TR201722603A2 - Metformi̇n ve si̇tagli̇pti̇n i̇çeren sicak eri̇tme ekstrüzyonu i̇le gerçekleşti̇ri̇len tablet formülasyonlari - Google Patents

Metformi̇n ve si̇tagli̇pti̇n i̇çeren sicak eri̇tme ekstrüzyonu i̇le gerçekleşti̇ri̇len tablet formülasyonlari Download PDF

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Publication number
TR201722603A2
TR201722603A2 TR2017/22603A TR201722603A TR201722603A2 TR 201722603 A2 TR201722603 A2 TR 201722603A2 TR 2017/22603 A TR2017/22603 A TR 2017/22603A TR 201722603 A TR201722603 A TR 201722603A TR 201722603 A2 TR201722603 A2 TR 201722603A2
Authority
TR
Turkey
Prior art keywords
sitagliptin
metformin
hot
melt extrusion
processed
Prior art date
Application number
TR2017/22603A
Other languages
English (en)
Inventor
Ataman Seval
Zengi̇ner Si̇bel
Türkyilmaz Ali̇
Original Assignee
Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi filed Critical Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority to TR2017/22603A priority Critical patent/TR201722603A2/tr
Priority to PCT/TR2018/050918 priority patent/WO2019240699A2/en
Priority to EP18918420.3A priority patent/EP3731828A2/en
Publication of TR201722603A2 publication Critical patent/TR201722603A2/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mevcut buluş, metformin ve sitagliptin ve en az bir farmasötik olarak kabul edilebilir eksipiyan içeren farmasötik tablet formülasyonları ile ilgilidir. Ayrıca mevcut buluş, söz konusu kompozisyonu hazırlamaya yönelik bir sıcak eritme ekstrüzyon yöntemi de sunmaktadır.
TR2017/22603A 2017-12-28 2017-12-28 Metformi̇n ve si̇tagli̇pti̇n i̇çeren sicak eri̇tme ekstrüzyonu i̇le gerçekleşti̇ri̇len tablet formülasyonlari TR201722603A2 (tr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
TR2017/22603A TR201722603A2 (tr) 2017-12-28 2017-12-28 Metformi̇n ve si̇tagli̇pti̇n i̇çeren sicak eri̇tme ekstrüzyonu i̇le gerçekleşti̇ri̇len tablet formülasyonlari
PCT/TR2018/050918 WO2019240699A2 (en) 2017-12-28 2018-12-27 Tablet formulations comprising metformin and sitagliptin processed with hot-melt extrusion
EP18918420.3A EP3731828A2 (en) 2017-12-28 2018-12-27 Tablet formulations comprising metformin and sitagliptin processed with hot-melt extrusion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2017/22603A TR201722603A2 (tr) 2017-12-28 2017-12-28 Metformi̇n ve si̇tagli̇pti̇n i̇çeren sicak eri̇tme ekstrüzyonu i̇le gerçekleşti̇ri̇len tablet formülasyonlari

Publications (1)

Publication Number Publication Date
TR201722603A2 true TR201722603A2 (tr) 2019-07-22

Family

ID=67900715

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2017/22603A TR201722603A2 (tr) 2017-12-28 2017-12-28 Metformi̇n ve si̇tagli̇pti̇n i̇çeren sicak eri̇tme ekstrüzyonu i̇le gerçekleşti̇ri̇len tablet formülasyonlari

Country Status (3)

Country Link
EP (1) EP3731828A2 (tr)
TR (1) TR201722603A2 (tr)
WO (1) WO2019240699A2 (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020013777A2 (en) 2018-04-27 2020-01-16 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Tablet formulations comprising metformin and sitagliptin
CN113081973A (zh) * 2021-05-07 2021-07-09 郑州泰丰制药有限公司 一种盐酸二甲双胍组合物及其制备方法
CN115715768B (zh) * 2022-11-24 2024-07-05 浙江昂利泰制药有限公司 一种小型西格列汀-二甲双胍缓释片及其制备方法
EP4563144A1 (en) * 2023-11-30 2025-06-04 Sanovel Ilac Sanayi ve Ticaret A.S. A tablet comprising an extended-release formulation for metformin and immediate release formulation comprising sitagliptin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
JO2625B1 (en) 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salts of dipeptidyl betidase inhibitor 4
BRPI0616694B8 (pt) * 2005-09-29 2021-05-25 Novartis Ag processo para preparar comprimido farmacêutico com 80 e 96% em peso com base no peso seco de vildagliptina e metformina ou seus sais farmaceuticamente aceitáveis
US8414921B2 (en) 2005-12-16 2013-04-09 Merck Sharp & Dohme Corp. Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with metformin
US20080064701A1 (en) * 2007-04-24 2008-03-13 Ramesh Sesha Anti-diabetic combinations
MX2010009731A (es) * 2008-03-04 2010-09-30 Merck Sharp & Dohme Composiciones farmaceuticas de una combinacion de metformina y un inhibidor de dipeptidil peptidasa-iv.
EP2295083A1 (de) 2009-09-15 2011-03-16 Ratiopharm GmbH Pharmazeutische Zusammensetzung mit den Wirkstoffen Metformin und Sitagliptin oder Vildagliptin
EP3813801A4 (en) * 2018-05-25 2022-03-30 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi OSMOTIC EXTENDED RELEASE TABLET DOSAGE FORM WITH METFORMIN AND SITAGLIPTIN

Also Published As

Publication number Publication date
EP3731828A2 (en) 2020-11-04
WO2019240699A2 (en) 2019-12-19
WO2019240699A3 (en) 2020-02-13

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