TR201722353A2 - Dabi̇gatran eteksi̇lat i̇çeren oral uygulama i̇çi̇n farmasöti̇k formülasyon - Google Patents
Dabi̇gatran eteksi̇lat i̇çeren oral uygulama i̇çi̇n farmasöti̇k formülasyonInfo
- Publication number
- TR201722353A2 TR201722353A2 TR2017/22353A TR201722353A TR201722353A2 TR 201722353 A2 TR201722353 A2 TR 201722353A2 TR 2017/22353 A TR2017/22353 A TR 2017/22353A TR 201722353 A TR201722353 A TR 201722353A TR 201722353 A2 TR201722353 A2 TR 201722353A2
- Authority
- TR
- Turkey
- Prior art keywords
- pharmaceutical formulation
- dabigatran
- skirt
- oral application
- dabigatran etexilate
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- YBSJFWOBGCMAKL-UHFFFAOYSA-N dabigatran Chemical compound N=1C2=CC(C(=O)N(CCC(O)=O)C=3N=CC=CC=3)=CC=C2N(C)C=1CNC1=CC=C(C(N)=N)C=C1 YBSJFWOBGCMAKL-UHFFFAOYSA-N 0.000 title 1
- 229960003850 dabigatran Drugs 0.000 title 1
- 229960000288 dabigatran etexilate Drugs 0.000 abstract 2
- KSGXQBZTULBEEQ-UHFFFAOYSA-N dabigatran etexilate Chemical compound C1=CC(C(N)=NC(=O)OCCCCCC)=CC=C1NCC1=NC2=CC(C(=O)N(CCC(=O)OCC)C=3N=CC=CC=3)=CC=C2N1C KSGXQBZTULBEEQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Mevcut buluş, dabigatran eteksilat serbest bazını veya dabigatran eteksilatın farmasötik olarak kabul edilebilir tuzlarını ve en az iki tür partikül içeren oral uygulamaya yönelik farmasötik formülasyon ile ilgilidir.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2017/22353A TR201722353A2 (tr) | 2017-12-27 | 2017-12-27 | Dabi̇gatran eteksi̇lat i̇çeren oral uygulama i̇çi̇n farmasöti̇k formülasyon |
| PCT/TR2018/050903 WO2019132840A1 (en) | 2017-12-27 | 2018-12-26 | A pharmaceutical formulation for oral administration comprising dabigatran etexilate |
| EP18877294.1A EP3731823A1 (en) | 2017-12-27 | 2018-12-26 | A pharmaceutical formulation for oral administration comprising dabigatran etexilate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2017/22353A TR201722353A2 (tr) | 2017-12-27 | 2017-12-27 | Dabi̇gatran eteksi̇lat i̇çeren oral uygulama i̇çi̇n farmasöti̇k formülasyon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201722353A2 true TR201722353A2 (tr) | 2019-07-22 |
Family
ID=66476808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2017/22353A TR201722353A2 (tr) | 2017-12-27 | 2017-12-27 | Dabi̇gatran eteksi̇lat i̇çeren oral uygulama i̇çi̇n farmasöti̇k formülasyon |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3731823A1 (tr) |
| TR (1) | TR201722353A2 (tr) |
| WO (1) | WO2019132840A1 (tr) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101005716B1 (ko) | 2002-03-07 | 2011-01-05 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | ３－［（２－｛［４－（헥실옥시카보닐아미노－이미노-메틸）－페닐아미노］－메틸｝－１－메틸－１ｈ－벤즈이미다졸－５－카보닐）－피리딘－２－일－아미노］ 프로피온산 에틸에스테르의 경구 투여 형태 |
| ES2895918T3 (es) * | 2012-02-21 | 2022-02-23 | Towa Pharmaceutical Europe S L | Composiciones farmacéuticas orales de dabigatrán etexilato |
| CN104095830A (zh) * | 2014-05-22 | 2014-10-15 | 万特制药(海南)有限公司 | 一种甲磺酸盐达比加群酯胶囊的制备方法 |
| KR20170070635A (ko) * | 2015-12-14 | 2017-06-22 | 한미약품 주식회사 | 다비가트란 이텍실레이트를 함유하는 복합 캡슐제 |
| WO2017111637A1 (en) * | 2015-12-23 | 2017-06-29 | Zaklady Farmaceutyczne Polpharma Sa | Pharmaceutical composition comprising dabigatran or a pharmaceutically acceptable salt thereof |
-
2017
- 2017-12-27 TR TR2017/22353A patent/TR201722353A2/tr unknown
-
2018
- 2018-12-26 EP EP18877294.1A patent/EP3731823A1/en not_active Withdrawn
- 2018-12-26 WO PCT/TR2018/050903 patent/WO2019132840A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019132840A1 (en) | 2019-07-04 |
| EP3731823A1 (en) | 2020-11-04 |
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