEIR USE OF THESE AS TISSUE SCAFFOLD
PCT/TR2018/050489 WO2019054971A2 (en) 2017-09-15 2018-09-14 Coacervate production method using coacervation and the usage of coacervates obtained by this method as tissue scaffold

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2017/13643A TR201713643A2 (en) 2017-09-15 2017-09-15 COASERVAT PRODUCTION METHOD WITH THE COASERVATION METHOD AND THE COASERVATS OBTAINED BY THIS PRODUCTION METHOD AND THEIR USE OF THESE AS TISSUE SCAFFOLD

Publications (1)

Publication Number Publication Date
TR201713643A2 true TR201713643A2 (en) 2019-03-21

Family

ID=65723555

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2017/13643A TR201713643A2 (en) 2017-09-15 2017-09-15 COASERVAT PRODUCTION METHOD WITH THE COASERVATION METHOD AND THE COASERVATS OBTAINED BY THIS PRODUCTION METHOD AND THEIR USE OF THESE AS TISSUE SCAFFOLD

Country Status (2)

Country Link
TR (1) TR201713643A2 (en)
WO (1) WO2019054971A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114920966B (en) * 2022-06-20 2023-06-20 湖北工业大学 A tissue-adhesive antibacterial hydrogel film and its preparation method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005034852A2 (en) * 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
US7704714B2 (en) * 2004-07-26 2010-04-27 Agency For Science, Technology & Research Encapsulation of cells in biologic compatible scaffolds by coacervation of charged polymers

Also Published As

Publication number Publication date
WO2019054971A2 (en) 2019-03-21
WO2019054971A3 (en) 2019-06-13

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