TR201809231T4 - Hiyalüronidaz ve bir tümör-güdümlü taksan ile kombinasyon terapisi. - Google Patents
Hiyalüronidaz ve bir tümör-güdümlü taksan ile kombinasyon terapisi. Download PDFInfo
- Publication number
- TR201809231T4 TR201809231T4 TR2018/09231T TR201809231T TR201809231T4 TR 201809231 T4 TR201809231 T4 TR 201809231T4 TR 2018/09231 T TR2018/09231 T TR 2018/09231T TR 201809231 T TR201809231 T TR 201809231T TR 201809231 T4 TR201809231 T4 TR 201809231T4
- Authority
- TR
- Turkey
- Prior art keywords
- combination therapy
- tumor
- taxane
- driven
- hyaluronidase
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 238000002648 combination therapy Methods 0.000 title abstract 3
- 229940123237 Taxane Drugs 0.000 title abstract 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
- 108010003272 Hyaluronate lyase Proteins 0.000 title 1
- 102000001974 Hyaluronidases Human genes 0.000 title 1
- 229960002773 hyaluronidase Drugs 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012829 chemotherapy agent Substances 0.000 abstract 1
- 229940099552 hyaluronan Drugs 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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Abstract
Burada, bir anti-hiyalüronan madde, örneğin bir polimere konjüge edilmiş hiyalüronan-parçalayan enzim ve bir tümör-güdümlü taksan ve isteğe bağlı olarak bir başka kemoterapi maddesi, örneğin bir nükleosid analoğu içeren kombinasyon terapisi sağlanmaktadır. Kombinasyon terapisi kanserlerin ve özellikle katı tümör kanserlerinin tedavisine yönelik usullerde kullanılabilir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261686429P | 2012-04-04 | 2012-04-04 | |
| US201261714719P | 2012-10-16 | 2012-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201809231T4 true TR201809231T4 (tr) | 2018-07-23 |
Family
ID=48050937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2018/09231T TR201809231T4 (tr) | 2012-04-04 | 2013-03-15 | Hiyalüronidaz ve bir tümör-güdümlü taksan ile kombinasyon terapisi. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9913822B2 (tr) |
| EP (1) | EP2833905B1 (tr) |
| JP (4) | JP6042527B2 (tr) |
| KR (2) | KR101809858B1 (tr) |
| CN (2) | CN108686203A (tr) |
| AU (1) | AU2013243873B2 (tr) |
| BR (1) | BR112014024848A2 (tr) |
| CA (3) | CA2869460C (tr) |
| CY (1) | CY1120523T1 (tr) |
| DK (1) | DK2833905T3 (tr) |
| EA (1) | EA031986B1 (tr) |
| ES (1) | ES2673093T3 (tr) |
| HR (1) | HRP20181187T1 (tr) |
| HU (1) | HUE038744T2 (tr) |
| IL (2) | IL234703B (tr) |
| LT (1) | LT2833905T (tr) |
| MX (2) | MX360092B (tr) |
| NZ (1) | NZ700073A (tr) |
| PL (1) | PL2833905T3 (tr) |
| PT (1) | PT2833905T (tr) |
| RS (1) | RS57449B1 (tr) |
| SG (1) | SG11201406340QA (tr) |
| SI (1) | SI2833905T1 (tr) |
| SM (1) | SMT201800366T1 (tr) |
| TR (1) | TR201809231T4 (tr) |
| WO (1) | WO2013151774A1 (tr) |
| ZA (1) | ZA201406969B (tr) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| NZ542873A (en) | 2003-03-05 | 2008-07-31 | Halozyme Inc | Soluble, neutral-active hyaluronidase activity glycoprotein (sHASEGP) that is produced with high yield in a mammalian expression system by introducing nucleic acids that lack a narrow region encoding amino acids in the carboxy terminus of the human PH20 cDNA |
| WO2015081096A2 (en) * | 2013-11-26 | 2015-06-04 | The Brigham And Women's Hospital, Inc. | Receptor-targeted nanoparticles for enhanced transcytosis mediated drug delivery |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| KR20130116386A (ko) | 2008-04-14 | 2013-10-23 | 할로자임, 아이엔씨 | 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| WO2010043049A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
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